Kurihara Kensuke 栗原研輔

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KURIHARA Kensuke 栗原研輔

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Researcher Number	90531997
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定助教
Affiliation (based on the past Project Information) *help	2014: 京都大学, 医学研究科, 助教 2012 – 2013: 京都大学, 医学(系)研究科(研究院), 助教 2011: 京都大学, 医学研究科, 特定助教 2010 – 2011: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Radiation science Except Principal Investigator Radiation science
Keywords	Principal Investigator ABC現象 / 転移モデル / 腫瘍イメージング / EPR効果 / SPECT / ミセル / ナノキャリア / 核医学 / SPECT-CT / 内照射療法 / PET / 分子イメージング … More Except Principal Investigator … More インビボ / マウス / 放射性標識合成 / ラクトソーム / 放射性標識 / SPECT / PET / 腫瘍 / 分子イメージング Less

Development of nuclear medicinal molecular imaging probe using nanocarrier "Lactosome"
- Principal Investigator
  
  YAMAMOTO FUMIHIKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku Pharmaceutical University
A development of Tumor imaging by I-123 Lactsome using small animal SPECT/CTPrincipal Investigator
- Principal Investigator
  
  KURIHARA Kensuke
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Study of improvement depiction of carcinoma in Lactsome fluorescence/PET imagingPrincipal Investigator
- Principal Investigator
  
  KURIHARA Kensuke
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University

All 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Patent

[Journal Article] Evasion from accelerated blood clearance of nanocarrier named as "Lactosome" induced by excessive administration of Lactosome.2013
- Author(s)
  Hara, E., Makino, A., Kurihara, K., Sugai, M., Shimizu, A., Hara, I., Ozeki, E. and Kimura, S.
- Journal Title
  
  Biochem. Biophys. Acta-General Sub.
  
  Volume: 1830 Issue: 8 Pages: 4046-4052
- DOI
  10.1016/j.bbagen.2013.03.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390077, KAKENHI-PROJECT-24390073, KAKENHI-PROJECT-24659147, KAKENHI-PROJECT-24659148, KAKENHI-PROJECT-24791298, KAKENHI-PROJECT-25293069
[Journal Article] Radionuclide Therapy Using Nanoparticle of 131I-Lactosome in Combination with Percutaneous Ethanol Injection Therapy2013
- Author(s)
  Eri Hara, Akira Makino, Kensuke Kurihara, Motoki Ueda, Isao Hara, Takashi Kawabe, Fumihiko Yamamoto, Eiichi Ozeki, Kaori Togashi, Shunsaku Kimura
- Journal Title
  
  J Nanopart Res
  
  Volume: 15(12) Issue: 12 Pages: 1-10
- DOI
  10.1007/s11051-013-2131-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591821, KAKENHI-PROJECT-24791298
[Journal Article] Radiosynthesis and initial evaluation of 18F labeled nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide.2013
- Author(s)
  F.Yamamoto, R.Yamahara, A.Makino, K.Kurihara, H.Tsukada, E.Hara, I.Hara, S.Kizaka-Kondoh, Y.Ohkubo, E.Ozeki, S.Kimura
- Journal Title
  
  Nucl. Med. Biol.
  
  Volume: 40 Issue: 3 Pages: 387-394
- DOI
  10.1016/j.nucmedbio.2012.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591821, KAKENHI-PROJECT-24791298, KAKENHI-PROJECT-25250012, KAKENHI-PLANNED-22112009
[Journal Article] Control of in vivo blood clearance time of polymeric micelle by stereochemistry of amphiphilic polydepsipeptides2012
- Author(s)
  A.Makino, E.Hara, I.Hara, R.Yamahara, K.Kurihara, E.Ozeki, F.Yamamoto, S.Kimura
- Journal Title
  
  J.Control. Release
  
  Volume: 161 Issue: 3 Pages: 821-825
- DOI
  10.1016/j.jconrel.2012.05.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591821, KAKENHI-PROJECT-24791298
[Journal Article] Pharmacokinetic Change of Nanoparticulate Formulation “Lactosome” on Multiple Administrations2012
- Author(s)
  E.Hara, A.Makino, K.Kurihara, F.Yamamoto, E.Ozeki,　S.Kimura
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 14 Issue: 3 Pages: 261-266
- DOI
  10.1016/j.intimp.2012.07.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591821, KAKENHI-PROJECT-24791298
[Patent] 病変部位の内照射治療用ナノ粒子及び治療システム2014
- Inventor(s)
  竹内恵理、栗原研輔、原功、小関英一、山原亮、牧野顕、木村俊作
- Industrial Property Rights Holder
  国立大学法人京都大学、株式会社島津製作所
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-03
- Data Source
  KAKENHI-PROJECT-24791298
[Patent] 病変部位の内照射治療用ナノ粒子および治療システム2014
- Inventor(s)
  竹内恵理, 栗原研輔, 原功, 小関英一, 山原亮, 牧野顕, 木村俊作
- Industrial Property Rights Holder
  京都大学, 島津製作所
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-12
- Overseas
- Data Source
  KAKENHI-PROJECT-24791298
[Patent] 病変部位の内照射治療用ナノ粒子および治療システム2014
- Inventor(s)
  竹内恵理, 栗原研輔, 原功, 小関英一, 山原亮, 牧野顕, 木村俊作
- Industrial Property Rights Holder
  京都大学, 島津製作所
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-03
- Data Source
  KAKENHI-PROJECT-24791298
[Patent] 病変部位の内照射治療用ナノ粒子及び治療システム2014
- Inventor(s)
  竹内恵理、栗原研輔、原功、小関英一、山原亮、牧野顕、木村俊作
- Industrial Property Rights Holder
  国立大学法人京都大学、株式会社島津製作所
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-12
- Overseas
- Data Source
  KAKENHI-PROJECT-24791298
[Patent] 病変部位の内照射治療用ナノ粒子および治療システム2014
- Inventor(s)
  竹内恵理, 栗原研輔, 原功, 小関英一, 山原亮, 牧野顕, 木村俊作
- Industrial Property Rights Holder
  京都大学, 島津製作所
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-14
- Overseas
- Data Source
  KAKENHI-PROJECT-24791298
[Patent] 病変部位の内照射治療用ナノ粒子及び治療システム2014
- Inventor(s)
  竹内恵理、栗原研輔、原功、小関英一、山原亮、牧野顕、木村俊作
- Industrial Property Rights Holder
  国立大学法人京都大学、株式会社島津製作所
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-14
- Overseas
- Data Source
  KAKENHI-PROJECT-24791298
[Patent] 病変部位の治療システム2011
- Inventor(s)
  栗原研輔、竹内恵理、原功、山原亮、小関英一、木村俊作
- Industrial Property Rights Holder
  京都大学(50%)、島津製作所(50%)
- Filing Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22791192
[Patent] 病変部位の治療システム2011
- Inventor(s)
  栗原研輔、竹内恵理、原功、山原亮、小関英一、木村俊作
- Industrial Property Rights Holder
  京都大学(50%)、島津製作所(50%)
- Filing Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] 放射線金属核種を標識したラクトソームによる固形癌のイメージング2013
- Author(s)
  上田一樹, 栗原研輔, 原功, 佐野紘平, 小関英一, 富樫かおり, 佐治英郎, 木村俊作
- Organizer
  第13回放射性医薬品・画像診断薬研究会
- Place of Presentation
  京都
- Year and Date
  2013-12-14
- Data Source
  KAKENHI-PROJECT-24791298
[Presentation] 放射線金属核種を標識したラクトソームによる固形癌のイメージング2013
- Author(s)
  上田一樹栗原研輔原功佐野紘平小関英一富樫かおり佐治英郎木村俊作
- Organizer
  第13回放射性医薬品・画像診断薬研究会
- Place of Presentation
  京都ガーデンパレス/「鞍馬-くらま」
- Data Source
  KAKENHI-PROJECT-24791298
[Presentation] 111In 標識A3B 型ラクトソームの開発と固形癌のSPECTイメージング2013
- Author(s)
  上田一樹, 栗原研輔, 原功, 小関英一, 富樫かおり, 木村俊作
- Organizer
  第53回日本核医学会学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24791298
[Presentation] 111In標識A3B型ラクトソームの開発と固形癌のＳＰＥＣＴイメージング2013
- Author(s)
  上田一樹栗原研輔原功小関英一富樫かおり木村俊作
- Organizer
  第53回日本核医学会学術総会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24791298
[Presentation] 両親媒性ナノキャリア｢ラクトソーム｣開発の現状と問題点～イメージングから治療を目指して～2012
- Author(s)
  栗原　研輔
- Organizer
  第1回腫瘍分子イメージング夏季集中セミナー
- Place of Presentation
  ニセコの“いこいの村”セミナーハウス
- Data Source
  KAKENHI-PROJECT-24791298
[Presentation] 両親媒性ナノキャリア「ラクトソーム」開発の現状と問題点~イメージングから治療を目指して~2012
- Author(s)
  栗原研輔
- Organizer
  第1回腫瘍分子イメージング夏季集中セミナー
- Place of Presentation
  北海道ニセコ
- Data Source
  KAKENHI-PROJECT-24791298
[Presentation] 高分子ミセル"ラクトソーム"の構造制御と体内動態解析2011
- Author(s)
  牧野顕、山原亮、原功、竹内恵、小関英一、栗原研輔、塚田秀夫、山本文彦、佐治英郎、清水章、木村俊作
- Organizer
  第51回日本核医学会学術総会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] I-131標識ラクトソームを用いた内用療法2011
- Author(s)
  竹内恵理、原功、山原亮、山原亮、栗原研輔、木村光晴、山本文彦、清水章、小関英一、木村俊作
- Organizer
  第51回日本核医学会学術総会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] Escape from the accelerated blood clearance (ABC) phenomenon of "Lactosome" by control of micelle size and surface2011
- Author(s)
  A.Makino, E.Takeuchi, I.Hara, R.Yamahara, E.Ozeki, K.Kurihara, F.Yamamoto, S.Kimura
- Organizer
  the World Molecular Imaging Congress 2011
- Place of Presentation
  San Diego,USA
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] Escape from the accelerated blood clearance(ABC) phenomenon of"Lactosome"by control of micelle size and surface2011
- Author(s)
  A. Makino, E. Takeuchi, I. Hara, R. Yamahara, E. Ozeki, K. Kurihara, F. Yamamoto, S. Kimura
- Organizer
  the World Molecular Imaging Congress 2011
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] 両親媒性ナノキャリア「ラクトソーム」開発の現状と展望～イメージングから治療につながる可能性～2010
- Author(s)
  栗原研輔
- Organizer
  第37回滋賀成人病センター研究所セミナー
- Place of Presentation
  滋賀成人病センター研究所(招待講演)
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] Development of Near-Infrared Fluorescence Probes for In Vivo Tumor Imaging with Using an Amphiphilic Polydepsipeptide Micelle"Lactosome"2010
- Author(s)
  I. Hara, R. Yamahara, E. Takeuchi, A. Makino, K. Kurihara, F. Yamamoto, S. Kizaka-Kondoh, A. Shimizu, E. Ozeki, S. Kimura
- Organizer
  the World Molecular Imaging Congress2010
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] Development of novel radioiodine-labelednanocarrier "Lactosome" and initial evaluationas a tumor imaging probe2010
- Author(s)
  F. Yamamoto, R. Yamahara, I. Hara, A. Makino, K. Kurihara, E. Takeuchi, S. Kizaka-Kondoh, A. Shimizu, E. Ozeki, S. Kimura
- Organizer
  the World Molecular Imaging Congress2010
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] 新規ナノキャリア「ラクトソーム」を用いた脳腫瘍同所移植モデルマウスにおける蛍光イメージングおよび病理組織との比較2010
- Author(s)
  栗原研輔、山本文彦、山口真、荒川芳輝、原功、牧野顕、小関英一、富樫かおり、清水章、木村俊作
- Organizer
  第26回日本DDS学会総会・学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] ABC phenomenon with lacto some studied byin vivo NIRF imaging2010
- Author(s)
  E. Takeuchi, I. Hara, R. Yamahara, A. Makino, K. Kurihara, F. Yamamoto, S. Kizaka-Kondoh, A. Shimizu, E. Ozeki, S. Kimura
- Organizer
  the World Molecular Imaging Congress2010
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] A fluorescent imaging and biodistribution, comparison with histopathology in the murine orthotopic brain tumor U87, using new nanocarrier "Lactosome"2010
- Author(s)
  栗原研輔
- Organizer
  World Molecular Imaging Congress 2010
- Place of Presentation
  Salt Palace Convention Center
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] Development and initial evaluation of novelfluorine-18 labeled nanocarrier "Lacto some" as a tumor imaging probe for PET2010
- Author(s)
  F. Yamamoto, R. Yamahara, K. Kurihara, H. Tsukada, E. Takeuchi, I. Hara, M. Akira, H. Saiki, S. Kizaka-Kondoh, E. Ozeki, S. Kimura
- Organizer
  Society of Nuclear Medicine Annual Meeting2010
- Place of Presentation
  Salt Lake Sity, USA
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] ABC現象の可視化とその抑制方法の探究-近赤外蛍光剤標識された高分子ミセル型ナノキャリア「ICGラクトソーム」を用いて2010
- Author(s)
  栗原研輔、山本文彦、竹内恵理、原功、山原亮、小関英一、牧野顕、富樫かおり、清水章、木村俊作
- Organizer
  第5回日本分子イメージング学会総会・学術集会
- Place of Presentation
  滋賀
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] Lactosome"a potential nano-ordered carrierforacid derivatives molecular imaging composed of apoly(l-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide and poly(lactic acid)2010
- Author(s)
  A. Makino, R. Yamahara, I. Hara, E. Takeuchi, E. Ozeki, K. Kurihara, S. Kizaka-Kondoh, F. Yamamoto, A. Shimizu, S. Kimura
- Organizer
  the World Molecular Imaging Congress2010
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] A fluorescent imaging of the murineorthotopic brain tumor, using new nanocarrier Lactosome2010
- Author(s)
  K. Kurihara, F. Yamamoto, M. Yamaguchi, Y. Arakawa, I. Hara, E. Ozeki, A. Makino, K. Togashi, A. Shimizu, S. Kimura
- Organizer
  the World Molecular Imaging Congress2010
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] Development of a novel radioisotope labeledtumor imaging probe for PET"^<18> F-Lacto some"2010
- Author(s)
  R. Yamahara, F. Yamamoto, K. Kurihara, H. Tsukada, E. Takeuchi, I. Hara, A. Makino, A. Shimizu, S. Kizaka-Kondoh, E. Ozeki, S. Kimura
- Organizer
  the World Molecular Imaging Congress2010
- Place of Presentation
  Kyoto, Japanin
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] ABC現象の可視化とその抑制方法の探究…近赤外蛍光剤標識された高分子ミセル型ナノキャリア「ICGラクトソーム」を用いて2010
- Author(s)
  栗原研輔
- Organizer
  第5回日本分子イメージング学会総会・学術集会
- Place of Presentation
  大津ピアザ淡海
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] Lactosome"a Potential Nano-Ordered Carrier Composed of a Poly(L-latic acid)-block-Poly(sarcosine) Amphiphilic Polydepsipeptide and Poly(lactic acid) Derivatives2010
- Author(s)
  A. Makino, R. Yamahara, I. Hara, E. Takeuchi, E. Ozeki, K. Kurihara, S. Kizaka-Kondoh, F. Yamamoto, A. Shimizu, S. Kimura
- Organizer
  International Symposium of Nanomaterials
- Place of Presentation
  Nara
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] 新規ナノキャリア「ラクトソーム」を用いた脳腫瘍同所移植モデルマウスにおける蛍光イメージングおよび病理組織との比較2010
- Author(s)
  栗原研輔
- Organizer
  第26回日本DDS学会総会・学術集会
- Place of Presentation
  大阪国際交流センター
- Data Source
  KAKENHI-PROJECT-22791192
[Presentation] 90Y-ラクトソームを用いたPEIT後の化学内照射療法　ドキシルとドキソルビシンの比較
- Author(s)
  栗原研輔、上田一樹、原功、原恵理、佐野紘平、牧野顕、小関英一、山本文彦、佐治英郎、富樫かおり、木村俊作
- Organizer
  第54回日本核医学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2014-11-06 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-24591821
[Presentation] Chemotherapy and Radionuclide Therapy Using 90Y-DOTA-Lactosome after Percutaneous Ethanol Injection Therapy Compared with Using Doxorubicin and Pegylated liposomal doxorubicin
- Author(s)
  Kensuke Kurihara, Motoki Ueda, Isao Hara, Eri Hara, Kohei Sano, Akira Makino, Eiichi Ozeki, Fumihiko Yamamoto, Hideo Saji, Kaori Togashi and Shunsaku Kimura
- Organizer
  27 th Annual Congress of the European Association of Nuclear Medicine
- Place of Presentation
  Gothenburg, Sweden
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-24591821

1. YAMAMOTO FUMIHIKO (40253471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. KIMURA Shunsaku (80150324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. FUNAKI Yoshihito (50261491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 清水章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kurihara Kensuke 栗原 研輔

KURIHARA Kensuke 栗原 研輔

Research Projects

Research Products

Co-Researchers

Development of nuclear medicinal molecular imaging probe using nanocarrier "Lactosome"

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A development of Tumor imaging by I-123 Lactsome using small animal SPECT/CTPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of improvement depiction of carcinoma in Lactsome fluorescence/PET imagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Evasion from accelerated blood clearance of nanocarrier named as "Lactosome" induced by excessive administration of Lactosome.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Radionuclide Therapy Using Nanoparticle of 131I-Lactosome in Combination with Percutaneous Ethanol Injection Therapy2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Radiosynthesis and initial evaluation of 18F labeled nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Control of in vivo blood clearance time of polymeric micelle by stereochemistry of amphiphilic polydepsipeptides2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pharmacokinetic Change of Nanoparticulate Formulation “Lactosome” on Multiple Administrations2012

Author(s)

Journal Title

DOI

Data Source

[Patent] 病変部位の内照射治療用ナノ粒子及び治療システム2014

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 病変部位の内照射治療用ナノ粒子および治療システム2014

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 病変部位の内照射治療用ナノ粒子および治療システム2014

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

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[Patent] 病変部位の内照射治療用ナノ粒子及び治療システム2014

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 病変部位の内照射治療用ナノ粒子および治療システム2014

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 病変部位の内照射治療用ナノ粒子及び治療システム2014

Inventor(s)

Kurihara Kensuke 栗原研輔

KURIHARA Kensuke 栗原研輔