Shimizu Fumitaka 清水文崇

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SHIMIZU Fumitaka 清水文崇

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Researcher Number	90535254
Other IDs
Affiliation (Current)	2025: 山口大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2024: 山口大学, 大学院医学系研究科, 准教授 2021 – 2023: 山口大学, 医学部附属病院, 講師 2018 – 2020: 山口大学, 医学部附属病院, 助教 2012 – 2014: 山口大学, 医学(系)研究科(研究院), 助教 2010 – 2011: 山口大学, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator 血液神経関門 / 血液脳関門 / 自己免疫性ニューロパチー / 血液筋関門 / 自己免疫性神経筋疾患 / 細胞モデル / 新規抗体製剤開発 / 自己免疫性神経疾患 / 自己抗体 / MAGニューロパチー … More / 神経免疫 / 神経免疫疾患 / 傍腫瘍性小脳変性症 / 視神経脊髄炎 / GRP78抗体 / 多国籍 / 国際情報交換 / 末梢神経障害 / 自己免疫性末梢神経疾患 / 多巣性運動ニューロパチー / 慢性炎症性脱髄性根ニューロパチー / 末梢神経神経内膜内血管内皮細胞 / ペリサイト / 糖尿病性細小血管障害 / 糖尿病性末梢神経障害 / 後期糖化反応生成物 … More Except Principal Investigator 自己抗体 / ペリサイト / アストロサイト / 血管内皮細胞 / 血液脳関門 Less

難治性神経筋疾患の病態解明と治療開発のための新規血液脳・神経・筋関門モデルの確立Principal Investigator
- Principal Investigator
  
  清水文崇
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Yamaguchi University
Mechanism of breakdown of blood-brain barrier/blood-nerve barrier in neuroimmunological disorderPrincipal Investigator
- Principal Investigator
  
  SHIMIZU FUMITAKA
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Yamaguchi University
Novel strategy to treat intractable CNS disorders, utilizing the properties of BBB-composing cells
- Principal Investigator
  
  神田隆
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Yamaguchi University
Discovery of new drug target modifiying the function of blood-brain barrier and blood-nerve barrierPrincipal Investigator
- Principal Investigator
  
  Shimizu Fumitaka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Yamaguchi University
Investigation into the mechanism of the blood-nerve barrier disruption in chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathyPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Fumitaka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Yamaguchi University
The effect of advanced glycation end-products on blood-nerve barrierPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Fumitaka
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Yamaguchi University

All 2024 2023 2022 2021 2020 2019 2018 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] 日本臨床　多発性硬化症と視神経脊髄炎- 血液神経関門とその障害モデル-2014
- Author(s)
  清水文崇，神田　隆．
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-24790886
[Book] The Blood-Brain Barrier in Neuroinflammation. In Suzumura A, Ikenaka K, editors. Neuron-Glia Interaction in Neuroinflammation.2013
- Author(s)
  Shimizu F, Kanda T
- Total Pages
  22
- Publisher
  New York, NY: Springer Science+Business Media New York.
- Data Source
  KAKENHI-PROJECT-24790886
[Book] 医学のあゆみ,血管内皮異常2011
- Author(s)
  清水文崇, 神田隆
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-22790821
[Book] 血管内皮異常2011
- Author(s)
  清水文崇, 神田隆
- Total Pages
  4
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-22790821
[Journal Article] Contribution of Complement, Microangiopathy and Inflammation in Idiopathic Inflammatory Myopathies2024
- Author(s)
  Honda Masaya、Shimizu Fumitaka、Sato Ryota、Nakamori Masayuki
- Journal Title
  
  Journal of Neuromuscular Diseases
  
  Volume: 11 Issue: 1 Pages: 5-16
- DOI
  10.3233/jnd-230168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-19K22597
[Journal Article] Highlighting In Vitro the Role of Brain-like Endothelial Cells on the Maturation and Metabolism of Brain Pericytes by SWATH Proteomics2023
- Author(s)
  Menaceur Camille、Hachani Johan、Dib Shiraz、Duban-Deweer Sophie、Karamanos Yannis、Shimizu Fumitaka、Kanda Takashi、Gosselet Fabien、Fenart Laurence、Saint-Pol Julien
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 7 Pages: 1010-1010
- DOI
  10.3390/cells12071010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-20H00529
[Journal Article] 【運動失調症の病態と治療】自己免疫性小脳失調症の治療2023
- Author(s)
  清水文崇
- Journal Title
  
  脳神経内科
  
  Volume: 99 (4) Pages: 495-501
- Data Source
  KAKENHI-PROJECT-21K07416
[Journal Article] Autocrine TNF-α Increases Penetration of Myelin-Associated Glycoprotein Antibodies Across the Blood-Nerve Barrier in Anti-MAG Neuropathy2023
- Author(s)
  Sato Ryota、Shimizu Fumitaka、Kuwahara Motoi、Mizukami Yoichi、Watanabe Kenji、Maeda Toshihiko、Sano Yasuteru、Takeshita Yukio、Koga Michiaki、Kusunoki Susumu、Kanda Takashi
- Journal Title
  
  Neurology - Neuroimmunology Neuroinflammation
  
  Volume: 10 Issue: 3
- DOI
  10.1212/nxi.0000000000200086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-18K16255, KAKENHI-PROJECT-21K08644, KAKENHI-PROJECT-21K07437, KAKENHI-PROJECT-20H00529
[Journal Article] TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA12023
- Author(s)
  Dib Shiraz、Loiola Rodrigo Azevedo、Sevin Emmanuel、Saint-Pol Julien、Shimizu Fumitaka、Kanda Takashi、Pahnke Jens、Gosselet Fabien
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 6 Pages: 5992-5992
- DOI
  10.3390/ijms24065992
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-20H00529
[Journal Article] Jo-1 Antibodies From Myositis Induce Complement-Dependent Cytotoxicity and TREM-1 Upregulation in Muscle Endothelial Cells2023
- Author(s)
  Honda Masaya、Shimizu Fumitaka、Sato Ryota、Mizukami Yoichi、Watanabe Kenji、Takeshita Yukio、Maeda Toshihiko、Koga Michiaki、Kanda Takashi
- Journal Title
  
  Neurology - Neuroimmunology Neuroinflammation
  
  Volume: 10 Issue: 4 Pages: 1-11
- DOI
  10.1212/nxi.0000000000200116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16255, KAKENHI-PROJECT-21K08644, KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-21K07437, KAKENHI-PROJECT-20H00529, KAKENHI-PROJECT-20H00632, KAKENHI-PROJECT-21H03358
[Journal Article] ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells2023
- Author(s)
  Cicero Julien、Trouvilliez Sarah、Palma Martine、Ternier Gaetan、Decoster Laurine、Happernegg Eloise、Barois Nicolas、Van Outryve Alexandre、Dehouck Lucie、Bourette Roland P.、Adriaenssens Eric、Lagadec Chann、Tarhan Cagatay Mehmet、Collard Dominique、Shimizu Fumitaka、Kanda Takashi、et al.
- Journal Title
  
  Experimental Hematology and Oncology
  
  Volume: 12 Issue: 1 Pages: 104-104
- DOI
  10.1186/s40164-023-00463-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07416
[Journal Article] 運動失調症をきたす神経疾患】自己免疫性小脳失調症のバイオマーカー -GRP78抗体を含めた自己抗体-2023
- Author(s)
  清水文崇
- Journal Title
  
  脳神経内科
  
  Volume: 98(1) Pages: 7-12
- Data Source
  KAKENHI-PROJECT-21K07416
[Journal Article] Paraneoplastic Neuromyelitis Optica Spectrum Disorder Related to Glucose-regulated Protein 78 (GRP78) Autoantibodies in a Patient with Lynch Syndrome-associated Colorectal Cancer2023
- Author(s)
  Minomo Shogo、Ichijo Masahiko、Shimizu Fumitaka、Sato Ryota、Kanda Takashi、Takai Yoshiki、Misu Tatsuro、Sakurai Yoshiki、Amino Takeshi、Kamata Tomoyuki
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 11 Pages: 1653-1657
- DOI
  10.2169/internalmedicine.9783-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07416
[Journal Article] Exploring lipophilic compounds that induce BDNF secretion in astrocytes beyond the BBB using a new multi-cultured human in vitro BBB model2022
- Author(s)
  Fujisawa Miwako、Takeshita Yukio、Fujikawa Susumu、Matsuo Kinya、Okamoto Masashi、Tamada Masaya、Shimizu Fumitaka、Sano Yasuteru、Koga Michiaki、Kanda Takashi
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 362 Pages: 577783-577783
- DOI
  10.1016/j.jneuroim.2021.577783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-21K07437, KAKENHI-PROJECT-20H00529
[Journal Article] Heterozygous NOTCH1 Variants Cause Immune Activation and Microangiopathy2022
- Author(s)
  Helman Guy、Zarekiani Parand、Tromp Samantha A.M.、Andrews Ashley、Botto Lorenzo D.、Bonkowsky Joshua L.、Chassevent Anna、Giorgio Elisa、Pippucci Tommaso、Wei Shen、Smith‐Hicks Constance、Vaula Giovanna、Willemsen Mich、Schimmel Mareike、Vollert Kurt、Shimizu Fumitaka、Kanda Takashi、et al
- Journal Title
  
  Annals of Neurology
  
  Volume: 92 Issue: 5 Pages: 895-901
- DOI
  10.1002/ana.26477
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-20H00529
[Journal Article] Interaction of surfactant coated PLGA nanoparticles with in vitro human brain-like endothelial cells2022
- Author(s)
  Moya Elisa L.J.、Lombardo Sonia M.、Vandenhaute Elodie、Schneider Marc、Mysiorek Caroline、Treli Akif E.、Kanda Takashi、Shimizu Fumitaka、Sano Yasuteru、Maubon Nathalie、Gosselet Fabien、Gnday-Treli Nazende、Dehouck Marie-Pierre
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 621 Pages: 121780-121780
- DOI
  10.1016/j.ijpharm.2022.121780
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-20H00529
[Journal Article] Novel heterozygous variants of SLC12A6 in Japanese families with Charcot-Marie-Tooth disease.2022
- Author(s)
  Ando Masahiro、Higuchi Yujiro、Yuan Junhui、Yoshimura Akiko、Taniguchi Takaki、Takei Jun、Takeuchi Mika、Hiramatsu Yu、Shimizu Fumitaka、Kubota Masaya、Takeshima Akari、et al.
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 9 Issue: 7 Pages: 902-911
- DOI
  10.1002/acn3.51603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-22K15713, KAKENHI-PROJECT-21H02842, KAKENHI-PROJECT-19K16910, KAKENHI-PROJECT-21K15702
[Journal Article] Pioglitazone Attenuates the Effects of Peripheral Inflammation in a Human In Vitro Blood-Brain Barrier Model2022
- Author(s)
  da Rocha Gustavo Henrique Oliveira、Loiola Rodrigo Azevedo、de Paula-Silva Marina、Shimizu Fumitaka、Kanda Takashi、Vieira Andrea、Gosselet Fabien、Farsky Sandra Helena Poliselli
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 21 Pages: 12781-12781
- DOI
  10.3390/ijms232112781
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-20H00529
[Journal Article] GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder2021
- Author(s)
  Shimizu F, Ogawa R, Mizukami Y, Watanabe K, Hara K, Kadono C, Takahashi T, Misu T, Takeshita Y, Sano Y, Fujisawa M, Maeda T, Nakashima I, Fujihara K, Kanda T.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflamm
  
  Volume: 9 Issue: 1
- DOI
  10.1212/nxi.0000000000001038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07953, KAKENHI-PROJECT-18K11128, KAKENHI-PROJECT-20K07892, KAKENHI-PROJECT-21K07416, KAKENHI-PROJECT-21K08644, KAKENHI-PROJECT-18K16255, KAKENHI-PROJECT-21H03358, KAKENHI-PROJECT-20H00529
[Journal Article] A Triple Culture Cell System Modeling the Human Blood-Brain Barrier.2021
- Author(s)
  Eleonora Rizzi, Clemence Deligne, Lucie Dehouck, Roberta Bilardo, Yasutero Sano, Fumitaka Shimizu, Takashi Kanda, Marina Resmini, Fabien Gosselet, Marie-Pierre Dehouck, Caroline Mysiorek.
- Journal Title
  
  J　Vis Exp
  
  Volume: 177 Issue: 177 Pages: 30-30
- DOI
  10.3791/63134
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00529, KAKENHI-PROJECT-21K07416
[Journal Article] New BBB Model Reveals That IL-6 Blockade Suppressed the BBB Disorder, Preventing Onset of NMOSD.2021
- Author(s)
  Takeshita Y, Fujikawa S, Serizawa K, Fujisawa M, Matsuo K, Nemoto J, Shimizu F, Sano Y, Tomizawa-Shinohara H, Miyake S, Ransohoff RM, Kanda T.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflamm
  
  Volume: 8 Issue: 6
- DOI
  10.1212/nxi.0000000000001076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00529
[Journal Article] Glial cell line-derived neurotrophic factor and basic fibroblast growth factor derived from skeletal muscle pericytes increase the barrier function of endothelial cells in the endomysium.2021
- Author(s)
  Eri Ishiguchi, Yasuteru Sano, Toshihiko Maeda, Fumitaka Shimizu, Miwako Fujisawa, Masaya Honda, Yukio Takeshita, Michiaki Koga, Takashi Kanda.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 12 Issue: 4 Pages: 258-267
- DOI
  10.1111/cen3.12674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00529, KAKENHI-PROJECT-21K07437
[Journal Article] Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage2021
- Author(s)
  Loiola Rodrigo Azevedo、Garcia-Gabilondo Miguel、Grayston Alba、Bugno Paulina、Kowalska Agnieszka、Duban-Deweer Sophie、Rizzi Eleonora、Hachani Johan、Sano Yasuteru、Shimizu Fumitaka、Kanda Takashi、Mysiorek Caroline、Mazurek Maciej Piotr、Rosell Anna、Gosselet Fabien
- Journal Title
  
  Stem Cell Research Therapy
  
  Volume: 12 Issue: 1 Pages: 552-552
- DOI
  10.1186/s13287-021-02608-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07416
[Journal Article] Lambert-Eaton筋無力症とGRP78自己抗体2020
- Author(s)
  清水文崇, 神田隆
- Journal Title
  
  医学のあゆみ
  
  Volume: 274 Pages: 1299-1300
- Data Source
  KAKENHI-PROJECT-18K07526
[Journal Article] 総説ペリサイトと神経系-生理的役割と病理的意義2020
- Author(s)
  清水文崇、神田隆
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 72 Issue: 2 Pages: 151-158
- DOI
  10.11477/mf.1416201495
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2020-02-01
- Data Source
  KAKENHI-PROJECT-18K07526
[Journal Article] Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging2020
- Author(s)
  Salman Mootaz M.、Marsh Graham、Kusters Ilja、Delinc Matthieu、Di Caprio Giuseppe、Upadhyayula Srigokul、de Nola Giovanni、Hunt Ronan、Ohashi Kazuka G.、Gray Taylor、Shimizu Fumitaka、Sano Yasuteru、Kanda Takashi、Obermeier Birgit、Kirchhausen Tom
- Journal Title
  
  Frontiers in Bioengineering and Biotechnology
  
  Volume: 8 Pages: 573755-573755
- DOI
  10.3389/fbioe.2020.573775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07526
[Journal Article] Advancing human induced pluripotent stem cell‐derived blood‐brain barrier models for studying immune cell interactions2020
- Author(s)
  Nishihara Hideaki、Gastfriend Benjamin D.、Soldati Sasha、Perriot Sylvain、Mathias Amandine、Sano Yasuteru、Shimizu Fumitaka、Gosselet Fabien、Kanda Takashi、Palecek Sean P.、Du Pasquier Renaud、Shusta Eric V.、Engelhardt Britta
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 12 Pages: 16693-16715
- DOI
  10.1096/fj.202001507rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07526, KAKENHI-PROJECT-20H00529
[Journal Article] Serotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression2020
- Author(s)
  Sugimoto Kotaro、Ichikawa-Tomikawa Naoki、Nishiura Keisuke、Kunii Yasuto、Sano Yasuteru、Shimizu Fumitaka、Kakita Akiyoshi、Kanda Takashi、Imura Tetsuya、Chiba Hideki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 1 Pages: 254-254
- DOI
  10.3390/ijms22010254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07526, KAKENHI-PROJECT-19K16615
[Journal Article] Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells2020
- Author(s)
  Heymans Marjolein、Figueiredo Ricardo、Dehouck Lucie、Francisco David、Sano Yasuteru、Shimizu Fumitaka、Kanda Takashi、Bruggmann Rumy、Engelhardt Britta、Winter Peter、Gosselet Fabien、Culot Maxime
- Journal Title
  
  Fluids and Barriers of the CNS
  
  Volume: 17 Issue: 1 Pages: 37-37
- DOI
  10.1186/s12987-020-00208-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07526
[Journal Article] 【免疫性神経疾患update-基礎・臨床研究の最新知見-】自己免疫性神経疾患でのGRP78抗体2020
- Author(s)
  清水文崇, 神田隆
- Journal Title
  
  日本臨床
  
  Volume: 78 Pages: 1951-1956
- Data Source
  KAKENHI-PROJECT-18K07526
[Journal Article] Development of a human in vitro blood-brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance2020
- Author(s)
  Deligne Clmence、Hachani Johan、Duban-Deweer Sophie、Meignan Samuel、Leblond Pierre、Carcaboso Angel M.、Sano Yasuteru、Shimizu Fumitaka、Kanda Takashi、Gosselet Fabien、Dehouck Marie-Pierre、Mysiorek Caroline
- Journal Title
  
  Fluids and Barriers of the CNS
  
  Volume: 17 Issue: 1 Pages: 37-37
- DOI
  10.1186/s12987-020-00198-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07526
[Journal Article] GRP78 antibodies are associated with blood-brain barrier breakdown in paraneoplastic cerebellar degeneration in Lambert-Eaton myasthenic syndrome.2020
- Author(s)
  Shimizu F, Kanda T.
- Journal Title
  
  Clin. Exp. Neuroimmunol
  
  Volume: 11 Issue: 2 Pages: 88-89
- DOI
  10.1111/cen3.12575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07526
[Journal Article] Increased IP-10 production by blood-nerve barrier in multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy.2019
- Author(s)
  Shimizu F, Oishi M, Sawai S, Beppu M, Misawa S, Matsui N, Miyashiro A, Maeda T, Takeshita Y, Nishihara H, Sano Y, Sato R, Kaji R, Kuwabara S, Kanda T.
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 90 Issue: 4 Pages: 444-450
- DOI
  10.1136/jnnp-2018-319270
- NAID
  120006713015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07526, KAKENHI-PROJECT-19K07815, KAKENHI-PROJECT-17H04197
[Journal Article] GRP78 antibodies damage the blood-brain barrier and relate to cerebellar degeneration in Lambert-Eaton myasthenic syndrome.2019
- Author(s)
  Shimizu F, Takeshita Y, Sano Y, Hamamoto Y, Shiraishi H, Sato T, Yoshimura S, Maeda T, Fujikawa S, Nishihara H, Kitanosono H, Tsujino A, Motomura M, Kanda T.
- Journal Title
  
  Brain.
  
  Volume: 142 Issue: 8 Pages: 2253-2264
- DOI
  10.1093/brain/awz168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09787, KAKENHI-PROJECT-18K07526, KAKENHI-PROJECT-17H04197
[Journal Article] GRP 78 antibodies are associated with clinical phenotype in neuromyelitis optica2019
- Author(s)
  Shimizu Fumitaka、Takeshita Yukio、Hamamoto Yuka、Nishihara Hideaki、Sano Yasuteru、Honda Masaya、Sato Ryota、Maeda Toshihiko、Takahashi Toshiyuki、Fujikawa Susumu、Kanda Takashi
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 6 Issue: 10 Pages: 2079-2087
- DOI
  10.1002/acn3.50905
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07526, KAKENHI-PROJECT-17H04197
[Journal Article] Blood-brain barrier dysfunction in immuno-mediated neurological diseases.2018
- Author(s)
  Shimizu F, Nishihara H, Kanda T.
- Journal Title
  
  Immunol Med
  
  Volume: 41 Issue: 3 Pages: 120-128
- DOI
  10.1080/25785826.2018.1531190
- Data Source
  KAKENHI-PROJECT-18K07526
[Journal Article] Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis.2015
- Author(s)
  Nishihara H, Shimizu F, Sano Y, Takeshita Y, Maeda T, Abe M, Koga M, Kanda T.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 3 Pages: e0121488-e0121488
- DOI
  10.1371/journal.pone.0121488
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790886, KAKENHI-PROJECT-26461271, KAKENHI-PROJECT-26860669, KAKENHI-PROJECT-25293203
[Journal Article] Markedly Increased IP-10 Production by Blood-Brain Barrier in Neuromyelitis Optica.2015
- Author(s)
  Shimizu F, Nishihara H, Sano Y, Takeshita Y, Takahashi S, Maeda T, Takahashi T, Abe M, Koga M, Kanda T.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 3 Pages: e0122000-e0122000
- DOI
  10.1371/journal.pone.0122000
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790886, KAKENHI-PROJECT-26461271, KAKENHI-PROJECT-26860669, KAKENHI-PROJECT-25293203
[Journal Article] Severity and patterns of blood-nerve barrier breakdown in patients with chronic inflammatory demyelinating polyradiculoneuropathy: correlations with clinical subtypes.2014
- Author(s)
  Shimizu F, Sawai S, Sano Y, Beppu M, Misawa S, Nishihara H, Koga M, Kuwabara S, Kanda T.
- Journal Title
  
  PLOS One
  
  Volume: 9 Issue: 8 Pages: e104205-e104205
- DOI
  10.1371/journal.pone.0104205
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790886, KAKENHI-PROJECT-25293203, KAKENHI-PROJECT-26670443
[Journal Article] Sera from remitting and secondary progressive multiple sclerosis patients disrupt the blood-brain barrier.2014
- Author(s)
  Shimizu F, Tasaki A, Sano Y, Ju M, Nishihara H, Oishi M, Koga M, Kawai M, Kanda T.
- Journal Title
  
  PLOS One
  
  Volume: 9 Issue: 3 Pages: e92872-e92872
- DOI
  10.1371/journal.pone.0092872
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790886
[Journal Article] Breakdown of the blood-brain barrier in neuromyelitis optica: Roles of matrix-metalloproteinases-2/9, vascular endothelial growth factor and autoantibodies against the blood-brain barrier.2014
- Author(s)
  Shimizu F, Tasaki A, Kanda T.
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 5 Pages: 2-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24790886
[Journal Article] 血液神経関門と自己免疫性ニューロパチー2014
- Author(s)
  清水文崇，神田　隆
- Journal Title
  
  Peripheral Nerve
  
  Volume: 24 Pages: 54-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790886
[Journal Article] Autocrine MMP-2/9 secretion increases the BBB permeability in neuromyelitis optica.2014
- Author(s)
  Tasaki A, Shimizu F, Sano Y, Fujisawa M, Takahashi T, Haruki H, Abe M, Koga M, Kanda T.
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 85 Issue: 4 Pages: 419-430
- DOI
  10.1136/jnnp-2013-305907
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790886, KAKENHI-PROJECT-26860669
[Journal Article] 血液脳関門と神経免疫疾患2013
- Author(s)
  清水文崇，神田　隆
- Journal Title
  
  Brain and Nerve
  
  Volume: 65 Pages: 165-176
- Data Source
  KAKENHI-PROJECT-24790886
[Journal Article] Advanced glycation end-products disrupt the blood-brain barrier by stimulating the release of transforming growth factor-β by pericytes and vascular endothelial growth factor and matrix metalloproteinase-2 by endothelial cells in vitro.2013
- Author(s)
  Fumitaka Shimizu
- Journal Title
  
  Neurobiol Aging
  
  Volume: 34 Issue: 7 Pages: 1902-1912
- DOI
  10.1016/j.neurobiolaging.2013.01.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659457, KAKENHI-PROJECT-24790886
[Journal Article] Blood-brain barrier destruction determines Fischer/Bickerstaff clinical phenotypes: an in vitro study2013
- Author(s)
  Kazuyuki Saito, Fumitaka Shimizu, Michiaki Koga, Yasuteru Sano, Ayako Tasaki, Masa-aki Abe, Hiroyo Haruki, Toshihiko Maeda, S. Suzuki, Susumu Kusunoki, Hidehiro Mizusawa, Takashi Kanda.
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 84 Issue: 7 Pages: 756-765
- DOI
  10.1136/jnnp-2012-304306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790994, KAKENHI-PROJECT-24790886
[Journal Article] Sera from patients with multifocal motor neuropathy disrupt the blood-nerve barrier.2013
- Author(s)
  Shimizu F, Omoto M, Sano Y, Mastui N, Miyashiro A, Tasaki A, Maeda T, Koga M, Kaji R, Kanda T.
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 7 Issue: 5 Pages: 526-537
- DOI
  10.1136/jnnp-2013-305405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790886, KAKENHI-PROJECT-25870472, KAKENHI-PROJECT-25870477
[Journal Article] Pericyte-derived Glial Cell Line-derived Neurotrophic Factor Increase the Expression of Claudin-5 in the Blood-brain Barrier and the Blood-nerve Barrier2012
- Author(s)
  Shimizu F, Sano Y, Saito K, Abe MA, Maeda T, Haruki H, Kanda T
- Journal Title
  
  Neurochem Res
  
  Volume: 37 Pages: 401-409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790821
[Journal Article] Sera from neuromyelitis optica patients disrupt the blood-brain barrier2012
- Author(s)
  Shimizu F, Kanda T
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Pages: 288-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790821
[Journal Article] Pericyte-derived glial cell line-derived neurotrophic factor increase the expression of claudin-5 in the blood-brain barrier and the blood-nerve barrier2012
- Author(s)
  Shimizu F, Sano Y, Saito K, Abe MA, Maeda T, Haruki H, Kanda T
- Journal Title
  
  Neurochem Res
  
  Volume: 37 Issue: 2 Pages: 401-409
- DOI
  10.1007/s11064-011-0626-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390268, KAKENHI-PROJECT-23659457, KAKENHI-PROJECT-23790994, KAKENHI-PROJECT-24790886
[Journal Article] Sera from neuromyelitis optica patients disrupt the blood-brain barrier2012
- Author(s)
  Shimizu F, Sano Y, Takahashi T, Haruki H, Saito K, Koga M, Kanda T
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 83(3) Pages: 288-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790821
[Journal Article] Sera from neuromyelitis optica patients disrupt the blood-brain barrier2012
- Author(s)
  Shimizu F, Sano Y, Takahashi T, Haruki H, Saito K, Koga M, Kanda T
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 83 Issue: 3 Pages: 288-297
- DOI
  10.1136/jnnp-2011-300434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390268, KAKENHI-PROJECT-23659457, KAKENHI-PROJECT-24790886
[Journal Article] Advanced glycation end-products induce basement membrane hypertrophy in endoneurial microvessels and disrupt the blood-nerve barrier by stimulating the release of TGF-β and vascular endothelial growth factor (VEGF) by pericytes.2011
- Author(s)
  Shimizu F
- Journal Title
  
  Diabetologia.
  
  Volume: 16(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790821
[Journal Article] Advanced glycation end-products induce basement membrane hypertrophy in endoneurial microvessels and disrupt the blood-nerve barrier by stimulating the release of TGF-and vascular endothelial growth factor(VEGF) by pericytes2011
- Author(s)
  Shimizu F, Sano Y, Haruki H, Kanda T
- Journal Title
  
  Diabetologia
  
  Volume: 54(6) Pages: 1517-1526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790821
[Journal Article] Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors.2011
- Author(s)
  Shimizu F
- Journal Title
  
  J Cell Physiol.
  
  Volume: 226 Pages: 255-266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790821
[Journal Article] Advanced glycation end-products induce basement membrane hypertrophy in endoneurial microvessels and disrupt the blood-nerve barrier by stimulating the release of TGF-β and vascular endothelial growth factor (VEGF) by pericytes2011
- Author(s)
  Shimizu F, Kanda T
- Journal Title
  
  Diabetologia
  
  Volume: 54 Pages: 1517-1526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790821
[Journal Article] Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors2011
- Author(s)
  Shimizu F, Sano Y, Abe M, Maeda T, Ohtsuki S, Terasaki T, Kanda T
- Journal Title
  
  J Cell Physiol
  
  Volume: 226 Pages: 255-266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790821
[Presentation] The effect of IgG from CIDP and MMN on the blood-nerve barrier2023
- Author(s)
  Fumitaka Shimizu, Ryota Sato, Yoichi Mizukami, Kenji Watanabe, Sonoko Misawa, Naoko Matsui, Yukio Takeshita, Toshihiko Maeda, Michiaki Koga, Yuishin Izumi, Satoshi Kuwabara and Takashi Kanda
- Organizer
  第64回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] ギラン・バレー症候群で血液神経関門破綻をきたすU1-snRNP抗体の同定．2023
- Author(s)
  清水文崇，古賀道明，水上洋一，渡邊健司，佐藤亮太，前田敏彦，神田　隆，中森雅之
- Organizer
  第34回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] 免疫性ニューロパチーにおける血液神経関門（BNB）の意義2023
- Author(s)
  清水文崇
- Organizer
  第35回日本神経免疫学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] 遠位潜時延長が遷延した軸索型ギラン・バレー症候群の2例2023
- Author(s)
  清水文崇，大石真莉子，藤川晋，山中菜々美，西岡光昭，大田勇，鉄田有希乃，古賀道明，中森雅之．
- Organizer
  日本臨床神経生理学会第53回学術大会/第60回技術講習会
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] 免疫性ニューロパチーと血液神経関門2023
- Author(s)
  清水文崇
- Organizer
  第34回日本末梢神経学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] ギラン・バレー症候群で血液神経関門破綻をきたすU1-snRNP抗体の同定2023
- Author(s)
  清水文崇，古賀道明，水上洋一，渡邊健司，佐藤亮太，前田敏彦，神田　隆，中森雅之．
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] ギラン・バレー症候群で血液神経関門破綻をきたすU1-snRNP抗体の同定．2023
- Author(s)
  清水文崇，古賀道明，水上洋一，渡邊健司，佐藤亮太，前田敏彦，神田　隆，中森雅之．
- Organizer
  第34回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] 血液脳関門の破綻と自己免疫2023
- Author(s)
  清水文崇
- Organizer
  第51回日本臨床免疫学会総会ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] The effect of IgG from CIDP and MMN on the blood-nerve barrier2023
- Author(s)
  Fumitaka Shimizu, Ryota Sato, Yoichi Mizukami, Kenji Watanabe, Sonoko Misawa, Naoko Matsui, Yukio Takeshita, Toshihiko Maeda, Michiaki Koga, Yuishin Izumi, Satoshi Kuwabara and Takashi Kanda.
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] 糖尿病合併CIDP5例の臨床的/電気生理学的特徴の検討2023
- Author(s)
  清水文崇，大石真莉子，西岡光昭，神田創，大田勇，鉄田有希乃，古賀道明，中森雅之
- Organizer
  日本臨床神経生理学会第53回学術大会/第60回技術講習会
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] Effect of IgG from Guillain-Barre syndrome on the blood-nerve barrier.2022
- Author(s)
  Fumitaka Shimizu, Michiaki Koga, Ryota Sato, Yoichi Mizukami, Kenji Watanabe, Natsumi Fujii, Ken Matsukage, Yukio Takeshita, Yasuteru Sano, Toshihiko Maeda and Takashi Kanda
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] MAGニューロパチー患者では，血管内皮細胞の自己分泌TNF-αがMAG抗体の微小血管透過性を亢進させている2022
- Author(s)
  佐藤亮太，清水文崇，桑原基，渡邉健司，水上洋一，前田敏彦，竹下幸男，古賀道明，楠進，神田　隆
- Organizer
  第33回日本末梢神経学会学術研究会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Effects of sera in NMO, MOG, and MS on IgG translocation to central nervous system.2022
- Author(s)
  Miwako Fujisawa, Yukio Takeshita, Susumu Fujikawa, Kinya Mastuo, Fumitaka Shimizu, Yasuteru Sano, Michiaki Koga, Takashi Kanda.
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] 慢性炎症性脱髄性多発ニューロパチーと多巣性運動ニューロパチー患者免疫グロブリンGが血液神経関門に及ぼす影響の解析．2022
- Author(s)
  清水文崇，佐藤亮太，水上洋一，渡邊健司，三澤園子，松井尚子，竹下幸男，前田敏彦，和泉唯信, 桑原　聡，神田　隆, 古賀道明
- Organizer
  第33回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] 慢性炎症性脱髄性多発ニューロパチーと多巣性運動ニューロパチー患者免疫グロブリンGが血液神経関門に及ぼす影響の解析．2022
- Author(s)
  清水文崇，佐藤亮太，水上洋一，渡邊健司，三澤園子，松井尚子，竹下幸男，前田敏彦，和泉唯信, 桑原　聡，神田　隆, 古賀道明
- Organizer
  第34回日本神経免疫学会学術集会．
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] 「治療可能な運動失調症; 自己免疫性小脳性運動失調症の最近の進歩」血液脳関門破綻と自己免疫性小脳性運動失調症．2022
- Author(s)
  清水文崇
- Organizer
  第63回日本神経学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] Autocrine TNF-α increases penetration of MAG antibodies across the blood-nerve barrier in anti-MAG neuropathy.2022
- Author(s)
  Ryota Sato, Fumitaka Shimizu, Motoi Kuwahara, Yoichi Mizukami, Kenji Watanabe, Toshihiko Maeda, Yasuteru Sano, Yukio Takeshita, Michiaki Koga, Susumu Kusunoki, Takashi Kanda.
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Effect of IgG from Guillain-Barre syndrome on the blood-nerve barrier2022
- Author(s)
  Fumitaka Shimizu, Michiaki Koga, Ryota Sato, Yoichi Mizukami, Kenji Watanabe, Natsumi Fujii, Ken Matsukage, Yukio Takeshita, Yasuteru Sano, Toshihiko Maeda and Takashi Kanda.
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Effect of immunoglobulin G from idiopathic inflammatory myopathy patients on human muscle microvascular endothelial cell．2022
- Author(s)
  Masaya Honda, Fumitaka Shimizu, Takashi Kanda
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] 多発性硬化症でのCD20抗体によるB細胞療法における血液脳関門を中心とした新しい病態機序2021
- Author(s)
  竹下幸男,藤澤美和子,松尾欣哉,福迫陽人, 藤川晋, 玉田雅也, 岡本雅史, 西原秀明, 清水文崇, 古賀道明, 神田隆
- Organizer
  第33回日本神経免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] ギラン・バレー症候群での血液神経関門破綻メカニズムの解析．2021
- Author(s)
  清水文崇，古賀道明，佐藤亮太，竹下幸男，佐野泰照，松影　顕，藤井菜月美，前田敏彦，神田　隆．
- Organizer
  第32回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] ヒトin vitro BBBモデルを用いたアストロサイトからのBDNF分泌を促進させる脂質化合物の同定2021
- Author(s)
  藤澤美和子, 竹下幸男, 藤川　晋, 松尾欣哉, 清水文崇, 古賀道明, 神田　隆
- Organizer
  第33回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] ギラン・バレー症候群での血液神経関門破綻メカニズムの解析．2021
- Author(s)
  清水文崇，古賀道明，佐藤亮太，竹下幸男，佐野泰照，松影　顕，藤井菜月美，前田敏彦，神田　隆．
- Organizer
  第33回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] Blood-brain barrier-breakdown in anti-myelin oligodendrocyte glycoprotein antibody associated disorders2021
- Author(s)
  Shimizu F, Ogawa R, Takahashi T, Takeshita Y, Misu T, Sano Y, Maeda T, Nakashima I, Fujihara K, Kanda T
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] 視神経脊髄炎でのIL-6を介した血液脳関門破綻の病態機序と「BBBを治療する」というIL-6受容体阻害薬の新たな作用機序2021
- Author(s)
  竹下幸男, 藤川晋, 芹澤賢一，藤澤美和子,西原秀明,松尾欣哉, 清水文崇, 古賀道明,Richard Ransohoff , 神田隆
- Organizer
  第33回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] New in vitro and in ex-vivo triple co-culture BBB models and in vivo EAE model revealed that NMO-IgG increased the intracerebral transferability of NMO-IgG and satralizumab and that IL-6 blockade suppressed the NMO-IgG-induced leukocyte transmigration and barrier dysfunction, leading to prevention of onset of NMOSD.2021
- Author(s)
  Takeshita Y, Fujikawa S, Serizawa K, Fujisawa M, Matsuo K, Nemoto J, Shimizu F, Sano Y, Tomizawa-Shinohara H, Miyake S, Ransohoff RM, Kanda T
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] ギラン・バレー症候群での血液神経関門破綻メカニズムの解析2021
- Author(s)
  清水文崇，古賀道明，佐藤亮太，竹下幸男，佐野泰照，松影　顕，藤井菜月美，前田敏彦，神田　隆
- Organizer
  第32回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Intracerebral transferability of satralizumab in neuromyelitis optica using a new multi-cultured in vitro BBB model2021
- Author(s)
  Matsuo K, Takeshita Y, Fujikawa S, Fujisawa M, Serizawa K, Shimizu F, Sano Y, Koga M, Kanda T.
- Organizer
  第62回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] 傍腫瘍性小脳変性症：GRP78抗体．2021
- Author(s)
  清水文崇
- Organizer
  第62回日本神経学会学術大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K07416
[Presentation] Blood-brain barrier-activation in myelin oligodendrocyte glycoprotein antibody associated disorders2020
- Author(s)
  Shimizu F, Ogawa R, Takahashi T, Takeshita Y, Misu T, Sano Y, Maeda T, Nakashima I, Fujihara K, Kanda T
- Organizer
  第61回日本神経学会学術大会．
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] MOG抗体関連疾患での血液脳関門破綻メカニズムの解明2020
- Author(s)
  清水文崇, 小川諒, 原佳那子, 門野ちひろ, 高橋利幸, 竹下幸男, 三須建郎, 佐野泰照, 前田敏彦, 中島一郎, 藤原一男, 神田隆
- Organizer
  第32回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] Effects of sera in NMO and MOG on IgG translocation to central nervous system2020
- Author(s)
  Fujisawa M, Takeshita Y, Fujikawa S, Shimizu F, Maeda T, Sano Y, Koga M, Kanda T
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] Blood-brain barrier-activation in myelin oligodendrocyte glycoprotein antibody associated disorders2020
- Author(s)
  Shimizu F, Ogawa R, Takahashi T, Takeshita Y, Misu T, Sano Y, Maeda T, Nakashima I, Fujihara K, Kanda T
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] 中国四国地域発で世界的に展開した学術業績　GRP78抗体とNMO　この研究の発展から見えてきたこと2020
- Author(s)
  清水文崇
- Organizer
  第61回日本神経学会学術大会．
- Invited
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] 当院で診療したCIDP30例の臨床病型と長期経過2020
- Author(s)
  清水文崇, 前田敏彦, 佐藤亮太, 大石真莉子, 竹下幸男, 松尾欣也, 佐野泰照, 古賀道明, 神田隆
- Organizer
  第31回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] Exploring lipophilic compounds which induce BDNF secretion from astrocytes beyond the BBB2020
- Author(s)
  Takeshita Y, Fujikawa S, Okino T, Fujisawa M, Shimizu F, Maeda T, Sano Y, Koga M, Kanda T
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H00529
[Presentation] 血液神経関門に注目したギラン・バレー症候群患者の新規バイオマーカーの探索．2019
- Author(s)
  清水文崇，古賀道明，藤井菜月美，竹下幸男，佐野泰照，前田敏彦，佐藤亮太，神田　隆.
- Organizer
  第30回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] 小脳性運動失調を合併したLambert-Eaton筋無力症候群患者から血液脳関門破綻に関与するGRP78抗体の同定．2019
- Author(s)
  清水文崇，竹下幸男，佐野泰照，前田敏彦，藤川　晋，吉村俊祐，北之園寛子，白石裕一，辻野　彰, 本村政勝，神田　隆．
- Organizer
  第31回神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] Blood-brain barrier-activation in anti-myelin oligodendrocyte glycoprotein antibody associated disorders.2019
- Author(s)
  Fumitaka Shimizu, Ryo Ogawa, Kanako Hara, Toshiyuki Takahashi, Yukio Takeshita, Tatsuro Misu, Yasuteru Sano, Toshihiko Maeda, Susumu Fujikawa, Ichiro Nakashima, Kazuo Fujihara, Takashi Kanda.
- Organizer
  Sendai Conference
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] 自己免疫性神経疾患から血液脳関門/血液神経関門を人為的に操作する新規標的分子の同定とその臨床応用2019
- Author(s)
  清水文崇
- Organizer
  第60回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] Blood-brain barrier-activation in anti-myelin oligodendrocyte glycoprotein antibody associated disorders.2019
- Author(s)
  Fumitaka Shimizu, Ryo Ogawa, Kanako Hara, Toshiyuki Takahashi, Yukio Takeshita, Tatsuro Misu, Yasuteru Sano, Toshihiko Maeda, Susumu Fujikawa, Ichiro Nakashima, Kazuo Fujihara, Takashi Kanda.
- Organizer
  EctriMS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] Blood-brain barrier-activation induced by immunoglobulin G in neuromyelitis optica spectrum disorder.2018
- Author(s)
  Fumitaka Shimizu , Yuka Hamamoto, Yukio Takeshita, Yasuteru Sano, Toshihiko Maeda, Susumu Fujikawa, Masaya Honda and Takashi Kanda
- Organizer
  日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] Identification of antibody-target from patients with central nervous system autoimmune diseases to modify the drug penetration in the blood-brain barrier.2018
- Author(s)
  Fumitaka Shimizu, Yukio Takeshita, Yuka Hamamoto, Yasuteru Sano and Takashi Kanda.
- Organizer
  lood-Brain Barrier - World Preclinical Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] 血液脳関門と血液神経関門を破綻させる自己免疫性神経疾患患者免疫グロブリンGの同定2018
- Author(s)
  清水文崇，竹下幸男，古賀道明，佐野泰照，藤井菜月美，浜本優佳，前田敏彦，藤川　晋，神田　隆．
- Organizer
  第30回神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] ギラン・バレー症候群患者由来の免疫グロブリンＧは血液神経関門を破綻させる．2018
- Author(s)
  清水文崇，古賀道明，藤井菜月美，竹下幸男，佐野泰照，前田敏彦，神田　隆.
- Organizer
  第29回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] Blood-brain barrier-activation induced by immunoglobulin G in multiple sclerosis.2018
- Author(s)
  Fumitaka Shimizu, Kanako Hara, Yukio Takeshita, Yasuteru Sano, Toshihiko Maeda, Susumu Fujikawa, Masaya Honda, Ryota Sato and Takashi Kanda.
- Organizer
  EctriMS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07526
[Presentation] 血液神経関門の破綻が慢性炎症性脱髄性多発根ニューロパチーの臨床病型を決定する.2013
- Author(s)
  清水文崇，澤井　摂，佐野泰照，別府美奈子，三澤園子，前田敏彦，古賀道明，桑原　聡，神田　隆
- Organizer
  第25回日本神経免疫学会学術集会．
- Place of Presentation
  下関（海峡メッセ）
- Data Source
  KAKENHI-PROJECT-24790886
[Presentation] Sera from remitting and secondary progressive multiple sclerosis patients disrupt the blood-brain barrier.2013
- Author(s)
  Fumitaka Shimizu, Ayako Tasaki, Yasuteru Sano, Takashi Kanda.
- Organizer
  PACTRIMS
- Place of Presentation
  Kyot (ウェスティンホテル京都）,
- Data Source
  KAKENHI-PROJECT-24790886
[Presentation] 多発性硬化症患者血清が血液脳関門に及ぼす影響の解析2013
- Author(s)
  清水文崇，田崎彩子，佐野泰照，朱　美和，前田敏彦，大石真莉子，古賀道明，神田　隆.
- Organizer
  第54回日本神経学会学術集会総会
- Place of Presentation
  東京(東京国際フォーラム)
- Data Source
  KAKENHI-PROJECT-24790886
[Presentation] The effect of sera from multifocal motor neuropathy on blood-nerve barrier.2013
- Author(s)
  Fumitaka Shimizu, Yasuteru Sano, Naoko Mastui, Ai Miyashiro, Ryuji Kaji, Takashi Kanda.
- Organizer
  Neuroscience
- Place of Presentation
  San Diego, U.S.A
- Data Source
  KAKENHI-PROJECT-24790886
[Presentation] 血液神経関門の破綻が慢性炎症性脱髄性多発根ニューロパチーの臨床病型を決定する.2013
- Author(s)
  清水文崇，澤井　摂，佐野泰照，別府美奈子，三澤園子，前田敏彦，古賀道明，桑原　聡，神田　隆.
- Organizer
  第24回日本末梢神経学会学術集会．
- Place of Presentation
  新潟（朱鷺メッセ）
- Data Source
  KAKENHI-PROJECT-24790886
[Presentation] 傍腫瘍性小脳変性症を合併したLambert-Eaton筋無力症候群では血液脳関門が破綻する.2013
- Author(s)
  清水文崇，本村政勝，中田るか，白石裕一，佐野泰照，神田　隆
- Organizer
  第25回日本神経免疫学会学術集会
- Place of Presentation
  下関（海峡メッセ）
- Data Source
  KAKENHI-PROJECT-24790886
[Presentation] 多巣性運動ニューロパチー血清による血液神経関門破綻メカニズムの解析．2012
- Author(s)
  清水文崇，佐野泰照，古賀道明，田崎彩子，安部真彰，前田敏彦，春木明代，松井尚子，宮城　愛，梶龍兒，神田　隆.
- Organizer
  第24回日本神経免疫学会学術集会．
- Place of Presentation
  軽井沢プリンスホテルウエスト（長野）
- Data Source
  KAKENHI-PROJECT-24790886
[Presentation] The effect of advanced glycation end-products on blood-brain barrier.2012
- Author(s)
  Fumitaka Shimizu, Yasuteru Sano, Hiroyo Haruki, and Takashi Kanda.
- Organizer
  Neuroscience 13 Oct 2012.
- Place of Presentation
  New Orleans (USA)
- Data Source
  KAKENHI-PROJECT-24790886
[Presentation] 多巣性運動ニューロパチー血清による血液神経関門破綻メカニズムの解析．2012
- Author(s)
  清水文崇，佐野泰照，古賀道明，田崎彩子，安部真彰，前田敏彦，春木明代，松井尚子，宮城　愛，梶龍兒，神田　隆.
- Organizer
  第23回日本末梢神経学会学術集会．
- Place of Presentation
  九州大学医学部百年講堂（福岡）
- Data Source
  KAKENHI-PROJECT-24790886
[Presentation] 多巣性運動ニューロパチー血清は血液神経関門を破綻させる．2012
- Author(s)
  清水文崇，佐野泰照，斎藤和幸，安部真彰，前田敏彦，春木明代，松井尚子，宮城　愛，梶　龍兒, 神田　隆.
- Organizer
  第53回日本神経学会学術集会総会．
- Place of Presentation
  東京国際フォーラム(東京)
- Data Source
  KAKENHI-PROJECT-24790886
[Presentation] 視神経脊髄炎血清での血液脳関門破綻メカニズムの解析2011
- Author(s)
  清水文崇
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22790821
[Presentation] Sera from neuromyelitis optica patients disrupt the blood-brain barrier2011
- Author(s)
  Fumitaka Shimizu, Yasuteru Sano, Toshiyuki Takahashi, Hiroyo Haruki, and Takashi Kanda
- Organizer
  ECTRIMS
- Place of Presentation
  Amsterdam, Netherland
- Data Source
  KAKENHI-PROJECT-22790821
[Presentation] Sera from neuromyelitis optica patients disrupt the blood-brain barrier2011
- Author(s)
  Fumitaka Shimizu
- Organizer
  ECTRIMS
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-22790821
[Presentation] 多巣性運動ニューロパチー血清が血液神経関門に及ぼす影響の解析2011
- Author(s)
  清水文崇
- Organizer
  第22回日本末梢神経学会総会
- Place of Presentation
  沖縄コンベンションセンター(那覇)
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-22790821
[Presentation] 多巣性運動ニューロパチー血清が血液神経関門に及ぼす影響の解析2011
- Author(s)
  清水文崇, 佐野泰照, 安部真彰, 前田敏彦, 斎藤和幸, 春木明代, 松井尚子, 梶龍兒, 神田隆
- Organizer
  第22回日本末梢神経学会総会
- Place of Presentation
  沖縄コンベンションセンター,沖縄
- Data Source
  KAKENHI-PROJECT-22790821
[Presentation] 視神経脊髄炎血清での血液脳関門破綻メカニズムの解析2011
- Author(s)
  清水文崇, 佐野泰照, 斎藤和幸, 春木明代, 前田敏彦, 安部真彰, 神田隆
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋国際会議場,名古屋
- Data Source
  KAKENHI-PROJECT-22790821
[Presentation] The effect of advanced glycation end-products on blood-nerve barrier.2010
- Author(s)
  Fumitaka Shimizu
- Organizer
  Neuroscience
- Place of Presentation
  San-Diego, U.S.A
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-22790821
[Presentation] AGEが血液神経関門に及ぼす影響の解析2010
- Author(s)
  清水文崇
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京東京国際フォーラム
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22790821
[Presentation] AGEによる血液神経関門破綻メカニズムの解析2010
- Author(s)
  清水文崇
- Organizer
  第21回日本末梢神経学会総会
- Place of Presentation
  仙台フォレスト仙台
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-22790821
[Presentation] 傍腫瘍性小脳変性症を合併したLambert-Eaton筋無力症候群では血液脳関門が破綻する．
- Author(s)
  清水文崇, 本村政勝, 中田るか，白石裕一，佐野泰照, 神田　隆．
- Organizer
  第55回日本神経学会学術集会総会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2014-05-23 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24790886

1. 神田隆 (40204797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
2. 竹下幸男 (70749829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
3. SANO Yasuteru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 三須建郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 本村政勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 白石裕一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 吉村俊祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 渡邉健司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Fumitaka 清水 文崇

SHIMIZU Fumitaka 清水 文崇

Research Projects

Research Products

Co-Researchers

難治性神経筋疾患の病態解明と治療開発のための新規血液脳・神経・筋関門モデルの確立Principal Investigator

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Mechanism of breakdown of blood-brain barrier/blood-nerve barrier in neuroimmunological disorderPrincipal Investigator

Principal Investigator

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Novel strategy to treat intractable CNS disorders, utilizing the properties of BBB-composing cells

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Discovery of new drug target modifiying the function of blood-brain barrier and blood-nerve barrierPrincipal Investigator

Principal Investigator

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Investigation into the mechanism of the blood-nerve barrier disruption in chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathyPrincipal Investigator

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Research Institution

The effect of advanced glycation end-products on blood-nerve barrierPrincipal Investigator

Principal Investigator

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Research Institution

[Book] 日本臨床 多発性硬化症と視神経脊髄炎- 血液神経関門とその障害モデル-2014

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[Book] The Blood-Brain Barrier in Neuroinflammation. In Suzumura A, Ikenaka K, editors. Neuron-Glia Interaction in Neuroinflammation.2013

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[Book] 医学のあゆみ,血管内皮異常2011

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[Book] 血管内皮異常2011

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[Journal Article] Contribution of Complement, Microangiopathy and Inflammation in Idiopathic Inflammatory Myopathies2024

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[Journal Article] Highlighting In Vitro the Role of Brain-like Endothelial Cells on the Maturation and Metabolism of Brain Pericytes by SWATH Proteomics2023

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[Journal Article] 【運動失調症の病態と治療】自己免疫性小脳失調症の治療2023

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[Journal Article] Autocrine TNF-α Increases Penetration of Myelin-Associated Glycoprotein Antibodies Across the Blood-Nerve Barrier in Anti-MAG Neuropathy2023

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[Journal Article] TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA12023

Author(s)

Shimizu Fumitaka 清水文崇

SHIMIZU Fumitaka 清水文崇

[Book] 日本臨床　多発性硬化症と視神経脊髄炎- 血液神経関門とその障害モデル-2014