Okuda Shinichi 奥田真一

… Alternative Names

OKUDA Shinichi 奥田真一

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Researcher Number	90530212
Other IDs
Affiliation (Current)	2025: 山口大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 山口大学, 医学部附属病院, 助教 2015: 山口大学, 大学院医学系研究科, 助教 2014 – 2015: 山口大学, 医学部附属病院, 助教 2011 – 2012: 山口大学, 医学部附属病院, 助教 2009 – 2010: Yamaguchi University, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Basic Section 53020:Cardiology-related Except Principal Investigator Cardiovascular medicine
Keywords	Principal Investigator リアノジン受容体 / 肥大型心筋症 / カルモジュリン依存性プロテインキナーゼII / カルモジュリン / カルシウム依存性カルモジュリンキナーゼ / 致死性不整脈 / ドメイン連関 / カルシウムハンドリング / 心室性不整脈 / カルモジュリンキナーゼ / 興奮収縮連関 / リアンジン受容体 / カテコラミン誘発性心室頻拍 … More Except Principal Investigator … More カルシウムハンドリング / カルシウムリーク / リアノジン受容体 / 肥大型心筋症 Less

Development of novel molecular targeted therapy by stabilizing cardiac ryanodine receptors in hypertrophic cardiomyopathyPrincipal Investigator
- Principal Investigator
  
  OKUDA Shinichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
New molecular targeting therapy for regression of cardiac hypertrophy by inhibiting abnormal Ca2+ leak through RyR2 in hypertrophic cardiomyopathy
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
The therapeutic approach of inductive lethal arrhythmia by inhibiting Ca2+ leak through the cardiac ryanodine receptor in hypertrophic cardiomyopathyPrincipal Investigator
- Principal Investigator
  
  OKUDA Shinichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Correction of the defective inter-domain interaction of cardiac ryanodine receptor prevents catecholaminergic polymorphic ventricular tachycardiaPrincipal Investigator
- Principal Investigator
  
  OKUDA Shinichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University

All 2021 2020 2019 2018 2016 2015 2014 2013 2012 2011 2010 2009

All Journal Article Presentation Book

[Book] 心不全における心筋の興奮収縮連関とカルシウム；クリニカルカルシウム2013
- Author(s)
  奥田真一
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-23790856
[Book] シグナル伝達系からみた心不全の機序と治療戦略；Cardioligy Frontier2011
- Author(s)
  奥田真一、矢野雅文
- Total Pages
  8
- Publisher
  ライフサイエンス
- Data Source
  KAKENHI-PROJECT-23790856
[Book] シグナル伝達系からみた心不全の機序と治療戦略2011
- Author(s)
  奥田真一、矢野雅文
- Publisher
  Cardioligy Frontier
- Data Source
  KAKENHI-PROJECT-21790726
[Book] 慢性心不全の治療2011
- Author(s)
  奥田真一、矢野雅文
- Publisher
  Medicament News
- Data Source
  KAKENHI-PROJECT-21790726
[Book] 慢性心不全の治療；Medicament News2011
- Author(s)
  奥田真一、矢野雅文
- Total Pages
  3
- Publisher
  ライフサイエンス
- Data Source
  KAKENHI-PROJECT-23790856
[Book] シグナル伝達系からみた心不全の機序と治療戦略2011
- Author(s)
  奥田真一、矢野雅文
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23790856
[Book] Cardioligy Frontier(シグナル伝達系からみた心不全の機序と治療戦略)2011
- Author(s)
  奥田真一
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21790726
[Book] Medicament News(慢性心不全の治療)2011
- Author(s)
  奥田真一
- Total Pages
  3
- Publisher
  ライフサイエンス
- Data Source
  KAKENHI-PROJECT-21790726
[Book] 慢性心不全治療ガイドライン；冠動脈疾患　下巻2011
- Author(s)
  奥田真一、矢野雅文
- Total Pages
  10
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-23790856
[Book] 慢性心不全の治療2011
- Author(s)
  奥田真一、矢野雅文
- Publisher
  ライフ・サイエンス
- Data Source
  KAKENHI-PROJECT-23790856
[Book] 性心不全治療ガイドライン2011
- Author(s)
  奥田真一、矢野雅文
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-23790856
[Book] 不全心筋における逆リモデリングの分子生物学的機序呼吸と循環2010
- Author(s)
  奥田真一、矢野雅文
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21790726
[Book] 呼吸と循環2010年7月号(不全心筋における逆リモデリングの分子生物学的機序)2010
- Author(s)
  奥田真一
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21790726
[Journal Article] Images in Vascular Medicine: Usefulness of carotid ultrasonography for diagnosis and management of polymyalgia rheumatica-associated large-vessel vasculitis2021
- Author(s)
  Nawata Takashi、Ariyoshi Toru、Okuda Shinichi、Wada Yasuaki、Kubo Makoto、Yano Masafumi
- Journal Title
  
  Vascular Medicine
  
  Volume: - Issue: 4 Pages: 459-461
- DOI
  10.1177/1358863x21995582
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08076
[Journal Article] Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice2020
- Author(s)
  Sufu-Shimizu Yoko、Okuda Shinichi、Kato Takayoshi、Nishimura Shigehiko、Uchinoumi Hitoshi、Oda Tetsuro、Kobayashi Shigeki、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 2 Pages: 431-438
- DOI
  10.1016/j.bbrc.2020.01.107
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-18K08039
[Journal Article] Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts2020
- Author(s)
  Kajii Toshiro、Kobayashi Shigeki、Shiba Sho、Fujii Shohei、Tamitani Masaki、Kohno Michiaki、Nakamura Yoshihide、Nanno Takuma、Kato Takayoshi、Okuda Shinichi、Uchinoumi Hitoshi、Oda Tetsuro、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 521 Issue: 1 Pages: 57-63
- DOI
  10.1016/j.bbrc.2019.10.071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178
[Journal Article] G790del mutation in DSC2 alone is insufficient to develop the pathogenesis of ARVC in a mouse model2020
- Author(s)
  Hamada Yoriomi、Yamamoto Takeshi、Nakamura Yoshihide、Sufu-Shimizu Yoko、Nanno Takuma、Fukuda Masakazu、Ono Makoto、Oda Tesuro、Okuda Shinichi、Ueyama Takeshi、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 21 Pages: 100711-100711
- DOI
  10.1016/j.bbrep.2019.100711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-18K15890
[Journal Article] Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling2020
- Author(s)
  Kohno Michiaki、Kobayashi Shigeki、Yamamoto Takeshi、Yoshitomi Ryosuke、Kajii Toshiro、Fujii Shohei、Nakamura Yoshihide、Kato Takayoshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Watanabe Kenji、Mizukami Yoichi、Yano Masafumi
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 714-714
- DOI
  10.1038/s42003-020-01443-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11128, KAKENHI-PROJECT-18K16255, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-18K08572, KAKENHI-PROJECT-20H03677
[Journal Article] Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca 2+ level and ER stress2020
- Author(s)
  Tamitani M, Yamamoto T, Yamamoto N, Fujisawa K, Tanaka S, Nakamura Y, Uchinoumi H, Oda T, Okuda S, Takami T, Kobayashi S, Sakaida I, Yano M.
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 23:100787. Pages: 100787-100793
- DOI
  10.1016/j.bbrep.2020.100787
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08005, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20H03663
[Journal Article] Detection of Active Inflammation Status Around Ventricular Aneurysms in Patients With Cardiac Sarcoidosis2019
- Author(s)
  Nanno Takuma、Kobayashi Shigeki、Yoshitomi Ryosuke、Fujii Shohei、Kajii Toshiro、Kohno Michiaki、Ishiguchi Hironori、Okuda Shinichi、Okada Munemasa、Suga Kazuyoshi、Yano Masafumi
- Journal Title
  
  Circ J
  
  Volume: 83 Issue: 12 Pages: 2494-2504
- DOI
  10.1253/circj.CJ-19-0248
- NAID
  130007751174
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2019-11-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-19K09824, KAKENHI-PROJECT-17H02110
[Journal Article] Addition of a β1-Blocker to Milrinone Treatment Improves Cardiac Function in Patients with Acute Heart Failure and Rapid Atrial Fibrillation2019
- Author(s)
  Kobayashi Shigeki、Myoren Takeki、Kajii Toshiro、Kohno Michiaki、Nanno Takuma、Ishiguchi Hironori、Nishimura Shigehiko、Fukuda Masakazu、Hino Akihiro、Fujimura Tatsuhiro、Ono Makoto、Uchinoumi Hitoshi、Tateishi Hiroki、Mochizuki Mamoru、Oda Tetsuro、Okuda Shinichi、Yoshiga Yasuhiro、Kawano Reo、Yano Masafumi
- Journal Title
  
  Cardiology
  
  Volume: 142 Issue: 4 Pages: 195-202
- DOI
  10.1159/000499400
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K15890
[Journal Article] CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca 2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy2018
- Author(s)
  Okuda Shinichi、Sufu-Shimizu Yoko、Kato Takayoshi、Fukuda Masakazu、Nishimura Shigehiko、Oda Tetsuro、Kobayashi Shigeki、Yamamoto Takeshi、Morimoto Sachio、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 496 Issue: 4 Pages: 1250-1256
- DOI
  10.1016/j.bbrc.2018.01.181
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08540, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin2018
- Author(s)
  Oda Tetsuro、Yamamoto Takeshi、Kato Takayoshi、Uchinoumi Hitoshi、Fukui Go、Hamada Yoriomi、Nanno Takuma、Ishiguchi Hironori、Nakamura Yoshihide、Okamoto Yoko、Kono Michiaki、Okuda Shinichi、Kobayashi Shigeki、Bers Donald M.、Yano Masafumi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 125 Pages: 87-97
- DOI
  10.1016/j.yjmcc.2018.10.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-16K09502, KAKENHI-PROJECT-17H04178
[Journal Article] Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.2018
- Author(s)
  Nishimura S, Yamamoto T, Nakamura Y, Kohno M, Hamada Y, Sufu Y, Fukui G, Nanno T, Ishiguchi H, Kato T, Xu X, Ono M, Oda T, Okuda S, Kobayashi S, Yano M.
- Journal Title
  
  Heart Rhythm
  
  Volume: 印刷中 Issue: 6 Pages: 905-914
- DOI
  10.1016/j.hrthm.2018.02.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-16K19409, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] An oxidative stress biomarker, urinary 8-hydroxy-2'-deoxyguanosine, predicts cardiovascular-related death after steroid therapy for patients with active cardiac sarcoidosis.2016
- Author(s)
  Myoren T, Kobayashi S, Oda S, Nanno T, Ishiguchi H, Murakami W, Okuda S, Okada M, Takemura G, Suga K, Matsuzaki M, Yano M.
- Journal Title
  
  Int J Cardiol
  
  Volume: 17 Pages: 206-213
- DOI
  10.1016/j.ijcard.2016.03.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670404, KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-16K09509, KAKENHI-PROJECT-26463081, KAKENHI-PROJECT-16K15443
[Journal Article] A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.2015
- Author(s)
  Kobayashi S, Susa T, Ishiguchi H, Myoren T, Murakami W, Kato T, Fukuda M, Hino A, Suetomi T, Ono M, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Okuda S, Doi M, Yamamoto T, Yano M
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 1 Pages: e0114314-e0114314
- DOI
  10.1371/journal.pone.0114314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-26670404
[Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine as a novel biomarker of inflammatory activity in patients with cardiac sarcoidosis2015
- Author(s)
  Kobayashi S, Myoren T, Oda S, Inari M, Ishiguchi H, Murakami W, Fukuda M, Tanaka T, Okuda S, Nao T, Doi M, Yamada J, Okamura T, Hoshii Y, Suga K, Matsuzaki M, Yano M.
- Journal Title
  
  Int J Cardiol.
  
  Volume: 190 Pages: 319-328
- DOI
  10.1016/j.ijcard.2015.04.144
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-26670404, KAKENHI-PROJECT-26293189
[Journal Article] Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes2014
- Author(s)
  Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 448(1) Issue: 1 Pages: 1-7
- DOI
  10.1016/j.bbrc.2014.03.152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23591082, KAKENHI-PROJECT-23592256, KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-26670404
[Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine as a novel biomarker for predicting cardiac events and evaluating the effectiveness of carvedilol treatment in patients with chronic systolic heart failure2012
- Author(s)
  usa T, Kobayashi S, Tanaka T, Murakami W, Akashi S, Kunitsugu I, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Ueyama T, Okamura T, Yano M, Matsuzaki M
- Journal Title
  
  Circ J
  
  Volume: 76(1) Pages: 117-26
- NAID
  10030034360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790856
[Journal Article] Low-dose β-blocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternans in patients with acute decompensated heart failure2012
- Author(s)
  Kobayashi S, Susa T, Tanaka T, Murakami W, Fukuta S, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T, Yano M, Matsuzaki M
- Journal Title
  
  Circ J
  
  Volume: 76(7) Pages: 1646-53
- NAID
  10030503344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790856
[Journal Article] Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts2012
- Author(s)
  Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M
- Journal Title
  
  Cardiovasc Res
  
  Volume: 96 Pages: 433-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790856
[Journal Article] Does a ripple of Ca(2+) leak develop into a rogue wave that can trigger pathological hypertrophy?2012
- Author(s)
  Yano M, Okuda S
- Journal Title
  
  J Am Coll Cardiol
  
  Volume: 63(15) Issue: 15 Pages: 1580-2
- DOI
  10.1016/j.jacc.2013.10.064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-26670404
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca^release leading to catecholaminergic polymorphic ventricular tachycardia2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, OkudaS, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Circulation
  
  Volume: 124 Pages: 682-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790856
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca2+release leading to catecholaminergic polymorphic ventricular tachycardia.2011
- Author(s)
  Takeshi Suetomi, Masafumi Yano, Hitoshi Uchinoumi, Masakazu Fukuda, Akihiro Hino, Makoto Ono, Xiaojuan Xu, Hiroki Tateishi, Shinichi Okuda, Masunori Matsuzaki,et.al..
- Journal Title
  
  Circulation
  
  Volume: 124 Pages: 682-694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790856
[Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure.2011
- Author(s)
  Shigeki Kobayashi, Takehisa Susa, Takeo Tanaka, Wakako Murakami, Seiko Fukuta, Shinichi Okuda,Masafumi Yano, Masunori Matsuzaki.,et.al.
- Journal Title
  
  European Journal of Heart Faililure
  
  Volume: 13 Pages: 29-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790856
[Journal Article] Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2(R2474S/+) Knock-In Mouse Model.2010
- Author(s)
  Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T, Matsuzaki M.
- Journal Title
  
  Circ J. 74
  
  Pages: 2579-2584
- NAID
  10027424202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790726
[Journal Article] Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor.2010
- Author(s)
  Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cir Res. 106
  
  Pages: 1413-1424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790726
[Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.2010
- Author(s)
  Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Biochem Biophys Res Commun. 394
  
  Pages: 660-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790726
[Journal Article] Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure.2010
- Author(s)
  Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 87
  
  Pages: 609-617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790726
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.2009
- Author(s)
  Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.
- Journal Title
  
  J Am Coll Cardiol. 53
  
  Pages: 1993-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790726
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 Mediated through P harmacological Enhancement of Calmodulin Binding to RyR2 Prevents the Development of Cardiac Dysfunction2020
- Author(s)
  Yoko Sufu-Shimizu , Shinichi Okuda , Yoko Okamoto , Takayoshi Kato , Hitoshi Uchinoumi , Tetsuro Oda , Shigeki Kobayashi , Takeshi Yamamoto , Masafumi Yano
- Organizer
  Journal of Circulation Society Scientific Meeting 2020
- Data Source
  KAKENHI-PROJECT-18K08076
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 by dantrolene prevents the development of age-related cardiomyopathy in CaMKIIδc transgenic mice2019
- Author(s)
  Yoko Sufu-Shimizu, Shinichi Okuda, Yoko Okamoto, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  Japanese Society of Cardiology 2019
- Data Source
  KAKENHI-PROJECT-18K08076
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 By Dantrolene Prevents the Development of Age-related Cardiomyopathy in CaMKIIδc Transgenic Mice2019
- Author(s)
  Yoko Sufu-Shimizu , Shinichi Okuda , Yoko Okamoto , Takayoshi Kato , Hitoshi Uchinoumi , Tetsuro Oda , Shigeki Kobayashi , Takeshi Yamamoto , Masafumi Yano
- Organizer
  American Heart Association Scientific Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08076
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 By Dantrolene Prevents the Development of Age-related Cardiomyopathy in CaMKIIδc Transgenic Mice2019
- Author(s)
  Yoko Sufu-Shimizu , Shinichi Okuda , Yoko Okamoto , Takayoshi Kato , Hitoshi Uchinoumi , Tetsuro Oda , Shigeki Kobayashi , Takeshi Yamamoto , Masafumi Yano
- Organizer
  Journal of Heart Failure Scientific Meeting 2019
- Data Source
  KAKENHI-PROJECT-18K08076
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 prevents the development of age-related cardiomyopathy caused by transgenic CaMKIIδc overexpression2018
- Author(s)
  Yoko Sufu-Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, and Masafumi Yano
- Organizer
  International Society for Heart Research 2018 Japanese Section
- Data Source
  KAKENHI-PROJECT-18K08076
[Presentation] Dantrolene Prevents the Development of Age-Related Cardiomyopathy by Stabilization of CaMKII-Phosphorylated RyR2 in CaMKIIδC Transgenic Mice2018
- Author(s)
  Yoko Sufu-Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, and Masafumi Yano
- Organizer
  American Heart Association Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08076
[Presentation] Inhibition of aberrant Ca2+ release through RyR2 mediated by CaMKII and Ca2+ buffering suppresses arrhythmogenesis in troponin T-related hypertrophic cardiomyopathy2016
- Author(s)
  Okuda S, Kato T, Sufu Y, Fukuda M, Nichimura S, Kobayashi S, Oda T, Yamamoto T, Yano M
- Organizer
  Japanese Society of Cardiology
- Place of Presentation
  宮城県仙台市　せんだい青葉山交流会場　特設会場
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-26670404
[Presentation] Dantrolene Cannot Inhibit Aberrant Ca2+ Release and Arrhythmias Without Calmodulin in Pressure Overload Heart Failure.2015
- Author(s)
  Fuykui G, Yamamoto T, Kato T, Maeda T, Nishimura S, Hino A, Suetomi T, Ono M, Mochizuki M, Oda T, Okuda, Kobayashi S, Yano M
- Organizer
  American Heart Association Scientific Meeting 2015
- Place of Presentation
  Orland, USA
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-26670404
[Presentation] Dantrolene Enhances Binding of Calmodulin to RyR2 in CPVT Which Mutation Located at Central Domain but Does Not Enhance That in CPVT With Mutation at CaM-like Domain.2015
- Author(s)
  Nishimura S, Yamamoto T, Fukui G, Maeda T, Hino A, Suetomi T, Ono M, Mochozuki M, Oda T, Okuda S, Kobayashi S, Yano M
- Organizer
  American Heart Association Scientific Meeting 2015
- Place of Presentation
  Orland, USA
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-26670404
[Presentation] RyR2 stabilization by inhibiting aberrant Ca2+ release mediated by CaMKII signaling and Ca2+ buffering function suppresses arrhythmogenesis in Troponin T-related familial hypertrophic cardiomyopathy2015
- Author(s)
  Okuda S, Kato T, Fukuda M, Nichimura S, Kobayashi S, Oda T, Yamamoto T, Yano M
- Organizer
  European Society of Cardiology
- Place of Presentation
  London, UK
- Year and Date
  2015-08-29
- Data Source
  KAKENHI-PROJECT-26670404
[Presentation] Dantrolene suppresses arrhythmogenesis by inhibition of aberrant Ca2+ release mediated by CaMKII and Ca2+ buffering in troponin T-related hypertrophic cardiomyopathy2015
- Author(s)
  Okuda S, Fukuda M, Kato T, Nichimura S, Kobayashi S, Oda T, Yamamoto T, Yano M
- Organizer
  Japanese Society of Heart Failure
- Place of Presentation
  大阪府大阪市　グランフロント大阪
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26670404
[Presentation] High Affinity CaM, but Not Normal Affinity CaM Can Prevent Arrhythmias in CPVT Which Mutation is Located at CaM-like Domain of RyR2.2015
- Author(s)
  Nishimura S, Yamamoto T, Fukui G, Maeda T, Hino A, Suetomi T, Ono M, Mochozuki M, Oda T, Okuda S, Kobayashi S, Yano M
- Organizer
  American Heart Association Scientific Meeting 2015
- Place of Presentation
  Orland, USA
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-26670404
[Presentation] A Marked Increase in Myocardial Oxidative Stress Associated With Sympathetic Hyperactivity is Related to Transient Myocardial Dysfunction in Patients With Takotsubo Cardiomyopathy2015
- Author(s)
  Nannno T, Kobayashi S, Oda S, Ishiguchi H, Myoren T, Miyazaki Y, Suetomi T, Ono M, Mochizuki M, Oda T, Okuda S, Yamada J, Okamura T, Yano M
- Organizer
  American Heart Association Scientific Meeting 2015
- Place of Presentation
  Orland, USA
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-26670404
[Presentation] Dissociation of Calmodulin From RyR2 Causes Diastolic Ca2+ leak and Induces Lethal Arrhythmias in Pressure-overload Heart Failure2014
- Author(s)
  Kato T, Yamamoto T, Maeda T, Nishimura S, Murakami W, Suetomi T, Ono M, Mochizuki M, Oda T, Okuda S, Kobayashi S, Yano M
- Organizer
  American Heart Association Scientific Meeting 2014
- Place of Presentation
  Chicago (USA)
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-26670404
[Presentation] Stabilization of RyR2 by inhibition of CaMKII-mediated aberrant Ca2+ release may suppress arrhythmogenesis in cardiac troponin T-related familial hypertrophic cardiomyopathy2014
- Author(s)
  Okuda S, Fukuda M, Kato T, Nishimura S, Oda T, Kobayashi S, Yamamoto T, Yano M
- Organizer
  European Society of Cardiology Scientific Meeting 2014
- Place of Presentation
  Barcelona (Spain)
- Year and Date
  2014-09-01
- Data Source
  KAKENHI-PROJECT-26670404
[Presentation] RyR2 Stabilization by Inhibiting Aberrant Ca2+ Release Mediated by CaMKII Signaling Within the Increase of Ca2+ Buffering Capacity Suppress Arrhythmogenesis in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2014
- Author(s)
  Okuda S,Kato T, Fukuda M, Nishimura S, Oda T, Kobayashi S, Yamamoto T, Yano M
- Organizer
  American Heart Association Scientific Meeting 2014
- Place of Presentation
  Chicago (USA)
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-26670404
[Presentation] CaMKII-mediated aberrant Ca^release play a key role in the arrhythmogenesis in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2013
- Author(s)
  Okuda S, Fukuda M, Yano M, Suetomi T, Hino A, Kato T, Doi M, Kobayashi S, Yamamoto T, Matsuzaki M
- Organizer
  apanese Circulation Society Scientific Meeting 2013
- Place of Presentation
  Pacifico Yokohama, Japan
- Year and Date
  2013-03-15
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] CaMKII-mediated aberrant Ca2+ release play a key role in the arrhythmogenesis in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy.2013
- Author(s)
  Shinichi Okuda
- Organizer
  Japanese Circulation Spciety Scientific Meeting 2013
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] Correcting inter-domain interaction of cardiac ryanodine receptor inhibits aberrant Ca^ release in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy mouse model2012
- Author(s)
  Okuda S, Yano M, Fukuda M, Suetomi T, Hino A, Kato T, Doi M, Kobayashi S, Yamamoto T, Matsuzaki M
- Organizer
  The 16th Annual Scientific Meeting of the Japanese Heart Failure Society
- Place of Presentation
  Sendai International center, Japan
- Year and Date
  2012-11-30
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] Enhanced Binding of Calmodulin to RyR2 Inhibits Aberrant Ca2+ Release and Arrhythmogenesis in CPVT-Associated Mutation2012
- Author(s)
  Fukuda M, Yamamoto T, Kato T, Hino A, Suetomi T, Tateishi H, Doi M, Okuda S, Kobayashi S, Matsuzaki M, Yano M
- Organizer
  American Heart association Scientific meeting
- Place of Presentation
  Los Angels, USA
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] Correcting inter-domain interaction of cardiac ryanodine receptor inhibits aberrant Ca2+ release in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy mouse model.2012
- Author(s)
  Shinichi Okuda
- Organizer
  Japanese Heart Failure Society Scientific Meeting 2012
- Place of Presentation
  仙台国際センター(仙台)
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] CaMKII-mediated aberrant Ca2+ release may play a key role in the arrhythmogenesis in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy.2012
- Author(s)
  Shinichi Okuda
- Organizer
  American Heart Association Scientific Meeting 2012
- Place of Presentation
  Los Angels (USA)
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] CaMKII-mediated aberrant Ca^release may play a key role in the arrhythmogenesis in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2012
- Author(s)
  Okuda S, Fukuda M, Yano M, Suetomi T, Hino A, Kato T, Doi M, Kobayashi S, Yamamoto T, Matsuzaki M
- Organizer
  American Heart association Scientific meeting 2012
- Place of Presentation
  Los Angels, USA
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] Conformational Changes in the Local and Global Inter-Domain Interactions Trigger Diastolic Ca2+ Release and Lethal Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).2011
- Author(s)
  Takeshi Suetomi, Masafumi Yano, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki.
- Organizer
  American Heart association Scientific meeting 2011
- Place of Presentation
  Orland,USA
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Biomarker of Inflammatory Activity in Patients with Cardiac Sarcoidosis: Insight From Immunohistochemical Technique and 18F-FDG PET/CT.2011
- Author(s)
  Seiko Fukuta, Shigeki Kobayashi, Takeo Tanaka, Takamasa Susa, Wakako Murakami, Shinichi Okuda, Masafumi Yano, Masunori Matsuzaki,et al.
- Organizer
  American Heart association Scientific meeting 2011
- Place of Presentation
  Orland,USA
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] Enhancement of Calmodulin Binding to RyR2 Inhibits Aberrant Ca2+ Release in CPVT-Associated Mutation.2011
- Author(s)
  Masakazu Fukuda, Masafumi Yano, Takayoshi Kato, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki.
- Organizer
  American Heart association Scientific meeting 2011
- Place of Presentation
  Orland,USA
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Biomarker of Inflammatory Activity in Patients with Cardiac Sarcoidosis: Insight From Immunohistochemical Technique and 18F-FDG PET/CT2011
- Author(s)
  Fukuta S, Kobayashi S, Tanaka T, Susa T, Murakami W, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Ueyama T, Okamura T, Kawamura S, Yano M, Matsuzaki M
- Organizer
  American Heart association Scientific meeting 2011
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] Coupled Conformational Changes in the Local and Global Inter-Domain Interactions Trigger Diastolic Ca2+ Release and Lethal Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2011
- Author(s)
  Suetomi T, Yano M, Kato T, Fukuda M, Hino A, Doi M, Okuda S, Kobayashi S, Ikeda Y, Yamamoto T, Matsuzaki M
- Organizer
  American Heart association Scientific meeting 2011
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] Enhancement of Calmodulin Binding to RyR2 Inhibits Aberrant Ca2+ Release in CPVT-Associated Mutation2011
- Author(s)
  Fukuda M, Yano M, Kato T, Hino A, Suetomi T, Doi M, Okuda S, Kobayashi S, Ikeda Y, Yamamoto T, Matsuzaki M
- Organizer
  American Heart association Scientific meeting 2011
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-23790856
[Presentation] Mutation-linked Defective Domain Interaction within the Ryanodine Receptor Causes Ca2+ Leak Leading to Catecholaminergic Polymorphic Ventricular Tachycardia2010
- Author(s)
  Suetomi T, Yano M, Fukuda M, Hino A, Ono M, Xu X, Susa T, Uchinoumi H, Oda T, Okuda S, Kobayashi S, Yamamoto T, Ikeda Y, Matsuzaki M.
- Organizer
  Circulation
- Place of Presentation
  シカゴアメリカ合衆国
- Year and Date
  2010-11-23
- Data Source
  KAKENHI-PROJECT-21790726
[Presentation] Increased Affinity of Calmodulin Binding to Cardiac Ryanodine Receptor Corrects the Defective Channel Gating in Failing Hearts2010
- Author(s)
  Hino A, Yano M, Fukuda M, Suetomi T, Ono M, Xu X, Uchinoumi H, Susa T, Doi M, Okuda S, Kobayashi S, Yamamoto T, Matsuzaki M.
- Organizer
  Circulation
- Place of Presentation
  シカゴアメリカ合衆国
- Year and Date
  2010-11-23
- Data Source
  KAKENHI-PROJECT-21790726
[Presentation] Correction of Defective Calmodulin Binding to Cardiac Ryanodine Receptor Inhibits Aberrant Ca2+ Release in CPVT-associated Mutation2010
- Author(s)
  Fukuda M, Yano M, Hino A, Suetomi T, Xu X, Ono M, Uchinoumi H, Doi M, Okuda S, Kobayashi S, Yamamoto T, Matsuzaki M.
- Organizer
  Circulation
- Place of Presentation
  シカゴアメリカ合衆国
- Year and Date
  2010-11-23
- Data Source
  KAKENHI-PROJECT-21790726
[Presentation] Interruption of Novel Inter-domain Interaction Within RyR2 as a Common Therapeutic Target by Channel Stabilization in Heart Failure and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2010
- Author(s)
  Yamamoto T, Yano M, Fukuda M, Hino A, Suetomi T, Doi M, Okuda S, Kobayashi S, Matsuzaki M.
- Organizer
  Circulation
- Place of Presentation
  シカゴアメリカ合衆国
- Year and Date
  2010-11-23
- Data Source
  KAKENHI-PROJECT-21790726
[Presentation] Mutation-linked Channel Disorder in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is Caused by Abnormally Tight Domain-Domain Interaction in RyR22009
- Author(s)
  Suetomi T, Yano M, Hino A, Ono M, Xu X, Susa T, Uchinoumi H, Oda T, Doi M, Okuda S, Kobayashi S, Ikeda Y, Yamamoto T, Matsuzaki M.
- Organizer
  Circulation
- Place of Presentation
  オーランドアメリカ合衆国
- Data Source
  KAKENHI-PROJECT-21790726
[Presentation] Low-dose of β Blocker Improves Cardiac Function in Patients With Acute Heart Failure Partly by Inhibiting Ca2+ Leak Through the Ryanodine Receptor2009
- Author(s)
  Kobayashi S, Tanaka T, Susa T, Ono M, Uchinoumi H, Okuda S, Doi M, Kawamura S, Yamamoto T, Yano M, Matsuzaki M.
- Organizer
  Circulation
- Place of Presentation
  オーランドアメリカ合衆国
- Data Source
  KAKENHI-PROJECT-21790726
[Presentation] Decreased Affinity of Calmodulin to RyR2 May Be a Sauce Mechanism of Leaky Channel in CPVT-associated Mutation2009
- Author(s)
  Xu X, Yano M, Hino A, Suetomi T, Ono M, Uchinoumi H, Oda T, Doi M, Okuda S, Kobayashi S, Ikeda Y, Yamamoto T, Ohkusa T, Matsuzaki M.
- Organizer
  Circulation
- Place of Presentation
  オーランドアメリカ合衆国
- Data Source
  KAKENHI-PROJECT-21790726
[Presentation] Correction of Defective Inter-domain Interaction Within the Cardiac Ryanodine Receptor as a New Therapeutic Strategy Against Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2009
- Author(s)
  Uchinoumi H, Yano M, Hino A, Suetomi T, Ono M, Xu X, Oda T, Doi M, Okuda S, Kobayashi S, Yamamoto T, Ikeda Y, Matsuzaki M.
- Organizer
  Circulation
- Place of Presentation
  オーランドアメリカ合衆国
- Data Source
  KAKENHI-PROJECT-21790726

1. YANO Masafumi (90294628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
2. KOBAYASHI Shigeki

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
3. YAMAMOTO Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. TANI Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. FUJISAWA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山本健

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. 小田哲郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 水上洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 高見太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 森本幸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okuda Shinichi 奥田 真一

OKUDA Shinichi 奥田 真一

Research Projects

Research Products

Co-Researchers

Development of novel molecular targeted therapy by stabilizing cardiac ryanodine receptors in hypertrophic cardiomyopathyPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

New molecular targeting therapy for regression of cardiac hypertrophy by inhibiting abnormal Ca2+ leak through RyR2 in hypertrophic cardiomyopathy

Principal Investigator

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Research Field

Research Institution

The therapeutic approach of inductive lethal arrhythmia by inhibiting Ca2+ leak through the cardiac ryanodine receptor in hypertrophic cardiomyopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Correction of the defective inter-domain interaction of cardiac ryanodine receptor prevents catecholaminergic polymorphic ventricular tachycardiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 心不全における心筋の興奮収縮連関とカルシウム ；クリニカルカルシウム2013

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[Book] シグナル伝達系からみた心不全の機序と治療戦略；Cardioligy Frontier2011

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[Book] シグナル伝達系からみた心不全の機序と治療戦略2011

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[Book] 慢性心不全の治療2011

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[Book] 慢性心不全の治療 ；Medicament News2011

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[Book] シグナル伝達系からみた心不全の機序と治療戦略2011

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[Book] Cardioligy Frontier(シグナル伝達系からみた心不全の機序と治療戦略)2011

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[Book] Medicament News(慢性心不全の治療)2011

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[Book] 慢性心不全治療ガイドライン；冠動脈疾患 下巻2011

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[Book] 慢性心不全の治療2011

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[Book] 性心不全治療ガイドライン2011

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[Book] 不全心筋における逆リモデリングの分子生物学的機序呼吸と循環2010

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Okuda Shinichi 奥田真一

OKUDA Shinichi 奥田真一

[Book] 心不全における心筋の興奮収縮連関とカルシウム；クリニカルカルシウム2013

[Book] 慢性心不全の治療；Medicament News2011

[Book] 慢性心不全治療ガイドライン；冠動脈疾患　下巻2011