Yamada Akimitsu 山田顕光

… Alternative Names

山田顕光ヤマダアキミツ

Akimitsu Yamada 山田顕光

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Researcher Number	90567603
Affiliation (Current)	2025: 横浜市立大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 横浜市立大学, 医学部, 講師 2016 – 2018: 横浜市立大学, 医学研究科, 客員研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Pathological medical chemistry
Keywords	Principal Investigator 乳癌幹細胞 / 癌微小環境 / 乳癌 / 腫瘍内細菌叢 / 癌幹細胞 / 腸内細菌叢 / 脂質メディエーター / 微小環境 / スフィンゴシン１リン酸 / S1P / ABC輸送体

Interaction of tumor microbiome and breast cancer stem cell via tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  山田顕光
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Yokohama City University
Effect of lipid mediator pumped out by ABC transporter to breast cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  Akimitsu Yamada
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Yokohama City University

All 2023 2018 2017 2016

All Journal Article Presentation

[Journal Article] Dramatic Improvement of Pulmonary Tumor Thrombotic Microangiopathy in a Breast Cancer Patient Treated With Bevacizumab2023
- Author(s)
  Kimura Aki、Yamada Akimitsu、Oshi Masanori、Nakayama Mina、Komura Naohiro、Sugano Teruyasu、Yamamoto Shinya、Narui Kazutaka、Endo Itaru
- Journal Title
  
  World Journal of Oncology
  
  Volume: 14 Issue: 6 Pages: 575-579
- DOI
  10.14740/wjon1691
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15535
[Journal Article] 術前化学療法中のG-CSF製剤投与により大動脈炎を発症した乳癌の１例2023
- Author(s)
  1.山﨑雅明，押正徳，木村安希，山田顕光，江中牧子，藤井誠志，遠藤　格
- Journal Title
  
  日本臨床外科学会誌
  
  Volume: 84 Pages: 862-867
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15535
[Journal Article] Clinicopathological Characteristics and Prognosis of Triple-Negative Apocrine Carcinoma: A Case-Control Study2023
- Author(s)
  Suzuki Chiho、Yamada Akimitsu、Kawashima Kei、Sasamoto Mahato、Fujiwara Yoshie、Adachi Shoko、Oshi Masanori、Wada Tomoko、Yamamoto Shinya、Shimada Kazuhiro、Ota Ikuko、Narui Kazutaka、Sugae Sadatoshi、Shimizu Daisuke、Tanabe Mikiko、Chishima Takashi、Ichikawa Yasushi、Ishikawa Takashi、Endo Itaru
- Journal Title
  
  World Journal of Oncology
  
  Volume: 14 Issue: 6 Pages: 551-557
- DOI
  10.14740/wjon1694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15535
[Journal Article] Breast carcinoma with spontaneous regression after needle biopsy: a case report and literature review2023
- Author(s)
  Sasamoto Mahato、Yamada Akimitsu、Oshi Masanori、Ota Ikuko、Yoshida Kenichi、Yakeishi Mayumi、Tsuura Yukio、Masui Hidenobu、Endo Itaru
- Journal Title
  
  Gland Surgery
  
  Volume: 12 Issue: 6 Pages: 853-859
- DOI
  10.21037/gs-22-629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15535
[Journal Article] Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis2018
- Author(s)
  Nagahashi Masayuki、Yamada Akimitsu、Katsuta Eriko、Aoyagi Tomoyoshi、Huang Wei-Ching、Terracina Krista P.、Hait Nitai C.、Allegood Jeremy C.、Tsuchida Junko、Yuza Kizuki、Nakajima Masato、Abe Manabu、Sakimura Kenji、Milstien Sheldon、Wakai Toshifumi、Spiegel Sarah、Takabe Kazuaki
- Journal Title
  
  Cancer Research
  
  Volume: 78 Issue: 7 Pages: 1713-1725
- DOI
  10.1158/0008-5472.can-17-1423
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05676, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-25000015, KAKENHI-PROJECT-17K01972, KAKENHI-PROJECT-16H04650, KAKENHI-PROJECT-17K19444, KAKENHI-PROJECT-16K19055, KAKENHI-PROJECT-16K19888
[Journal Article] Lnc RNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness.2018
- Author(s)
  Shima H, Kida K, Adachi S, Yamada A, Sugae S, Narui K, Miyagi Y, Nishi M, Ryo A, Murata S, Taniguchi H, Ichikawa Y, Ishikawa T, Endo I.
- Journal Title
  
  Breast Cancer Res Treat.
  
  Volume: 170(3) Issue: 3 Pages: 507-516
- DOI
  10.1007/s10549-018-4793-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09000, KAKENHI-PROJECT-16K19055
[Journal Article] 1.ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer2018
- Author(s)
  Yamada A, Nagahashi M, Aoyagi T, Huang WC, Lima S, Hait NC, Maiti A, Kida K, Terracina KP, Miyazaki H, Ishikawa T, Endo I, Waters MR, Qi Q, Yan L, Milstien S, Spiegel S, Takabe K.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 印刷中 Issue: 6 Pages: 1059-1070
- DOI
  10.1158/1541-7786.mcr-17-0353
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19055, KAKENHI-PROJECT-15H05676
[Journal Article] Are breast cancer stem cells the key to resolving clinical issues in breast cancer therapy?2017
- Author(s)
  Shima H，Yamada A, Ishikawa T, Endo I
- Journal Title
  
  Gland Surgery
  
  Volume: 6(1) Issue: 1 Pages: 82-88
- DOI
  10.21037/gs.2016.08.03
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K19055
[Journal Article] Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.2016
- Author(s)
  Nagahashi M, Yamada A, Miyazaki H, Allegood JC, Tsuchida J, Aoyagi T, Huang WC, Terracina KP, Adams BJ, Rashid OM, Milstien S, Wakai T, Spiegel S, Takabe K.
- Journal Title
  
  J Mammary Gland Biol Neoplasia
  
  Volume: 21 Issue: 1-2 Pages: 9-17
- DOI
  10.1007/s10911-016-9354-7
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04927, KAKENHI-PROJECT-15H05676, KAKENHI-PROJECT-16K19055, KAKENHI-PROJECT-16K19888
[Journal Article] Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods.2016
- Author(s)
  Nagahashi M, Yamada A, Aoyagi T, Allegood J, Wakai T, Spiegel S, Takabe K
- Journal Title
  
  Heliyon
  
  Volume: 2 Issue: 12 Pages: e00219-e00219
- DOI
  10.1016/j.heliyon.2016.e00219
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04927, KAKENHI-PROJECT-15H05676, KAKENHI-PROJECT-16K15610, KAKENHI-PROJECT-16K19055
[Journal Article] Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans2016
- Author(s)
  Huang WC, Liang J, Nagahashi M, Avni D, Yamada A, Maceyka M, Wolen AR, Kordula T, Milstien S, Takabe K, Oravecz T, Spiegel S
- Journal Title
  
  FASEB J
  
  Volume: 30 Issue: 8 Pages: 2945-2958
- DOI
  10.1096/fj.201600394r
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05676, KAKENHI-PROJECT-16K19055
[Journal Article] Operation with less adjuvant therapy for elderly breast cancer2016
- Author(s)
  Yamada A, Narui K, Sugae S, Shimizu D, Takabe K, Ichikawa Y, Ishikawa T, Endo I
- Journal Title
  
  J Surg Res
  
  Volume: 204 Issue: 2 Pages: 410-417
- DOI
  10.1016/j.jss.2016.05.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19055
[Presentation] argeting the SphK1/S1P/S1PR1 axis that connects obesity, chronic inflammation, and breast cancer metastasis2017
- Author(s)
  Nagahashi M, Yamada A, Aoyagi T, Huang W-C, Terracina KP, Hait N, Allegood JC, Tsuchida J, Nakajima M, Katsuta E, Milstien S, Wakai T, Spiegel S, Takabe K
- Organizer
  40th Annual CTRC-AACR San Antonio Breast Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19055
[Presentation] Sphingosine-1- phosphate Produced by Sphingosine Kinase 1 and Exported via ABCC1 Shortens Survival of Mice and Humans with Breast Cancer2017
- Author(s)
  Yamada A, Nagahashi M, Aoyagi T, Huang W-C, Lima S, Miyazaki H, Narui K, Ishikawa T, Endo I, Waters MR, Milstien S, Spiegel S, Takabe K
- Organizer
  40th Annual CTRC-AACR San Antonio Breast Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19055
[Presentation] ABCC11はスフィンゴシン１リン酸（S1P）を輸送して微小環境を整え，乳癌の増殖に寄与する2017
- Author(s)
  5.山田顕光，永橋昌幸，鈴木千穂，足立祥子，島秀栄，菅江貞亨，成井一隆，市川靖史，高部和明，石川孝，遠藤格
- Organizer
  第26回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-16K19055
[Presentation] Long non-coding RNA H19 promotes cancer stemness and worsen breast cancer survival2017
- Author(s)
  Shima H, Kida K, Yamada A, Sugae S, Narui K, Miyagi Y, Ryo A, Ichikawa Y, Ishikawa T, Endo I
- Organizer
  40th Annual CTRC-AACR San Antonio Breast Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19055
[Presentation] 当院の超高齢者乳癌に対する集学的治療の現状2016
- Author(s)
  山田顕光、成井一隆、足立祥子、田辺美樹子、島秀栄、喜多久美子、菅江貞亨、市川靖史、石川孝、遠藤格
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場（大阪）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-16K19055
[Presentation] 肥満によって促進される乳癌の血管新生に対する抗スフィンゴシン-1-リン酸受容体治療2016
- Author(s)
  永橋昌幸、大渓彩香、遠藤麻巳子、土田純子、諸和樹、庭野稔之、辰田久美子、利川千絵、長谷川美樹、五十嵐麻由子、中島真人、小山諭、山田顕光、青柳智義、高部和明、若井俊文
- Organizer
  第24回日本乳癌学会学術総会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-16K19055

1. WAKAI Toshifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. NAGAHASHI Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
3. Takabe Kazuaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 西真由子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamada Akimitsu 山田 顕光

山田 顕光 ヤマダ アキミツ

Akimitsu Yamada 山田 顕光

Research Projects

Research Products

Co-Researchers

Interaction of tumor microbiome and breast cancer stem cell via tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effect of lipid mediator pumped out by ABC transporter to breast cancer microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dramatic Improvement of Pulmonary Tumor Thrombotic Microangiopathy in a Breast Cancer Patient Treated With Bevacizumab2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 術前化学療法中のG-CSF製剤投与により大動脈炎を発症した乳癌の１例2023

Author(s)

Journal Title

Data Source

[Journal Article] Clinicopathological Characteristics and Prognosis of Triple-Negative Apocrine Carcinoma: A Case-Control Study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Breast carcinoma with spontaneous regression after needle biopsy: a case report and literature review2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lnc RNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1.ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Are breast cancer stem cells the key to resolving clinical issues in breast cancer therapy?2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Operation with less adjuvant therapy for elderly breast cancer2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] argeting the SphK1/S1P/S1PR1 axis that connects obesity, chronic inflammation, and breast cancer metastasis2017

Author(s)

Organizer

Yamada Akimitsu 山田顕光

山田顕光ヤマダアキミツ

Akimitsu Yamada 山田顕光