Kobayashi Naoki 小林直木

… Alternative Names

KOBAYASHI Naoki 小林直木

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Researcher Number	90532250
Other IDs
Affiliation (Current)	2025: 摂南大学, 農学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 摂南大学, 農学部, 助教 2015 – 2019: 摂南大学, 薬学部, 助教 2011 – 2014: 帝京平成大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy / Environmental and hygienic pharmacy
Keywords	Principal Investigator S1P / 脂質メディエーター / 赤血球 / トランスポーター / スフィンゴシン1リン酸 / MFSD2B / 輸送体 / 免疫沈降 / リゾリン脂質 / 創傷治癒 … More / 血小板 / リン酸化 / CRISPR/Cas9 / 蛍光測定 / S1P輸送体 / 情報伝達物質 / NBD-S1P / 蛍光プレートリーダー / 脂質 / スフィンゴシン / スフィンゴシン１リン酸 Less

S1P輸送体MFSD2Bの活性が細胞内分子により制御されるメカニズムPrincipal Investigator
- Principal Investigator
  
  小林直木
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Setsunan University
Regulation mechanism of the novel S1P transporter MFSD2B activityPrincipal Investigator
- Principal Investigator
  
  Kobayashi Naoki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Setsunan University
Regulation mechanisms of lymphocyte trafficking by sphingosine 1-phosphate (S1P) transportersPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Naoki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Setsunan University
Establishment of a rapid method for measuring sphingosine-1-phosphate transporter activityPrincipal Investigator
- Principal Investigator
  
  Kobayashi Naoki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Setsunan University
  Teikyo Heisei University
Photoaffinity labeling of sphingosine 1-phosphate transportersPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Naoki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo Heisei University

All 2024 2022 2021 2019 2018 2017 2016 2015 2014 2012 2011

All Journal Article Presentation Book

[Book] A Rapid Fluorescence Assay for Measuring Sphingosine-1-Phosphate Transporter Activity in Erythrocytes2017
- Author(s)
  Naoki Kobayashi, Tsuyoshi Nishi
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25870695
[Journal Article] Pentafluorosulfanyl-substituted biaryl derivatives as MATE-type transporter inhibitors targeting drug-resistant bacteria2024
- Author(s)
  Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 99 Pages: 117606-117606
- DOI
  10.1016/j.bmc.2024.117606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06514, KAKENHI-PROJECT-23K06125, KAKENHI-PROJECT-20K07059
[Journal Article] Fluorophenylalkyl-substituted cyanoguanidine derivatives as bacteria-selective MATE transporter inhibitors for the treatment of antibiotic-resistant infections2022
- Author(s)
  Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 74 Pages: 117042-117042
- DOI
  10.1016/j.bmc.2022.117042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07059, KAKENHI-PROJECT-22K06514
[Journal Article] リゾリン脂質輸送体と疾患制御2019
- Author(s)
  小林直木, 久野悠, 西毅
- Journal Title
  
  医学のあゆみ
  
  Volume: 269 Pages: 1082-1088
- Data Source
  KAKENHI-PROJECT-17K08399
[Journal Article] 赤血球における新規S1P輸送体MFSD2Bの同定2018
- Author(s)
  小林直木、西（川崎）晶子、大塚正人、久野悠、山口明人、西毅
- Journal Title
  
  脂質生化学研究
  
  Volume: 60 Pages: 200-200
- Data Source
  KAKENHI-PROJECT-17K08399
[Journal Article] Identification of a novel S1P transporter in erythrocytes2018
- Author(s)
  小林直木、西（川崎）晶子、西毅
- Journal Title
  
  生化学
  
  Volume: 90 Issue: 5 Pages: 581-587
- DOI
  10.14952/SEIKAGAKU.2018.900581
- ISSN
  0037-1017
- Year and Date
  2018-10-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08399
[Journal Article] MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells2018
- Author(s)
  Kobayashi Naoki、Kawasaki-Nishi Shoko、Otsuka Masato、Hisano Yu、Yamaguchi Akihito、Nishi Tsuyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 4969-4969
- DOI
  10.1038/s41598-018-23300-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08399
[Journal Article] Update Review 新しい創薬標的としての脂質メディエーター分泌輸送体2016
- Author(s)
  西毅、久野悠、小林直木、山口明人
- Journal Title
  
  実験医学
  
  Volume: 34 Pages: 2356-2361
- Data Source
  KAKENHI-PROJECT-25870695
[Journal Article] Fluorescence-based rapid measurement of sphingosine-1-phosphate transport activity in erythrocytes2016
- Author(s)
  Naoki Kobayashi, Masato Otsuka, Akihito Yamaguchi and Tsuyoshi Nishi
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 57 Issue: 11 Pages: 2088-2094
- DOI
  10.1194/jlr.d071068
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25870695
[Journal Article] β-Lactam Selectivity of Multidrug Transporters AcrB and AcrD Resides in the Proximal Binding Pocket2014
- Author(s)
  Kobayashi,N., Tamura,N., van Veen, HW., Murakami,S. and Yamaguchi,A.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Issue: 15 Pages: 10680-10690
- DOI
  10.1074/jbc.m114.547794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790093, KAKENHI-PROJECT-25870695
[Journal Article] Molecular and physiological functions of sphingosine 1-phosphate transporters2014
- Author(s)
  Nishi, T., Kobayashi, N., Hisano, Y., Kawahara, A. and Yamaguchi, A
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1841 Issue: 5 Pages: 759-765
- DOI
  10.1016/j.bbalip.2013.07.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790093, KAKENHI-PROJECT-24790075, KAKENHI-PUBLICLY-25116722, KAKENHI-PROJECT-25670024, KAKENHI-PROJECT-25870695, KAKENHI-PROJECT-26460088
[Journal Article] Mouse SPNS2 functions as a sphingoshine 1-phosphate transporter in vascular endothelial cells2012
- Author(s)
  Hisano, Y., Kobayashi, N., Yamaguchi, A., Nishi T.
- Journal Title
  
  PloS ONE
  
  Volume: 7 Issue: 6 Pages: 38941-38941
- DOI
  10.1371/journal.pone.0038941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200071, KAKENHI-PROJECT-21570137, KAKENHI-PROJECT-23790093, KAKENHI-PROJECT-24790075
[Presentation] S1P輸送体MFSD2Bのリン酸化による活性制御2024
- Author(s)
  小林直木, 金澤豊, 中村透唯, 大塚正人, 西毅
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-20K07059
[Presentation] S1P輸送体MFSD2Bのリン酸化による活性制御2024
- Author(s)
  小林直木, 金澤豊, 中村透唯, 大塚正人, 西毅
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06125
[Presentation] S1P輸送体MFSD2Bの活性制御機構の解析2022
- Author(s)
  小林直木, 金澤豊, 中村透唯, 大塚正人, 西毅
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07059
[Presentation] 赤血球・血小板S1P輸送体MFSD2Bの活性制御機構の解析2021
- Author(s)
  小林直木, 中村透唯, 大塚正人, 西毅
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07059
[Presentation] シメチジン類縁体を用いたヒトMATE1輸送体阻害作用の構造活性相関研究2021
- Author(s)
  新屋進, 河合健太郎, 小林直木, 軽尾友紀子, 樽井敦, 佐藤和之, 大塚正人, 表雅章
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] シメチジン類縁体を用いたヒトMATE1輸送体阻害作用の構造活性相関研究2021
- Author(s)
  新屋進, 河合健太郎, 小林直木, 軽尾友紀子, 樽井敦, 佐藤和之, 大塚正人, 表雅章
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07059
[Presentation] トランスポーターが制御する体内の脂質輸送2021
- Author(s)
  小林直木
- Organizer
  第10回摂大農学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] 赤血球・血小板S1P輸送体MFSD2Bの活性制御機構の解析2021
- Author(s)
  小林直木, 中村透唯, 大塚正人, 西毅
- Organizer
  第15回スフィンゴテラピィ研究会
- Data Source
  KAKENHI-PROJECT-20K07059
[Presentation] トランスポーターが制御する体内の脂質輸送2021
- Author(s)
  小林直木
- Organizer
  第10回摂大農学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K07059
[Presentation] Characterization of the erythrocyte S1P transporter MFSD2B2019
- Author(s)
  Naoki Kobayashi, Shoko Kawasaki-Nishi, Masato Otsuka, Yu Hisano, Akihito Yamaguchi, Tsuyoshi Nishi
- Organizer
  The 2019 FASEB Science Research Conference on Lysophospholipid and Related Mediators: From Bench to Clinic
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] HEK293/SphK細胞におけるNBD標識スフィンゴシン1リン酸（NBD-S1P）輸送体の同定2019
- Author(s)
  武田隼聖, 道下誠也, 小林直木, 大塚正人
- Organizer
  医療薬学フォーラム2019
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] 赤血球の新規S1P輸送体MFSD2B2019
- Author(s)
  小林直木, 西(川崎)晶子, 大塚正人, 久野悠, 山口明人, 西毅
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] 赤血球S1P輸送体MFSD2Bの生化学的解析2019
- Author(s)
  小林直木, 西(川崎)晶子, 大塚正人, 久野悠, 山口明人, 西毅
- Organizer
  第14回スフィンゴテラピィ（STC）研究会 2020年1月24日
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] Characterization of the novel sphingosine 1-phosphate transporter MFSD2B2019
- Author(s)
  Naoki Kobayashi, Shoko Kawasaki-Nishi, Masato Otsuka, Yu Hisano, Akihito Yamaguchi, Tsuyoshi Nishi
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] 赤血球における新規S1P輸送体MFSD2Bの同定2018
- Author(s)
  小林直木、西（川崎）晶子、大塚正人、久野悠、山口明人、西毅
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] MFSD2Bは赤血球前駆細胞株のスフィンゴシン1リン酸輸送体として機能する2018
- Author(s)
  小林直木、西（川崎）晶子、大塚正人、久野悠、山口明人、西毅
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] 赤血球前駆細胞株の新規S1P輸送体MFSD2Bの同定2018
- Author(s)
  小林直木、西（川崎）晶子、大塚正人、久野悠、山口明人、西毅
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] 赤血球の新規スフィンゴシン1リン酸輸送体MFSD2Bの同定2018
- Author(s)
  小林直木、西（川崎）晶子、大塚正人、久野悠、山口明人、西毅
- Organizer
  第68 回日本薬学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] MFSD2B is a novel sphingosine 1-phosphate transporter in erythroid cells2018
- Author(s)
  Naoki Kobayashi, Shoko Kawasaki-Nishi, Masato Otsuka, Yu Hisano, Akihito Yamaguchi, and Tsuyoshi Nishi
- Organizer
  2nd Japan-Korea Lipid Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] 赤血球前駆細胞株における新規スフィンゴシン1リン酸輸送体の同定2017
- Author(s)
  小林直木、西（川崎）晶子、土井康平、三木悠史、大塚正人、久野悠、山口明人、西毅
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17K08399
[Presentation] Fluorescence-based rapid measurement of sphingosine 1-phosphate transport activity in rat erythrocytes2015
- Author(s)
  Naoki Kobayashi, Masato Otsuka, Akihito yamaguchi, Tsuyoshi Nishi
- Organizer
  14th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases
- Place of Presentation
  The Hungarian Academy of Sciences (Budapest, Hungary)
- Year and Date
  2015-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870695
[Presentation] スフィンゴシン１リン酸（S1P）の蛍光標識体を用いた赤血球S1P輸送体の活性測定2015
- Author(s)
  小林直木、大塚正人、山口明人、西毅
- Organizer
  BMB2015（第38回日本分子生物学会年会・第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25870695
[Presentation] 蛍光標識分子を用いた赤血球スフィンゴシン１リン酸（S1P）輸送体の活性測定2015
- Author(s)
  小林直木、山口明人、西毅
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸（兵庫県神戸市）
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-25870695
[Presentation] 光反応性アナログを用いたスフィンゴシン１リン酸（S1P）輸送体の探索2014
- Author(s)
  小林直木、山口明人、西毅
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25870695
[Presentation] 光反応性アナログを用いたスフィンゴシン1リン酸(S1P)輸送体の探索2014
- Author(s)
  小林直木、山口明人、西毅
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-23790093
[Presentation] 光反応性アナログを用いたスフィンゴシン１リン酸（S1P）輸送体の探索2014
- Author(s)
  小林直木、山口明人、西毅
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790093
[Presentation] 光反応性分子を用いたスフィンゴシン1リン酸輸送体の探索2012
- Author(s)
  小林直木、山口明人、西毅
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-23790093
[Presentation] 光反応性分子を用いたスフィンゴシン１リン酸輸送体の探索2012
- Author(s)
  小林直木、山口明人、西毅
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  マリンメッセ福岡（福岡県）
- Data Source
  KAKENHI-PROJECT-23790093
[Presentation] Characterization of the ATP-dependent sphingosine 1-phosphate (S1P) transporter in rat erythrocytes2011
- Author(s)
  Kobayashi, N., Kobayashi, N., Adachi, H., Yamaguchi, A. and Nishi, T
- Organizer
  The 30th Naito Conference on Membrane Dynamics and Lipid Biology [II]
- Place of Presentation
  Domains, Droplets and Diseases (Sapporo)
- Data Source
  KAKENHI-PROJECT-23790093
[Presentation] Characterization of the ATP-dependent sphingosine 1-phosphate (S1P) transporter in rat erythrocytes2011
- Author(s)
  Kobayashi, N., Kobayashi, N., Adachi, H., Yamaguchi, A. and Nishi, T.
- Organizer
  The 30th Naito Conference on Membrane Dynamics and Lipid Biology [II], Domains, Droplets and Diseases
- Place of Presentation
  CHATERAISE Gateaux Kingdom SAPPORO (Hokkaido)
- Data Source
  KAKENHI-PROJECT-23790093

1. OMOTE Masaaki

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# of Collaborated Products: 1 results
2. NISHI Tsuyoshi

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# of Collaborated Products: 1 results
3. 大塚正人

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# of Collaborated Products: 1 results
4. 軽尾友紀子

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# of Collaborated Products: 1 results
5. 河合健太郎

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# of Collaborated Products: 1 results

Kobayashi Naoki 小林 直木

KOBAYASHI Naoki 小林 直木

Research Projects

Research Products

Co-Researchers

S1P輸送体MFSD2Bの活性が細胞内分子により制御されるメカニズムPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation mechanism of the novel S1P transporter MFSD2B activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation mechanisms of lymphocyte trafficking by sphingosine 1-phosphate (S1P) transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a rapid method for measuring sphingosine-1-phosphate transporter activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Photoaffinity labeling of sphingosine 1-phosphate transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] A Rapid Fluorescence Assay for Measuring Sphingosine-1-Phosphate Transporter Activity in Erythrocytes2017

Author(s)

Publisher

Data Source

[Journal Article] Pentafluorosulfanyl-substituted biaryl derivatives as MATE-type transporter inhibitors targeting drug-resistant bacteria2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fluorophenylalkyl-substituted cyanoguanidine derivatives as bacteria-selective MATE transporter inhibitors for the treatment of antibiotic-resistant infections2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] リゾリン脂質輸送体と疾患制御2019

Author(s)

Journal Title

Data Source

[Journal Article] 赤血球における新規S1P輸送体MFSD2Bの同定2018

Author(s)

Journal Title

Data Source

[Journal Article] Identification of a novel S1P transporter in erythrocytes2018

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Update Review 新しい創薬標的としての脂質メディエーター分泌輸送体2016

Author(s)

Journal Title

Data Source

[Journal Article] Fluorescence-based rapid measurement of sphingosine-1-phosphate transport activity in erythrocytes2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] β-Lactam Selectivity of Multidrug Transporters AcrB and AcrD Resides in the Proximal Binding Pocket2014

Kobayashi Naoki 小林直木

KOBAYASHI Naoki 小林直木