ISHIKAWA Misao 石川美佐緒

Researcher Number	90582445
Affiliation (Current)	2023: 鶴見大学, 歯学部, 講師
Affiliation (based on the past Project Information) *help	2023: 鶴見大学, 歯学部, 講師 2013 – 2022: 鶴見大学, 歯学部, 助教 2021: 鶴見大学, 歯学部, 講師 2012: 鶴見大学, 歯学部, 学部助手
Review Section/Research Field	Principal Investigator Basic Section 57070:Developmental dentistry-related / Orthodontic/Pediatric dentistry / Orthodontics/Pediatric dentistry Except Principal Investigator Basic Section 57070:Developmental dentistry-related / Orthodontics/Pediatric dentistry
Keywords	Principal Investigator 歯根膜線維芽細胞 / アルカリフォスファターゼ / 骨芽細胞 / マイクロアレイ / RT-PCR法 / バイサルファイトシーケンス / 歯科矯正治療 / エピジェネティクス / 矯正力 / 歯の移動 … More / ナトリウム依存性リン酸トランスポーター / リン酸 / ナトリウム依存性リン酸トランスポター / 高リン血症 / 高リン血症モデルラット / フォスフォノギ酸 … More Except Principal Investigator 歯根膜 / メカニカルストレス / 骨芽細胞 / Nrf2 / エピジェネティクス / G9a / 歯肉 / Glp / H3K9 / H3K9 metyltransferases / H3k9me1 / H3k9me2 / H3k9me3 / マイクロRNA / 矯正学的歯の移動 / 歯槽骨 / 歯周組織 / シグナル伝達 / 歯根膜細胞 / 歯の移動 / 破骨細胞 / 骨形成 / 骨吸収 / サイトカイン / ENPP1 / 石灰化 / ピロリン酸 / 歯根膜線維芽細胞 / エクソソーム / 骨代謝 / 線維芽細胞 / 運命 / エピゲノム / 分化 / 瘢痕形成 / 唇顎口蓋裂 / EMT / 細胞膜透過性ペプチド Less

歯髄・歯根膜細胞間の異所性石灰化耐性相違における細胞内リン酸流入機構の関与Principal Investigator
- Principal Investigator
  
  石川美佐緒
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Tsurumi University
Exploration for exosome-borne signal transduction during alveolar bone remodeling under orthodontic force application
- Principal Investigator
  
  新井千博
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Tsurumi University
Exploration for epigenomic regulation of the cell fate among gingival and periodontal ligament fibroblasts
- Principal Investigator
  
  中村芳樹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Tsurumi University
Inhibition of scar formation by Nrf2 activating via cell-penetrating peptide
- Principal Investigator
  
  勝又裕太
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Tsurumi University
Inhibition of abnormal calcification by augmented ENPP1 via Nrf2
- Principal Investigator
  
  菅崎弘幸
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Tsurumi University
Basic Study on the Differentiation Mechanism of Periodontal Ligament Fibroblasts by Phosphoric Acid dependent on ALP ActivityPrincipal Investigator
- Principal Investigator
  
  Ishikawa Misao
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Tsurumi University
Elucidation of the epigenetically regulation of the phenotype of the periodontal ligament fibroblast
- Principal Investigator
  
  Yoshiki Nakamura
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Tsurumi University
Elucidation of the microRNA-mediated control of the alveolar bone metabolism by PDL cells under each mechanical stresses
- Principal Investigator
  
  Noda Koji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Tsurumi University
Study of osteoblasts differentiation of periodontal ligament fibroblasts by epigenetic control in tension zone during orthodontic tooth movementPrincipal Investigator
- Principal Investigator
  
  Ishikawa Misao
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Tsurumi University
Research of marker gene expression by epigenetic control in human periodontal ligament fibroblastsPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Misao
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Tsurumi University

All 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in mice.2022
- Author(s)
  Hayakawa Y, Suita K, Ohnuki Y, Mototani Y, Ishikawa M, Ito A, Nariyama M, Morii A, Kiyomoto K, Tsunoda M, Matsuo I, Kawahara H, Okumura S
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 72 Pages: 2-16
- DOI
  10.1186/s12576-022-00826-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06862, KAKENHI-PROJECT-18K09848, KAKENHI-PROJECT-19K24109, KAKENHI-PROJECT-20K10305, KAKENHI-PROJECT-21K17171
[Journal Article] Effects of chronic Porphylomonas gingivalis lipopolysaccharide infusion on cardiac function in mice.2021
- Author(s)
  Matsuo I, Ohnuki Y, Suita K, Ishikawa M, Mototani Y, Ito A, Hayakawa Y, Nariyama M, Morii A, Kiyomoto K, Tsunoda M, Gomi K, Okumura S
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 63 Pages: 394-400
- DOI
  10.1016/j.job.2021.10.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06862, KAKENHI-PROJECT-18K09848, KAKENHI-PROJECT-19K24109, KAKENHI-PROJECT-17K11977, KAKENHI-PROJECT-20K10304, KAKENHI-PROJECT-20K10305, KAKENHI-PROJECT-21K10242, KAKENHI-PROJECT-21K17171
[Journal Article] Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte DNA damage in mice2020
- Author(s)
  Yagisawa Y, Suita K, Ohnuki Y, Ishikawa M, Mototani Y, Ito A, Matsuo I, Hayakawa Y, Nariyama M, Umeki D, Saeki Y, Amitani Y, Nakamura Y, Tomonari H, Okumura
- Journal Title
  
  PLOS ONE
  
  Volume: 15(7)
- DOI
  10.1371/journal.pone.0236547
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11977, KAKENHI-PROJECT-18K06862, KAKENHI-PROJECT-18K09848, KAKENHI-PROJECT-20K10304, KAKENHI-PROJECT-20K10305, KAKENHI-PROJECT-17K12067
[Journal Article] Phosphate Through the Sodium-Dependent Phosphate Cotransporters, Pit-1 and Pit-2 is the Key Factor of Periodontal Ligament Calcification2018
- Author(s)
  Ishikawa Misao、Matsuzawa Ayami、Itohiya Kanako、Nakamura Yoshiki
- Journal Title
  
  J. hard tissue biol.
  
  Volume: 27 Issue: 4 Pages: 321-326
- DOI
  10.2485/jhtb.27.321
- NAID
  40021727336
- ISSN
  1341-7649, 1880-828X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09848
[Journal Article] Orthodontic tensile strain induces angiogenesis via type IV collagen degradation by matrix metalloproteinase-12.2017
- Author(s)
  Narimiya, T. Wada, S. Kanzaki, H. Ishikawa, M. Tsuge, A. Yamaguchi, Y. Nakamura, Y.
- Journal Title
  
  Journal of periodontal research
  
  Volume: 印刷中 Pages: 1-11
- DOI
  10.1111/jre.12453
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11376, KAKENHI-PROJECT-16K11797, KAKENHI-PROJECT-16H05552, KAKENHI-PROJECT-15K11356
[Journal Article] Occlusal hypofunction mediates alveolar bone apposition via relative augmentation of TGF-β signaling by decreased Asporin production in rats.2016
- Author(s)
  Kanako Itohiya Hiroyuki Kanzaki Misao Ishikawa Satoshi Wada Yutaka Miyamoto Tsuyoshi Narimiya Yoshiki Nakamura
- Journal Title
  
  Dental, Oral and Craniofacial Research
  
  Volume: 3 Pages: 1-8
- DOI
  10.15761/docr.1000192
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11376
[Journal Article] Nrf2 activation attenuates both orthodontic tooth movement and relapse.2015
- Author(s)
  Kanzaki H, Shinohara F, Itohiya-Kasuya K, Ishikawa M, Nakamura Y.
- Journal Title
  
  J Dent Res
  
  Volume: 94 Pages: 787-794
- DOI
  10.1177/0022034515577814
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11356
[Presentation] 咬合異常によるストレスはレニンアンジオテンシン系を介し心筋のアポトーシスを引き起こす.2021
- Author(s)
  伊藤愛子, 大貫芳樹, 吹田憲治, 石川美佐緒, 松尾一朗, 早川佳男, 成山明具美, 友成　博, 奥村　敏.
- Organizer
  第63回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] Mitf 遺伝子変異は酸化ストレスにより咬筋組織リモデリングを誘導する.2021
- Author(s)
  成山明具美, 大貫芳樹, 吹田憲治, 伊藤愛子, 石川美佐緒, 松尾一朗, 早川佳男, 朝田芳信, 奥村　敏.
- Organizer
  第63回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] 急性症状を伴った顎関節ピロリン酸カルシウム結晶沈着症の１例.2021
- Author(s)
  井出信次, 石川美佐緒, 豊田長隆, 下田信治, 里村一人.
- Organizer
  第55回NPO法人日本口腔科学会関東地方部会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] 咬合異常により惹起された慢性交感神経刺激状態による心機能障害に対する抗ヘルペス薬(ビダラビン)の予防効果.2021
- Author(s)
  早川佳男, 大貫芳樹, 吹田憲治, 石川美佐緒, 伊藤愛子, 松尾一朗, 清本賢一, 角田通則, 河原　博, 奥村　敏.
- Organizer
  第63回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] Porphylomonas gingivalis 由来 LPS の慢性投与下における心疾患発症メカニズムの解明.2021
- Author(s)
  松尾一朗, 吹田憲治, 早川佳男, 伊藤愛子, 石川美佐緒, 清本賢一, 角田通則, 大貫芳樹, 五味一博, 奥村　敏.
- Organizer
  第63回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] レニン-アンジオテンシン系が歯周病菌由来 LPS による心筋線維化に及ぼす影響.2021
- Author(s)
  清本賢一, 吹田憲治, 大貫芳樹, 松尾一朗, 角田通則, 森井彰仲, 伊藤愛子, 石川美佐緒, 奥村　敏, 五味一博.
- Organizer
  第63回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] 咬合異常によるストレスはレニンアンジオテンシン系を介し心機能に影響を及ぼす2020
- Author(s)
  伊藤愛子、大貫芳樹、梅木大輔、吹田憲治、石川美佐緒、八木澤由佳、松尾一朗、早川佳男、友成博、奥村敏
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] Role of renin-angiotensin system for the development of cardiac dysfunction induced by occlusal disharmony2020
- Author(s)
  Ito A, Umeki D, Ishikawa M, Yagisawa Y, Okumura S, Tomonari H
- Organizer
  The 9th InternationalOrthodontic Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] Phosphate via the Sodium-Dependent Phosphate Cotransporters is the Key Factor of Periodontal Ligament Calcification2020
- Author(s)
  Misao Ishikawa, Ayami Matsuzawa, Shinji Shimoda
- Organizer
  The 9th InternationalOrthodontic Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] Porphylomonas gingivalis由来LPSの慢性投与下におけるβ-アドレナリン受容体シグナルを介した心機能低下に対する影響2020
- Author(s)
  松尾一朗、吹田憲治、早川佳男、清本賢一、角田通則、伊藤愛子、石川美佐緒、大貫芳樹、五味一博、奥村敏
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] 口腔ストレスに起因する心疾患に対する抗ヘルペス薬 (ビダラビン) の予防効果2020
- Author(s)
  早川佳男、吹田憲治、大貫芳樹、石川美佐緒、伊藤愛子、八木澤由佳、松尾一朗、奥村敏、河原博
- Organizer
  第40回日本歯科薬物療法学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] 抗ヘルペス薬（ビダラビン）は咬合異常に起因する心機能障害に対して心機能に影響を及ぼすことなく予防効果を示す2020
- Author(s)
  早川佳男、大貫芳樹、吹田憲治、石川美佐緒、伊藤愛子、松尾一朗、清本賢一、角田通則、河原博、奥村敏
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] 歯根膜におけるナトリウム依存性リン酸トランスポーター (Pit-1/Pit-2) の発現とその局在2019
- Author(s)
  石川美佐緒、松澤綾美、下田信治
- Organizer
  第124回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-18K09848
[Presentation] 歯の移動時の歯根膜におけるメチル化修飾に関する免疫組織化学的研究2017
- Author(s)
  石川美佐緒、松澤綾美、千葉敏江、下田信治
- Organizer
  第122回　日本解剖学会総会・全国学術集会
- Place of Presentation
  長崎大学坂本キャンパス（長崎県長崎市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-26861802
[Presentation] Asporinは咬合機能低下に伴う新生歯槽骨添加における制御因子である2016
- Author(s)
  糸日谷佳菜子、菅崎弘幸、石川美佐緒、下田信治、中村芳樹
- Organizer
  第75回日本矯正歯科学会
- Place of Presentation
  アスティ徳島(徳島県徳島市)
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-15K11356
[Presentation] 歯髄内血管および全身の動脈の石灰変性との関連に関する研究2016
- Author(s)
  関水　健宏、塩崎　一成、石川　美佐緒、千葉　敏江、下田　信治、細谷　哲康
- Organizer
  第121回日本解剖学会総会・全国学術集会
- Place of Presentation
  ビックパレット福島（福島県郡山市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26861802
[Presentation] Sodium-Dependent Phosphate Cotransporters are essential in the Calcification by human Periodontal Ligament Cell2016
- Author(s)
  石川美佐緒、糸日谷佳菜子、高野吉郎、中村芳樹、下田信治
- Organizer
  第58回　歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-26861802
[Presentation] 歯の移動時における歯根膜中のH3K9メチル化修飾の免疫組織化学的研究2015
- Author(s)
  石川　美佐緒、糸日谷　佳菜子、菅崎　弘幸、高野　吉郎、中村　芳樹、下田　信治
- Organizer
  第74回日本矯正歯科学会大会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26861802
[Presentation] Asporinは咬合機能低下に伴う歯根膜腔狭窄の制御因子である2015
- Author(s)
  糸日谷　佳菜子、菅崎　弘幸、石川　美佐緒、下田　信治、中村　芳樹
- Organizer
  第74回日本矯正歯科学会
- Place of Presentation
  福岡国際会議場(福岡市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K11356
[Presentation] Asporinは咬合機能低下に伴う歯根膜腔狭窄の制御因子である2015
- Author(s)
  糸日谷　佳菜子、菅崎　弘幸、石川　美佐緒、下田　信治、中村　芳樹
- Organizer
  第74回日本矯正歯科学会大会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26861802
[Presentation] 石灰化培地におけるヒト歯根膜線維芽細胞の遺伝子発現について探索
- Author(s)
  石川　美佐緒、野村　義明、粕谷　佳菜子、花田　信弘、中村　芳樹
- Organizer
  第73回日本矯正歯科学会大会
- Place of Presentation
  幕張メッセ（千葉県、千葉市）
- Year and Date
  2014-10-20 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-26861802

1. 菅崎弘幸 (30333826)

# of Collaborated Projects: 7 results

# of Collaborated Products: 5 results
2. 和田悟史 (20581119)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. Yoshiki Nakamura (10097321)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. 勝又裕太 (70886423)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 遠山俊之介 (10908940)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. Noda Koji (10148059)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 新井千博 (10460221)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 宮本豊 (00633588)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 高野吉郎 (90126425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 下田信治 (30139620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 成宮毅 (00803074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NARIYAMA Megumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 奥村敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
14. 伊藤愛子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 吹田憲治

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
16. 大貫芳樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 梅木大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIKAWA Misao 石川 美佐緒

Research Projects

Research Products

Co-Researchers

歯髄・歯根膜細胞間の異所性石灰化耐性相違における細胞内リン酸流入機構の関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration for exosome-borne signal transduction during alveolar bone remodeling under orthodontic force application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration for epigenomic regulation of the cell fate among gingival and periodontal ligament fibroblasts

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inhibition of scar formation by Nrf2 activating via cell-penetrating peptide

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inhibition of abnormal calcification by augmented ENPP1 via Nrf2

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Basic Study on the Differentiation Mechanism of Periodontal Ligament Fibroblasts by Phosphoric Acid dependent on ALP ActivityPrincipal Investigator

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Elucidation of the epigenetically regulation of the phenotype of the periodontal ligament fibroblast

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Elucidation of the microRNA-mediated control of the alveolar bone metabolism by PDL cells under each mechanical stresses

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Study of osteoblasts differentiation of periodontal ligament fibroblasts by epigenetic control in tension zone during orthodontic tooth movementPrincipal Investigator

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Research of marker gene expression by epigenetic control in human periodontal ligament fibroblastsPrincipal Investigator

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[Journal Article] Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in mice.2022

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[Journal Article] Effects of chronic Porphylomonas gingivalis lipopolysaccharide infusion on cardiac function in mice.2021

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[Journal Article] Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte DNA damage in mice2020

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[Journal Article] Phosphate Through the Sodium-Dependent Phosphate Cotransporters, Pit-1 and Pit-2 is the Key Factor of Periodontal Ligament Calcification2018

ISHIKAWA Misao 石川美佐緒