Fujita Hidetoshi 藤田英俊

… Alternative Names

Researcher Number	90571802
Other IDs
Affiliation (Current)	2020: 東京医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2013 – 2019: 東京医科大学, 医学部, 講師 2012: 東京医科大学, 医学部, 助教 2010 – 2011: 独立行政法人放射線医学総合研究所, 重粒子医科学センター, 研究員
Review Section/Research Field	Principal Investigator Radiation science / Collagenous pathology/Allergology / Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Pathological medical chemistry / Collagenous pathology/Allergology
Keywords	Principal Investigator 小胞体ストレス / シノビオリン / 炭素線 / 肺線維症 / MMP-9 / 系統差 / 肺晩期障害 / 肺線維化 / 放射線治療 / 肺照射 … More Except Principal Investigator 遺伝子 / タンパク質 / 動物 / 関節リウマチ / 滑膜細胞 / 小胞体関連分解 / 骨代謝 / サルコペニア / 遺伝子改変動物 / タンパク質分解 / シノビオリン / ユビキチン化 / ゲノム解析 / 感受性遺伝子 / インスリン抵抗性 / 疾患感受性遺伝子 / 遺伝素因 / 2型糖尿病 / ゲノム Less

ウォルフラム症候群の糖尿病発症の分子機序の解明Principal InvestigatorOngoing
- Principal Investigator
  
  藤田英俊
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tokyo Medical University
Involvement of Synoviolin in Muscle metabolism via two distinct pathways
- Principal Investigator
  
  Nakajima Toshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical University
Function of type 2 diabetes susceptibility genes SLC16A11/13
- Principal Investigator
  
  Hara Kazuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical University
The study of bone destruction mechanism of rheumatoid arthritis by synoviolin
- Principal Investigator
  
  YAGISHITA Naoko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  St. Marianna University School of Medicine
Analysis of mechanisms of rheumatoid arthritis associated with obesityPrincipal Investigator
- Principal Investigator
  
  Fujita Hidetoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Tokyo Medical University
Establishment of the molecule mechanism on the suppression of metastasis by radiationPrincipal Investigator
- Principal Investigator
  
  FUJITA Hidetoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Tokyo Medical University
Analysis of molecular mechanisms of lung injury by carbon-ion therapyPrincipal Investigator
- Principal Investigator
  
  FUJITA Hidetoshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book Patent

[Book] New Developments in the Pathogenesis of Rheumatoid Arthritis　Synoviolin is a novel pathogenic factor of arthropathy and chronic inflammation.2016
- Author(s)
  edited by Lazaros I. Sakkas　Yagishita N, Aratani S, Fujita H, Yamano Y, Nishioka K, Nakajima T.
- Total Pages
  151
- Publisher
  INTECH
- Data Source
  KAKENHI-PROJECT-16H05157
[Journal Article] Novel Notch signaling inhibitor NS-1 suppresses nuclear translocation of the Notch intracellular domain.2019
- Author(s)
  Shibata K., Yoshimura Y., Kikuiri T., Hasegawa T., Taniguchi Y., Deyama Y., Suzuki K., Iida J
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 28 Pages: 1574-1584
- DOI
  10.3892/ijmm
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-21390499, KAKENHI-PROJECT-21591337, KAKENHI-PROJECT-24791801, KAKENHI-PROJECT-25893221, KAKENHI-PROJECT-26670479, KAKENHI-PROJECT-15H02567, KAKENHI-PROJECT-18K17028, KAKENHI-PUBLICLY-18H04851
[Journal Article] An E3 Ubiquitin Ligase, Synoviolin, Is Involved in the Degradation of Homocysteine-Inducible Endoplasmic Reticulum Protein.2018
- Author(s)
  Maeda T, Fujita Y, Tanabe-Fujimura C, Zou K, Liu J, Liu S, Kikuchi K, Shen X, Nakajima T, Komano H.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 41(6) Pages: 915-919
- NAID
  130007382735
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05157
[Journal Article] The NRF2-PGC-1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, Synoviolin, in a cecal ligation/perforation -induced septic mouse model.2018
- Author(s)
  Ishida Y, Fujita H, Aratani S, Chijiiwa M, Taniguchi N, Yokota M, Ogihara Y, Uoshima N, Nagashima F, Uchino H, Nakajima T.
- Journal Title
  
  Mol. Med. Rep.
  
  Volume: 18(2) Pages: 2467-2475
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05157
[Journal Article] Identification of the inhibitory activity of E3 ligase Syvn1 in walnut extract.2018
- Author(s)
  Fujita H, Aratani S, Yagishita N, Nishioka K, Nakajima T.
- Journal Title
  
  Mol. Med. Rep.
  
  Volume: 8(6) Pages: 5701-5708
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05157
[Journal Article] What occurs in human papilloma virus vaccination-associated neuro-immunopathic syndrome (HANS)? : implications of previous animal model studies2018
- Author(s)
  Aratani S, Kuroiwa Y, Fujita H, Usui C, Yokota S, Nakamura I, Nishioka K, Nakajima T
- Journal Title
  
  The Autonomic Nervous System (自律神経 @日本自律神経学会)
  
  Volume: 55(3) Pages: 165-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05157
[Journal Article] The NRF2-PGC-1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, Synoviolin, in a cecal ligation/perforation -induced septic mouse model.2018
- Author(s)
  Ishida Y, Fujita H, Aratani S, Chijiiwa M, Taniguchi N, Yokota M, Ogihara Y, Uoshima N, Nagashima F, Uchino H, Nakajima T.
- Journal Title
  
  Mol. Med. Rep
  
  Volume: 18(2) Pages: 2467-2475
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06972
[Journal Article] Identification of the inhibitory activity of E3 ligase Syvn1 in walnut extract.2018
- Author(s)
  Fujita H, Aratani S, Yagishita N, Nishioka K, Nakajima T.
- Journal Title
  
  Mol. Med. Rep
  
  Volume: 8(6) Pages: 5701-5708
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06972
[Journal Article] Inhibitory effects of ubiquitination of synoviolin by PADI4.2017
- Author(s)
  Aratani S, Fujita H, Yagishita N, Yamano Y, Okubo Y, Nishioka K, Nakajima T
- Journal Title
  
  Mol. Med. Rep
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05157
[Journal Article] A Study of Brain Metabolism in Fibromyalgia by Positron Emission Tomography.2017
- Author(s)
  Usui C, Soma T, Hatta K, Aratani S, Fujita H, Nishioka K, Machida Y, Kuroiwa Y, Nakajima T, Nishioka K
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Volume: 75 Pages: 120-127
- DOI
  10.1016/j.pnpbp.2017.01.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05157, KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-15K15091, KAKENHI-PROJECT-17K08675
[Journal Article] NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of homocysteine-inducible endoplasmic reticulum protein.2016
- Author(s)
  Maeda T, Tanabe-Fujimura C, Fujita Y, Abe C, Nanakida Y, Kun Zou, Liu J, Liu S, Nakajima T, Komano H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 473（4） Pages: 1276-1280
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05157
[Journal Article] Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress2016
- Author(s)
  Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K and Nakajima T
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 37 Pages: 1611-1618
- DOI
  10.3892/ijmm.2016.2566
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-15K15091, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-16H05157, KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-25461490, KAKENHI-PROJECT-26461478
[Journal Article] Inhibitory effects of ubiquitination of synoviolin by PADI42016
- Author(s)
  *Aratani S, Fujita H, Yagishita N, Yamano Y, Okubo Y, Nishioka K, Nakajima T
- Journal Title
  
  Mol. Med. Rep. in press
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461478
[Journal Article] A case of fibromyalgia involving pain throughout the body treated with site-specific targeted pain control2016
- Author(s)
  Nakajima F, Aratani S, Fujita H, Nakatani K, Makita K, Nakajima T
- Journal Title
  
  Springerplus
  
  Volume: 5 Pages: 1027-1027
- DOI
  10.1186/s40064-016-2572-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05157, KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-26461478, KAKENHI-PROJECT-15K15091
[Journal Article] Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin.2016
- Author(s)
  Aratani S, Fujita H, Kuroiwa Y, Usui C, Yokota S, Nakamura I, Nishioka K, Nakajima T
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Pages: 36943-36943
- DOI
  10.1038/srep36943
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05157, KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-15K15091
[Journal Article] NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of homocysteine-inducible endoplasmic reticulum protein.2016
- Author(s)
  Maeda T, Tanabe-Fujimura C, Fujita Y Abe C, Nanakida Y, Zou K, Liu J, Liu S, Nakajima T, Komano H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 473 Pages: 1276-1280
- DOI
  10.1016/j.bbrc.2016.04.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460100, KAKENHI-PROJECT-26461478
[Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β2015
- Author(s)
  Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
- Journal Title
  
  EMBO J
  
  Volume: 34 Pages: 1042-1042
- DOI
  10.15252/embj.201489897
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592282, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-26670479, KAKENHI-PROJECT-26670793, KAKENHI-PROJECT-26461478, KAKENHI-PROJECT-26461961, KAKENHI-PROJECT-15K15091, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-15K15667, KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293385
[Journal Article] Synoviolin inhibitor LS102 reduces endoplasmic reticulum stress-induced collagen synthesis in an in vitro model of stress-related interstitial pneumonia2015
- Author(s)
  Nakajima F, Aratani S, Fujita H, Yagishita N, Ichinose S, Makita K, Setoguchi Y, Nakajima T.
- Journal Title
  
  Int J Mol Med
  
  Volume: 35 Pages: 110-116
- DOI
  10.3892/ijmm.2014.1984
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592282, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-26461478
[Journal Article] Strain-dependent Damage in Mouse Lung After Carbon Ion Irradiation2012
- Author(s)
  Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T.
- Journal Title
  
  Int J Radiat Oncol Biol Phy
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791235
[Journal Article] Strain-dependent Damage in Mouse Lung After Carbon Ion Irradiation2012
- Author(s)
  Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T
- Journal Title
  
  International Journal of Radiation Oncology biology physics
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791235
[Journal Article] Attenuated lung fibrosis in interleukin 6 knock-out mice after C-ion irradiation to lung2011
- Author(s)
  Saito-Fujita T, Iwakawa M, Nakamura E, Nakawatari M, Fujita H, Moritake T, Imai T.
- Journal Title
  
  J Radiat Res
  
  Volume: 52 Pages: 270-277
- NAID
  10028111041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791235
[Journal Article] Subtypes of cervical adenosquamous carcinomas classified by EpCAM expression related to radiosensitivity2010
- Author(s)
  Imadome K, Iwakawa M, Nakawatari M, Fujita H, Kato S, Ohno T, Nakamura E, Ohkubo Y, Tamaki T, Kiyohara H, Imai T.
- Journal Title
  
  Cancer Biol. Ther
  
  Volume: 10 Pages: 1019-1026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791235
[Patent] ウォルフラム症候群の治療剤2019
- Inventor(s)
  中島　利博、藤田　英俊、他5名
- Industrial Property Rights Holder
  中島　利博、藤田　英俊、他5名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-061768
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16H05157
[Patent] ウォルフラム症候群の治療剤2019
- Inventor(s)
  中島、藤田、黒田、金蔵、平本、熊谷、青野
- Industrial Property Rights Holder
  中島、藤田、黒田、金蔵、平本、熊谷、青野
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-061768
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K06972
[Presentation] 脳内炎症に関わるキヌレニンの代謝機構の解明2018
- Author(s)
  藤田　英俊、石田　裕介、荒谷　聡子、横田　真穂、内野　博之、中島　利博
- Organizer
  日本線維筋痛症学会第 10 回学術集会
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] 脳内炎症に関わるキヌレニンの代謝機構の解明2018
- Author(s)
  藤田　英俊、石田　裕介、荒谷　聡子、横田　真穂、内野　博之、中島　利博
- Organizer
  日本線維筋痛症学会第 10 回学術集会
- Data Source
  KAKENHI-PROJECT-18K06972
[Presentation] モデルマウスを用いたヒトパピローマウイルスワクチン関連神経免疫異常症候群の病態解析2017
- Author(s)
  荒谷聡子、藤田英俊、黒岩義之、臼井千恵、横田俊平、中村郁郎、西岡久寿樹、中島利博
- Organizer
  日本線維筋痛症学会　第 9 回学術集会
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] Development of novel regulatory methods of mitochondrial functions2017
- Author(s)
  Fujita H, Aratani S, Yokota M and Nakajima T
- Organizer
  The 16th International Symposium on Advanced Technology (ISAT-16)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] A study on our novel murine model of Humanpapillomavirus-associated Neuroimmunopathic Syndrome (HANS)2017
- Author(s)
  Nakajima T, Aratani S, Fujita H, Kuroiwa Y, Usui C, Yokota S, Nakamura I, Nishioka K
- Organizer
  国際自律神経学会 ISAN2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] シノビオリン阻害剤の探索。2016
- Author(s)
  藤田英俊、荒谷聡子、西岡久寿樹、中島利博
- Organizer
  日本線維筋痛症学会第 8 回学術集会
- Place of Presentation
  KFC Hall & Rooms（東京　墨田区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] E3 ユビキチン化酵素シノビリオン阻害剤の臨床応用への可能性。2016
- Author(s)
  荒谷聡子、藤田英俊、西岡久寿樹、中島利博
- Organizer
  第 177 回東京医科大学医学会総会
- Place of Presentation
  (東京医科大学病院）東京都新宿区
- Year and Date
  2016-06-04
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] マウスモデルを用いたシノビオリン阻害活性を有する天然物の効果の検証。2016
- Author(s)
  藤田英俊、荒谷聡子、西岡久寿樹、中島利博
- Organizer
  日本線維筋痛症学会第 8 回学術集会
- Place of Presentation
  KFC Hall & Rooms（東京　墨田区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] ヒトにおけるシノビオリン阻害剤の効果の検証。2016
- Author(s)
  藤田英俊、荒谷聡子、西岡久寿樹、中島利博
- Organizer
  日本線維筋痛症学会第 8 回学術集会
- Place of Presentation
  KFC Hall & Rooms（東京　墨田区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] Synoviolin is a key regulator in chronic inflammation2016
- Author(s)
  藤田英俊、荒谷聡子、須藤カツ子、稲津正人、原直美、内野博之、西岡久寿樹、中島利博
- Organizer
  第 5 回医薬工 3 大学包括連携推進シンポジウム
- Place of Presentation
  (東京医科大学病院）東京都新宿区
- Year and Date
  2016-06-18
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] リウマチ発症因子シノビオリンによるエネルギー代謝調節の解明。2016
- Author(s)
  藤田英俊
- Organizer
  第17 回運動器科学研究会
- Place of Presentation
  大阪大学中之島センター（大阪府　大阪市）
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] E3 Ubiquitin ligase synoviolin inhibitors has effects on obesity.2016
- Author(s)
  Aratani S, Fujita H, Yagishita N*, Yokota M, Nishioka K, Nakajima T
- Organizer
  International Conference on Obesity and Chronic Diseases(WCC 2016)
- Place of Presentation
  Las Vegas(USA)
- Year and Date
  2016-07-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] リウマチ発症因子シノビオリンによるエネルギー代謝調節の解明。2016
- Author(s)
  藤田英俊
- Organizer
  第17 回運動器科学研究会
- Place of Presentation
  （大阪大学中之島センター）大阪府大阪市
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] シノビオリン阻害剤の探索。2016
- Author(s)
  藤田英俊、荒谷聡子、西岡久寿樹、中島利博
- Organizer
  日本線維筋痛症学会第 8 回学術集会
- Place of Presentation
  （KFC Hall&Rooms)東京都墨田区
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] 関節リウマチにおける転写後修飾による多重化シグナル調節機構の解析。2016
- Author(s)
  荒谷聡子、藤田英俊、八木下尚子*、山野嘉久*、西岡久寿樹、中島利博
- Organizer
  第 3 回 JCR ベーシックリサーチカンファレンス
- Place of Presentation
  （アキバホール）東京都千代田区
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] ヒトにおけるシノビオリン阻害剤の効果の検証。2016
- Author(s)
  藤田英俊、荒谷聡子、西岡久寿樹、中島利博
- Organizer
  日本線維筋痛症学会第 8 回学術集会
- Place of Presentation
  (KFCHall&Rooms)東京都墨田区
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] 関節リウマチにおける転写後修飾による多重化シグナル調節機構の解析。2016
- Author(s)
  荒谷聡子、藤田英俊、八木下尚子、山野嘉久、西岡久寿樹、中島利博
- Organizer
  第 3 回 JCR ベーシックリサーチカンファレンス
- Place of Presentation
  アキバホール（東京　千代田区）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] リウマチ発症因子シノビオリンによる新規エネルギー代謝機構の解明。2016
- Author(s)
  藤田英俊、荒谷聡子、八木下尚子、山野嘉久、須藤カツ子、内野博之、西岡久寿樹、中島利博
- Organizer
  第 3 回 JCR ベーシックリサーチカンファレンス
- Place of Presentation
  アキバホール（東京　千代田区）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16H05157
[Presentation] シノビオリン阻害剤の実用化に向けて。2016
- Author(s)
  荒谷聡子、藤田英俊、八木下尚子*、中島若巳、西岡久寿樹、中島利博
- Organizer
  第 5 回医薬工 3 大学包括連携推進シンポジウム
- Place of Presentation
  (東京医科大学病院）東京都新宿区
- Year and Date
  2016-06-18
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] リウマチ発症因子シノビオリンによる新規エネルギー代謝機構の解明。2016
- Author(s)
  藤田英俊、荒谷聡子、八木下尚子*、山野嘉久*、須藤カツ子*、内野博之、西岡久寿樹、中島利博
- Organizer
  第 3 回 JCR ベーシックリサーチカンファレンス
- Place of Presentation
  （アキバホール）東京都千代田区
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] E3 Ubiquitin ligase synoviolin inhibitors has effects on obesity2016
- Author(s)
  Aratani S, Fujita H, Yagishita N*, Yokota M, Nishioka K, Nakajima T
- Organizer
  International Conference on Obesity and Chronic Diseases (ICOCD-2016)
- Place of Presentation
  Las Vegas(USA)
- Year and Date
  2016-07-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] マウスモデルを用いたシノビオリン阻害活性を有する天然物の効果の検証。2016
- Author(s)
  藤田英俊、荒谷聡子、西岡久寿樹、中島利博
- Organizer
  日本線維筋痛症学会第 8 回学術集会
- Place of Presentation
  (KFC Hall&Rooms)東京都墨田区
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] 慢性炎症に関わるシノビオリンの新規エネルギー代謝調節機構2015
- Author(s)
  藤田英俊、荒谷聡子、八木下尚子、須藤カツ子、中島若巳、内野博之、西岡久寿樹、中島利博
- Organizer
  BMB2015 (第38回　日本分子生物学会年会、第88回日本生化学会大会　合同大会）
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26670479
[Presentation] 慢性炎症と肥満とをつなぐシノビリオンにおるエネルギー代謝調節機構2015
- Author(s)
  藤田英俊、荒谷聡子、中島利博、須藤カツ子、中島若巳、稲津正人、西岡久寿樹、原直美、内野博之
- Organizer
  第175回東京医科大学医学会総会
- Place of Presentation
  東京医科大学
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-26670479
[Presentation] 慢性炎症に機能するシノビオリンの新しい生体機能2015
- Author(s)
  藤田英俊
- Organizer
  第 16回運動器科学研究会
- Place of Presentation
  南日本新聞社みなみホール、鹿児島
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26670479
[Presentation] 慢性炎症に関わるシノビオリンの新しい生体機能2015
- Author(s)
  藤田　英俊、荒谷聡子、八木下尚子、西岡久寿樹、中島利博
- Organizer
  日本線維筋痛症学会第7回学術集会
- Place of Presentation
  ベルサール新宿
- Year and Date
  2015-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-26670479
[Presentation] リウマチ発症因子シノビオリンによるエネルギー代謝調節機構2014
- Author(s)
  藤田英俊、荒谷聡子、中島利博、中島若巳、西岡久寿樹、諸田沙織、内野博之、須藤カツ子
- Organizer
  第174回東京医科大学医学会総会
- Place of Presentation
  東京医大（東京）
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-26670479
[Presentation] E3ユビキチンリガーセであるシノビオリンによる体重制御機構2014
- Author(s)
  藤田英俊、荒谷聡子、八木下尚子、西岡久寿樹、中島利博
- Organizer
  第58回日本リウマチ学会
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-26670479
[Presentation] Combination therapy of carbon-ion irradiation and dendritic cell immunotherapy in mouse lung metastatic model2013
- Author(s)
  藤田英俊、荒谷聡子、中島利博
- Organizer
  第172回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Year and Date
  2013-11-02
- Data Source
  KAKENHI-PROJECT-24659577
[Presentation] 放射線による転移抑制機構の解析2013
- Author(s)
  藤田　英俊
- Organizer
  第172回　東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Data Source
  KAKENHI-PROJECT-24659577
[Presentation] 放射線による転移抑制機構の解析2012
- Author(s)
  藤田英俊、荒谷聡子、西岡久寿樹、中島利博
- Organizer
  第170回東京医科大学医学会総会
- Place of Presentation
  東京医科大学病院
- Year and Date
  2012-11-17
- Data Source
  KAKENHI-PROJECT-24659577
[Presentation] Combination therapy of carbon-ion irradiation and dendritic cell immunotherapy in mouse lung metastatic model.2012
- Author(s)
  藤田　英俊
- Organizer
  第170回東京医科大学医学会総会
- Place of Presentation
  東京医科大学
- Data Source
  KAKENHI-PROJECT-24659577
[Presentation] 重粒子線治療がもたらす生物学的効果-がん転移抑制と肺晩発障害-2011
- Author(s)
  藤田英俊
- Organizer
  第12回運動器科学研究会
- Place of Presentation
  高知
- Data Source
  KAKENHI-PROJECT-22791235
[Presentation] Strain-dependent intra-alveolar hemorrhage with the accumulation of CD44 and Mac3 positive cells after carbon-ion irradiation2011
- Author(s)
  Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T
- Organizer
  14th International Congress of Radiation Research (ICRR'2011)
- Place of Presentation
  Warsaw, Poland
- Data Source
  KAKENHI-PROJECT-22791235
[Presentation] 重粒子線治療がもたらす生物学的効果-がん転移抑制と肺晩発障害-2011
- Author(s)
  藤田英俊
- Organizer
  運動器科学研究会
- Place of Presentation
  高知県土佐ロイヤルホテル
- Year and Date
  2011-09-02
- Data Source
  KAKENHI-PROJECT-22791235
[Presentation] 炭素イオン線誘発肺線維症における肺組織りモデリング関連タンパク質の系統間発現解析2011
- Author(s)
  藤田英俊
- Organizer
  日本放射線影響学会
- Place of Presentation
  兵庫県神戸商工会議所会館
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22791235
[Presentation] 炭素イオン線誘発肺線維症における肺組織リモデリング関連タンパク質の系統間発現解析2011
- Author(s)
  藤田英俊、中渡美也子、中村悦子、森竹浩之、下川卓志、今井高志
- Organizer
  第54回日本放射線影響学会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-22791235
[Presentation] Strain-dependent intra-alveolar hemorrhage with the accumulation of CD44 and Mac3 positive cells after carbon-ion irradiation2011
- Author(s)
  Moritake T, Fujita H, Yanagisawa M, Nakawatari M, Imadome K, Nakamura E, Iwakawa M, Imai T.
- Organizer
  14th International Congress of Radiation Research
- Place of Presentation
  Warszawa
- Data Source
  KAKENHI-PROJECT-22791235
[Presentation] Reduction of lung fibrosis aftercarbon-ion irradiation in Interleukin-6 knock-out mice2010
- Author(s)
  Fujita H, Saito-Fujita T, Iwakawa M, Nakamura E, Nakawatari M, Moritake T and Imai T.
- Organizer
  第53回日本放射線影響学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22791235
[Presentation] The role of E3 ubiquitin ligase Synoviolin in bone destruction of rheumatoid arthritis.
- Author(s)
  Yagishita N, Aratani S, Fujita H, Yamano Y, Nishioka K, Nakajima T.
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京都（港区）〔グランドプリンスホテル新高輪〕
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26461478
[Presentation] リウマチ発症因子シノビオリンによる新規エネルギー代謝調節機構
- Author(s)
  藤田英俊
- Organizer
  第15回運動器科学研究会
- Place of Presentation
  ベルサール三田（東京）
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-26670479

1. YAGISHITA Naoko (40367389)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
2. Nakajima Toshihiro (90260752)

# of Collaborated Projects: 2 results

# of Collaborated Products: 35 results
3. 荒谷聡子 (40387064)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
4. Hara Kazuo (50359600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 稲津正人 (00297269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 熊谷勝義 (20567911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAWAHARA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SATO Tomoo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. YAMANO Yoshihisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. ARAYA Natsumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 西順一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
12. 藤井亮爾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 吉村善隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 小林圭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 佐伯武頼

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 玉川俊次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 澤田俊輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 福永真佐美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 鈴木利治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 伊藤隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 丸山征郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 須藤カツ子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 前田智司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujita Hidetoshi 藤田 英俊

FUJITA Hidetoshi 藤田 英俊

Research Projects

Research Products

Co-Researchers

ウォルフラム症候群の糖尿病発症の分子機序の解明Principal InvestigatorOngoing

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Involvement of Synoviolin in Muscle metabolism via two distinct pathways

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Function of type 2 diabetes susceptibility genes SLC16A11/13

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The study of bone destruction mechanism of rheumatoid arthritis by synoviolin

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Analysis of mechanisms of rheumatoid arthritis associated with obesityPrincipal Investigator

Principal Investigator

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Establishment of the molecule mechanism on the suppression of metastasis by radiationPrincipal Investigator

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Analysis of molecular mechanisms of lung injury by carbon-ion therapyPrincipal Investigator

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[Book] New Developments in the Pathogenesis of Rheumatoid Arthritis Synoviolin is a novel pathogenic factor of arthropathy and chronic inflammation.2016

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[Journal Article] Novel Notch signaling inhibitor NS-1 suppresses nuclear translocation of the Notch intracellular domain.2019

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[Journal Article] An E3 Ubiquitin Ligase, Synoviolin, Is Involved in the Degradation of Homocysteine-Inducible Endoplasmic Reticulum Protein.2018

Author(s)

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NAID

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[Journal Article] The NRF2-PGC-1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, Synoviolin, in a cecal ligation/perforation -induced septic mouse model.2018

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[Journal Article] Identification of the inhibitory activity of E3 ligase Syvn1 in walnut extract.2018

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[Journal Article] What occurs in human papilloma virus vaccination-associated neuro-immunopathic syndrome (HANS)? : implications of previous animal model studies2018

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[Journal Article] The NRF2-PGC-1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, Synoviolin, in a cecal ligation/perforation -induced septic mouse model.2018

Author(s)

Journal Title

Data Source

[Journal Article] Identification of the inhibitory activity of E3 ligase Syvn1 in walnut extract.2018

Author(s)

Fujita Hidetoshi 藤田英俊

FUJITA Hidetoshi 藤田英俊

[Book] New Developments in the Pathogenesis of Rheumatoid Arthritis　Synoviolin is a novel pathogenic factor of arthropathy and chronic inflammation.2016