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Akiyama Naotaro  穐山 直太郎

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AKIYAMA Naotaro  穐山 直太郎

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Researcher Number 90554238
Other IDs
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Affiliation (Current) 2025: 東京歯科大学, 歯学部, 講師
2025: 東京慈恵会医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2018 – 2023: 東邦大学, 医学部, 講師
2018: 東京慈恵会医科大学, 医学部, 助教
2016 – 2017: 東邦大学, 医学部, 助教
2016: 東京慈恵会医科大学, 医学部, 助教
2014 – 2015: 長崎大学, 医歯薬学総合研究科(医学系), 助教
2012 – 2013: 長崎大学, 大学病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology
Except Principal Investigator
Basic Section 56050:Otorhinolaryngology-related / General anatomy (including histology/embryology)
Keywords
Principal Investigator
外耳道扁平上皮癌 / 糖鎖修飾 / 細胞間接着分子 / 癌微小環境 / メカノトランスダクション / 外耳道癌 / PDK1 / エレクトロポレーション / PDPK1 / EGF … More / 癌生存シグナル / 口腔咽頭科 / 再生医療 / Wnt5a / DNAメチル化 / 粘膜再生 / 口腔潰瘍 / 中人粘膜上皮 / 培養細胞 / 再生 / 中耳粘膜上皮 / 中耳 … More
Except Principal Investigator
シングルセル解析 / 中耳真珠腫 / 腫瘍幹細胞 / 腫瘍幹細胞化Key分子 / 時空間的解析法 / 多細胞間ネットワーク / 幹細胞性規定遺伝子 / ミャンマー / 地域的部族的差異 / 民族差 / 鉄 / 若年性肝癌発症 / p15INK4b / 変異型p53 / ミャンマー / 居住地域性 / Bcl9 / 組織化学的解析 / ヒ素 / 鉄過剰摂取 / 若年発症 / 肝癌 Less
  • Research Projects

    (7 results)
  • Research Products

    (42 results)
  • Co-Researchers

    (8 People)
  •  中耳真珠腫幹細胞性規定遺伝子同定:多細胞間ネットワークの時空間的解析法を用いて

    • Principal Investigator
      福田 智美
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Jikei University School of Medicine
  •  外耳道扁平上皮癌発症におけるメカノトランスダクション機構の解明Principal Investigator

    • Principal Investigator
      穐山 直太郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Toho University
  •  To identify the key molecules of stem cell : Possible involvement of neural crest-derived cells against the pathogenesis of middle ear cholesteatoma

    • Principal Investigator
      Yamamoto-fukuda Tomomi
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Jikei University School of Medicine
  •  Development of a novel conservative treatment for targeting survival signaling in the External auditory canal squamous cell carcinoma.Principal Investigator

    • Principal Investigator
      Akiyama Naotaro
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Toho University
  •  Local differences in juvenile development of hepatocellular carcinoma in multi-racial Myanmar; focusing on the effect of iron and arsenic

    • Principal Investigator
      KOJI Takehiko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General anatomy (including histology/embryology)
    • Research Institution
      Nagasaki University
  •  Epigenetic regulation in the process of oral mucosal regeneration in a rat oral ulcer modelPrincipal Investigator

    • Principal Investigator
      AKIYAMA Naotaro
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Toho University
      Nagasaki University
  •  Evaluation of in situ tissue enginnering of the middle ear mucosaPrincipal Investigator

    • Principal Investigator
      AKIYAMA Naotaro
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Nagasaki University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012

All Journal Article Presentation

  • [Journal Article] Epigenetic Regulation as a New Therapeutic Target for Middle Ear Cholesteatoma.2023

    • Author(s)
      Yamamoto-Fukuda T, Akiyama N, Hirabayashi M, Shimmura H, Kojima H.
    • Journal Title

      Otol Neurotol.

      Volume: 44 Issue: 3 Pages: 273-280

    • DOI

      10.1097/mao.0000000000003795

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16908, KAKENHI-PROJECT-19K18786
  • [Journal Article] Analysis of the epidermal growth factor receptor/phosphoinositide-dependent protein kinase-1 axis in tumor of the external auditory canal in response to epidermal growth factor stimulation2022

    • Author(s)
      Naotaro Akiyama, Tomomi Yamamoto‐Fukuda, Mamoru Yoshikawa, Hiromi Kojima
    • Journal Title

      Laryngoscope Investigative Otolaryngology

      Volume: -

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Journal Article] miR-34a predicts the prognosis of advanced-stage external auditory canal squamous cell carcinoma.2022

    • Author(s)
      Naotaro Akiyama, Tomomi Yamamoto‐Fukuda, Hiromi Kojima.
    • Journal Title

      Acta Otolaryngol.

      Volume: 142 Issue: 6 Pages: 537-541

    • DOI

      10.1080/00016489.2022.2086292

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Journal Article] Menin-MLL inhibitor blocks progression of middle ear cholesteatoma in vivo2021

    • Author(s)
      Yamamoto-Fukuda Tomomi、Akiyama Naotaro、Tatsumi Norifumi、Okabe Masataka、Kojima Hiromi
    • Journal Title

      International Journal of Pediatric Otorhinolaryngology

      Volume: 140 Pages: 110545-110545

    • DOI

      10.1016/j.ijporl.2020.110545

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09857
  • [Journal Article] Super-enhancer Acquisition Drives FOXC2 Expression in Middle Ear Cholesteatoma2021

    • Author(s)
      Yamamoto-Fukuda Tomomi、Akiyama Naotaro、Kojima Hiromi
    • Journal Title

      Journal of the Association for Research in Otolaryngology

      Volume: ‐ Issue: 4 Pages: 405-424

    • DOI

      10.1007/s10162-021-00801-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09857
  • [Journal Article] Keratinocyte growth factor signaling promotes stem/progenitor cell proliferation under p63 expression during middle ear cholesteatoma formation2020

    • Author(s)
      Yamamoto-Fukuda Tomomi、Akiyama Naotaro
    • Journal Title

      Current Opinion in Otolaryngology & Head & Neck Surgery

      Volume: 28 Issue: 5 Pages: 291-295

    • DOI

      10.1097/moo.0000000000000655

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09857
  • [Journal Article] L1CAM-ILK-YAP Mechanotransduction Drives Proliferative Activity of Epithelial Cells in Middle Ear Cholesteatoma2020

    • Author(s)
      Yamamoto-Fukuda Tomomi、Akiyama Naotaro、Kojima Hiromi
    • Journal Title

      The American Journal of Pathology

      Volume: 190 Issue: 8 Pages: 1667-1679

    • DOI

      10.1016/j.ajpath.2020.04.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16908, KAKENHI-PROJECT-19K09857
  • [Journal Article] Regulation of DNA Methylation Levels in the Process of Oral Mucosal Regeneration in a Rat Oral Ulcer Model2020

    • Author(s)
      Akiyama N, Yamamoto-Fukuda T, Yoshikawa M, Kojima H.
    • Journal Title

      Histology and Histopathology

      Volume: 35 Pages: 247-256

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Journal Article] Keratinocyte Growth Factor (KGF) Modulates Epidermal Progenitor Cell Kinetics through Activation of p63 in Middle Ear Cholesteatoma2018

    • Author(s)
      Yamamoto-Fukuda Tomomi、Akiyama Naotaro、Takahashi Masahiro、Kojima Hiromi
    • Journal Title

      Journal of the Association for Research in Otolaryngology

      Volume: Epub ahead of print Issue: 3 Pages: 1-19

    • DOI

      10.1007/s10162-018-0662-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462608, KAKENHI-PROJECT-16K11186
  • [Journal Article] Evaluation of YAP signaling in a rat tympanic membrane under a continuous negative pressure load and in human middle ear cholesteatoma.2017

    • Author(s)
      Akiyama N, Yamamoto-Fukuda T, Yoshikawa M, Kojima H.
    • Journal Title

      Acta Otolaryngol.

      Volume: 137 Issue: 11 Pages: 1158-1165

    • DOI

      10.1080/00016489.2017.1351040

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10792, KAKENHI-PROJECT-26462608, KAKENHI-PROJECT-16K11186
  • [Journal Article] In situ tissue engineering with synthetic self-assembling peptide nanofiber scaffolds, PuraMatrix, for mucosal regeneration in the rat middle ear2013

    • Author(s)
      Naotaro Akiyama, Tomomi Yamamoto-Fukuda, Haruo Takahashi, Takehiko Koji
    • Journal Title

      International Journal of Nanomedicine

      Volume: 8 Pages: 2629-2640

    • DOI

      10.2147/ijn.s47279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791787
  • [Presentation] Negative pressure in the middle ear and the mechanism of induction of middle ear cholesteatoma2024

    • Author(s)
      Naotaro Akiyama, Tomomi Yamamoto-Fukuda
    • Organizer
      The 11th International Conference on Cholesteatoma and Ear Surgery (CHOLE 2023)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09754
  • [Presentation] Negative pressure in the middle ear and the mechanism of induction of middle ear cholesteatoma2024

    • Author(s)
      Naotaro Akiyama, Tomomi Yamamoto-Fukuda
    • Organizer
      The 11th International Conference on Cholesteatoma and Ear Surgery (CHOLE 2023)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Presentation] 外耳道扁平上皮癌におけるmiR-34aの発現解析2023

    • Author(s)
      穐山直太郎、福田智美、吉川衛、小島博己
    • Organizer
      第33回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Presentation] 外耳道扁平上皮癌におけるmiR-34aの発現解析2023

    • Author(s)
      穐山直太郎、福田智美、吉川 衛、小島博己
    • Organizer
      第33回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-22K09754
  • [Presentation] 真珠腫性中耳炎発症機序に基づいた抗体療法の可能性2023

    • Author(s)
      福田智美、穐山直太郎、小島博己
    • Organizer
      第33回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Presentation] 真珠腫性中耳炎発症機序に基づいた抗体療法の可能性2023

    • Author(s)
      福田智美、穐山直太郎、小島博己
    • Organizer
      第33回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-22K09754
  • [Presentation] 外耳道EGF過剰発現マウスモデルを用いたEGFR/PDPK1シグナル阻害効果の解析2022

    • Author(s)
      穐山直太郎、福田智美、吉川 衛、小島博己
    • Organizer
      第32回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-22K09754
  • [Presentation] 外耳道EGF過剰発現マウスモデルを用いたEGFR/PDPK1シグナル阻害効果の解析2022

    • Author(s)
      穐山直太郎、福田智美、吉川 衛、小島博己
    • Organizer
      第32回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Presentation] EGFR/PDPK1 axis in squamous cell carcinoma of the external auditory canal2022

    • Author(s)
      Naotaro Akiyama, Tomomi Yamamoto-Fukuda, Mamoru Yoshikawa, Hiromi Kojima
    • Organizer
      The 7th East Asian Symposium on Otology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Presentation] 後天性真珠腫発症メカニズムの解析 ~中耳陰圧の観点から~2021

    • Author(s)
      穐山直太郎、福田智美
    • Organizer
      第31回日本耳科学会総会・学術講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Presentation] ラット中耳陰圧モデル鼓膜上皮および中耳真珠腫上皮における ILK-YAP シグナルの解析2019

    • Author(s)
      穐山直太郎、福田 智美、高橋 昌寛、吉川 衛、小島 博己
    • Organizer
      第29回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Presentation] Evaluation of YAP signaling in a Rat Tympanic Membrane Under a Continuous Negative Pressure Load and in Human Middle Ear Cholesteatoma2019

    • Author(s)
      Naotaro Akiyama, Tomomi Yamamoto-Fukuda, Masahiro Takahashi, Mamoru Yoshikawa, Hiromi Kojima
    • Organizer
      ARO 42nd Annual MidWinter Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Presentation] 中耳真珠腫間質におけるYAPシグナルの解析2018

    • Author(s)
      穐山直太郎、福田 智美、高橋 昌寛、吉川 衛、小島 博己
    • Organizer
      第28回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-18K16908
  • [Presentation] Evaluation of mechanotransduction in a rat tympanic membrane under a continuous negative pressure load and in human middle ear cholesteatoma.2018

    • Author(s)
      Akiyama N, Yamamoto-Fukuda T, Yoshikawa M, Kojima H
    • Organizer
      Association for Research in Otolaryngology The 41th Annual MidWinter Meeting
    • Data Source
      KAKENHI-PROJECT-26462608
  • [Presentation] Keratinocyte growth factor (KGF) modulates epidermal progenitor cell kinetics through activation of p63 in middle ear cholesteatoma.2018

    • Author(s)
      Yamamoto-Fukuda T, Akiyama N, Masahiro T, Kojima H
    • Organizer
      Association for Research in Otolaryngology The 41th Annual MidWinter Meeting
    • Data Source
      KAKENHI-PROJECT-26462608
  • [Presentation] ラット口腔潰瘍上皮化過程における Wnt5a 発現の解析2017

    • Author(s)
      穐山直太郎、福田 智美、吉川 衛
    • Organizer
      第118回日本耳鼻咽喉科学会通常総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-26462608
  • [Presentation] Novel Experimental model for Negative Pressure in the Middle Ear and Effects of Epithelial-cell Proliferation in the Tympanic Membrane.2017

    • Author(s)
      Naotaro Akiyama, Tomomi Yamamoto-Fukuda, Haruo Takahashi and Hiromi Kojima
    • Organizer
      40th Annual MidWinter Meeting, Association for Research in Otolaryngology
    • Place of Presentation
      Baltimore, Maryland, USA
    • Year and Date
      2017-02-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462608
  • [Presentation] 中耳真珠腫発症機序の解明:中耳真珠腫形成における神経堤由来細胞の役割2017

    • Author(s)
      福田智美、穐山直太郎、高橋昌寛、小島博己
    • Organizer
      第27回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-26462608
  • [Presentation] ラット中耳陰圧モデルおよび弛緩部型真珠腫における YAPシグナルの解析2017

    • Author(s)
      穐山直太郎、福田 智美、吉川 衛、小島 博己
    • Organizer
      第27回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-26462608
  • [Presentation] ラット口腔潰瘍上皮化過程での粘膜上皮細胞における DNAメチルトランスフェラーゼ(Dnmt)発現の解析2016

    • Author(s)
      穐山直太郎、遠藤 大輔、小路 武彦
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(郡山市)
    • Year and Date
      2016-03-28
    • Data Source
      KAKENHI-PROJECT-26462608
  • [Presentation] ペプチドハイドロゲルを用いたラット中耳粘膜培養細胞による中耳粘膜再生の検討2014

    • Author(s)
      穐山直太郎、福田智美、髙橋晴雄、小路武彦
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      栃木県下野市、自治医科大学
    • Data Source
      KAKENHI-PROJECT-24791787
  • [Presentation] ペプチドハイドロゲルを用いたラット中耳粘膜培養細胞による中耳粘膜再生の検討2014

    • Author(s)
      穐山直太郎
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      栃木
    • Data Source
      KAKENHI-PROJECT-24791787
  • [Presentation] KGF/FGF-7過剰発現モデルにおける上皮細胞増殖制御機構の解析2014

    • Author(s)
      穐山直太郎、福田智美、原川さゆみ、遠藤大輔、小路武彦
    • Organizer
      第46回日本臨床分子形態学会総会・学術集会
    • Place of Presentation
      TKP市ヶ谷カンファレンスセンター(東京都)
    • Year and Date
      2014-10-17
    • Data Source
      KAKENHI-PROJECT-26462608
  • [Presentation] ペプチドハイドロゲル被包細胞移植によるラット中耳粘膜再生の検討2014

    • Author(s)
      穐山直太郎、福田智美、高橋晴雄、小路武彦
    • Organizer
      第55回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      松本市中央公民館(M ウイング文化センター)(長野県松本市)
    • Year and Date
      2014-09-27
    • Data Source
      KAKENHI-PROJECT-26462608
  • [Presentation] Otoendoscopic Examination and Micro-computed Tomography Image Analysis of a New Animal Model of Continuous Negative Pressure in the Middle Ear2013

    • Author(s)
      Naotaro Akiyama
    • Organizer
      1st Global Otology Research Meeting/ the 29th Politzer Society Meeting
    • Place of Presentation
      Antalya, Turky
    • Data Source
      KAKENHI-PROJECT-24791787
  • [Presentation] Otoendoscopic Examination and Micro-computed Tomography Image Analysis of a New Animal Model of Continuous Negative Pressure in the Middle Ear2013

    • Author(s)
      Naotaro Akiyama, Tomomi Yamamoto-Fukuda, Haruo Takahashi
    • Organizer
      1st Global Otology Research Meeting/ the 29th Politzer Society Meeting
    • Place of Presentation
      Susesi hotel convention center, Antalyya,Turkey
    • Data Source
      KAKENHI-PROJECT-24791787
  • [Presentation] Evaluation of in situ tissue engineering for mucosal regeneration of rat middle ear.2012

    • Author(s)
      穐山 直太郎
    • Organizer
      第14回国際組織細胞科学学会(ICHC)
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-24791787
  • [Presentation] 外耳道後壁軟組織再建術にM-meatoplasty を併用した手術症例の検討2012

    • Author(s)
      穐山直太郎
    • Organizer
      第22回日本耳科学会総会学術講演会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24791787
  • [Presentation] Evaluation of in situ tissue engineering for mucosal regeneration of rat middle ear2012

    • Author(s)
      Naotaro Akiyama
    • Organizer
      14th International Congress of Histochemistry and Cytochemistry
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-24791787
  • [Presentation] Ultrastructure of regenerated middle ear mucosa after transplantation of cultured epithelial cells2012

    • Author(s)
      Naotaro Akiyama
    • Organizer
      the 9th International Conference on Cholesteatoma and Ear Surgery
    • Place of Presentation
      Nagasaki, Japan
    • Data Source
      KAKENHI-PROJECT-24791787
  • [Presentation] Ultrastructure of regenerated middle ear mucosa after transplantation of cultured epithelial cells.2012

    • Author(s)
      穐山 直太郎
    • Organizer
      The 9th International Conference on Cholesteatoma and Ear surgery
    • Place of Presentation
      Nagasaki
    • Data Source
      KAKENHI-PROJECT-24791787
  • 1.  Yamamoto-fukuda Tomomi (40372776)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 16 results
  • 2.  KOJI Takehiko (30170179)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  柴田 恭明 (80253673)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  遠藤 大輔 (90516288)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  Kyaw Soe
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Kyaw Myat Phone
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Kyaw Zin Thant
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  吉川 衛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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