Yamada Kohji 山田幸司

Researcher Number	90570979
Other IDs	https://orcid.org/0000-0001-9493-5269
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京慈恵会医科大学, 医学部, 准教授 2020 – 2022: 東京慈恵会医科大学, 医学部, 講師 2016 – 2019: 東京慈恵会医科大学, 医学部, 助教 2018: 国立研究開発法人医薬基盤・健康・栄養研究所, 細胞核輸送ダイナミクスプロジェクト, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Tumor biology Except Principal Investigator Basic Section 50010:Tumor biology-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Cell biology
Keywords	Principal Investigator 肝がん / CUPS / 型破り分泌 / PKCδ / がん / 肝癌 / 細胞外局在 / 小胞体 / 局在多様性 / 強皮症 … More / PKC / マーカー / 分泌 / タンパク質分泌 / タンパク質の多機能性 / がん微小環境 / ヘパラン硫酸プロテオグリカン / キナーゼ / 腫瘍マーカー / 細胞外分泌 / 病理学 / 蛋白質 / 生体分子 / 癌 / 細胞外放出 / 微小環境 / 核輸送因子 … More Except Principal Investigator がん細胞 / 髄芽腫 / 基底細胞腫 / DYRK2 / 発がん / Hedgehogシグナル / 抗体薬剤複合体 / scFV / 免疫担当細胞 / single chain Fv / 核内移行 / モノクローナル抗体 / 抗体抗がん剤結合薬ADC / RNAポリメラーゼII / 抗体療法 / Antibody-Drug Conjugate / 分子標的療法 / 核移行 / 抗体 / スーパーエンハンサー / がん / CD26 / 老化 / 癌 / 細胞・組織 / ノックアウトマウス / importin / 核輸送 Less

Hedgehogシグナルの新規な活性化機構に基づく薬剤耐性がん細胞の克服
- Principal Investigator
  
  吉田彩舟
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Toho University
核抗原の細胞膜局在誘導に基づく抗核抗体の新規機構と強皮症病態の解明Principal Investigator
- Principal Investigator
  
  山田幸司
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Jikei University School of Medicine
Development of transportable scFV monoclonal antibody into nucleus
- Principal Investigator
  
  Yamada Taketo
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Saitama Medical University
Study of unconventional protein secretion in cancerPrincipal Investigator
- Principal Investigator
  
  YAMADA Kohji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Jikei University School of Medicine
Novel anti-cancer therapy against super-enhancer using humanized monoclonal antibody with transportation activity into nucleus
- Principal Investigator
  
  YAMADA TAKETO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Saitama Medical University
Extracellular localization of the intracellular kinase in cancerPrincipal Investigator
- Principal Investigator
  
  Yamada Kohji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Jikei University School of Medicine
Roles of importin alpha1 in tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Yamada Kohji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Jikei University School of Medicine
The roles of importin-alpha subfamilies in mammals
- Principal Investigator
  
  Yoneda Yoshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

[Book] 人体の細胞生物学2018
- Author(s)
  山田幸司、米田悦啓
- Total Pages
  20
- Publisher
  日本医事新報社
- ISBN
  9784784932320
- Data Source
  KAKENHI-PROJECT-16K18434
[Book] 人体の細胞生物学2018
- Author(s)
  山田幸司、米田悦啓
- Publisher
  日本医事新報社
- ISBN
  9784784932320
- Data Source
  KAKENHI-PROJECT-18K15253
[Book] 次世代がん治療　－発症・転移メカニズムからがん免疫療法・ウイルス、診断法まで2017
- Author(s)
  山田幸司、米田悦啓、岡正啓
- Total Pages
  347
- Publisher
  NTS
- Data Source
  KAKENHI-PROJECT-16H04789
[Book] 次世代がん治療2017
- Author(s)
  山田幸司、米田悦啓、岡正啓
- Total Pages
  347
- Publisher
  ＮＴＳ
- ISBN
  9784860435035
- Data Source
  KAKENHI-PROJECT-16K18434
[Journal Article] HDAC Inhibition Induces CD26 Expression on Multiple Myeloma Cells via the c-Myc/Sp1-mediated Promoter Activation2024
- Author(s)
  Nishida H, Suzuki R, Nakajima K, Hayashi M, Morimoto C, Yamada T
- Journal Title
  
  Cancer Res Commun
  
  Volume: 4(2) Issue: 2 Pages: 349-364
- DOI
  10.1158/2767-9764.crc-23-0215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07682, KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-23K27395
[Journal Article] Cancer-Related Unconventional Protein Secretion: A New Role of the Endoplasmic Reticulum2023
- Author(s)
  Yamada Kohji、Yoshida Kiyotsugu
- Journal Title
  
  DNA and Cell Biology
  
  Volume: 42 Issue: 5 Pages: 1-4
- DOI
  10.1089/dna.2023.0044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07621
[Journal Article] Leakage? or Secretion? unconventional protein secretion in cancer2023
- Author(s)
  Yamada Kohji、Yoshida Kiyotsugu
- Journal Title
  
  Oncotarget
  
  Volume: 14 Issue: 1 Pages: 146-147
- DOI
  10.18632/oncotarget.28368
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07621
[Journal Article] GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c-MET tyrosine kinase.2023
- Author(s)
  Okayama M, Fujimori K, Sato M, Samata K, Kurita K, Sugiyama H, Suto Y, Iwasaki G, Yamada T, Kiuchi F, Ichikawa D, Matsushita M, Hirao M, Kunieda H, Yamazaki K, Hattori Y.
- Journal Title
  
  Cancer Medicine
  
  Volume: - Issue: 8 Pages: 9749-9759
- DOI
  10.1002/cam4.5691
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08763, KAKENHI-PROJECT-23K07869, KAKENHI-PROJECT-22K19387
[Journal Article] Protein Kinase C Delta Is a Novel Biomarker for Hepatocellular Carcinoma.2023
- Author(s)
  Oikawa T, Yamada K, Tsubota A, Saeki C, Tago N, Nakagawa C, Ueda K, Kamioka H, Taniai T, Haruki K, Nakano M, Torisu Y, Ikegami T, Yoshida K, and Saruta M.
- Journal Title
  
  Gastro Hep Advances
  
  Volume: 2 Issue: 1 Pages: 83-95
- DOI
  10.1016/j.gastha.2022.07.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08063, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621
[Journal Article] Inhibition of protein kinase C delta leads to cellular senescence to induce anti‐tumor effects in colorectal cancer2023
- Author(s)
  Shimoyama Yuya、Yamada Kohji、Yoshida Saishu、Kawamura Akira、Hannya Yoshito、Imaizumi Yuta、Kumamoto Tomotaka、Takeda Yasuhiro、Shimoda Masayuki、Eto Ken、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Science
  
  Volume: in press Issue: 6 Pages: 2471-2484
- DOI
  10.1111/cas.15768
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06192, KAKENHI-PROJECT-20K07621
[Journal Article] Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies2023
- Author(s)
  Kobayashi Eiji、Kamihara Yusuke、Arai Miho、Wada Akinori、Kikuchi Shohei、Hatano Ryo、Iwao Noriaki、Susukida Takeshi、Ozawa Tatsuhiko、Adachi Yuichi、Kishi Hiroyuki、Dang Nam H.、Yamada Taketo、Hayakawa Yoshihiro、Morimoto Chikao、Sato Tsutomu
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 16 Pages: 2059-2059
- DOI
  10.3390/cells12162059
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06501, KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-21H02782, KAKENHI-PROJECT-23K27395
[Journal Article] IgM to IgG Class Switching Is a Necessary Step for Pemphigus Phenotype Induction in Desmoglein 3?Specific B Cell Receptor Knock-in Mouse2022
- Author(s)
  Nomura Hisashi、Wada Naoko、Takahashi Hayato、Kase Yuko、Yamagami Jun、Egami Shohei、Iriki Hisato、Mukai Miho、Kamata Aki、Ito Hiromi、Fujii Hideki、Ishikura Tomoyuki、Koseki Haruhiko、Watanabe Takashi、Yamada Taketo、Ohara Osamu、Koyasu Shigeo、Amagai Masayuki
- Journal Title
  
  The Journal of Immunology
  
  Volume: 208 Issue: 3 Pages: 582-593
- DOI
  10.4049/jimmunol.2100781
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-19H03519
[Journal Article] Increased alpha cell to beta cell ratio in patients with pancreatic cancer2022
- Author(s)
  Tsuchiya Tami、Saisho Yoshifumi、Inaishi Jun、Sasaki Hironobu、Sato Midori、Nishikawa Masaru、Masugi Yohei、Yamada Taketo、Itoh Hiroshi
- Journal Title
  
  Endocr J
  
  Volume: 69 Issue: 12 Pages: 1407-1414
- DOI
  10.1507/endocrj.EJ22-0170
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08535, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-20K17542
[Journal Article] Humanized anti-IL-26 monoclonal antibody as a novel targeted therapy for chronic graft-versus-host disease2022
- Author(s)
  Hatano Ryo、Itoh Takumi、Otsuka Haruna、Saeki Harumi、Yamamoto Ayako、Song Dan、Shirakawa Yuki、Iyama Satoshi、Sato Tsutomu、Iwao Noriaki、Harada Norihiro、Aune Thomas M.、Dang Nam H.、Kaneko Yutaro、Yamada Taketo、Morimoto Chikao、Ohnuma Kei
- Journal Title
  
  American Journal of Transplantation
  
  Volume: 22 Issue: 12 Pages: 2804-2820
- DOI
  10.1111/ajt.17178
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-21K16389, KAKENHI-PROJECT-22K15400, KAKENHI-PROJECT-20K07683
[Journal Article] Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer2022
- Author(s)
  Yamada Kohji、Yoshida Kiyotsugu
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 28 Issue: 2 Pages: 188-198
- DOI
  10.3748/wjg.v28.i2.188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621
[Journal Article] Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B<sup>+</sup>vesicle pathway in liver cancer2022
- Author(s)
  Yamada Kohji、Motohashi Saya、Oikawa Tsunekazu、Tago Naoko、Koizumi Rei、Ono Masaya、Tachibana Toshiaki、Yoshida Ayano、Yoshida Saishu、Shimoda Masayuki、Oka Masahiro、Yoneda Yoshihiro、Yoshida Kiyotsugu
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 36
- DOI
  10.1073/pnas.2202730119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06192, KAKENHI-PROJECT-22K08063, KAKENHI-PROJECT-20H03444, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621, KAKENHI-PROJECT-23K24116
[Journal Article] Serum soluble CD26/DPP4 titer variation is a potential prognostic biomarker in cancer therapy with a humanized anti-CD26 antibody.2021
- Author(s)
  Kaneko Y, Hatano R, Hirota N, Isambert N, Trillet-Lenoir V, You B, Alexandre J, Zalcman G, Valleix F, Podoll T, Umezawa Y, Takao S, Iwata S, Hosono O, Taguchi T, Yamada T, Dang NH, Ohnuma K, Angevin E, Morimoto C.
- Journal Title
  
  Biomark Res
  
  Volume: 9 Issue: 1 Pages: 21-21
- DOI
  10.1186/s40364-021-00273-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-19K22542
[Journal Article] Phase 2 Study of YS110, a Recombinant Humanized Anti-CD26 Monoclonal Antibody, in Japanese Patients With Advanced Malignant Pleural Mesothelioma2021
- Author(s)
  Nakagawa Kazuhiko、Kijima Takashi、Okada Morihito、Morise Masahiro、Kato Motoyasu、Hirano Katsuya、Fujimoto Nobukazu、Takenoyama Mitsuhiro、Yokouchi Hiroshi、Ohe Yuichiro、Hida Toyoaki、Aoe Keisuke、Kishimoto Takumi、Hirokawa Masato、Matsuki Hironori、Kaneko Yutaro、Yamada Taketo、Morimoto Chikao、Takeda Masayuki
- Journal Title
  
  JTO Clinical and Research Reports
  
  Volume: 2 Issue: 6 Pages: 100178-100178
- DOI
  10.1016/j.jtocrr.2021.100178
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03519
[Journal Article] IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells2021
- Author(s)
  Itoh Takumi、Hatano Ryo、Horimoto Yoshiya、Yamada Taketo、Song Dan、Otsuka Haruna、Shirakawa Yuki、Mastuoka Shuji、Iwao Noriaki、Aune Thomas M.、Dang Nam H.、Kaneko Yutaro、Okumura Ko、Morimoto Chikao、Ohnuma Kei
- Journal Title
  
  Cell Death and Disease
  
  Volume: 12 Issue: 6 Pages: 520-520
- DOI
  10.1038/s41419-021-03787-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-21K16389
[Journal Article] Unconventional Secretion of PKCδ Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer2020
- Author(s)
  Yamada Kohji、Oikawa Tsunekazu、Kizawa Ryusuke、Motohashi Saya、Yoshida Saishu、Kumamoto Tomotaka、Saeki Chisato、Nakagawa Chika、Shimoyama Yuya、Aoki Katsuhiko、Tachibana Toshiaki、Saruta Masayuki、Ono Masaya、Yoshida Kiyotsugu
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 2 Pages: 414-425
- DOI
  10.1158/0008-5472.can-20-2009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07621, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-19K16781, KAKENHI-PROJECT-19K08429
[Journal Article] Single-cell atlas of colonic CD8+ T-cells in ulcerative colitis.2020
- Author(s)
  Corridoni D, Antanaviciute A, Gupta T, Fawkner-Corbett D, Aulicino A, Jagielowicz M, Parikh K, Repapi E, Taylor S, Ishikawa D, Hatano R, Yamada T, Xin W, Slawinki H, Bowden R, Napolitani G, Brain O, Morimoto C, Koohy H, Simmons A.
- Journal Title
  
  Nat Med
  
  Volume: 26 Issue: 9 Pages: 1480-1490
- DOI
  10.1038/s41591-020-1003-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-19K22542
[Journal Article] Impairment of DYRK2 by DNMT1?mediated transcription augments carcinogenesis in human colorectal cancer2020
- Author(s)
  Kumamoto Tomotaka、Yamada Kohji、Yoshida Saishu、Aoki Katsuhiko、Hirooka Shinichi、Eto Ken、Yanaga Katsuhiko、Yoshida Kiyotsugu
- Journal Title
  
  International Journal of Oncology
  
  Volume: 56 Pages: 1529-1539
- DOI
  10.3892/ijo.2020.5020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19484, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-19K16781, KAKENHI-PROJECT-17H03584, KAKENHI-PROJECT-20H03519
[Journal Article] Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation2020
- Author(s)
  Sumiyoshi Mami、Kotani Yui、Ikuta Yuki、Suzue Kazutomo、Ozawa Madoka、Katakai Tomoya、Yamada Taketo、Abe Takaya、Bando Kana、Koyasu Shigeo、Kanaho Yasunori、Watanabe Toshio、Matsuda Satoshi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 206 Issue: 2 Pages: 366-375
- DOI
  10.4049/jimmunol.2000971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07555, KAKENHI-PROJECT-19K22528, KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-18H02601, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-19K16701, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K06545
[Journal Article] Mechanical insights into the regulation of programmed cell death by p53 via mitochondria.2019
- Author(s)
  Kohji Yamada, Kiyotsugu Yoshida
- Journal Title
  
  Biochim Biophys Acta Mol Cell Res
  
  Volume: 1866 Issue: 5 Pages: 839-848
- DOI
  10.1016/j.bbamcr.2019.02.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18434, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-17H03584
[Journal Article] Novel antibody-drug conjugate with anti-CD26 humanized monoclonal antibody and transcription factor IIH (TFIIH) inhibitor, triptolide, inhibits tumor rrowth via impairing mRNA synthesis2019
- Author(s)
  Hayashi M, Madokoro H, Yamada K, Nishida H, Morimoto C, Sakamoto M, Yanagawa H, Yamada T
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 8 Pages: 1138-1138
- DOI
  10.3390/cancers11081138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-19H03519
[Journal Article] Monoclonal Antibody Therapies in Multiple Myeloma: A Challenge to Develop Novel Targets2019
- Author(s)
  Nishida H, Yamada T
- Journal Title
  
  Journal of Oncology
  
  Volume: 2019 Pages: 6084012-6084012
- DOI
  10.1155/2019/6084012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-19H03519
[Journal Article] Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens2019
- Author(s)
  Hatano R, Yamada T, Madokoro H, Otsuka H, Komiya E, Itoh T, Narita Y, Iwata S, Yamazaki H, Matsuoka S, Dang NH, Morimoto C
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 6 Pages: e0218330-e0218330
- DOI
  10.1371/journal.pone.0218330
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-17K16353, KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-17K10008, KAKENHI-PROJECT-19K21278
[Journal Article] Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network.2016
- Author(s)
  Moriyama T, Tanaka S, Nakayama Y, Fukumoto M, Tsujimura K, Yamada K, Bamba T, Yoneda Y, Fukusaki E, Oka M.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 34648-34648
- DOI
  10.1038/srep34648
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25116008, KAKENHI-PROJECT-16H04789, KAKENHI-PROJECT-26870341, KAKENHI-PROJECT-16K14676, KAKENHI-PROJECT-16K18434
[Journal Article] Importin α: a key molecule in nuclear transport and non-transport functions.2016
- Author(s)
  Miyamoto Y, Yamada K, Yoneda Y.
- Journal Title
  
  J Biochem
  
  Volume: 160 Issue: 2 Pages: 69-75
- DOI
  10.1093/jb/mvw036
- NAID
  40020914020
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25116008, KAKENHI-PROJECT-16H04789, KAKENHI-PROJECT-15K07068, KAKENHI-PROJECT-16K18434
[Patent] ＰＫＣδとＥ－Ｓｙｔ１との相互作用阻害剤を含む新規肝癌治療薬2022
- Inventor(s)
  山田幸司、本橋沙耶、吉田清嗣
- Industrial Property Rights Holder
  山田幸司、本橋沙耶、吉田清嗣
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K07621
[Patent] 細胞外のPKCδを標的とする肝癌細胞増殖抑制剤及びそれを含む新規肝癌治療薬2020
- Inventor(s)
  山田幸司、木澤隆介、吉田清嗣
- Industrial Property Rights Holder
  慈恵大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-168678
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K07621
[Patent] 細胞外のPKCδを標的とする肝癌細胞増殖抑制剤及びそれを含む新規肝癌治療薬2019
- Inventor(s)
  19)山田幸司、木澤隆介、吉田清嗣
- Industrial Property Rights Holder
  学校法人慈恵大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-168678
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K15253
[Patent] 新規肝癌マーカー2018
- Inventor(s)
  山田幸司、吉田清嗣
- Industrial Property Rights Holder
  東京慈恵会医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-095674
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K18434
[Patent] 新規肝癌マーカー2018
- Inventor(s)
  山田幸司、吉田清嗣
- Industrial Property Rights Holder
  東京慈恵会医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-095674
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K15253
[Presentation] 核内移行する抗CD26ヒト化モノクローナル抗体を用いた新規抗体薬剤複合体の橋渡し研究2023
- Author(s)
  林　睦、間所裕子、山田健人
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K19387
[Presentation] CD26陽性がんに対する新規抗体-抗がん剤結合分子ADCの開発2022
- Author(s)
  林　睦、間所裕子、坂元亨宇、山田健人
- Organizer
  第111回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K19387
[Presentation] Up-regulation of CD26 on multiple myeloma cells by HDAC inhibition augments the efficacy of humanized antibody2021
- Author(s)
  Hiroko Nishida, Reiko Suzuki, Mari Fujiwara, Chikao Morimoto, Michiie Sakamoto, Taketo Yamada
- Organizer
  The 63rd AMERICAN SOCIETY OF HEMATOLOGY(ASH) ANNUAL MEETING
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03519
[Presentation] 悪性中皮腫に対する新規抗体-抗がん剤結合分子ADCの開発2021
- Author(s)
  山田健人
- Organizer
  第2回日本石綿・中皮腫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03519
[Presentation] Nuclear Transportable ADC with Triptolide Inhibits Tumor Cell Growth via Impaired Super-enhancer Function2021
- Author(s)
  Yamada T, Hayashi M
- Organizer
  The 80th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-19H03519
[Presentation] Extracellular localization of PKCδand its function as a growth factor to activate ERK signaling in liver cancer2021
- Author(s)
  山田幸司、及川恒一、本橋沙耶、吉田彩乃、小泉麗、吉田清嗣
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07621
[Presentation] サルコイドーシスにおけるCD26陽性T細胞サブセットの解析2021
- Author(s)
  相羽弘貴、山田健人
- Organizer
  第110回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19H03519
[Presentation] Anti-CD26 humanized antibody-triptolide conjugate trasnports into nucleus and inhibits RNA polymerase II activity2019
- Author(s)
  山田健人、坂元亨宇、森本幾夫、林睦
- Organizer
  第78回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-19H03519
[Presentation] Humanized anti-CD26 monoclonal antibody targets clonogenic side population cells in multiple myeloma2019
- Author(s)
  Nishida H, Yamada T
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03519
[Presentation] Anti-CD26 Humanized Monoclonal Antibody Conjugated to Triptolide Inhibits Tumor Cell Growth via Transportation into Nucleus and Impaired RNA Polymerase II2019
- Author(s)
  Hayashi M,Madokoro H, Yamada T
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03519
[Presentation] Analysis of molecular determinants of estrogen receptor α mobility.2018
- Author(s)
  Moriyama T, Yoneda Y, Oka M, Yamada M.
- Organizer
  第70回日本細胞生物学会
- Data Source
  KAKENHI-PROJECT-16H04789
[Presentation] 翻訳開始点の異なる2つのトランスアルドラーゼが糖代謝全体に影響を及ぼす2017
- Author(s)
  盛山哲嗣、田中秀、福本昌宏、辻村賢二、山田幸司、中山泰宗、馬場健史、福崎英一郎、米田悦啓、岡正啓
- Organizer
  第69回日本細胞生物学大会
- Data Source
  KAKENHI-PROJECT-16H04789
[Presentation] 寒冷刺激は強皮症患者由来抗核抗体の生物活性を惹起する2016
- Author(s)
  山田幸司、世良田聡、岡正啓、藤本譲、仲哲治、米田悦啓
- Organizer
  第68回日本細胞生物学会大会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16H04789
[Presentation] 細胞外放出されるimportinα1の生物活性の解析2016
- Author(s)
  生野雄大、山田幸司、宮本洋一、米田悦啓、岡正啓
- Organizer
  第68回日本細胞生物学会大会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16H04789
[Presentation] Identification of cell surface localization of a nuclear transport factor importin α1 and its significance in FGF signaling2016
- Author(s)
  K. Yamada, Y. Yoneda
- Organizer
  The 41st Naito Conference
- Place of Presentation
  北海道
- Year and Date
  2016-07-05
- Data Source
  KAKENHI-PROJECT-16K18434
[Presentation] Extracellular released importin α1 stimulates proliferation of cancer cells2016
- Author(s)
  山田幸司、米田悦啓、岡正啓
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-12-06
- Data Source
  KAKENHI-PROJECT-16K18434
[Presentation] ヌクレオポリン融合タンパク質Nup98-HoxA9の機能解析2016
- Author(s)
  岡正啓, 村苑子, 山田幸司, Percival Sangel1, 大川恭行, 木村宏, 米田悦啓
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H04789
[Presentation] Extracellular released importin α1 stimulates proliferation of cancer cells2016
- Author(s)
  山田幸司、米田悦啓、岡正啓
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H04789
[Presentation] Novel function of nuclear transport factor in cancer ＜cell surface localization of importin α1 affects cancer cell prokiferation by regulating FGF 1 signalling＞2016
- Author(s)
  山田幸司、宮本洋一、岡正啓、米田悦啓
- Organizer
  第41回内藤コンファレンス
- Place of Presentation
  札幌
- Year and Date
  2016-07-05
- Data Source
  KAKENHI-PROJECT-16H04789
[Presentation] Cold stimulation evokes cellular sensitivity to antinuclear antibodies of patients with systemic sclerosis via induction of cell surface localization of hnRNP-K2016
- Author(s)
  山田幸司、世良田聡、岡正啓、藤本穣、仲哲治、米田悦啓
- Organizer
  第68回日本分子生物学会年会・第11回日本ケミカルバイオロジー学会　合同学会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K18434
[Presentation] 異なる細胞内局在を示す２つのトランスアルドラーゼが糖代謝全体に影響を及ぼす2016
- Author(s)
  盛山哲嗣、田中秀、中山泰宗、福本昌宏、辻村賢二、山田幸司、馬場健史、米田悦啓、福崎英一郎、岡正啓
- Organizer
  第63回日本生化学会近畿支部例会
- Place of Presentation
  神戸
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-16H04789
[Presentation] 異なる核―細胞質間分布を示す２つのTransaldolase 1アイソフォームによる代謝ネットワークの制御2016
- Author(s)
  盛山哲嗣、田中秀、福本昌宏、辻村賢二、山田幸司、中山泰宗、馬場健史、福崎英一郎、米田悦啓、岡正啓
- Organizer
  第68回日本細胞生物学会大会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16H04789

1. YAMADA TAKETO (60230463)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
2. 吉田彩舟 (40772744)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. Yoneda Yoshihiro (80191667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
4. 岡正啓 (40432504)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
5. 林睦 (60327575)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. MIYAMOTO Yoichi (10379084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. MORIYAMA Tetsuji (50627990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. HIKIDA Takatoshi (70421378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TOMONAGA Takashi (80227644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 西田浩子 (80317130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. 立花利公 (80163476)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 持丸雄太 (50884623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OIKAWA Tsunekazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 波多野良

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. 高橋勇人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 山上淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 服部豊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 吉田清嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
19. 坪田昭人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 松田達志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamada Kohji 山田 幸司

Research Projects

Research Products

Co-Researchers

Hedgehogシグナルの新規な活性化機構に基づく薬剤耐性がん細胞の克服

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

核抗原の細胞膜局在誘導に基づく抗核抗体の新規機構と強皮症病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of transportable scFV monoclonal antibody into nucleus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of unconventional protein secretion in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel anti-cancer therapy against super-enhancer using humanized monoclonal antibody with transportation activity into nucleus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Extracellular localization of the intracellular kinase in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of importin alpha1 in tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The roles of importin-alpha subfamilies in mammals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 人体の細胞生物学2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 人体の細胞生物学2018

Author(s)

Publisher

ISBN

Data Source

[Book] 次世代がん治療 －発症・転移メカニズムからがん免疫療法・ウイルス、診断法まで2017

Author(s)

Total Pages

Publisher

Data Source

[Book] 次世代がん治療2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] HDAC Inhibition Induces CD26 Expression on Multiple Myeloma Cells via the c-Myc/Sp1-mediated Promoter Activation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cancer-Related Unconventional Protein Secretion: A New Role of the Endoplasmic Reticulum2023

Yamada Kohji 山田幸司

[Book] 次世代がん治療　－発症・転移メカニズムからがん免疫療法・ウイルス、診断法まで2017