JIN Linhua 金林花

Researcher Number	90531955
Affiliation (based on the past Project Information) *help	2012 – 2014: 順天堂大学, 医学(系)研究科(研究院), 研究員 2011: 順天堂大学, 医学部, ポスドクフェロー 2010 – 2011: 順天堂大学, 医学研究科, 研究員 2009: 順天堂大学, 大学院・医学研究科, 研究員
Review Section/Research Field	Except Principal Investigator Carcinogenesis / Hematology
Keywords	Except Principal Investigator 骨髄微小環境 / アポトーシス / 間質細胞 / miRNA / プロテオミクス / microRNA / 前がん細胞 / 微小環境 / 低線量放射線 / LYN … More / 脂質ラフト / チロシンキナーゼ阻害剤 / Lyn / CXCR4 / イマチニブ / 慢性骨髄性白血病 Less

Integrative genomic and proteomic analyses of low-dose ionizing radiation in EBV infected-B cells
- Principal Investigator
  
  TABE Yoko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Carcinogenesis
- Research Institution
  Juntendo University
Tyrosine kinase inhibitor induce CML migration to stromal microenvironment through Lyn/CXCR4 interactions in lipid rafts
- Principal Investigator
  
  TABE Yoko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Class IA PI3K inhibition inhibits cell growth and proliferation in mantle cell lymphoma.2014
- Author(s)
  Tabe Y, Jin L, Konopleva M, Shikami M, Kimura S, Andreeff M, Raffeld M, Miida T.
- Journal Title
  
  Acta Haematol.
  
  Volume: 131 Issue: 1 Pages: 59-69
- DOI
  10.1159/000353164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501306
[Journal Article] TGF-β-neutralizing antibody 1D11 enhances cytarabine-induced apoptosis in AML cells in the bone marrow microenvironment.2013
- Author(s)
  Tabe Y, Shi YX, Zeng Z, Jin L, Shikami M, Hatanaka Y, Miida T, Hsu FJ, Andreeff M, Konopleva M.
- Journal Title
  
  PLoS One
  
  Volume: ８
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501306
[Journal Article] TGF-β-neutralizing antibody 1D11 enhances cytarabine-induced apoptosis in AML cells in the bone marrow microenvironment.2013
- Author(s)
  Yoko Tabe, Yue Xi Shi, Zhihong Zeng, Linhua Jin, Masato Shikami,Yasuhito Hatanaka, Takashi Miida, Frank J. Hsu, Michael Andreeff, Marina Konopleva
- Journal Title
  
  PLOS ONE
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501306
[Journal Article] PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment.2013
- Author(s)
  Jin L, Tabe Y, Kojima K, Shikami M, Benito J, Ruvolo V, Wang RY, McQueen T, Ciurea SO, Miida T,
- Journal Title
  
  Mol Med (Berl)
  
  Volume: 91 Issue: 12 Pages: 1383-1397
- DOI
  10.1007/s00109-013-1076-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501306
[Journal Article] Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment.2012
- Author(s)
  Jin L, Tabe Y, Lu H, Borthakur G, Miida T, Kantarjian H, Andreeff M, Konopleva M.
- Journal Title
  
  Cancer Lett
  
  Volume: 329 Issue: 1 Pages: 45-58
- DOI
  10.1016/j.canlet.2012.09.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590689, KAKENHI-PROJECT-24501306
[Journal Article] Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts.2012
- Author(s)
  Tabe Y, Jin L, Iwabuchi K, Wang RY, Ichikawa N, Miida T, Cortes J, Andreeff M, Konopleva M.
- Journal Title
  
  Leukemia
  
  Volume: 26 Issue: 5 Pages: 883-892
- DOI
  10.1038/leu.2011.291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590689, KAKENHI-PROJECT-24501306, KAKENHI-PROJECT-24659293
[Journal Article] Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts2012
- Author(s)
  Tabe Y, Jin L, Iwabuchi K, Wang R, Ichikawa N, Miida T, Cortes J, Andreeff M, Konopleva M.
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 883-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591223
[Journal Article] Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma2011
- Author(s)
  Jin L, Tabe Y, Kimura S, Zhou Y, Kuroda J, Asou H, Inaba T, Konopleva M, Andreeff M, Miida T.
- Journal Title
  
  Br J Cancer
  
  Volume: 104 Pages: 91-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591223
[Journal Article] Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 via Mcl-1/Noxa axis2010
- Author(s)
  Kojima K, Konopleva M, Tsao T, Andreeff M, Ishida H, Shiotsu Y, Jin L, Tabe Y, NakakumaH.
- Journal Title
  
  Leukemia
  
  Volume: 24 Pages: 33-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591223
[Journal Article] MDM2 antagonist Nutlin-3 enhances bortezomib-mediated mitochondrial apoptosis in TP53-mutated mantle cell lymphoma2010
- Author(s)
  Jin L, Tabe Y, Kojima K, Zhou Y, Pittaluga S, Konopleva M, Miida T, Raffeld M.
- Journal Title
  
  Cancer Lett
  
  Volume: 229 Pages: 161-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591223
[Journal Article] The MDM2 antagonist Nutlin-3 displays anti-proliferative and pro-apoptotic activity in mantle cell lymphoma2009
- Author(s)
  Tabe Y, Sebasigari D, Jin L, Rudelius M, Davies-Hill T, Miyake K, Miida T, Pittaluga S, Raffeld M.
- Journal Title
  
  Clin. Cancer Res
  
  Volume: 15 Pages: 933-942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] Integrative genomic and proteomic analysis of low-dose ionizing irradiation effects on bone marrow stromal microenvironment and on survival of pre-leukemic cells.2013
- Author(s)
  Tabe Y, Jin L, Hatanaka Y, Matsushita H, Kazuno S, Fujimura T, Ueno T, Sasai K, Iwabuchi K, Andreeff M, Konopleva M, Miida T
- Organizer
  55th American Society of Hematology Annual Meeting
- Place of Presentation
  New Orleans,USA
- Data Source
  KAKENHI-PROJECT-24501306
[Presentation] Metabolic shift in hypoxia-adapted CML cells and mechanisms of acquired dasatinib resistance uncovered by proteomic iTRAQ profiling.2013
- Author(s)
  Tabe Y, Jin L, Iwanami H, Matsushita H, Kazuno S, Fujimura T, Ueno T, Miida T, Andreeff M, Konopleva M, Kimura S.
- Organizer
  55th American Society of Hematology Annual Meeting
- Place of Presentation
  New Orleans,USA
- Data Source
  KAKENHI-PROJECT-24501306
[Presentation] Molecular mechanisms of adipocyte-leukemia interactions revealed by the quantitative proteomics technology: pro-survival function of adipocyte-derived free fatty acids on acute monoblastic leukemia mitochondrial biogenesis.2013
- Author(s)
  Tabe Y, Jin L, Kazuno S, Fujimura T, Matsushita H, Ueno T, Miida T, Andreeff M, Konopleva M.
- Organizer
  55th American Society of Hematology Annual Meeting
- Place of Presentation
  New Orleans,USA
- Data Source
  KAKENHI-PROJECT-24501306
[Presentation] Molecular mechanisms of inhibition of ribosomal biogenesis and translational flux by the Selective Inhibitor of Nuclear Export (SINE) XPO1/CRM1 antagonist KPT-185 in mantle cell lymphoma.2013
- Author(s)
  Tabe Y, Kojima K, Jin L, Iwanami H, Matsushita H, Kazuno S, Kauffman M, Shacham S, Fujimura T,
- Organizer
  55th American Society of Hematology Annual Meeting
- Place of Presentation
  New Orleans,USA
- Data Source
  KAKENHI-PROJECT-24501306
[Presentation] Efficacy and mechanisms of the mTOR inhibitor AZD2014 combined with L-Asparaginase or JAK2 inhibitor TG101348 in ALL.2013
- Author(s)
  Tabe Y, Jin L, Iwanami H, Matsushita H, Kazuno S, Fujimura T, Ueno T, Miida T, Weinstock D, Thomas DA, Andreeff M, Konopleva M.
- Organizer
  55th American Society of Hematology Annual Meeting
- Place of Presentation
  New Orleans,USA
- Data Source
  KAKENHI-PROJECT-24501306
[Presentation] TGF-beta1 Supports Leukemia Cell Survival Via Negative Regulation of FLI-1 Transcription Factor, ERK Inactivation and MMP-1 Secretion.2012
- Author(s)
  Yoko Tabe, Linhua Jin, Yasuhito Hatanaka, Takashi Miida, Steven Kornblau, Michaell Andreeff, Marina Konopleva.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  Atlanta,USA
- Data Source
  KAKENHI-PROJECT-24501306
[Presentation] Molecular Mechanisms of Antitumor Activity of the Selective Inhibitor of Nuclear Export (SINE) CRM1 Antagonist KPT-185 in Mantle Cell Lymphoma.2012
- Author(s)
  Yoko Tabe, Kensuke Kojima, Linhua Jin, Takashi Miida, Shacham S, Kauffman M, Michaell Andreeff.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  Atlanta,USA
- Data Source
  KAKENHI-PROJECT-24501306
[Presentation] 低線量放射線被爆による生体微小環境内の発がん誘導機序．2012
- Author(s)
  田部陽子, 金林花, 畑中康人, 松下弘道, 笹井啓資, 三井田孝
- Organizer
  放射線影響学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24501306
[Presentation] Analysis of Dasatinib-Induced Molecular Mechanisms of Apoptosis in Hypoxia-Adopted CML Cells Utilizing Quantitative Proteomics Technology.2012
- Author(s)
  Yoko Tabe, Linhua Jin, Hiroko Iwanami, Kazuno S, Fujimura T, Hiromichi Matsushita, Takashi Ueno, Takashi Miida, Michaell Andreeff, Marina Konopleva, Shinya Kimura.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  Atlanta,USA
- Data Source
  KAKENHI-PROJECT-24501306
[Presentation] Molecular Mechanisms of Pro-Survival and Differentiating Function of Bone Marrow-Derived Adipocytes On Acute Monoblastic Leukemia Cells.2012
- Author(s)
  Linhua Jin, Marina Konopleva, Masato Shikami, Takako Ikegami, Kensuke Kojima , MichaellAndreeff, Takashi Miida, Yoko Tabe
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  Atlanta,USA
- Data Source
  KAKENHI-PROJECT-24501306
[Presentation] Bone marrow-derived adipocytes promote differentiation, proliferation and survival of acute monoblastic leukemia cells2011
- Author(s)
  Tabe Y, Jin L, Konopleva M, Andreeff M, Ohsaka A, Miida T.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] The anti-proliferative effects of tricyclic coumarin GUT-70 as an Hsp90 inhibitor in mantle cell lymphoma2011
- Author(s)
  Jin L, Kimura S, Zhou Y, Kuroda J, Asou H, Inaba T, Miida T, Konopleva M, Andreeff M, Tabe Y.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] Growth-inhibitory effects of a Class IA PI3K inhibitor GDC-0941 are modulated by hypoxia-induced mTOR pathway activation in mantle cell lymphoma2011
- Author(s)
  Tabe Y, Jin L, Miida T, Andreeff M, Konopleva M.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] TGF-βneutralizing antibody 1D11 inhibits LIF-JAK-Stat3 signaling and enhances cytarabine induced apoptosis in AML cells in bone marrow microenvironment2011
- Author(s)
  Tabe Y, Shi Y, Zeng Z, Jin L, Zhou Y, Miida T, Andreeff M, Konopleva M.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] 低酸素骨髄微小環境下での残存白血病に対するPI3KとFLT3.阻害の抗腫瘍作用機序2011
- Author(s)
  田部陽子、金林花、三井田孝
- Organizer
  日本臨床検査医学会学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] The Anti-Proliferative Effects of Tricyclic Coumarin GUT-70 as An Hsp90 Inhibitor In Mantle Cell Lymphoma2010
- Author(s)
  Jin L, Kimura S, Zhou Y, Kuroda J, Asou H, Inaba T, Andreeff M, Miida T, Tabe Y.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] MDM2 antagonist nutlin-3 enhances bortezomib-mediated mitochondrial apoptosis in TP53-mutated mantle cell lymphoma2010
- Author(s)
  Tabe Y, Jin L, Kojima K, Zhou Y, Pittaluga S, Konopleva M, Miida T, Raffeld M.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] Efficacy and Mechanisms of Apoptosis Induction by Simultaneous Inhibition of PI3K with GDC-0941 and Blockade of Bcl-2(ABT-737) or FLT3(Sorafenib) In AML Cells In the Hypoxic Bone Marrow Microenvironment2010
- Author(s)
  Jin L, Tabe Y, Miida T, Andreeff M, Konopleva M.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] Inhibition of TGF-βand CXCR4 signaling promotes cell cycle arrest and apoptosis in leukemic cells co-cultured with stromal cells2010
- Author(s)
  Zhou Y, Tabe Y, Jin L, Miida T, Zeng Z, Andreeff M, Konopleva M.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] チロシンキナーゼ阻害剤による慢性骨髄性白血病のCXCR4シグナル活性化と骨髄定着2009
- Author(s)
  金林花、周奕欣、田部陽子、三井田孝
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] The Tricyclic Coumarin GUT-70 Induces Apoptosis and Cell Cycle Arrest Preferentially in Mantle Cell Lymphomas with Mutant p53 New Orleans2009
- Author(s)
  Jin L, Kimura S, Zhou Y, Kuroda J, Asou H, Inaba T, Andreeff M, Miida T, Tabe Y.
- Organizer
  Annual Meeting of American Society of Hematology(ASH)
- Place of Presentation
  San Francisco, U. S. A
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] マントル細胞リンパ腫に対するプロテアソーム阻害剤BortezomibとMDM2阻害剤Nutlin-3の抗腫瘍相乗効果2009
- Author(s)
  田部陽子, 金林花, 周奕欣, 三井田孝
- Organizer
  第56回日本臨床検査医学会学術集会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] Selective FLT3 Inhibitor FI-700 Neutralizes Mcl-1 and Enhances p53-Mediated Apoptosis in Acute Myeloid Leukemia(AML) Cells with Activating Mutations of FLT3 Via Mcl-1/Noxa Axis New Orleans2009
- Author(s)
  Kojima K, Konopleva M, Tsao T, Andreeff M, Ishida H, Shiotsu Y, Jin L, Tabe Y, Nakakuma H.
- Organizer
  Annual Meeting of American Society of Hematology(ASH)
- Place of Presentation
  San Francisco, U. S. A
- Data Source
  KAKENHI-PROJECT-21591223
[Presentation] Molecular mechanisms of inhibition of ribosomal biogenesis and translational flux by the Selective Inhibitor of Nuclear Export (SINE) XPO1/CRM1 antagonist KPT-185 in mantle cell lymphoma
- Author(s)
  Yoko Tabe, Kensuke Kojima, Linhua Jin, Hiroko Iwanami, Hiromichi Matsushita, Saiko Kazuno, Michael Kauffman, Sharon Shacham, Tsutomu Fujimura, Takashi Ueno, Takashi Miida, Michael Andreeff
- Organizer
  Global Academic Programs 2014 Annual Conference
- Place of Presentation
  Soule, Korea
- Year and Date
  2014-05-01 – 2014-05-03
- Data Source
  KAKENHI-PROJECT-24501306

1. TABE Yoko (70306968)

# of Collaborated Projects: 2 results

# of Collaborated Products: 33 results
2. IWABUCHI Kazuhisa (10184897)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. TOMIKAWA Naoki (80468587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SASAI Keisuke (20225858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 三井田孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

JIN Linhua 金 林花

Research Projects

Research Products

Co-Researchers

Integrative genomic and proteomic analyses of low-dose ionizing radiation in EBV infected-B cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tyrosine kinase inhibitor induce CML migration to stromal microenvironment through Lyn/CXCR4 interactions in lipid rafts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Class IA PI3K inhibition inhibits cell growth and proliferation in mantle cell lymphoma.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TGF-β-neutralizing antibody 1D11 enhances cytarabine-induced apoptosis in AML cells in the bone marrow microenvironment.2013

Author(s)

Journal Title

Data Source

[Journal Article] TGF-β-neutralizing antibody 1D11 enhances cytarabine-induced apoptosis in AML cells in the bone marrow microenvironment.2013

Author(s)

Journal Title

Data Source

[Journal Article] PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts2012

Author(s)

Journal Title

Data Source

[Journal Article] Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma2011

Author(s)

Journal Title

Data Source

[Journal Article] Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 via Mcl-1/Noxa axis2010

Author(s)

Journal Title

Data Source

[Journal Article] MDM2 antagonist Nutlin-3 enhances bortezomib-mediated mitochondrial apoptosis in TP53-mutated mantle cell lymphoma2010

Author(s)

Journal Title

Data Source

[Journal Article] The MDM2 antagonist Nutlin-3 displays anti-proliferative and pro-apoptotic activity in mantle cell lymphoma2009

Author(s)

Journal Title

Data Source

[Presentation] Integrative genomic and proteomic analysis of low-dose ionizing irradiation effects on bone marrow stromal microenvironment and on survival of pre-leukemic cells.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Metabolic shift in hypoxia-adapted CML cells and mechanisms of acquired dasatinib resistance uncovered by proteomic iTRAQ profiling.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Molecular mechanisms of adipocyte-leukemia interactions revealed by the quantitative proteomics technology: pro-survival function of adipocyte-derived free fatty acids on acute monoblastic leukemia mitochondrial biogenesis.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Molecular mechanisms of inhibition of ribosomal biogenesis and translational flux by the Selective Inhibitor of Nuclear Export (SINE) XPO1/CRM1 antagonist KPT-185 in mantle cell lymphoma.2013

JIN Linhua 金林花