Maezawa So 前澤創

Researcher Number	90548174
Other IDs	https://orcid.org/0000-0002-9060-2042
Affiliation (Current)	2025: 東京理科大学, 創域理工学部生命生物科学科, 教授
Affiliation (based on the past Project Information) *help	2025: 東京理科大学, 創域理工学部生命生物科学科, 教授 2023 – 2025: 東京理科大学, 創域理工学部生命生物科学科, 准教授 2021 – 2023: 東京理科大学, 理工学部応用生物科学科, 准教授 2018 – 2019: 麻布大学, 獣医学部, 講師
Review Section/Research Field	Principal Investigator Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Transformative Research Areas, Section (III) / Basic Section 42030:Animal life science-related / Biological Sciences / 0702:Biology at cellular to organismal levels, and related fields Except Principal Investigator Basic Section 46010:Neuroscience-general-related / Transformative Research Areas, Section (III)
Keywords	Principal Investigator エピゲノム / 生殖科学 / 精子形成 / クロマチン / エピジェネティクス / 生殖細胞 / 分化 / 減数分裂 / 分化誘導 / エピゲノム編集 … More / 配偶子形成 / 性染色体 / 核ラミナ / 栄養 / 発生分化 / 発生 / メタボローム / 代謝 / 分化運命 / パイオニア因子 / 転写因子 / ATAC-seq / RNA-seq / A-MYB / エンハンサー … More Except Principal Investigator エキソサイトーシス / 分泌小胞 / CAPS2/CADPS2 / 神経ペプチド / 膵疾患 / CAPSタンパク質 / 分泌障害 / 有芯小胞 / 開口放出 / アミラーゼ / 分泌顆粒 / Cadps2 / CAPS2 / 腺房細胞 / 膵外分泌 / ドーパミン / 中脳黒質緻密部 / 中脳被蓋野 / 慢性膵炎 / 膵腺房細胞 / エピゲノム / 栄養 / 代謝 / ライフスパン / 生殖細胞 Less

Molecular mechanisms underlying Cadps2-dependent regulation of global exocytosis and pathological conditions caused by its deficiency
- Principal Investigator
  
  古市貞一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Tokyo University of Science
Multimodal regulation of chromatin structure during mouse spermatogenesisPrincipal Investigator
- Principal Investigator
  
  前澤創
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Tokyo University of Science
Metabolic regulation of reproductive lifespan
- Principal Investigator
  
  林陽平
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Science Tokyo
  Tohoku University
単一細胞クロマチン接近性解析に基づいた、エピゲノム編集による配偶子形成制御Principal Investigator
- Principal Investigator
  
  前澤創
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Tokyo University of Science
The role of CAPS in the activity-dependent dense-core vesicle exocytosis: function and impairment
- Principal Investigator
  
  古市貞一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Tokyo University of Science
Regulation of cell fate decision during mammalian spermatogenesisPrincipal Investigator
- Principal Investigator
  
  前澤創
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Science
Interplay between epigenetics and metabolism in transgenerational inheritancePrincipal Investigator
- Principal Investigator
  
  Maezawa So
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Tokyo University of Science
Establishment of germline-specific epigenome in mouse spermatogenesisPrincipal Investigator
- Principal Investigator
  
  Maezawa So
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0702:Biology at cellular to organismal levels, and related fields
- Research Institution
  Azabu University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] CTCF-mediated 3D chromatin predetermines the gene expression program in the male germline2023
- Author(s)
  Kitamura Yuka、Takahashi Kazuki、Maezawa So、Munakata Yasuhisa、Sakashita Akihiko、Kaplan Noam、Namekawa Satoshi H.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.11.30.569508
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18084, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-21H02383
[Journal Article] Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin2023
- Author(s)
  Sakashita Akihiko、Ooga Masatoshi、Otsuka Kai、Maezawa So、Takeuchi Chikara、Wakayama Sayaka、Wakayama Teruhiko、Namekawa Satoshi?H
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 13 Pages: 6668-6683
- DOI
  10.1093/nar/gkad479
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18084, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-21H02383
[Journal Article] Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin2023
- Author(s)
  *Sakashita A, Ooga M, Otsuka K, Maezawa S, Takeuchi C, Wakayama S, Wakayama T, and *Namekawa SH
- Journal Title
  
  Nucleic Acids Research
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02383
[Journal Article] KRAB-zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution2023
- Author(s)
  Otsuka Kai、Sakashita Akihiko、Maezawa So、Schultz Richard M.、Namekawa Satoshi H.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.06.24.546405
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18084, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-21H02383
[Journal Article] PRC1 directs PRC2-H3K27me3 deposition to shield adult spermatogonial stem cells from differentiation2023
- Author(s)
  Hu Mengwen、Yeh Yu-Han、Maezawa So、Nakagawa Toshinori、Yoshida Shosei、Namekawa Satoshi?H
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 52 Issue: 5 Pages: 2306-2322
- DOI
  10.1093/nar/gkad1203
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18084, KAKENHI-PLANNED-18H05551, KAKENHI-PROJECT-23H00380, KAKENHI-PROJECT-21H02383
[Journal Article] Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin2023
- Author(s)
  *Sakashita A, Ooga M, Otsuka K, Maezawa S, Takeuchi C, Wakayama S, Wakayama T, and *Namekawa SH
- Journal Title
  
  Nucleic Acids Research
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00233
[Journal Article] PRC1 suppresses a female gene regulatory network to ensure testicular differentiation2023
- Author(s)
  Maezawa So、Yukawa Masashi、Hasegawa Kazuteru、Sugiyama Ryo、Iizuka Mizuho、Hu Mengwen、Sakashita Akihiko、Vidal Miguel、Koseki Haruhiko、Barski Artem、DeFalco Tony、Namekawa Satoshi H.
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 8
- DOI
  10.1038/s41419-023-05996-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18084, KAKENHI-PLANNED-19H05745, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-21H02383
[Journal Article] PRC1-mediated epigenetic programming is required to generate the ovarian reserve2022
- Author(s)
  Hu Mengwen、Yeh Yu-Han、Munakata Yasuhisa、Abe Hironori、Sakashita Akihiko、Maezawa So、Vidal Miguel、Koseki Haruhiko、Hunter Neil、Schultz Richard M.、Namekawa Satoshi H.
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41467-022-31759-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02383, KAKENHI-PROJECT-21K15108, KAKENHI-PLANNED-19H05745, KAKENHI-PUBLICLY-21H00233, KAKENHI-PUBLICLY-22H04700
[Journal Article] Bioinformatics Pipelines for Identification of Super-Enhancers and 3D Chromatin Contacts2022
- Author(s)
  Sakashita Akihiko、Takeuchi Chikara、Maezawa So、Namekawa Satoshi H.
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 2577 Pages: 123-146
- DOI
  10.1007/978-1-0716-2724-2_9
- ISBN
  9781071627235, 9781071627242
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02383, KAKENHI-PROJECT-22KJ2696, KAKENHI-PUBLICLY-21H00233, KAKENHI-PUBLICLY-22H04700
[Journal Article] Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice2022
- Author(s)
  Sato Y、Tsuyusaki M、Takahashi-Iwanaga H、Fujisawa R、Masamune A、Hamada S、Matsumoto R、Tanaka Y、Kakuta Y、Yamaguchi-Kabata Y、Furuse T、Wakana S、Shimura T、Kobayashi R、Shinoda Y、Goitsuka R、Maezawa S、Sadakata T、Sano Y、Furuichi T
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 9 Pages: 1-18
- DOI
  10.3389/fmolb.2022.1040237
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07236, KAKENHI-PROJECT-22K06447, KAKENHI-PROJECT-21H02372, KAKENHI-PUBLICLY-21H05611, KAKENHI-PROJECT-23K23977
[Journal Article] ATAC-Seq Analysis of Accessible Chromatin: From Experimental Steps to Data Analysis2022
- Author(s)
  Tatara Mayu、Ikeda Taiyo、Namekawa Satoshi H.、Maezawa So
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 2577 Pages: 65-81
- DOI
  10.1007/978-1-0716-2724-2_5
- ISBN
  9781071627235, 9781071627242
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02383, KAKENHI-PUBLICLY-21H00233
[Journal Article] Use of Visual Information by Ant Species Occurring in Similar Urban Anthropogenic Environments2022
- Author(s)
  Notomi Yusuke、Kazawa Tomoki、Maezawa So、Kanzaki Ryohei、Haupt Stephan Shuichi
- Journal Title
  
  Zoological Science
  
  Volume: 39 Issue: 6 Pages: 529-544
- DOI
  10.2108/zs220035
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02383, KAKENHI-PUBLICLY-21H00233
[Journal Article] Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis2021
- Author(s)
  Alavattam Kris G.、Maezawa So、Andreassen Paul R.、Namekawa Satoshi H.
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 79 Issue: 1
- DOI
  10.1007/s00018-021-04075-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00233, KAKENHI-PROJECT-21H02383
[Journal Article] Endogenous retroviruses drive species-specific germline transcriptomes in mammals2020
- Author(s)
  Sakashita Akihiko、Maezawa So、Alavattam Kris G.、Yukawa Masashi、Barski Artem、Pavlicev Mihaela、Namekawa Satoshi H.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.03.11.987230
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21196
[Journal Article] Super-enhancer switching drives a burst in germline gene expression at the mitosis-to-meiosis transition2020
- Author(s)
  Maezawa So、Yukawa Masashi、Chen Xiaoting、Sakashita Akihiko、Alavattam Kris G.、Weirauch Matthew T.、Barski Artem、Namekawa Satoshi H.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.03.11.987180
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21196
[Presentation] マウス精子形成期におけるエピゲノムおよびクロマチン制御機構2023
- Author(s)
  前澤創
- Organizer
  第3回有性生殖研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00233
[Presentation] マウス精子形成期におけるエピゲノムおよびクロマチン制御機構2023
- Author(s)
  前澤創
- Organizer
  第3回有性生殖研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02383
[Presentation] Dynamic nuclear lamina-chromatin interactions during spermatogenesis2022
- Author(s)
  前澤創
- Organizer
  The International Symposium "Totipotency and Germ Cell Development"
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00233
[Presentation] 生命の連続性を担う、生殖細胞のエピゲノム形成機構2022
- Author(s)
  前澤創
- Organizer
  日本医科大学・東京理科大学　第9回合同シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00233
[Presentation] マウス精子形成過程における分化運命決定機構の解明2022
- Author(s)
  前澤創
- Organizer
  NGS EXPO 2022
- Data Source
  KAKENHI-PUBLICLY-21H00233
[Presentation] Dynamic nuclear lamina-chromatin interactions during spermatogenesis2022
- Author(s)
  前澤創
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02383
[Presentation] Polycomb suppresses a female gene regulatory network in Sertoli cells2022
- Author(s)
  前澤創
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PUBLICLY-21H00233
[Presentation] 生命の連続性を担う、生殖細胞のエピゲノム形成機構2022
- Author(s)
  前澤創
- Organizer
  日本医科大学・東京理科大学　第9回合同シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21H02383
[Presentation] Polycomb suppresses a female gene regulatory network in Sertoli cells2022
- Author(s)
  前澤創
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-21H02383
[Presentation] Dynamic nuclear lamina-chromatin interactions during spermatogenesis2022
- Author(s)
  前澤創
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-21H00233
[Presentation] Dynamic nuclear lamina-chromatin interactions during spermatogenesis2022
- Author(s)
  前澤創
- Organizer
  The International Symposium "Totipotency and Germ Cell Development"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02383
[Presentation] 生命の連続性を担う生殖細胞のエピゲノム形成機構2021
- Author(s)
  前澤創
- Organizer
  第114回日本繁殖生物学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00233
[Presentation] 生命の連続性に迫るー生殖細胞のエピゲノム形成機構2019
- Author(s)
  前澤創
- Organizer
  形態解析ワークショップー多様な顕微鏡を用いて
- Invited
- Data Source
  KAKENHI-PROJECT-19K21196
[Presentation] Super-enhancer switching drives a burst in germline gene expression at the mitosis-to-meiosis transition2019
- Author(s)
  前澤創
- Organizer
  EpiBio2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21196
[Presentation] Super-enhancer switching drives a burst in germline gene expression at the mitosis-to-meiosis transition2019
- Author(s)
  前澤創
- Organizer
  第13回エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-19K21196
[Presentation] マウス精子形成期におけるクロマチン構造変化による遺伝子発現制御機構2018
- Author(s)
  前澤創
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K21196
[Presentation] Genome-wide establishment of meiotic super-enhancers drives expression of spermatogenesis- specific genes2018
- Author(s)
  前澤創
- Organizer
  3R&3C Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21196

1. 林陽平 (00588056)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 古市貞一 (50219094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 篠田陽 (80403096)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 定方哲史 (90391961)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 大我政敏 (40644886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 平山明由 (00572405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 森大 (00588981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岩永ひろみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maezawa So 前澤 創

Research Projects

Research Products

Co-Researchers

Molecular mechanisms underlying Cadps2-dependent regulation of global exocytosis and pathological conditions caused by its deficiency

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multimodal regulation of chromatin structure during mouse spermatogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metabolic regulation of reproductive lifespan

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

単一細胞クロマチン接近性解析に基づいた、エピゲノム編集による配偶子形成制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of CAPS in the activity-dependent dense-core vesicle exocytosis: function and impairment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of cell fate decision during mammalian spermatogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Interplay between epigenetics and metabolism in transgenerational inheritancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of germline-specific epigenome in mouse spermatogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] CTCF-mediated 3D chromatin predetermines the gene expression program in the male germline2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin2023

Author(s)

Journal Title

Data Source

[Journal Article] KRAB-zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PRC1 directs PRC2-H3K27me3 deposition to shield adult spermatogonial stem cells from differentiation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin2023

Author(s)

Journal Title

Data Source

Maezawa So 前澤創