Hosoi Nobutake 細井延武

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HOSOI Nobutake 細井延武

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Researcher Number	90543570
Other IDs
Affiliation (Current)	2025: 群馬大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 群馬大学, 大学院医学系研究科, 准教授 2016 – 2019: 群馬大学, 大学院医学系研究科, 講師 2015: 群馬大学, 医学(系)研究科(研究院), 講師 2013 – 2014: 群馬大学, 医学(系)研究科(研究院), 助教 2010 – 2011: 群馬大学, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 48020:Physiology-related / Basic Section 46030:Function of nervous system-related / Neurochemistry/Neuropharmacology / Neurophysiology / General neuroscience / Fusional basic brain science Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 63030:Chemical substance influence on environment-related / Neurology / Neurophysiology / General neuroscience
Keywords	Principal Investigator 小脳 / プルキンエ細胞 / 登上線維 / 平行線維 / translocation / プロテインキナーゼC / 遺伝子発現解析 / 発達 / 短期シナプス可塑性 / cerebellum … More / inhibitory synapse / short-term plasticity / リハビリ / ＧＡＢＡｂ受容体 / 脊髄小脳失調症 / 活動依存的 / GABAb受容体 / baclofen / ATP受容体 / 二重感染 / グリア / AAV / GFAPプロモーター / レンチウイルス / GluR2 / バーグマングリア / Ca透過型AMPA受容体 / ニューロングリア相互作用 … More Except Principal Investigator 遺伝子発現 / 遺伝子治療 / AAV / 神経科学 / 遺伝子 / 脳神経疾患 / SCA1 / AAVベクター / 脊髄小脳失調症 / プルキンエ細胞 / 小脳 / 神経変性疾患 / microRNA / マウス / 大脳皮質 / カプシド / Iba1 / アルツハイマー病 / 血液脳関門 / ミクログリア / エピジェネティック / 核内受容体 / エストロゲン / エピゲノム / 内分泌かく乱化学物質 / 脳発達 / 甲状腺ホルモン / 内分泌かく乱 / 再生医学 / アデノ随伴ウイルスベクター / ウイルスベクター / ゲノム編集 / CRISPR/Cas9 / 細胞種特異的プロモーター / パッチクランプ / ロータロッド / ポリグルタミン病 / 脊髄小脳変性症 / 生理学 / シグナル伝達 / 運動記憶 / SCA3 / 運動失調 / バクロフェン / 運動学習 / mGluR1 Less

ガンマ型プロテインキナーゼCによる神経シグナルの時空間的調節機構とその役割Principal Investigator
- Principal Investigator
  
  細井延武
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Gunma University
Development of microglia-targeting AAV vectors and its application to neurodegenerative disorders
- Principal Investigator
  
  平井宏和
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Gunma University
A developmental switch in short-term synaptic plasticiyPrincipal Investigator
- Principal Investigator
  
  Hosoi Nobutake
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Gunma University
Epigenetic modulation by chemical substances on thyroid hormone-mediated brain development.
- Principal Investigator
  
  Koibuchi Noriyuki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Gunma University
Mechanism of activity-dependent motor improvement in SCAPrincipal Investigator
- Principal Investigator
  
  Hosoi Nobutake
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Gunma University
Development of gene therapy against neurodegenerative diseases using CRISPR/Cas9-based genome editing
- Principal Investigator
  
  Hirai Hirokazu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Gunma University
Elucidation of cellular and nuclear signals that regulate motor learning
- Principal Investigator
  
  Hirai Hirokazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Gunma University
Functional roles of glial ATP receptors in neuron-glia interactionPrincipal Investigator
- Principal Investigator
  
  HOSOI Nobutake
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Gunma University
Neuron-glia interaction during cerebellar development The role of Ca-permeable AMPA receptorsPrincipal Investigator
- Principal Investigator
  
  HOSOI Nobutake
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Fusional basic brain science
- Research Institution
  Gunma University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2011 Other

All Journal Article Presentation

[Journal Article] Elucidating the Mechanisms of Life using Patchclamp Technique and Live Imaging2023
- Author(s)
  細井延武
- Journal Title
  
  The Kitakanto Medical Journal
  
  Volume: 73 Issue: 3 Pages: 225-226
- DOI
  10.2974/kmj.73.225
- ISSN
  1343-2826, 1881-1191
- Year and Date
  2023-08-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K06906
[Journal Article] Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis2023
- Author(s)
  Ichinose Sotaro、Susuki Yoshihiro、Hosoi Nobutake、Kaneko Ryosuke、Ebihara Mizuho、Hirai Hirokazu、Iwasaki Hirohide
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.83276
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06457, KAKENHI-PROJECT-22K06805, KAKENHI-PROJECT-20K06906, KAKENHI-PROJECT-20K16104
[Journal Article] The neurotoxic effect of lactational PFOS exposure on cerebellar functional development in male mice2022
- Author(s)
  Ninomiya A, Mshaty A, Haijima A, Yajima H, Kokubo M, Khairinisa MA, Ariyani W, Fujiwara Y, Ishii S, Hosoi N, Hirai H, Amano I, Koibuchi N.
- Journal Title
  
  Food Chem Toxicol
  
  Volume: 159:112751 Pages: 112751-112751
- DOI
  10.1016/j.fct.2021.112751
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07103, KAKENHI-PROJECT-18H03379, KAKENHI-PROJECT-20K06906, KAKENHI-PROJECT-21K08569, KAKENHI-PROJECT-21K17266, KAKENHI-PROJECT-22KJ0445
[Journal Article] Protein kinase Cγ in cerebellar Purkinje cells regulates Ca 2+-activated large-conductance K + channels and motor coordination2022
- Author(s)
  Watanave M, Takahashi N, Hosoi N, Konno A, Yamamoto H, Yasui H, Kawachi M, Horii T, Matsuzaki Y, Hatada I, Hirai H.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 119(7) Issue: 7
- DOI
  10.1073/pnas.2113336119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07103, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-20K06906
[Journal Article] Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells2022
- Author(s)
  Hirai H, Fukai Y, Konno A, Hosoi N.
- Journal Title
  
  Cerebellum
  
  Volume: - Issue: 5 Pages: 776-783
- DOI
  10.1007/s12311-022-01384-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07103, KAKENHI-PROJECT-20K06906, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-22K06454
[Journal Article] Long-term depression?inductive stimulation causes long-term potentiation in mouse Purkinje cells with a mutant thyroid hormone receptor2022
- Author(s)
  Ninomiya Ayane、Amano Izuki、Kokubo Michifumi、Takatsuru Yusuke、Ishii Sumiyasu、Hirai Hirokazu、Hosoi Nobutake、Koibuchi Noriyuki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 45
- DOI
  10.1073/pnas.2210645119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06906, KAKENHI-PROJECT-21K08569
[Journal Article] Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo2022
- Author(s)
  Okada Yukihiro、Hosoi Nobutake、Matsuzaki Yasunori、Fukai Yuuki、Hiraga Akito、Nakai Junichi、Nitta Keisuke、Shinohara Yoichiro、Konno Ayumu、Hirai Hirokazu
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 1224-1224
- DOI
  10.1038/s42003-022-04200-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06906, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-22K06454
[Journal Article] GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter2021
- Author(s)
  Hoshino Chiaki、Konno Ayumu、Hosoi Nobutake、Kaneko Ryosuke、Mukai Ryo、Nakai Junichi、Hirai Hirokazu
- Journal Title
  
  Molecular Brain
  
  Volume: 14 Issue: 1 Pages: 1-18
- DOI
  10.1186/s13041-021-00746-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07103, KAKENHI-PROJECT-20K06906, KAKENHI-PROJECT-18H02521, KAKENHI-PROJECT-19K06899, KAKENHI-PUBLICLY-19H04895, KAKENHI-PROJECT-20H02932, KAKENHI-PROJECT-16H06276
[Journal Article] Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.2019
- Author(s)
  Hosoi N, Shibasaki K, Hosono M, Konno A, Shinoda Y, Kiyonari H, Inoue K, Muramatsu SI, Ishizaki Y, Hirai H, Furuichi T, Sadakata T
- Journal Title
  
  J Neurosci
  
  Volume: 39(32) Issue: 32 Pages: 6339-6353
- DOI
  10.1523/jneurosci.2002-18.2019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07103, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-19K06900, KAKENHI-PROJECT-18K19418, KAKENHI-PLANNED-15H05934, KAKENHI-PROJECT-18H02522, KAKENHI-PROJECT-18H03124, KAKENHI-PROJECT-17H03563
[Journal Article] Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice.2017
- Author(s)
  Shuvaev AN, Hosoi N, Sato Y, Yanagihara D, Hirai H.
- Journal Title
  
  The Journal of Physiology
  
  Volume: 595(1) Issue: 1 Pages: 141-164
- DOI
  10.1113/jp272950
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430003, KAKENHI-PROJECT-26750238, KAKENHI-PROJECT-15K01498, KAKENHI-PROJECT-15H04254
[Journal Article] Glycine release from astrocytes via functional reversal of GlyT1.2017
- Author(s)
  Shibasaki K, Hosoi N, Kaneko R, Ishizaki Y, Yamada K
- Journal Title
  
  J. Neurochem.
  
  Volume: 140 Issue: 3 Pages: 395-403
- DOI
  10.1111/jnc.13741
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05934, KAKENHI-PROJECT-15H03000, KAKENHI-PROJECT-16H05438, KAKENHI-PROJECT-25430003, KAKENHI-PROJECT-15K06696, KAKENHI-PROJECT-15KK0331
[Journal Article] Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice2011
- Author(s)
  Kazuhiro Mitsumura, Nobutake Hosoi, Nobuhiko Furuya, Hirokazu Hirai
- Journal Title
  
  The Journal of Physiology
  
  Volume: 589(13) Pages: 3191-3209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700431
[Presentation] Synaptic activation of protein kinase Cγ in cerebellar Purkinje cells2023
- Author(s)
  Nobutake Hosoi, Yuuki Fukai, Ayumu Konno, Hirokazu Hirai
- Organizer
  第13回国際放射線神経生物学会大会
- Data Source
  KAKENHI-PROJECT-20K06906
[Presentation] 小脳プルキンエ細胞におけるシナプス入力によって誘発されるガンマ型プロテインキナーゼCの細胞膜への移行2023
- Author(s)
  細井延武、深井悠貴、今野歩、平井宏和
- Organizer
  第101回日本生理学会
- Data Source
  KAKENHI-PROJECT-20K06906
[Presentation] microRNAターゲット配列を用いたAAVによる新規なマイクログリア特異的遺伝子発現法の応用例とこの手法の神経細胞への影響について2022
- Author(s)
  細井延武、岡田如弘、深井悠貴、平賀証人、松崎泰教、中井淳一、今野歩、平井宏和
- Organizer
  日本生理学会大会第100回記念大会
- Data Source
  KAKENHI-PROJECT-20K06906
[Presentation] 甲状腺ホルモンシグナルによる小脳シナプス可塑性の調節メカニズム2022
- Author(s)
  細井延武、二ノ宮彩音、天野出月、小久保倫文、平井宏和、鯉淵典之
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-18H03379
[Presentation] 授乳期におけるPFOS曝露は小脳機能の発達異常を引き起こす2022
- Author(s)
  二ノ宮彩音、ムシャティアブダラ、蓜島旭、矢島弘之、小久保倫文、カイリニサアグニャミスキ、アリヤニウィンダ、藤原悠基、石井角保、細井延武、平井宏和、天野出月、鯉淵典之
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-18H03379
[Presentation] 小脳機能維持における甲状腺ホルモンの新たな役割：プルキンエ細胞小胞体からのカルシウム放出調節における重要性2021
- Author(s)
  二ノ宮彩音，細井延武，天野出月，小久保倫文，高鶴裕介，平井宏和，鯉淵典之
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03379
[Presentation] 甲状腺ホルモンシグナルによる小脳シナプス可塑性の調節メカニズム2021
- Author(s)
  細井延武、二ノ宮彩音、小久保倫史、天野出月、平井宏和、鯉淵典之
- Organizer
  第９９回日本生理学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] 甲状腺ホルモンシグナルによる小脳シナプス可塑性の調節メカニズム2021
- Author(s)
  細井延武、二ノ宮彩音、小久保倫史、天野出月、平井宏和、鯉淵典之
- Organizer
  第９９回日本生理学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06906
[Presentation] Insufficiency of class II ARFs causes tremor by impairment of Nav1.6 localization to the axon initial segment of cerebellar Purkinje cells in mice2020
- Author(s)
  細井延武、柴崎貢志、古市貞一、平井宏和、定方哲史
- Organizer
  生理研研究会　2020 シナプス研究会
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] 甲状腺ホルモン受容体による小脳プルキンエ細胞におけるシナプス可塑性の調節機構2020
- Author(s)
  二ノ宮彩音，細井延武，小久保倫文，天野出月，蓜島旭，宮崎航，平井宏和，鯉淵典之
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-18H03379
[Presentation] Deletion of class II ARFs causes tremor by disruption of Nav1.6 localization to the axon initial segment of cerebellar Purkinje cells in mice2020
- Author(s)
  Nobutake Hosoi, Koji Shibasaki, Teiichi Furuichi, Hirokazu Hirai, Tetsushi Sadakata
- Organizer
  FENS 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] クラスIIARFはNav1.6を小脳プルキンエ細胞の軸索初節部に局在させる新規な役割を持つ2020
- Author(s)
  細井延武、柴崎貢志、古市貞一、平井宏和、定方哲史
- Organizer
  第９８回日本生理学会大会　Web開催
- Invited
- Data Source
  KAKENHI-PROJECT-20K06906
[Presentation] Insufficiency of class II ARFs causes tremor by impairment of Nav1.6 localization to the axon initial segment of cerebellar Purkinje cells in mice2020
- Author(s)
  細井延武、柴崎貢志、古市貞一、平井宏和、定方哲史
- Organizer
  生理研研究会　2020 シナプス研究会
- Data Source
  KAKENHI-PROJECT-20K06906
[Presentation] A Novel Role of Thyroid Hormone Receptor in Synaptic Plasticity in Cerebellar Purkinje Cells.2020
- Author(s)
  Ninomiya A, Hosoi N, Kokubo M, Amano I, Haijima A, Miyazaki W, Hirai H, Koibuchi N
- Organizer
  102nd Annual Meeting of the Endocrine Society (ENDO 2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03379
[Presentation] Deletion of class II ARFs causes tremor by disruption of Nav1.6 localization to the axon initial segment of cerebellar Purkinje cells in mice2020
- Author(s)
  Nobutake Hosoi, Koji Shibasaki, Teiichi Furuichi, Hirokazu Hirai, Tetsushi Sadakata
- Organizer
  FENS 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06906
[Presentation] クラスIIARFはNav1.6を小脳プルキンエ細胞の軸索初節部に局在させる新規な役割を持つ2020
- Author(s)
  細井延武、柴崎貢志、古市貞一、平井宏和、定方哲史
- Organizer
  第９８回日本生理学会大会　Web開催
- Invited
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] クラスII ARFタンパク質の欠失はNav1.6の輸送不全により振戦を発症させる2019
- Author(s)
  定方哲史、細井延武、柴崎貢志、今野歩、平井宏和、石崎泰樹、古市貞一
- Organizer
  第42回　日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] 甲状腺ホルモン受容体による小脳プルキンエ細胞におけるシナプス可塑性の調節機構2019
- Author(s)
  二ノ宮彩音，細井延武，小久保倫文，天野出月，蓜島旭，宮崎航，平井宏和，鯉淵典之
- Organizer
  第62回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03379
[Presentation] 甲状腺ホルモン受容体による小脳プルキンエ細胞におけるシナプス可塑性の調節機構2019
- Author(s)
  二ノ宮彩音、細井延武、小久保倫文、天野出月、蓜島旭、宮崎航、平井宏和、鯉淵典之
- Organizer
  第97回　日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] 甲状腺ホルモン受容体による小脳プルキンエ細胞での可塑性の調節機構2019
- Author(s)
  二ノ宮彩音，細井延武，小久保倫文，天野出月，蓜島旭，宮崎航，平井宏和，鯉淵典之
- Organizer
  第37回内分泌代謝学サマーセミナー
- Data Source
  KAKENHI-PROJECT-18H03379
[Presentation] クラスIIARF不全で動作時振戦を示すマウスの小脳プルキンエ細胞における活動電位発火とNa電流：クラスIIARFがNav1.6を軸索起始部へ局在させる役割を持つ可能性2019
- Author(s)
  細井延武、柴崎貢志、古市貞）、平井宏和、定方哲史
- Organizer
  第97回　日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] Impairment of Long-term Plasticity in Purkinje Cell with Dominant -negative Thyroid Hormone Receptor.2019
- Author(s)
  Ninomiya A, Hosoi N, Kokubo M, Amano I, Haijima A, Miyazaki W, Hirai H, Koibuchi N
- Organizer
  The 9th Federation of the Asian and Oceanian Physiological Societies Congress.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03379
[Presentation] The effect of orally-administered baclofen on spinocerebellar ataxia type 3 (SCA3) model mice2018
- Author(s)
  Nobutake Hosoi and Hirokazu Hirai
- Organizer
  FAOPS 2019 (第96回日本生理学会大会・第9回アジア・オセアニア生理学会連合大会合同大会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] 遺伝性脊髄小脳変性症に対するGPCRクロストークを利用した治療戦略2017
- Author(s)
  細井　延武
- Organizer
  第９回　光操作研究会
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] Pros and cons of an AAV double infection method combined with Tet system: an experimental study2017
- Author(s)
  Nobutake Hosoi, Masayuki Shichida, Ayumu Konno and Hirokazu Hirai
- Organizer
  Neuroscienc 2017 SfN annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] Pros and cons of an AAV double infection method combined with the Tet system :An experimental study2017
- Author(s)
  Nobutake Hosoi, Masayuki Shichida, Ayumu Konno, Hirokazu Hirai
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15477
[Presentation] GPCR(Gタンパク共役型受容体）クロストークを利用した脊髄小脳失調症(SCA1)に対する治療可能性2017
- Author(s)
  細井　延武、　アントン　シュワエフ、　平井　宏和
- Organizer
  第９５回　日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] Low concentration of a GABAb receptor agonist improves motor performance in spinocerebellar ataxia type 1 (SCA1) model mice2017
- Author(s)
  Nobutake Hosoi, Shuvaev N Anton, Hirokazu Hirai
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K15477
[Presentation] 低濃度GABAb受容体アゴニスト投与による遺伝性脊髄小脳変性症１型(SCA1)モデルマウスの運動機能の改善2017
- Author(s)
  細井　延武、　アントン　シュワエフ、　平井　宏和
- Organizer
  第40回　日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K07103
[Presentation] Low concentration of a GABAb receptor agonist improves motor performance in spinocerebellar ataxia type 1 (SCA1) model mice2017
- Author(s)
  Nobutake Hosoi, Shuvaev N Anton, Hirokazu Hirai
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15H04254
[Presentation] Progressive impairment of metabotropic glutamate receptor(mGluR) mediated signaling and carebellar synaptic plasticity in spinocerebellar ataxia type 1(SCA1) model mice2016
- Author(s)
  Nobutake Hosoi, Anton N Shuvaev, Hirokazu Hirai
- Organizer
  Neuroscience 2016
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04254
[Presentation] Probing expression pattern of a novel AAV double infection method combined with the Tet system and the glia specific GFAP promoter2016
- Author(s)
  Nobutake Hosoi, Masayuki Shichida, Ayumu Konno and Hirokazu Hirai
- Organizer
  10th FENS Forum of Neuroscience
- Place of Presentation
  コペンハーゲン　（デンマーク）
- Year and Date
  2016-07-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] 脊髄小脳変性症1型モデルマウスにおける短期・長期シナプス可塑性とCa2+シグナルの進行性異常2016
- Author(s)
  細井延武、アントンシュワエフ、平井宏和
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] 脊髄小脳変性症1型(SCA1)モデルマウスにおける短期・長期シナプス可塑性とCa2+シグナルの進行性異常2016
- Author(s)
  細井延武、 Anton Shuvaev、平井　宏和
- Organizer
  第39回　日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] Progressive abnormalities in short-and long term synaptic plasticity and dendritic Ca2+ signals in spinocerebellar ataxia type 1 (SCA1) model mice.2016
- Author(s)
  細井延武、シュワエフアントン、平井宏和
- Organizer
  第９３回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15H04254
[Presentation] Progressive impairment of metabotropic glutamate receptor (mGluR)-mediated signaling and cerebellar synaptic plasticity in spinocerebellar ataxia type 1 (SCA1) model mice2016
- Author(s)
  N. HOSOI, A. Shuvaev, H. Hirai
- Organizer
  Neuroscience 2016 SfN 46th Annual meeting
- Place of Presentation
  サンディエゴ　（アメリカ）
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] 脊髄小脳変性症１型(SCA1)モデルマウスにおけるmGluRを介したシナプス伝達の進行性異常2015
- Author(s)
  細井延武、平井宏和
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場、神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] 脊髄小脳変性症1型（SCA1)モデルマウスにおけるｍGluRを介したシナプス伝達の進行性異常2015
- Author(s)
  細井　延武、平井　宏和
- Organizer
  第5回国際放射線神経生物学会大会
- Place of Presentation
  高崎シティギャラリー　（群馬県高崎市）
- Year and Date
  2015-02-21
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] Progressive impairment of cerebellar mGluR signaling in SCA1 model mice.2015
- Author(s)
  Nobutake Hosoi, Hirokazu Hirai.
- Organizer
  第３８回日本神経科学大会
- Place of Presentation
  神戸国際会議場 (兵庫県神戸市)
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15H04254
[Presentation] 短縮型マウスGFAPプロモーターとTet systemを組み合わせたAAV二重感染法による遺伝子発現のグリア特異性の検討2015
- Author(s)
  七田　真之、細井　延武、　今野　歩、　平井　宏和
- Organizer
  第5回国際放射線神経生物学会大会
- Place of Presentation
  高崎シティギャラリー　（群馬県高崎市）
- Year and Date
  2015-02-21
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] 短縮型マウスGFAPプロモーターとTet systemを組み合わせた新規AAV二重感染法による遺伝子発現のグリア特異性の検討2015
- Author(s)
  七田真之、細井延武、今野歩、平井宏和
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場、神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] 小脳性運動失調とシナプス伝達異常2014
- Author(s)
  細井延武、平井宏和
- Organizer
  第９１回　日本生理学会大会
- Place of Presentation
  鹿児島大学　郡元キャンパス　（鹿児島）
- Invited
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] Staggerer小脳変性マウスにおける代謝型グルタミン酸受容体を介するシナプス伝達の異常2011
- Author(s)
  細井延武, 三ツ村一浩, 平井宏和
- Organizer
  第34回日本神経科学学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22700431
[Presentation] Staggerer小脳変性マウスにおける代謝型グルタミン酸受容体を介するシナプス伝達の異常2011
- Author(s)
  細井延武
- Organizer
  第34回日本神経科学学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22700431
[Presentation] Disruption of mGluR-mediated signalling at cerebellar parallel fiber-Purkinje cell synapses in staggerer mutant mice2011
- Author(s)
  細井延武, 三ツ村一浩, 平井宏和
- Organizer
  第4回国際小脳学会
- Place of Presentation
  東京大学山上会館
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-22700431
[Presentation] Disruption of mGluR-mediated signalling at cerebellar parallel fiber-Purkinje cell synapses in staggerer mutant mice2011
- Author(s)
  細井延武
- Organizer
  第4回国際小脳学会
- Place of Presentation
  東京大学山上会館(東京都)
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-22700431
[Presentation] ABNORMALITIES OF METABOTROPIC GLUTAMATE RECEPTOR (MGLUR)-MEDIATED SIGNALING AT CEREBELLAR PARALLEL FIBER-PURKINJE CELL SYNAPSES IN SPINOCEREBELLAR ATAXIA TYPE 1 (SCA1) MODEL MICE
- Author(s)
  Nobutake Hosoi, Hirokazu Hirai
- Organizer
  9th FENS Forum of Neuroscience
- Place of Presentation
  ミラノ (イタリア)
- Year and Date
  2014-07-05 – 2014-07-09
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] 脊髄小脳変性症1型（SCA1)モデルマウスにおけるｍGluRを介したシナプス伝達の進行性異常
- Author(s)
  細井　延武、平井　宏和
- Organizer
  生理学研究所　研究会　「シナプス・神経ネットワークの機能ダイナミクス」
- Place of Presentation
  生理学研究所（愛知県岡崎市）
- Year and Date
  2014-12-02 – 2014-12-03
- Data Source
  KAKENHI-PROJECT-25430003

1. KONNO Ayumu (40509048)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. HIRAI Hirokazu (70291086)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
3. MATSUZAKI Yasunori (50738200)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Koibuchi Noriyuki (80234681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 竹下章 (20322646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 配島旭 (70555672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 武田茂樹 (80282854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 下川哲昭 (90235680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 宮崎航 (90512278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 六本木麗子 (80719857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 金子涼輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. はい島旭

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 柴崎貢志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosoi Nobutake 細井 延武

HOSOI Nobutake 細井 延武

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ガンマ型プロテインキナーゼCによる神経シグナルの時空間的調節機構とその役割Principal Investigator

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Development of microglia-targeting AAV vectors and its application to neurodegenerative disorders

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A developmental switch in short-term synaptic plasticiyPrincipal Investigator

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Epigenetic modulation by chemical substances on thyroid hormone-mediated brain development.

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Mechanism of activity-dependent motor improvement in SCAPrincipal Investigator

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Development of gene therapy against neurodegenerative diseases using CRISPR/Cas9-based genome editing

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Elucidation of cellular and nuclear signals that regulate motor learning

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Functional roles of glial ATP receptors in neuron-glia interactionPrincipal Investigator

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Neuron-glia interaction during cerebellar development The role of Ca-permeable AMPA receptorsPrincipal Investigator

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[Journal Article] Elucidating the Mechanisms of Life using Patchclamp Technique and Live Imaging2023

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[Journal Article] Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis2023

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[Journal Article] The neurotoxic effect of lactational PFOS exposure on cerebellar functional development in male mice2022

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[Journal Article] Protein kinase Cγ in cerebellar Purkinje cells regulates Ca 2+-activated large-conductance K + channels and motor coordination2022

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Hosoi Nobutake 細井延武

HOSOI Nobutake 細井延武