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Yamada Kohji  山田 幸司

Researcher Number 90570979
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-9493-5269
Affiliation (Current) 2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 東京慈恵会医科大学, 医学部, 准教授
2020 – 2022: 東京慈恵会医科大学, 医学部, 講師
2016 – 2019: 東京慈恵会医科大学, 医学部, 助教
2018: 国立研究開発法人医薬基盤・健康・栄養研究所, 細胞核輸送ダイナミクスプロジェクト, 特任研究員
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Tumor biology
Except Principal Investigator
Basic Section 50010:Tumor biology-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Cell biology
Keywords
Principal Investigator
肝がん / CUPS / 型破り分泌 / PKCδ / がん / 肝癌 / 細胞外局在 / 小胞体 / 局在多様性 / 強皮症 … More / PKC / マーカー / 分泌 / タンパク質分泌 / タンパク質の多機能性 / がん微小環境 / ヘパラン硫酸プロテオグリカン / キナーゼ / 腫瘍マーカー / 細胞外分泌 / 病理学 / 蛋白質 / 生体分子 / 癌 / 細胞外放出 / 微小環境 / 核輸送因子 … More
Except Principal Investigator
がん細胞 / 髄芽腫 / 基底細胞腫 / DYRK2 / 発がん / Hedgehogシグナル / 抗体薬剤複合体 / scFV / 免疫担当細胞 / single chain Fv / 核内移行 / モノクローナル抗体 / 抗体抗がん剤結合薬ADC / RNAポリメラーゼII / 抗体療法 / Antibody-Drug Conjugate / 分子標的療法 / 核移行 / 抗体 / スーパーエンハンサー / がん / CD26 / 老化 / 癌 / 細胞・組織 / ノックアウトマウス / importin / 核輸送 Less
  • Research Projects

    (8 results)
  • Research Products

    (56 results)
  • Co-Researchers

    (20 People)
  •  Hedgehogシグナルの新規な活性化機構に基づく薬剤耐性がん細胞の克服

    • Principal Investigator
      吉田 彩舟
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Toho University
  •  核抗原の細胞膜局在誘導に基づく抗核抗体の新規機構と強皮症病態の解明Principal Investigator

    • Principal Investigator
      山田 幸司
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Jikei University School of Medicine
  •  Development of transportable scFV monoclonal antibody into nucleus

    • Principal Investigator
      Yamada Taketo
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Saitama Medical University
  •  Study of unconventional protein secretion in cancerPrincipal Investigator

    • Principal Investigator
      YAMADA Kohji
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Jikei University School of Medicine
  •  Novel anti-cancer therapy against super-enhancer using humanized monoclonal antibody with transportation activity into nucleus

    • Principal Investigator
      YAMADA TAKETO
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Saitama Medical University
  •  Extracellular localization of the intracellular kinase in cancerPrincipal Investigator

    • Principal Investigator
      Yamada Kohji
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Jikei University School of Medicine
  •  Roles of importin alpha1 in tumor microenvironmentPrincipal Investigator

    • Principal Investigator
      Yamada Kohji
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor biology
    • Research Institution
      Jikei University School of Medicine
  •  The roles of importin-alpha subfamilies in mammals

    • Principal Investigator
      Yoneda Yoshihiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cell biology
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

  • [Book] 人体の細胞生物学2018

    • Author(s)
      山田 幸司、米田 悦啓
    • Total Pages
      20
    • Publisher
      日本医事新報社
    • ISBN
      9784784932320
    • Data Source
      KAKENHI-PROJECT-16K18434
  • [Book] 人体の細胞生物学2018

    • Author(s)
      山田 幸司、米田 悦啓
    • Publisher
      日本医事新報社
    • ISBN
      9784784932320
    • Data Source
      KAKENHI-PROJECT-18K15253
  • [Book] 次世代がん治療 -発症・転移メカニズムからがん免疫療法・ウイルス、診断法まで2017

    • Author(s)
      山田幸司、米田悦啓、岡正啓
    • Total Pages
      347
    • Publisher
      NTS
    • Data Source
      KAKENHI-PROJECT-16H04789
  • [Book] 次世代がん治療2017

    • Author(s)
      山田幸司、米田悦啓、岡正啓
    • Total Pages
      347
    • Publisher
      NTS
    • ISBN
      9784860435035
    • Data Source
      KAKENHI-PROJECT-16K18434
  • [Journal Article] HDAC Inhibition Induces CD26 Expression on Multiple Myeloma Cells via the c-Myc/Sp1-mediated Promoter Activation2024

    • Author(s)
      Nishida H, Suzuki R, Nakajima K, Hayashi M, Morimoto C, Yamada T
    • Journal Title

      Cancer Res Commun

      Volume: 4(2) Issue: 2 Pages: 349-364

    • DOI

      10.1158/2767-9764.crc-23-0215

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07682, KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-23K27395
  • [Journal Article] Cancer-Related Unconventional Protein Secretion: A New Role of the Endoplasmic Reticulum2023

    • Author(s)
      Yamada Kohji、Yoshida Kiyotsugu
    • Journal Title

      DNA and Cell Biology

      Volume: 42 Issue: 5 Pages: 1-4

    • DOI

      10.1089/dna.2023.0044

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07621
  • [Journal Article] Leakage? or Secretion? unconventional protein secretion in cancer2023

    • Author(s)
      Yamada Kohji、Yoshida Kiyotsugu
    • Journal Title

      Oncotarget

      Volume: 14 Issue: 1 Pages: 146-147

    • DOI

      10.18632/oncotarget.28368

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07621
  • [Journal Article] GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c-MET tyrosine kinase.2023

    • Author(s)
      Okayama M, Fujimori K, Sato M, Samata K, Kurita K, Sugiyama H, Suto Y, Iwasaki G, Yamada T, Kiuchi F, Ichikawa D, Matsushita M, Hirao M, Kunieda H, Yamazaki K, Hattori Y.
    • Journal Title

      Cancer Medicine

      Volume: - Issue: 8 Pages: 9749-9759

    • DOI

      10.1002/cam4.5691

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08763, KAKENHI-PROJECT-23K07869, KAKENHI-PROJECT-22K19387
  • [Journal Article] Protein Kinase C Delta Is a Novel Biomarker for Hepatocellular Carcinoma.2023

    • Author(s)
      Oikawa T, Yamada K, Tsubota A, Saeki C, Tago N, Nakagawa C, Ueda K, Kamioka H, Taniai T, Haruki K, Nakano M, Torisu Y, Ikegami T, Yoshida K, and Saruta M.
    • Journal Title

      Gastro Hep Advances

      Volume: 2 Issue: 1 Pages: 83-95

    • DOI

      10.1016/j.gastha.2022.07.020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08063, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621
  • [Journal Article] Inhibition of protein kinase C delta leads to cellular senescence to induce anti‐tumor effects in colorectal cancer2023

    • Author(s)
      Shimoyama Yuya、Yamada Kohji、Yoshida Saishu、Kawamura Akira、Hannya Yoshito、Imaizumi Yuta、Kumamoto Tomotaka、Takeda Yasuhiro、Shimoda Masayuki、Eto Ken、Yoshida Kiyotsugu
    • Journal Title

      Cancer Science

      Volume: in press Issue: 6 Pages: 2471-2484

    • DOI

      10.1111/cas.15768

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06192, KAKENHI-PROJECT-20K07621
  • [Journal Article] Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies2023

    • Author(s)
      Kobayashi Eiji、Kamihara Yusuke、Arai Miho、Wada Akinori、Kikuchi Shohei、Hatano Ryo、Iwao Noriaki、Susukida Takeshi、Ozawa Tatsuhiko、Adachi Yuichi、Kishi Hiroyuki、Dang Nam H.、Yamada Taketo、Hayakawa Yoshihiro、Morimoto Chikao、Sato Tsutomu
    • Journal Title

      Cells

      Volume: 12 Issue: 16 Pages: 2059-2059

    • DOI

      10.3390/cells12162059

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K06501, KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-21H02782, KAKENHI-PROJECT-23K27395
  • [Journal Article] IgM to IgG Class Switching Is a Necessary Step for Pemphigus Phenotype Induction in Desmoglein 3?Specific B Cell Receptor Knock-in Mouse2022

    • Author(s)
      Nomura Hisashi、Wada Naoko、Takahashi Hayato、Kase Yuko、Yamagami Jun、Egami Shohei、Iriki Hisato、Mukai Miho、Kamata Aki、Ito Hiromi、Fujii Hideki、Ishikura Tomoyuki、Koseki Haruhiko、Watanabe Takashi、Yamada Taketo、Ohara Osamu、Koyasu Shigeo、Amagai Masayuki
    • Journal Title

      The Journal of Immunology

      Volume: 208 Issue: 3 Pages: 582-593

    • DOI

      10.4049/jimmunol.2100781

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-19H03519
  • [Journal Article] Increased alpha cell to beta cell ratio in patients with pancreatic cancer2022

    • Author(s)
      Tsuchiya Tami、Saisho Yoshifumi、Inaishi Jun、Sasaki Hironobu、Sato Midori、Nishikawa Masaru、Masugi Yohei、Yamada Taketo、Itoh Hiroshi
    • Journal Title

      Endocr J

      Volume: 69 Issue: 12 Pages: 1407-1414

    • DOI

      10.1507/endocrj.EJ22-0170

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08535, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-20K17542
  • [Journal Article] Humanized anti-IL-26 monoclonal antibody as a novel targeted therapy for chronic graft-versus-host disease2022

    • Author(s)
      Hatano Ryo、Itoh Takumi、Otsuka Haruna、Saeki Harumi、Yamamoto Ayako、Song Dan、Shirakawa Yuki、Iyama Satoshi、Sato Tsutomu、Iwao Noriaki、Harada Norihiro、Aune Thomas M.、Dang Nam H.、Kaneko Yutaro、Yamada Taketo、Morimoto Chikao、Ohnuma Kei
    • Journal Title

      American Journal of Transplantation

      Volume: 22 Issue: 12 Pages: 2804-2820

    • DOI

      10.1111/ajt.17178

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-21K16389, KAKENHI-PROJECT-22K15400, KAKENHI-PROJECT-20K07683
  • [Journal Article] Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer2022

    • Author(s)
      Yamada Kohji、Yoshida Kiyotsugu
    • Journal Title

      World Journal of Gastroenterology

      Volume: 28 Issue: 2 Pages: 188-198

    • DOI

      10.3748/wjg.v28.i2.188

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621
  • [Journal Article] Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B<sup>+</sup>vesicle pathway in liver cancer2022

    • Author(s)
      Yamada Kohji、Motohashi Saya、Oikawa Tsunekazu、Tago Naoko、Koizumi Rei、Ono Masaya、Tachibana Toshiaki、Yoshida Ayano、Yoshida Saishu、Shimoda Masayuki、Oka Masahiro、Yoneda Yoshihiro、Yoshida Kiyotsugu
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 36

    • DOI

      10.1073/pnas.2202730119

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06192, KAKENHI-PROJECT-22K08063, KAKENHI-PROJECT-20H03444, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-20K07621, KAKENHI-PROJECT-23K24116
  • [Journal Article] Serum soluble CD26/DPP4 titer variation is a potential prognostic biomarker in cancer therapy with a humanized anti-CD26 antibody.2021

    • Author(s)
      Kaneko Y, Hatano R, Hirota N, Isambert N, Trillet-Lenoir V, You B, Alexandre J, Zalcman G, Valleix F, Podoll T, Umezawa Y, Takao S, Iwata S, Hosono O, Taguchi T, Yamada T, Dang NH, Ohnuma K, Angevin E, Morimoto C.
    • Journal Title

      Biomark Res

      Volume: 9 Issue: 1 Pages: 21-21

    • DOI

      10.1186/s40364-021-00273-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-19K22542
  • [Journal Article] Phase 2 Study of YS110, a Recombinant Humanized Anti-CD26 Monoclonal Antibody, in Japanese Patients With Advanced Malignant Pleural Mesothelioma2021

    • Author(s)
      Nakagawa Kazuhiko、Kijima Takashi、Okada Morihito、Morise Masahiro、Kato Motoyasu、Hirano Katsuya、Fujimoto Nobukazu、Takenoyama Mitsuhiro、Yokouchi Hiroshi、Ohe Yuichiro、Hida Toyoaki、Aoe Keisuke、Kishimoto Takumi、Hirokawa Masato、Matsuki Hironori、Kaneko Yutaro、Yamada Taketo、Morimoto Chikao、Takeda Masayuki
    • Journal Title

      JTO Clinical and Research Reports

      Volume: 2 Issue: 6 Pages: 100178-100178

    • DOI

      10.1016/j.jtocrr.2021.100178

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03519
  • [Journal Article] IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells2021

    • Author(s)
      Itoh Takumi、Hatano Ryo、Horimoto Yoshiya、Yamada Taketo、Song Dan、Otsuka Haruna、Shirakawa Yuki、Mastuoka Shuji、Iwao Noriaki、Aune Thomas M.、Dang Nam H.、Kaneko Yutaro、Okumura Ko、Morimoto Chikao、Ohnuma Kei
    • Journal Title

      Cell Death and Disease

      Volume: 12 Issue: 6 Pages: 520-520

    • DOI

      10.1038/s41419-021-03787-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-21K16389
  • [Journal Article] Unconventional Secretion of PKCδ Exerts Tumorigenic Function via Stimulation of ERK1/2 Signaling in Liver Cancer2020

    • Author(s)
      Yamada Kohji、Oikawa Tsunekazu、Kizawa Ryusuke、Motohashi Saya、Yoshida Saishu、Kumamoto Tomotaka、Saeki Chisato、Nakagawa Chika、Shimoyama Yuya、Aoki Katsuhiko、Tachibana Toshiaki、Saruta Masayuki、Ono Masaya、Yoshida Kiyotsugu
    • Journal Title

      Cancer Research

      Volume: 81 Issue: 2 Pages: 414-425

    • DOI

      10.1158/0008-5472.can-20-2009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07621, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-20H03519, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-19K16781, KAKENHI-PROJECT-19K08429
  • [Journal Article] Single-cell atlas of colonic CD8+ T-cells in ulcerative colitis.2020

    • Author(s)
      Corridoni D, Antanaviciute A, Gupta T, Fawkner-Corbett D, Aulicino A, Jagielowicz M, Parikh K, Repapi E, Taylor S, Ishikawa D, Hatano R, Yamada T, Xin W, Slawinki H, Bowden R, Napolitani G, Brain O, Morimoto C, Koohy H, Simmons A.
    • Journal Title

      Nat Med

      Volume: 26 Issue: 9 Pages: 1480-1490

    • DOI

      10.1038/s41591-020-1003-4

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07683, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-20H03471, KAKENHI-PROJECT-19K22542
  • [Journal Article] Impairment of DYRK2 by DNMT1?mediated transcription augments carcinogenesis in human colorectal cancer2020

    • Author(s)
      Kumamoto Tomotaka、Yamada Kohji、Yoshida Saishu、Aoki Katsuhiko、Hirooka Shinichi、Eto Ken、Yanaga Katsuhiko、Yoshida Kiyotsugu
    • Journal Title

      International Journal of Oncology

      Volume: 56 Pages: 1529-1539

    • DOI

      10.3892/ijo.2020.5020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19484, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-19K16781, KAKENHI-PROJECT-17H03584, KAKENHI-PROJECT-20H03519
  • [Journal Article] Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation2020

    • Author(s)
      Sumiyoshi Mami、Kotani Yui、Ikuta Yuki、Suzue Kazutomo、Ozawa Madoka、Katakai Tomoya、Yamada Taketo、Abe Takaya、Bando Kana、Koyasu Shigeo、Kanaho Yasunori、Watanabe Toshio、Matsuda Satoshi
    • Journal Title

      The Journal of Immunology

      Volume: 206 Issue: 2 Pages: 366-375

    • DOI

      10.4049/jimmunol.2000971

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07555, KAKENHI-PROJECT-19K22528, KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-18H02601, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-19K16701, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K06545
  • [Journal Article] Mechanical insights into the regulation of programmed cell death by p53 via mitochondria.2019

    • Author(s)
      Kohji Yamada, Kiyotsugu Yoshida
    • Journal Title

      Biochim Biophys Acta Mol Cell Res

      Volume: 1866 Issue: 5 Pages: 839-848

    • DOI

      10.1016/j.bbamcr.2019.02.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K18434, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-17H03584
  • [Journal Article] Novel antibody-drug conjugate with anti-CD26 humanized monoclonal antibody and transcription factor IIH (TFIIH) inhibitor, triptolide, inhibits tumor rrowth via impairing mRNA synthesis2019

    • Author(s)
      Hayashi M, Madokoro H, Yamada K, Nishida H, Morimoto C, Sakamoto M, Yanagawa H, Yamada T
    • Journal Title

      Cancers

      Volume: 11 Issue: 8 Pages: 1138-1138

    • DOI

      10.3390/cancers11081138

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-19H03519
  • [Journal Article] Monoclonal Antibody Therapies in Multiple Myeloma: A Challenge to Develop Novel Targets2019

    • Author(s)
      Nishida H, Yamada T
    • Journal Title

      Journal of Oncology

      Volume: 2019 Pages: 6084012-6084012

    • DOI

      10.1155/2019/6084012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-19H03519
  • [Journal Article] Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens2019

    • Author(s)
      Hatano R, Yamada T, Madokoro H, Otsuka H, Komiya E, Itoh T, Narita Y, Iwata S, Yamazaki H, Matsuoka S, Dang NH, Morimoto C
    • Journal Title

      PLoS ONE

      Volume: 14 Issue: 6 Pages: e0218330-e0218330

    • DOI

      10.1371/journal.pone.0218330

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-17K16353, KAKENHI-PROJECT-18H02782, KAKENHI-PROJECT-19H03519, KAKENHI-PROJECT-17K10008, KAKENHI-PROJECT-19K21278
  • [Journal Article] Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network.2016

    • Author(s)
      Moriyama T, Tanaka S, Nakayama Y, Fukumoto M, Tsujimura K, Yamada K, Bamba T, Yoneda Y, Fukusaki E, Oka M.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 34648-34648

    • DOI

      10.1038/srep34648

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25116008, KAKENHI-PROJECT-16H04789, KAKENHI-PROJECT-26870341, KAKENHI-PROJECT-16K14676, KAKENHI-PROJECT-16K18434
  • [Journal Article] Importin α: a key molecule in nuclear transport and non-transport functions.2016

    • Author(s)
      Miyamoto Y, Yamada K, Yoneda Y.
    • Journal Title

      J Biochem

      Volume: 160 Issue: 2 Pages: 69-75

    • DOI

      10.1093/jb/mvw036

    • NAID

      40020914020

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25116008, KAKENHI-PROJECT-16H04789, KAKENHI-PROJECT-15K07068, KAKENHI-PROJECT-16K18434
  • [Patent] PKCδとE-Syt1との相互作用阻害剤を含む新規肝癌治療薬2022

    • Inventor(s)
      山田幸司、本橋沙耶、吉田清嗣
    • Industrial Property Rights Holder
      山田幸司、本橋沙耶、吉田清嗣
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-20K07621
  • [Patent] 細胞外のPKCδを標的とする肝癌細胞増殖抑制剤及びそれを含む新規肝癌治療薬2020

    • Inventor(s)
      山田幸司、木澤隆介、吉田清嗣
    • Industrial Property Rights Holder
      慈恵大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-168678
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-20K07621
  • [Patent] 細胞外のPKCδを標的とする肝癌細胞増殖抑制剤及びそれを含む新規肝癌治療薬2019

    • Inventor(s)
      19)山田幸司、木澤隆介、吉田清嗣
    • Industrial Property Rights Holder
      学校法人慈恵大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-168678
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-18K15253
  • [Patent] 新規肝癌マーカー2018

    • Inventor(s)
      山田幸司、吉田清嗣
    • Industrial Property Rights Holder
      東京慈恵会医科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-095674
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-16K18434
  • [Patent] 新規肝癌マーカー2018

    • Inventor(s)
      山田 幸司、吉田 清嗣
    • Industrial Property Rights Holder
      東京慈恵会医科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-095674
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-18K15253
  • [Presentation] 核内移行する抗CD26ヒト化モノクローナル抗体を用いた新規抗体薬剤複合体の橋渡し研究2023

    • Author(s)
      林 睦、間所裕子、山田健人
    • Organizer
      第112回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-22K19387
  • [Presentation] CD26陽性がんに対する新規抗体-抗がん剤結合分子ADCの開発2022

    • Author(s)
      林 睦、間所裕子、坂元亨宇、山田健人
    • Organizer
      第111回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-22K19387
  • [Presentation] Up-regulation of CD26 on multiple myeloma cells by HDAC inhibition augments the efficacy of humanized antibody2021

    • Author(s)
      Hiroko Nishida, Reiko Suzuki, Mari Fujiwara, Chikao Morimoto, Michiie Sakamoto, Taketo Yamada
    • Organizer
      The 63rd AMERICAN SOCIETY OF HEMATOLOGY(ASH) ANNUAL MEETING
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03519
  • [Presentation] 悪性中皮腫に対する新規抗体-抗がん剤結合分子ADCの開発2021

    • Author(s)
      山田健人
    • Organizer
      第2回日本石綿・中皮腫学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03519
  • [Presentation] Nuclear Transportable ADC with Triptolide Inhibits Tumor Cell Growth via Impaired Super-enhancer Function2021

    • Author(s)
      Yamada T, Hayashi M
    • Organizer
      The 80th Annual Meeting of the Japanese Cancer Association
    • Data Source
      KAKENHI-PROJECT-19H03519
  • [Presentation] Extracellular localization of PKCδand its function as a growth factor to activate ERK signaling in liver cancer2021

    • Author(s)
      山田幸司、及川恒一、本橋沙耶、吉田彩乃、小泉麗、吉田清嗣
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K07621
  • [Presentation] サルコイドーシスにおけるCD26陽性T細胞サブセットの解析2021

    • Author(s)
      相羽弘貴、山田健人
    • Organizer
      第110回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-19H03519
  • [Presentation] Anti-CD26 humanized antibody-triptolide conjugate trasnports into nucleus and inhibits RNA polymerase II activity2019

    • Author(s)
      山田 健人、坂元 亨宇、森本 幾夫、林 睦
    • Organizer
      第78回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-19H03519
  • [Presentation] Humanized anti-CD26 monoclonal antibody targets clonogenic side population cells in multiple myeloma2019

    • Author(s)
      Nishida H, Yamada T
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03519
  • [Presentation] Anti-CD26 Humanized Monoclonal Antibody Conjugated to Triptolide Inhibits Tumor Cell Growth via Transportation into Nucleus and Impaired RNA Polymerase II2019

    • Author(s)
      Hayashi M,Madokoro H, Yamada T
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H03519
  • [Presentation] Analysis of molecular determinants of estrogen receptor α mobility.2018

    • Author(s)
      Moriyama T, Yoneda Y, Oka M, Yamada M.
    • Organizer
      第70回日本細胞生物学会
    • Data Source
      KAKENHI-PROJECT-16H04789
  • [Presentation] 翻訳開始点の異なる2つのトランスアルドラーゼが糖代謝全体に影響を及ぼす2017

    • Author(s)
      盛山哲嗣、田中秀、福本昌宏、辻村賢二、山田幸司、中山泰宗、馬場健史、福崎英一郎、米田悦啓、岡正啓
    • Organizer
      第69回日本細胞生物学大会
    • Data Source
      KAKENHI-PROJECT-16H04789
  • [Presentation] 寒冷刺激は強皮症患者由来抗核抗体の生物活性を惹起する2016

    • Author(s)
      山田幸司、世良田聡、岡正啓、藤本譲、仲哲治、米田悦啓
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-16H04789
  • [Presentation] 細胞外放出されるimportinα1の生物活性の解析2016

    • Author(s)
      生野雄大、山田幸司、宮本洋一、米田悦啓、岡正啓
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-16H04789
  • [Presentation] Identification of cell surface localization of a nuclear transport factor importin α1 and its significance in FGF signaling2016

    • Author(s)
      K. Yamada, Y. Yoneda
    • Organizer
      The 41st Naito Conference
    • Place of Presentation
      北海道
    • Year and Date
      2016-07-05
    • Data Source
      KAKENHI-PROJECT-16K18434
  • [Presentation] Extracellular released importin α1 stimulates proliferation of cancer cells2016

    • Author(s)
      山田幸司、米田悦啓、岡正啓
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-12-06
    • Data Source
      KAKENHI-PROJECT-16K18434
  • [Presentation] ヌクレオポリン融合タンパク質Nup98-HoxA9の機能解析2016

    • Author(s)
      岡 正啓, 村 苑子, 山田 幸司, Percival Sangel1, 大川 恭行, 木村 宏, 米田 悦啓
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H04789
  • [Presentation] Extracellular released importin α1 stimulates proliferation of cancer cells2016

    • Author(s)
      山田 幸司、米田 悦啓、岡 正啓
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16H04789
  • [Presentation] Novel function of nuclear transport factor in cancer <cell surface localization of importin α1 affects cancer cell prokiferation by regulating FGF 1 signalling>2016

    • Author(s)
      山田幸司、宮本洋一、岡正啓、米田悦啓
    • Organizer
      第41回内藤コンファレンス
    • Place of Presentation
      札幌
    • Year and Date
      2016-07-05
    • Data Source
      KAKENHI-PROJECT-16H04789
  • [Presentation] Cold stimulation evokes cellular sensitivity to antinuclear antibodies of patients with systemic sclerosis via induction of cell surface localization of hnRNP-K2016

    • Author(s)
      山田幸司、世良田聡、岡正啓、藤本穣、仲哲治、米田悦啓
    • Organizer
      第68回日本分子生物学会年会・第11回日本ケミカルバイオロジー学会 合同学会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-16K18434
  • [Presentation] 異なる細胞内局在を示す2つのトランスアルドラーゼが糖代謝全体に影響を及ぼす2016

    • Author(s)
      盛山哲嗣、田中秀、中山泰宗、福本昌宏、辻村賢二、山田幸司、馬場健史、米田悦啓、福崎英一郎、岡正啓
    • Organizer
      第63回日本生化学会近畿支部例会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-21
    • Data Source
      KAKENHI-PROJECT-16H04789
  • [Presentation] 異なる核―細胞質間分布を示す2つのTransaldolase 1アイソフォームによる代謝ネットワークの制御2016

    • Author(s)
      盛山哲嗣、田中秀、福本昌宏、辻村賢二、山田幸司、中山泰宗、馬場健史、福崎英一郎、米田悦啓、岡正啓
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-16H04789
  • 1.  YAMADA TAKETO (60230463)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 17 results
  • 2.  吉田 彩舟 (40772744)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 3.  Yoneda Yoshihiro (80191667)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 4.  岡 正啓 (40432504)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 5.  林 睦 (60327575)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 6.  MIYAMOTO Yoichi (10379084)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  MORIYAMA Tetsuji (50627990)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 8.  HIKIDA Takatoshi (70421378)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  TOMONAGA Takashi (80227644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  西田 浩子 (80317130)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 11.  立花 利公 (80163476)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  持丸 雄太 (50884623)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  OIKAWA Tsunekazu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  波多野 良
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 15.  高橋 勇人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  山上 淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  服部 豊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  吉田 清嗣
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 19.  坪田 昭人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  松田 達志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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