Ueki Hideo 植木英雄

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UEKI Hideo 植木英雄

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Researcher Number	90537218
Other IDs
Affiliation (Current)	2025: 岡山大学, 総合技術部, 技術専門職員
Affiliation (based on the past Project Information) *help	2023: 岡山大学, 総合技術部, 技術専門職員 2011 – 2022: 岡山大学, 医学部, 技術専門職員 2014: 岡山大学, 医学部, その他 2011: 岡山大学, 医学部, 技術職員
Review Section/Research Field	Principal Investigator Urology / Basic Section 56030:Urology-related Except Principal Investigator Urology / Basic Section 56030:Urology-related / Tumor biology
Keywords	Principal Investigator 細胞検出 / 腫瘍 / 遺伝子治療 / 腫瘍学 Except Principal Investigator 腫瘍学 / 再生医学 / 前立腺癌 / 幹細胞 / REIC/DKK-3 / REIC/Dkk-3 … More / 再生 / 遺伝子治療 / REIC / 癌免疫 / 免疫原性 / 癌抗原 / SGTA / CD147 / 男性ホルモン / アンドロゲン / iPS細胞 / 癌ワクチン / 免疫逃避 / 腫瘍免疫応答 / 骨髄由来免疫抑制細胞 / 尿路腫瘍 / がん免疫 / 融合タンパク質 / サイトカイン / アデノウイルス / 癌ウイルス治療 / 局所治療 / 腫瘍 / Dickkoph / ステロイドホルモン / 腺管形成 / 前立腺肥大症 / 動物モデル / 排尿平滑筋 / 標的治療 / ips細胞 / 癌幹細胞 / 前立腺がん / チェックポイント阻害薬 / 免疫活性 / 抗癌免疫制御 / 制限増殖型アデノウイルスベクター / 抗癌免疫活性化 / 限増殖型アデノウイルスベクター / 抗癌免疫 / 前立腺 / がん制御遺伝子 / 代謝 / 悪性形質 / 細胞骨格 / 内分泌療法抵抗性 / 分化 / 腎幹細胞 / 病的ストレス / 腎移植 / 抗体 / Emmprin / 液性免疫 / ＣＤ147 / 癌治療 / 平滑筋再生 / 尿失禁 / 腎臓 / 再生医療 / エンハンサー / CMV / SV40 / hTERT / 遺伝子発現 / 自己癌ワクチン化 / 平滑筋細胞 / 尿道括約筋 / ＲＥＩＣ／Ｄｋｋ３ / 細胞傷害性Tリンパ球 / 骨髄系免疫制御細胞 / REIC/Dkk3 / 骨髄系免疫抑制細胞 Less

Oncolytic virus の多元的制癌性の解明と革新的癌治療への展開Principal Investigator
- Principal Investigator
  
  植木英雄
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Unraveling the anti-cancer immune evasion mechanism of immune suppressive cells and exploring the basis for innovative cancer therapy
- Principal Investigator
  
  HUANG Peng
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Study on prostatic cell proliferation mechanism by REIC/Dkk-3 gene
- Principal Investigator
  
  Takamoto Atsushi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Basic research on next-generation gene therapy using restricted-replication adenovirus
- Principal Investigator
  
  Kobayashi Yasuyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Adaptive immunity optimization targeting the novel cancer antigen CD147 and its application development in urinary genital tumors
- Principal Investigator
  
  Nasu Yasutomo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
The mechanism of release from immune exhaustion in tumor by a novel checkpoint inhibitor
- Principal Investigator
  
  Sadahira Takuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Establishment of a new gene therapy strategy for prostate cancer stem cells
- Principal Investigator
  
  HUANG PENG
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Creation and application of micturition smooth muscle stem cells for bladder regeneration
- Principal Investigator
  
  Watanabe Toyohiko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
制限増殖型アデノウィルスを用いた次世代遺伝子治療の基盤研究
- Principal Investigator
  
  江原伸
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Optimisation of a cancer detection and isolation technique using hTERT promoter, and establishment of its applicational foundationPrincipal Investigator
- Principal Investigator
  
  Ueki Hideo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Development of novel anti-cancer immune therapies targeting CD147 antigen
- Principal Investigator
  
  Kobayashi Yasuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Analysis of pathological stress control mechanism in kidney tissue stem cells
- Principal Investigator
  
  Araki Moto
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Elucidation of the unitary regulation on the malignant transformation and androgen insensitivity in prostate cancer.
- Principal Investigator
  
  Watanabe Masami
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Okayama University
Elucidation of the establishment of prostatic antigen presenting ability in dendritic cells, and development of novel medicines
- Principal Investigator
  
  Nasu Yasutomo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Development of novel cancer vaccine therapy using oncolytic Ad-REIC
- Principal Investigator
  
  huang peng
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Establishment and regenerative research of urinary smooth muscle stem cells for urethral sphincter
- Principal Investigator
  
  Watanabe Toyohiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Development of a novel technique for the detection and isolation of disseminated cancer cells, and establishment of its application foundationPrincipal Investigator
- Principal Investigator
  
  UEKI HIDEO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
尿路癌に対する次世代癌免疫療法の創成
- Principal Investigator
  
  賀来春紀
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Establishment and applicational research of androgen producing stem cells
- Principal Investigator
  
  Sugimoto Morito
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Induction and isolation of renal stem cells and establishment of foundation for renal regeneration research.
- Principal Investigator
  
  Watanabe Masami
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Okayama University
Investigation of the mechanisms of personalized-cancer vaccination by REIC/Dkk-3 based gene therapy.
- Principal Investigator
  
  KUMON Hiromi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Basic research of smooth muscle cells generated from induced pluripotent stem cells for urethral tissue engineering.
- Principal Investigator
  
  WATANABE Toyohiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University

All 2022 2021 2018 2017 2016 2015 2014 2013 2012 2011

All Journal Article Presentation Patent

[Journal Article] Identification of MICALL2 as a Novel Prognostic Biomarker Correlating with Inflammation and T Cell Exhaustion of Kidney Renal Clear Cell Carcinoma2022
- Author(s)
  Lin Wenfeng、Chen Wenwei、Zhong Jisheng、Ueki Hideo、Xu Abai、Watanabe Masami、Araki Motoo、Liu Chunxiao、Nasu Yasutomo、Huang Peng
- Journal Title
  
  Journal of Cancer
  
  Volume: 13 Issue: 4 Pages: 1214-1228
- DOI
  10.7150/jca.66922
- NAID
  120007188355
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09371
[Journal Article] Repurposing of posaconazole as a hedgehog/SMO signaling inhibitor for embryonal rhabdomyosarcoma therapy2021
- Author(s)
  Sun J, Lin W, Li C, Ueki H, Xue R, Sadahira T, Hu H, Wada K, Li N, Liu C, Araki M, Xu A, Huang P.
- Journal Title
  
  Am J Cancer Res .
  
  Volume: 11 Pages: 4528-4540
- NAID
  120007168212
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09371
[Journal Article] Induction of cells with prostate cancer stem-like properties from mouse induced pluripotent stem cells via conditioned medium2018
- Author(s)
  Xu N, Li X, Watanabe M, Ueki H, Hu H, Li N, Araki M, Wada K, Xu A, Liu C, Nasu Y, Huang P
- Journal Title
  
  Am J Cancer Res
  
  Volume: 8 Pages: 1624-1632
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11138
[Journal Article] Robust cancer-specific gene expression by a novel cassette with hTERT and CMV promoter elements.2017
- Author(s)
  Sakaguchi M, Sadahira T, Ueki H, Kinoshita R, Murata H, Yamamoto KI, Futami J, Nasu Y, Ochiai K, Kumon H, Huh NH, Watanabe M.
- Journal Title
  
  Oncology Reports
  
  Volume: 38 Issue: 2 Pages: 1108-1114
- DOI
  10.3892/or.2017.5710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11004, KAKENHI-PROJECT-16K19037, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-16K18440
[Journal Article] Tumor suppressor REIC/DKK-3 and co-chaperone SGTA: Their interaction and roles in the androgen sensitivity2016
- Author(s)
  Ochiai K, Morimatsu M, Kato Y, Ishiguro-Oonuma T, Udagawa C, Rungsuriyawiboon O, Azakami D, Michishita M, Ariyoshi Y, Ueki H, Nasu Y, Kumon H, Watanabe M, Omi T.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 3 Pages: 3283-3296
- DOI
  10.18632/oncotarget.6488
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462478, KAKENHI-PROJECT-26292161, KAKENHI-PROJECT-26293352, KAKENHI-PROJECT-26450400, KAKENHI-PROJECT-15K07754
[Journal Article] A vaccine strategy with multiple prostatic acid phosphatase-fused cytokines for prostate cancer treatment2015
- Author(s)
  Fujio K, Watanabe M, Ueki H, Li SA, Kinoshita R, Ochiai K, Futami J, Watanabe T, Nasu Y, Kumon H.
- Journal Title
  
  Oncology Reports
  
  Volume: 33 Issue: 4 Pages: 1585-1592
- DOI
  10.3892/or.2015.3770
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462478, KAKENHI-PROJECT-15H04974
[Journal Article] Significant association of the Axin2 rs2240308 single nucleotide polymorphism with the incidence of prostate cancer.2014
- Author(s)
  Chao Ma, Chunxiao Liu, Peng Huang, Haruki Kaku, Jie Chen, Kai Guo, Hideo Ueki, Akiko Sakai, Yasutomo Nasu, Hiromi Kumon, Kenji Shimizu, Masami Watanabe.
- Journal Title
  
  Oncology Letters
  
  Volume: 8 Pages: 789-794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462479
[Journal Article] A novel gene expression system strongly enhances the anticancer effects of a REIC/Dkk-3-encoding adenoviral vector2014
- Author(s)
  Watanabe M., Sakaguchi M., Kinoshita R., Kaku H., Ariyoshi Y., Ueki H., Tanimoto R., Ebara S., Ochiai K., Futami J., Li SA., Huang P., Nasu Y., Huh NH., Kumon H
- Journal Title
  
  Oncology Reports
  
  Volume: 31巻 Issue: 3 Pages: 1089-95
- DOI
  10.3892/or.2013.2958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390382, KAKENHI-PROJECT-24780313, KAKENHI-PROJECT-25462479, KAKENHI-PROJECT-25861425, KAKENHI-PROJECT-26290039
[Journal Article] Cancer stem cell-like characteristics of a CD133+ subpopulation in the J82 human bladder cancer cell line2013
- Author(s)
  Watanabe M, Ueki H
- Journal Title
  
  Molecular and Clinical Oncology
  
  Volume: 1(1) Pages: 180-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592369
[Journal Article] Preclinical biodistribution and safety study of reduced expression in immortalized cells/Dickkopf-3-encoding adenoviral vector for prostate cancer gene therapy2012
- Author(s)
  Sugimoto M., Watanabe M., Kaku H., Li SA., Noguchi H., Ueki H., Sakaguchi M., Huh NH., Nasu Y., Kumon H
- Journal Title
  
  Oncol Rep
  
  Volume: 28巻 Issue: 5 Pages: 1645-1652
- DOI
  10.3892/or.2012.2001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390382, KAKENHI-PROJECT-24390316, KAKENHI-PUBLICLY-24117711
[Journal Article] Preclinical biodistribution and safety study of REIC/Dkk-3 encoding adenovirus vector for prostate cancer gene therapy2012
- Author(s)
  Watanabe M, Ueki H
- Journal Title
  
  Oncol Rep
  
  Volume: 28(5) Pages: 1645-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592369
[Journal Article] Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-12011
- Author(s)
  Ochiai, K., Watanabe, M., Ueki, H., Huang, P., Fujii, Y., Nasu, Y., Sakaguchi, M., Huh, NH., Kashiwakura, Y., Kaku, H., and Kumon, H.
- Journal Title
  
  Biochem. Biophy. Res. Com
  
  Volume: 412(2) Issue: 2 Pages: 391-395
- DOI
  10.1016/j.bbrc.2011.07.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791476, KAKENHI-PROJECT-23390382
[Journal Article] Advanced two-step transcriptional amplification as a novel method for cancer-specific geneexpression and imaging2011
- Author(s)
  Watanabe M, Ueki H
- Journal Title
  
  Oncol Rep
  
  Volume: 26(4) Pages: 769-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592369
[Patent] REIC/Dkk-3タンパク質の部分領域ポリペプチド2011
- Inventor(s)
  公文裕巳, 渡部昌実, 二見淳一郎, 藤井康之, 植木英雄
- Industrial Property Rights Holder
  岡山大学, 桃太郎源(株)
- Industrial Property Rights Type
  特許
- Filing Date
  2011-07-01
- Overseas
- Data Source
  KAKENHI-PROJECT-23390382
[Presentation] A super geneexpression system strongly enhances the anticancer effects of the REIC/Dkk-3 encoding adenoviral vector2013
- Author(s)
  Watanabe M.,Sakaguchi M.,Kaku H.,Ueki H.,Ariyoshi Y.,Hirata T.,Yoshioka T.,Huang P.,Li S-A.,Nasu Y.,Huh N.,Kumon H.
- Organizer
  Annual　Meeting　of Japan Society of Gene Therapy
- Place of Presentation
  Okayama，Okayama Convention Center
- Data Source
  KAKENHI-PROJECT-23390382

1. WATANABE Masami (70444677)

# of Collaborated Projects: 11 results

# of Collaborated Products: 7 results
2. NASU Yasutomo (20237572)

# of Collaborated Projects: 10 results

# of Collaborated Products: 5 results
3. Sadahira Takuya (20733322)

# of Collaborated Projects: 8 results

# of Collaborated Products: 1 results
4. WATANABE Toyohiko (30432644)

# of Collaborated Projects: 8 results

# of Collaborated Products: 4 results
5. huang peng (00610841)

# of Collaborated Projects: 7 results

# of Collaborated Products: 4 results
6. KAKU Haruki (60346426)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
7. Araki Moto (90467746)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
8. NOGUCHI HIROFUMI (50378733)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. KUMON Hiromi (30144760)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
10. Sugimoto Morito (30613161)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. Kobayashi Yasuyuki (50366027)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. HUH Namho (70142023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. SAKAGUCHI Masakiyo (70379840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. Takamoto Atsushi (30716816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 江原伸 (70379741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KAZUHIKO Ochiai

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ueki Hideo 植木 英雄

UEKI Hideo 植木 英雄

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Co-Researchers

Oncolytic virus の多元的制癌性の解明と革新的癌治療への展開Principal Investigator

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Optimisation of a cancer detection and isolation technique using hTERT promoter, and establishment of its applicational foundationPrincipal Investigator

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Ueki Hideo 植木英雄

UEKI Hideo 植木英雄