Anazawa Takayuki 穴澤貴行

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ANAZAWA Takayuki 穴澤貴行

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Researcher Number	90566811
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 京都大学, 医学研究科, 講師 2016 – 2022: 京都大学, 医学研究科, 助教 2015: 京都大学, 医学(系)研究科(研究院), 助教 2010 – 2014: 福島県立医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Digestive surgery / General surgery Except Principal Investigator Digestive surgery / General surgery
Keywords	Principal Investigator 糖尿病 / 膵島移植 / 再生医療 / 細胞移植 / 皮下移植 / 免疫寛容 / 外科学 / 移植・再生医療 / 免疫抑制剤 / 免疫抑制 … More / 移植外科学 / 小胞体ストレス / 外科 / 細胞・組織 / イオンチャネル / 膵島分離 … More Except Principal Investigator 細胞死 / calreticulin / OK-432 / フィブリン / 徐放物質 / 腫瘍免疫 / 骨髄由来抑制細胞 / 膵癌 / MDSC / 担癌状態 / 免疫療法 / O-結合型糖鎖 / polyvinyl alcohol / polyethylene glycol / ムチン / Supported Molecular Matrix Electrophoresis(SMME)法 / マイトマイシンC / HMGB-1 / DAMPｓ / binding immunoglobulin protein / High-mobility group box 1 / 膵島移植 / 小胞体ストレス / 酸化ストレス / 移植 / HMGB1 / Mitomycin C / 細胞周期停止 / 免疫寛容 / 亜致死刺激 / 膵島 Less

Development of Immune Tolerance Space Construction Method for Cell Transplantation Based on Elucidation of Mechanism of Subcutaneous Vascular Induction ResponsePrincipal Investigator
- Principal Investigator
  
  穴澤貴行
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyoto University
Development of novel immunosuppressive method using MEK inhibitor to construct optimal environment for pancreatic islet transplantationPrincipal Investigator
- Principal Investigator
  
  Anazawa Takayuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyoto University
Bioinformatics approach to establish preconditioning method for beta cell replacementPrincipal Investigator
- Principal Investigator
  
  Anazawa Takayuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Induction of anti-tumor immune response using a Tissue Engineering technique
- Principal Investigator
  
  GOTOH Mitsukazu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Fukushima Medical University
Protection of pancreatic islets by controlling both the volume-sensitive chloride channel and endoplasmic reticulum stress responsePrincipal Investigator
- Principal Investigator
  
  ANAZAWA Takayuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Fukushima Medical University
Immunological effect of myeloid-derived suppressor cells in pancreatic cancer patients and its alteration after treatment
- Principal Investigator
  
  KENJO Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Fukushima Medical University
Optimization of collagenase activity and regulation of ion channel associated with cell viability for improving pancreatic islet transplantationPrincipal Investigator
- Principal Investigator
  
  ANAZAWA Takayuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Fukushima Medical University
Immunological tolerance induced by surviving but not dying cellsfollowing sublethal stress
- Principal Investigator
  
  GOTOH Mitsukazu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Fukushima Medical University
Long-term islet graft survival induced by regulating HMGB-1
- Principal Investigator
  
  SAITO Takaharu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Fukushima Medical University
新規糖鎖解析システム(SMME法)を用いた癌特異的糖鎖抗原の探索
- Principal Investigator
  
  後藤満一
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Fukushima Medical University

[Book] The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases2022
- Author(s)
  Takayuki Anazawa, Takashi Ito, Koichiro Hata, Toshihiko Masui, Kojiro Taura
- Total Pages
  8
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23K21446
[Book] Pancreas Transplantation;the Asian Experience　Islet Transplantation2021
- Author(s)
  Yuumi Akashi, Takayuki Anazawa, Junji Fujikura, Chung Gyu Park
- Total Pages
  13
- Publisher
  Springer
- ISBN
  9789811645976
- Data Source
  KAKENHI-PROJECT-23K21446
[Journal Article] Impact of Prevascularization on Immunological Environment and Early Engraftment in Subcutaneous Islet Transplantation2024
- Author(s)
  Inoguchi Kenta、Anazawa Takayuki、Fujimoto Nanae、Tada Seiichiro、Yamane Kei、Emoto Norio、Izuwa Aya、Su Hang、Fujimoto Hiroyuki、Murakami Takaaki、Nagai Kazuyuki、Hatano Etsuro
- Journal Title
  
  Transplantation
  
  Volume: -
- DOI
  10.1097/tp.0000000000004909
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16411, KAKENHI-PROJECT-23K21446
[Journal Article] 膵島移植の現状と課題2023
- Author(s)
  穴澤貴行、波多野悦朗、稲垣暢也
- Journal Title
  
  日本糖尿病眼学会誌
  
  Volume: 27 Pages: 1881-1881
- Data Source
  KAKENHI-PROJECT-23K21446
[Journal Article] 糖代謝異常に対する移植医療の現状と展望2023
- Author(s)
  穴澤貴行、山根佳、伊藤孝司、長井和之、内田洋一朗、福光　剣、石井隆道、秦浩一郎、波多野悦朗
- Journal Title
  
  日本外科学会雑誌
  
  Volume: 124 Pages: 190-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21446
[Journal Article] Evaluation of the Transplant Site Environment in Prevascularized Subcutaneous Islet Transplantation.2021
- Author(s)
  Anazawa T, Inoguchi K, Emoto N, Fujimoto N, Yamane K, Tada S, Hata K, Masui T, Taura K, Hatano E.
- Journal Title
  
  Transplantation
  
  Volume: 105(12S1)
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21446
[Journal Article] The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation2020
- Author(s)
  Seiichiro Tada, Takayuki Anazawa et al.
- Journal Title
  
  Transplantation Direct
  
  Volume: 6 Issue: 9 Pages: e591-e591
- DOI
  10.1097/txd.0000000000001045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08593, KAKENHI-PROJECT-19K08812
[Journal Article] β Cell Replacement Therapy: The Next 10 Years2018
- Author(s)
  Schuetz Christian、Anazawa Takayuki、Cross Sarah E.、Labriola Leticia、Meier Raphael P.H.、Redfield Robert R.、Scholz Hanne、Stock Peter G.、Zammit Nathan W.
- Journal Title
  
  Transplantation
  
  Volume: 102 Issue: 2 Pages: 215-229
- DOI
  10.1097/tp.0000000000001937
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10033
[Journal Article] Current state and future evolution of pancreatic islet transplantation2018
- Author(s)
  Anazawa Takayuki、Okajima Hideaki、Masui Toshihiko、Uemoto Shinji
- Journal Title
  
  Annals of Gastroenterological Surgery
  
  Volume: 3 Issue: 1 Pages: 34-42
- DOI
  10.1002/ags3.12214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08593, KAKENHI-PROJECT-18K08677
[Journal Article] Ex vivo Pretreatment of Islets with Mitomycin C2017
- Author(s)
  Sato Naoya、Haga Junichiro、Anazawa Takayuki、Kenjo Akira、Kimura Takashi、Wada Ikuo、Mori Tsutomu、Marubashi Shigeru、Gotoh Mitsukazu
- Journal Title
  
  Cell Transplantation
  
  Volume: 26 Issue: 8 Pages: 1392-1404
- DOI
  10.1177/0963689717721233
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16512, KAKENHI-PROJECT-15K10033, KAKENHI-PROJECT-17K19687
[Journal Article] Ex vivo pretreatment of islets with mitomycin C: Reduction in immunogenic potential of islets by suppressing secretion of multiple chemotactic factors2017
- Author(s)
  Sato N, Anazawa T et al.
- Journal Title
  
  Cell Transplantation
  
  Volume: In press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10033
[Journal Article] Serum levels of vascular endothelial growth factor are increased and correlate with malnutrition, immunosuppression involving MDSCs and systemic inflammation in patients with cancer of the digestive system.2013
- Author(s)
  Nakamura I, Shibata M, Gonda K, Yazawa T, Shimura T, Anazawa T, Suzuki S, Sakurai K, Koyama Y, Ohto H, Tomita R, Gotoh M, Takenoshita S.
- Journal Title
  
  Oncology Letters
  
  Volume: 5 Issue: 5 Pages: 1682-1686
- DOI
  10.3892/ol.2013.1231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592035
[Journal Article] 膵島移植症例登録報告（2012）2013
- Author(s)
  穴澤　貴行
- Journal Title
  
  移植
  
  Volume: 48 Pages: 384-389
- Data Source
  KAKENHI-PROJECT-25861208
[Journal Article] Severely fibrotic pancreases from young patients with chronic pancreatitis: evidence for a ductal origin of islet neogenesis2013
- Author(s)
  （Soltani SM）、Anazawa T
- Journal Title
  
  Acta Diabetol
  
  Volume: 50 Issue: 5 Pages: 807-814
- DOI
  10.1007/s00592-011-0306-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861208
[Journal Article] Factors affecting transplant outcomes in diabetic nude mice receiving human, porcine, and nonhuman primate islets: analysis of 335 transplantations.2013
- Author(s)
  （Loganathan G）、Anazawa T
- Journal Title
  
  Transplantation
  
  Volume: 95 Issue: 12 Pages: 1439-1447
- DOI
  10.1097/tp.0b013e318293b7b8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861208
[Journal Article] A new enzyme mixture to increase the yield and transplant rate of autologous and allogeneic human islet product2012
- Author(s)
  （Balamurugan AN） Takayuki Anazawa
- Journal Title
  
  Transplantation
  
  Volume: 93 Issue: 7 Pages: 693-702
- DOI
  10.1097/tp.0b013e318247281b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791554
[Journal Article] Adenine nucleotide levels in a closed enzymatic digestion system for porcine islet isolation2012
- Author(s)
  Oshibe I, Saito T, Sato Y, Saito T, Tsukada M, Ise K, Kenjo A, Kimura T, Anazawa T, Suzuki S, Hashimoto Y, Gotoh M
- Journal Title
  
  Cell Transplantation.
  
  Volume: 21(2-3) Issue: 2-3 Pages: 483-491
- DOI
  10.3727/096368911x605394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390248, KAKENHI-PROJECT-22591412
[Journal Article] Preservation of pancreatic islets in cold UW solution Preservation of pancreatic islets in cold UW solution2012
- Author(s)
  Ishii S, Saito T, Ise K, Yamashita M, Sato Y, Saito T, Tsukada M, Oshibe I, Kenjo A, Kimura T, Anazawa T, Suzuki S, Gotoh M
- Journal Title
  
  Islets
  
  Volume: 4(1) Issue: 1 Pages: 32-39
- DOI
  10.4161/isl.18607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390248, KAKENHI-PROJECT-22591412, KAKENHI-PROJECT-23591507, KAKENHI-PROJECT-23591871
[Journal Article] A model to evaluate toxic factors influencing islets during collagenase digestion: the role of serine protease inhibitor in the protection of islets.2012
- Author(s)
  Tsukada M, Saito T, Ise K, Kenjo A, Kimura T, Satoh Y, Sai to T, Anazawa T, Oshibe I, Suzuki S, Hashimoto Y, Gotoh M
- Journal Title
  
  Cell Transplantation.
  
  Volume: 21(2-3) Issue: 2-3 Pages: 473-482
- DOI
  10.3727/096368911x605385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390248, KAKENHI-PROJECT-22591412
[Journal Article] 膵島移植症例登録報告（2011）2012
- Author(s)
  穴澤　貴行
- Journal Title
  
  移植
  
  Volume: 47 Pages: 443-449
- NAID
  10030209416
- Data Source
  KAKENHI-PROJECT-23791554
[Journal Article] Mitomycin-C treatment significantly reduces central damage of islets in culture2012
- Author(s)
  Saito T, Saito T, Sato Y, Ise K, Anazawa T, Oshibe I, Haga J, Yamamoto M, Waguri S, Gotoh M.
- Journal Title
  
  Pancreas.
  
  Volume: 41(2) Issue: 2 Pages: 245-252
- DOI
  10.1097/mpa.0b013e31822461c7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390248, KAKENHI-PROJECT-22591412, KAKENHI-PROJECT-22591527, KAKENHI-PROJECT-23791554
[Journal Article] Improved islet yield and function by use of a chloride channel blocker during collagenase digestion.2011
- Author(s)
  Anazawa T, Sato Y, Saito T, Tsuchiya T, Kenjo A, Kimura T, Haga J, Miyake M, Waguri S, Hazama A, Gotoh M.
- Journal Title
  
  Transplantation
  
  Volume: 92(8) Issue: 8 Pages: 871-877
- DOI
  10.1097/tp.0b013e31822e6eb4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390248, KAKENHI-PROJECT-22591527, KAKENHI-PROJECT-23791554
[Journal Article] Prediction of pancreatic tissue densities by an analytical test gradient system before purification maximizes human islet recovery for isletautotransplantation/allotransplantation2011
- Author(s)
  Anazawa T, Matsumoto S, Yonekawa Y, Loganathan G, Wilhelm JJ, Soltani SM, Papas KK, Sutherland DE, Hering BJ, Balamurugan AN
- Journal Title
  
  Transplantation
  
  Volume: 91(5) Issue: 5 Pages: 508-514
- DOI
  10.1097/tp.0b013e3182066ecb
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791554
[Journal Article] Actions of the Japanese Pancreas and Islet Transplantation Association Regarding Transplanted Human Islets Isolated Using Liberase HI2010
- Author(s)
  Saito T, Anazawa T, Gotoh M, Uemoto S, Kenmochi T, Kuroda Y, Satomi S, Itoh T, Yasunami Y, Kitamoto T, Mohri S, Teraoka S
- Journal Title
  
  Transplantation Proceedings.
  
  Volume: 42(10) Issue: 10 Pages: 4213-4216
- DOI
  10.1016/j.transproceed.2010.09.142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390248
[Patent] 細胞分離用酵素溶液及び細胞分離方法、並びに膵島分離方法2013
- Inventor(s)
  穴澤貴行
- Industrial Property Rights Holder
  穴澤貴行、狹間章博、後藤満一
- Filing Date
  2013-01-29
- Overseas
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] 膵島移植の発展に向けた方策：膵島移植医の視点から2023
- Author(s)
  穴澤貴行、藤倉純二、山根佳、江本憲央、出羽彩、蘇航、井山なおみ、松山陽子、伊藤孝司、秦浩一郎、波多野悦朗
- Organizer
  第50回日本膵・膵島移植研究会
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] 膵島移植CIT-J003臨床試験の結果と今後の発展への課題2023
- Author(s)
  穴澤貴行、丸橋繁、小玉正太、後藤昌文、江口英利、丸山通弘、霜田雅之、野口洋文、伊藤泰平、剣持敬、波多野悦朗、後藤満一
- Organizer
  第59回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] 膵・膵島移植の臨床成績比較から導く治療選択基準2023
- Author(s)
  穴澤貴行、山根佳、波多野悦朗
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] 先進医療から展開した細胞移植治療：インスリン依存糖尿病に対する膵島移植2023
- Author(s)
  穴澤貴行、山根佳、江本憲央、出羽彩、蘇航、伊藤孝司、秦浩一郎、波多野悦朗
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] Islet Transplantation using Donors After Brain and Cardiac Death: A Multicenter Clinical Trial in Japan2023
- Author(s)
  Takayuki Anazawa, Shigeru Marubashi, Shohta Kodama, Masafumi Goto, Hidetoshi Eguchi, Michihiro Maruyama, Masayuki Shimoda, Hirofumi Noguchi, Takuhiro Yamaguchi, Taihei Ito, Takashi Kenmochi, Mitsukazu Gotoh
- Organizer
  IPITA-IXA-CTRMS Joint Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] 膵・膵島移植と再生医療2023
- Author(s)
  穴澤貴行
- Organizer
  第18回日本移植・再生医療看護学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] Clinical experiences and prospects of pancreatic islet transplantation2022
- Author(s)
  Takayuki Anazawa, Takashi Ito, Kazuyuki Nagai, Takamichi Ishii, Satoru Seo, Koichiro Hata, Etsuro Hatano
- Organizer
  第34回日本肝胆膵外科学会・学術集会
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] 糖尿病に対する膵島移植の現状と近未来2022
- Author(s)
  穴澤　貴行、波多野　悦朗
- Organizer
  第70回日本輸血・細胞治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] Islet Transplantation and β Cell Regenerative Medicine2022
- Author(s)
  Takayuki Anazawa, Takashi Ito, Yuuki Masano, Shinya Okumura, Norio Emoto, Aya Izuwa, Su Hang, Nanae Fujimoto, Koichiro Hata, Etsuro Hatano
- Organizer
  Transplantation Science Symposium Asian Regional meeting 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] 保険適用となった膵島移植の現状と展望2021
- Author(s)
  穴澤貴行、伊藤孝司、秦浩一郎、増井俊彦、田浦康二朗、波多野悦朗藤倉純二、稲垣暢也
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] Evaluation of the transplant site environment in prevascularized subcutaneous islet transplantation2021
- Author(s)
  Anazawa T, Inoguchi K, Emoto N, Fujimoto N, Yamane K, Tada S, Hata K, Masui T, Taura K, Hatano E.
- Organizer
  The 2021 Virtual Congress of the International Pancreas and Islet TransplantationAssociation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] Islet Transplantation in Japan2021
- Author(s)
  Takayuki Anazawa
- Organizer
  The 2nd Congress of Asian Pancreas and Islet Transplant Association Pancreas and islet transplantation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08593
[Presentation] 1型糖尿病に対するアプローチ：膵島移植と再生医療の現在地2021
- Author(s)
  穴澤貴行、伊藤孝司,江本憲央,秦浩一郎,増井俊彦,田浦康二朗,波多野悦朗、藤倉純二,稲垣暢也
- Organizer
  第57回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-23K21446
[Presentation] Efficacy and safety of islet transplantation in patients with type 1 diabetes:a Japanese single center experience2020
- Author(s)
  Takayuki Anazawa, et al.
- Organizer
  28th International Congress of The Transplantation Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08593
[Presentation] 膵島移植における新たな作用機序による免疫抑制療法の開発と今後の展望2019
- Author(s)
  多田誠一郎、穴澤貴行、他
- Organizer
  第119回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08593
[Presentation] 膵島移植におけるMEK阻害剤の可能性2019
- Author(s)
  多田誠一郎、穴澤貴行、他
- Organizer
  第55回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-18K08593
[Presentation] 膵島移植における新たな作用機序による免疫抑制療法の開発：MEK阻害剤の応用可能性2019
- Author(s)
  多田誠一郎、穴澤貴行、他
- Organizer
  第46回日本膵膵島移植研究会
- Data Source
  KAKENHI-PROJECT-18K08593
[Presentation] Establishment of islet allograft acceptance by mitogen-activated protein kinase kinase via suppression of alloreactive T cells2019
- Author(s)
  Seiichiro Tada, Takayuki Anazawa
- Organizer
  17th World Congress of the International Pancreas & Islet Transplant Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08593
[Presentation] MEK阻害剤トラメチニブはMHC不適合マウス膵島移植で膵島毒性を示すことなく拒絶反応を抑制する2019
- Author(s)
  多田誠一郎、穴澤貴行、他
- Organizer
  第28回日本組織適合性学会大会
- Data Source
  KAKENHI-PROJECT-18K08593
[Presentation] レシピエントの免疫応答が血管床誘導による皮下膵島移植に与える影響2018
- Author(s)
  多田誠一郎、穴澤貴行、他
- Organizer
  第54回日本移植学会総会
- Data Source
  KAKENHI-PROJECT-18K08593
[Presentation] A simple and promising strategy for pancreatic islet preconditioning to reduce immunogenicity and improve islet graft longevity2018
- Author(s)
  Takayuki Anazawa, Kei Yamane, Seiichiro Tada, Kenta Inoguchi, Toshihiko Masui, Kazuyuki Nagai, Naoya Sato, Shoichiro Sumi, Hideaki Okajima, Shinji Uemoto
- Organizer
  27th International Congress of The Transplantation Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10033
[Presentation] A simple and promising strategy for pancreatic islet preconditioning to reduce immunogenicity and improve islet graft longevity2018
- Author(s)
  Takayuki Anazawa, et al.
- Organizer
  27th International Congress of the transplantation society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08593
[Presentation] 血管床の誘導が皮下膵島移植に与える免疫学的な影響因子の検討2018
- Author(s)
  多田誠一郎、穴澤貴行、他
- Organizer
  第45回日本臓器保存生物医学会
- Data Source
  KAKENHI-PROJECT-18K08593
[Presentation] 膵島移植の方向性：臨床経験からの成果と課題2017
- Author(s)
  穴澤貴行、岡島英明、増井俊彦、伊藤孝司、多田誠一郎、山根　佳、井ノ口健太、海道利美、上本伸二
- Organizer
  第53回日本移植学会
- Data Source
  KAKENHI-PROJECT-15K10033
[Presentation] A comparative analysis of the clinical outcome of islet transplantation using donors after cardiac death vs intensive insulin therapy in patients with type 1 diabetes with severe hypoglycaemia unawareness: a 10-year follow-up at a single centre2017
- Author(s)
  Takayuki Anazawa, Hideaki Okajima, Yasuhiro Iwanaga, Toshihiko Masui, Seiichiro Tada, Kei Yamane,Kenta Inokuchi, Kyoichi Takaori, Yoshiya Kawaguchi, Shinji Uemoto
- Organizer
  16th International Congress of International Pancreas and Islet Transplant Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10033
[Presentation] 膵島移植の現状と今後の展開：膵島移植技術は日本で活かせるのか？2017
- Author(s)
  穴澤貴行
- Organizer
  第72回日本消化器外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K10033
[Presentation] 膵島移植が拓く近未来の組織・細胞治療2017
- Author(s)
  穴澤貴行
- Organizer
  第16回日本組織移植学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K10033
[Presentation] A 10-year outcome of pancreatic islet transplantation2016
- Author(s)
  Anazawa T, et al
- Organizer
  IAP and JPS and AOPA 2016
- Place of Presentation
  Sendai, Japan
- Year and Date
  2016-08-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10033
[Presentation] 次世代の細胞移植療法開発における探索的医療研究の役割：膵島移植からの成果報告2016
- Author(s)
  穴澤貴行、他
- Organizer
  第116回日本外科学会定期学術集会（ワークショップ）
- Place of Presentation
  大阪
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15K10033
[Presentation] Comprehensive gene analysis on ex-vivo Mitomycin-C treatment as a potential protocol for inducing unresponsiveness to islet engraftment: harmonized downregulation of multiple chemotaxis factors2015
- Author(s)
  Naoya Sato, Takayuki Anazawa, et al.
- Organizer
  IPITA-IXA-CTS 2015 Joint Congress
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2015-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10033
[Presentation] Pancreatic islet culture induces tolerogenic effects as well as stimulates immune cell trafficking by regulating inflammatory cytokines2015
- Author(s)
  Takayuki Anazawa, et al.
- Organizer
  IPITA-IXA-CTS 2015 Joint Congress
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2015-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10033
[Presentation] Clinical islet transplantation in Japan2014
- Author(s)
  Takayuki Anazawa
- Organizer
  Japan Korea Transplantation Forum 2014
- Place of Presentation
  Tokyo
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-25861208
[Presentation] Long-term follow-up of clinical islet transplantation using donors after cardiac death: Report of the Japan Islet Transplantation Registry2013
- Author(s)
  Takayuki Anazawa
- Organizer
  Congress of the Asian Society of Transplantation
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-25861208
[Presentation] "Long-term Outcomes of Clinical Islet Transplantation Using Donors After Cardiac Death: A Multicenter Experience in Japan"2013
- Author(s)
  Takayuki Anazawa
- Organizer
  World congress of International pancreas and islet transplantation association
- Place of Presentation
  Monterey, CA　USA
- Data Source
  KAKENHI-PROJECT-25861208
[Presentation] 再生医学研究が変える膵島移植医療の近未来2013
- Author(s)
  穴澤　貴行
- Organizer
  日本外科学会定期学術集会
- Place of Presentation
  福岡県
- Data Source
  KAKENHI-PROJECT-25861208
[Presentation] 脳死ドナー膵島移植：期待と課題2013
- Author(s)
  穴澤　貴行
- Organizer
  日本移植学会総会
- Place of Presentation
  京都府
- Data Source
  KAKENHI-PROJECT-25861208
[Presentation] 本邦の臨床膵島移植の成績と課題2013
- Author(s)
  穴澤　貴行
- Organizer
  日本肝胆膵外科学会・学術集会
- Place of Presentation
  栃木県
- Data Source
  KAKENHI-PROJECT-25861208
[Presentation] Disappeared islet graft after intraportal transplantation in the recipient suffered from recurrent sepsis2012
- Author(s)
  Takayuki Anazawa
- Organizer
  24th International Congress of The Transplantation Society
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] 先進的組織細胞移植医療発展の先駆的モデルとしての膵島移植臨床開発:その展望と課題2012
- Author(s)
  穴澤貴行, 土屋貴男, 見城明, 伊勢一哉, 齋藤拓朗, 後藤満一
- Organizer
  第11回日本組織移植学会学術集会
- Place of Presentation
  東京
- Year and Date
  2012-08-04
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] 膵島移植の現状と今後の展望2012
- Author(s)
  穴澤貴行, 土屋貴男, 見城明, 伊勢一哉, 芳賀淳一郎, 齋藤拓朗, 後藤満一
- Organizer
  第48回日本移植学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] Disappeared islet graft after intraportal transplantation in the recipient suffered from recurrent sepsis2012
- Author(s)
  Anazawa T, Tsuchiya T, Kenjo A, Haga J, Sato T, Sato N, Ise K, Saito T,Tasaki K, Gotoh M
- Organizer
  24th International Congress of the Transplantation Society
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] Mitomycin-C treatment protects islets from the progression of central damage during culture2011
- Author(s)
  Haga J, Saito T, Anazawa T, Tsuchiya T, Kenjo A, Sato S, Sato N, Saito T, Ise K, Yamamoto M, Waguri S, Gotoh M
- Organizer
  The 13th World congress of International pancreas and islet transplantation association
- Place of Presentation
  Prague, Czech Republic
- Data Source
  KAKENHI-PROJECT-22591527
[Presentation] Cl^-チャネル阻害による細胞保護効果の膵島分離への応用-臨床膵島移植確立への細胞生理学的アプローチ-2011
- Author(s)
  穴澤貴行, 土屋貴男, 見城明, 芳賀淳一郎, 佐藤哲, 三宅将生, 狭間章博, 後藤満一
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  東京(誌上開催)
- Data Source
  KAKENHI-PROJECT-22390248
[Presentation] Cl-チャネル阻害による細胞保護効果の膵島分離への応用-臨床膵島移植確立への細胞生理学的アプローチ-2011
- Author(s)
  穴澤貴行, 土屋貴男, 見城明, 芳賀淳一郎, 佐藤哲, 三宅将生, 狹間章博, 後藤満一
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] Inhibition of chloride ion influx into islet cells protects islets during pancreatic islet isolation.2011
- Author(s)
  Anazawa T, Tsuchiya T, Kenjo A, Haga J, Sato T, Sato N, Saito T, Sat o Y, Miyake M, Hazama A, Gotoh M
- Organizer
  The 13th World congress of International pancreas and islet transplantation association
- Place of Presentation
  Prague, Czech Republic.
- Data Source
  KAKENHI-PROJECT-22390248
[Presentation] 重症低血糖発作を伴うインスリン依存性糖尿病に対する心停止ドナーからの膵島移植:日本膵・膵島移植研究会事務局報告2011
- Author(s)
  穴澤貴行, 土屋貴男, 伊勢一哉, 見城明, 齋藤拓朗, 後藤満一
- Organizer
  第47回日本移植学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] Cl-チャネル阻害による細胞保護効果の膵島分離への応用-臨床膵島移植確立への細胞生理学的アプローチ-2011
- Author(s)
  穴澤貴行, 土屋貴男, 見城明, 芳賀淳一郎, 佐藤哲, 三宅将生, 狹間章博, 後藤満一
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22591527
[Presentation] 重症低血糖発作を伴うインスリン依存性糖尿病に対する心停止ドナーからの膵島移植:日本膵・膵島移植研究会事務局報告2011
- Author(s)
  穴澤貴行,土屋貴男,見城明,芳賀淳一郎,佐藤哲,三宅将生,狹間章博,後藤満一
- Organizer
  第47回日本移植学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22390248
[Presentation] Cl-チャネル阻害による細胞保護効果の膵島分離への応用-臨床膵島移植確立への細胞生理学的アプローチ-2011
- Author(s)
  穴澤貴行, 土屋貴男, 見城明, 芳賀淳一郎, 佐藤哲, 三宅将生, 狹間章博, 後藤満一
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  東京(誌上開催)
- Data Source
  KAKENHI-PROJECT-22591527
[Presentation] 重症低血糖発作を伴うインスリン依存性糖尿病に対する心停止ドナーからの膵島移植:日本膵・膵島移植研究会事務局報告.2011
- Author(s)
  穴澤貴行, 土屋貴男, 伊勢一哉, 見城明, 齋藤拓朗, 後藤満一
- Organizer
  第47回日本移植学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22591527
[Presentation] Mitomycin-C treatment protects islets from the progression of central damage during culture2011
- Author(s)
  Haga J, Saito T, Anazawa T, Tsuchiya T, Kenjo A, Sato S, Sato N, Saito T, Ise K, Yamamoto M, Waguri S, Gotoh M
- Organizer
  The 13th World congress of International pancreas and islet transplantation association
- Place of Presentation
  Prague, Czech Republic.
- Data Source
  KAKENHI-PROJECT-22591527
[Presentation] Inhibition of chloride ion influx into islet cells protects islets during pancreatic islet isolation2011
- Author(s)
  Anazawa T, Tsuchiya T, Kenjo A, Haga J, Sato T, Sato N, Saito T, Sato Y, Miyake M, Hazama A, Gotoh M
- Organizer
  The 13th World congress of International pancreas and islet transplantation association
- Place of Presentation
  Prague, Czech Republic
- Data Source
  KAKENHI-PROJECT-22390248
[Presentation] Mitomycin-C treatment protects islets from the progression of central damage during culture.2011
- Author(s)
  Haga J, Saito T, Anazawa T, Tsuchiya T, Kenjo A, Sato S, Sato N, Saito T, Ise K, Yamamoto M, Waguri S, Gotoh M
- Organizer
  The 13th World congress of International pancreas and islet transplantation association
- Place of Presentation
  Prague, Czech Republic
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] Mitomycin-C treatment protects islets from the progression of central damage during culture2011
- Author(s)
  Haga J, Saito T, Anazawa T, Tsuchiya T, Kenjo A, Sato S, Sato N, Saito T, Ise K, Yamamoto M, Waguri S, Gotoh M
- Organizer
  The 13th World congress of International pancreas and islet transplantation association
- Place of Presentation
  Prague, Czech Republic
- Data Source
  KAKENHI-PROJECT-22390248
[Presentation] Inhibition of chloride ion influx into islet cells protects islets during pancreatic islet isolation2011
- Author(s)
  Takayuki Anazawa
- Organizer
  13th World congress of International pancreas and islet transplantation association
- Place of Presentation
  チェコ・プラハ
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] Inhibition of chloride ion influx into islet cells protects islets during pancreatic islet isolation2011
- Author(s)
  Anazawa T, Tsuchiya T, Kenjo A, Haga J, Sato T, Sato N, Saito T, Sato Y, Miyake M, Hazama A, Gotoh M
- Organizer
  The 13th World congress of International pancreas and islet transplantation association
- Place of Presentation
  Prague, Czech Republic
- Data Source
  KAKENHI-PROJECT-22591527
[Presentation] Predicting porcine islet yield by acute C-peptide response to arginine stimulation of donor pigs and pancreas dithizone scoring system.2011
- Author(s)
  Anazawa T, Graham M, Abouaish J, Loganathan G, Hering BJ, A.N. Balamurugan
- Organizer
  The 13th World congress of International pancreas and islet transplantation association
- Place of Presentation
  Prague, Czech Republic.
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] Inhibition of chloride ion influx into islet cells protects islets during pancreatic islet isolation2011
- Author(s)
  Anazawa T, Tsuchiya T, Kenjo A, Haga J, Sato T, Sato N, Saito T, Sato Y, Miyake M, Hazama A, Gotoh M
- Organizer
  The 13th World congress of International pancreas and islet transplantation association
- Place of Presentation
  Prague, Czech Republic
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] 重症低血糖発作を伴うインスリン依存性糖尿病に対する心停止ドナーからの膵島移植:日本膵・膵島移植研究会事務局報告2011
- Author(s)
  穴澤貴行, 土屋貴男, 伊勢一哉, 見城明, 齊藤拓朗, 後藤満一
- Organizer
  第47回日本移植学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22591527
[Presentation] 先進的組織細胞移植医療発展の先駆的モデルとしての膵島移植臨床開発：その展望と課題
- Author(s)
  穴澤　貴行
- Organizer
  第11回日本組織移植学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791554
[Presentation] β細胞置換療法発展へのバイオインフォマティクス的アプローチ
- Author(s)
  穴澤　貴行
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-16 – 2015-04-18
- Data Source
  KAKENHI-PROJECT-25861208
[Presentation] 術前Transarterial Immunoembolization(TIE: 経動脈免疫塞栓療法)による肝細胞癌切除後再発抑制効果に対する基礎研究
- Author(s)
  佐藤　哲、見城　明、土屋貴男、斎藤拓朗、佐藤直哉、芳賀淳一郎、穴澤貴行、木村　隆、後藤満一
- Organizer
  第114回日本外科学会定期学術集会
- Place of Presentation
  国立京都国際会館・グランドプリンスホテル京都（京都府京都市）
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-25670558
[Presentation] 膵島移植の臨床展開における問題点と展望
- Author(s)
  穴澤　貴行
- Organizer
  第41回日本臓器保存生物医学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-11-28 – 2014-11-29
- Data Source
  KAKENHI-PROJECT-25861208
[Presentation] Comprehensive analysis of pancreatic islet gene expression suggests inflammatory response and immune cell trafficking following islet isolation and culture
- Author(s)
  Junichiro Haga, Takayuki Anazawa
- Organizer
  World Transplant Congress
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-07-26 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-25861208

1. GOTOH Mitsukazu (50162160)

# of Collaborated Projects: 5 results

# of Collaborated Products: 20 results
2. KENJO Akira (40305355)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
3. SAITO Takuro (20305361)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
4. TSUCHIYA Takao (70343390)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. ISE Kazuya (90363746)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
6. KIMURA Takashi (00381369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. SUZUKI Hiroyuki (30322340)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. SAITO Takaharu (60508795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. SATO Yoshihiro (60347218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 藤本七恵 (00838691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 佐藤直哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 村上隆亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Anazawa Takayuki 穴澤 貴行

ANAZAWA Takayuki 穴澤 貴行

Research Projects

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Co-Researchers

Development of Immune Tolerance Space Construction Method for Cell Transplantation Based on Elucidation of Mechanism of Subcutaneous Vascular Induction ResponsePrincipal Investigator

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Development of novel immunosuppressive method using MEK inhibitor to construct optimal environment for pancreatic islet transplantationPrincipal Investigator

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Bioinformatics approach to establish preconditioning method for beta cell replacementPrincipal Investigator

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Induction of anti-tumor immune response using a Tissue Engineering technique

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Protection of pancreatic islets by controlling both the volume-sensitive chloride channel and endoplasmic reticulum stress responsePrincipal Investigator

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Immunological effect of myeloid-derived suppressor cells in pancreatic cancer patients and its alteration after treatment

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Optimization of collagenase activity and regulation of ion channel associated with cell viability for improving pancreatic islet transplantationPrincipal Investigator

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Immunological tolerance induced by surviving but not dying cellsfollowing sublethal stress

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Long-term islet graft survival induced by regulating HMGB-1

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新規糖鎖解析システム(SMME法)を用いた癌特異的糖鎖抗原の探索

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[Book] The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases2022

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[Book] Pancreas Transplantation;the Asian Experience Islet Transplantation2021

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[Journal Article] Impact of Prevascularization on Immunological Environment and Early Engraftment in Subcutaneous Islet Transplantation2024

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Anazawa Takayuki 穴澤貴行

ANAZAWA Takayuki 穴澤貴行

[Book] Pancreas Transplantation;the Asian Experience　Islet Transplantation2021