Ieguchi Katsuaki 家口勝昭

… Alternative Names

家口勝昭イエグチカツアキ

IEGUCHI Katsuaki 家口勝昭

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Researcher Number	90586348
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 大学共同利用機関等の部局等, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 昭和大学, 大学共同利用機関等の部局等, 講師 2021: 昭和大学, 大学共同利用機関等の部局等, 講師 2016 – 2017: 東京女子医科大学, 医学部, 助教 2013 – 2014: 東京女子医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related / General internal medicine(including psychosomatic medicine) / Respiratory surgery / Biological Sciences Except Principal Investigator Biological Sciences
Keywords	Principal Investigator ephrin / Eph / 転移 / PD-L1 / がん / 交感神経 / 免疫逃避 / 腫瘍微小環境 / ADAM12 / ephrin-A1 … More / EphA2 / 自律神経 / βブロッカー / 交感神経β受容体遮断薬 / 転移前微小環境 / 炎症性サイトカイン / ADAM / 造血幹細胞 / ノルエピネフリン / ノルアドレナリン / カテコラミン / 腫瘍 … More Except Principal Investigator 増殖因子 / ケモカイン / 癌 / がん / 転移 / TLR / 内因性リガンド / 炎症 / ADAM12 / CCR2 / がん転移 / 自然免疫 / ephrinA1 / CCL2 / S100A8 / SAA3 / TLR4 Less

Analysis of EphA2/ephrin-A1-mediated PD-L1 expression and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  家口勝昭
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Showa University
Molecular mechanisms of EphA2/ephrin-A1-mediated immune escape in the tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Ieguchi Katsuaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Showa University
Role of the sympathetic nervous system in metastasisPrincipal Investigator
- Principal Investigator
  
  Ieguchi Katsuaki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Tokyo Women's Medical University
交感神経による血管支配におけるephrin-A1の機能解析Principal Investigator
- Principal Investigator
  
  家口勝昭
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Women's Medical University
Role of ephrin-A1 in lung metastasisPrincipal Investigator
- Principal Investigator
  
  IEGUCHI Katsuaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Tokyo Women's Medical University
Endogenous TLR4 ligands in tumor metastasis.
- Principal Investigator
  
  MARU Yoshiro
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Women's Medical University

All 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 血液内科2014
- Author(s)
  家口勝昭、丸義朗
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-25870760
[Journal Article] Savior or not: ADAM17 inhibitors overcome radiotherapy-resistance in non-small cell lung cancer2016
- Author(s)
  Ieguchi K, Maru Y.
- Journal Title
  
  J Thoracic Disease
  
  Volume: 8 Issue: 8 Pages: E813-E813
- DOI
  10.21037/jtd.2016.07.56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15417
[Journal Article] Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor.2015
- Author(s)
  Tomita T, Ieguchi K, Sawamura T, Maru Y
- Journal Title
  
  PLoS One
  
  Volume: 10(3) Issue: 3 Pages: e0118835-e0118835
- DOI
  10.1371/journal.pone.0118835
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25122716, KAKENHI-PROJECT-25293063, KAKENHI-PROJECT-25870760, KAKENHI-PROJECT-26440063
[Journal Article] LINGO-1 Protein Interacts with the p75 Neurotrophin Receptor in Intracellular Membrane Compartments2015
- Author(s)
  Meabon JS, De Laat R, Ieguchi K, Wiley JC, Hudson MP, Bothwell M
- Journal Title
  
  J Biol Chem
  
  Volume: 290(15) Issue: 15 Pages: 9511-20
- DOI
  10.1074/jbc.m114.608018
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25122716, KAKENHI-PROJECT-25870760
[Journal Article] ZFC3H1, a Zinc Finger Protein, Modulates IL-8 Transcription by Binding with Celastramycin A, a Potential Immune Suppressor2014
- Author(s)
  Tomita T, Ieguchi K, Coin F, Kato Y, Kikuchi H, Oshima Y, Kurata S, Maru Y
- Journal Title
  
  PLoS One
  
  Volume: 30 Issue: 9 Pages: e108957-e108957
- DOI
  10.1371/journal.pone.0108957
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390014, KAKENHI-PUBLICLY-25122716, KAKENHI-PROJECT-25870760, KAKENHI-PROJECT-26440063
[Journal Article] ADAM12-cleaved ephrin-A1 contributes to lung metastasis2014
- Author(s)
  Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, Duffy S, Coulthard M, Boyd A, Maru Y
- Journal Title
  
  Oncogene
  
  Volume: 33(17) Pages: 2179-2190
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] がん転移における炎症と血管新生2014
- Author(s)
  家口勝昭、丸義朗
- Journal Title
  
  血液内科
  
  Volume: 69(3) Pages: 349-55
- Data Source
  KAKENHI-PUBLICLY-25122716
[Journal Article] ADAM12-cleaved ephrin-A1 contributes to lung metastasis.2014
- Author(s)
  Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, Duffy SL, Coulthard MG, Boyd A, Maru Y.
- Journal Title
  
  Oncogene
  
  Volume: 未定 Issue: 17 Pages: 2179-90
- DOI
  10.1038/onc.2013.180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590347, KAKENHI-PROJECT-24501321, KAKENHI-PUBLICLY-25122716, KAKENHI-PROJECT-25860797, KAKENHI-PROJECT-25870760, KAKENHI-PROJECT-26640079
[Journal Article] An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R2013
- Author(s)
  Fujita M, Ieguchi K, Cedano-Prieto DM, Fong A, Wilkerson C, Chen JQ, Wu M, Lo SH, Cheung AT, Wilson MD, Cardiff RD, Borowsky AD, Takada YK, Takada Y
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Issue: 27 Pages: 19593-19603
- DOI
  10.1074/jbc.m113.470872
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25122716, KAKENHI-PROJECT-25870760
[Journal Article] Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 42013
- Author(s)
  Ieguchi K, Omori T, Komatsu A, Tomita T, Deguchi A, Maru Y
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 440(4) Pages: 623-629
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 42013
- Author(s)
  Ieguchi K, Omori T, Komatsu A, Tomita T, Deguchi A, Maru Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 440(4) Issue: 4 Pages: 623-629
- DOI
  10.1016/j.bbrc.2013.09.119
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008, KAKENHI-PROJECT-23590347, KAKENHI-PROJECT-24501321, KAKENHI-PUBLICLY-25122716, KAKENHI-PROJECT-25870760
[Presentation] Role of the sympathetic nervous system in lung metastasis2015
- Author(s)
  Ieguchi, K. and Maru Y
- Organizer
  2nd International symposium 2015 “Neuro-Vascular wiring”
- Place of Presentation
  関西セミナーハウス（京都府・左京区）
- Year and Date
  2015-01-18
- Data Source
  KAKENHI-PUBLICLY-25122716
[Presentation] Breakdown of the Eph/ephrin system in vascular endothelial cells causes lung metastasis2014
- Author(s)
  Ieguchi K, Tomita , Maru Y
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  京都市勧業館みやこめっせ（京都府・左京区）
- Year and Date
  2014-04-16
- Data Source
  KAKENHI-PROJECT-25870760
[Presentation] Breakdown of the Eph/ephrin system in vascular endothelial cells causes lung metastasis2014
- Author(s)
  Ieguchi, K., Tomita, T. and Maru, Y
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  京都市勧業館みやこめっせ（京都府・左京区）
- Year and Date
  2014-04-16
- Data Source
  KAKENHI-PUBLICLY-25122716
[Presentation] ADAM12-cleaved ephrin-A1 contributes to lung metastasis2013
- Author(s)
  Ieguchi Katsuaki, Tomita Takeshi, Yoshiro Maru
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PUBLICLY-25122716
[Presentation] ADAM12-cleaved ephrin-A1 contributes to lung metastasis.2013
- Author(s)
  Ieguchi Katsuaki, Tomita Takeshi, Yoshiro Maru
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜、日本
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] ADAM12-cleaved ephrin-A1 contributes to lung metastasis2013
- Author(s)
  Ieguchi Katsuaki, Tomita Takeshi, Yoshiro Maru
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25870760
[Presentation] Role of the sympathetic nervous system in lung metastasis
- Author(s)
  Ieguchi K, Maru Y
- Organizer
  2nd International symposium 2015 “Neuro-Vascular wiring”
- Place of Presentation
  関西セミナーハウス（京都府・左京区）
- Year and Date
  2015-01-18 – 2015-01-19
- Data Source
  KAKENHI-PROJECT-25870760

1. 和田聡 (30420102)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. MARU Yoshiro (00251447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. NAKAMURA Sachie (60313087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TSUKAHARA Fujiko (40119996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TOMITA Takeshi (20302242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. DEGUCHI Atsuko (10422932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. TAKITA Morichika (80533455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 倉田祥一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ieguchi Katsuaki 家口 勝昭

家口 勝昭 イエグチ カツアキ

IEGUCHI Katsuaki 家口 勝昭

Research Projects

Research Products

Co-Researchers

Analysis of EphA2/ephrin-A1-mediated PD-L1 expression and its clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of EphA2/ephrin-A1-mediated immune escape in the tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of the sympathetic nervous system in metastasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

交感神経による血管支配におけるephrin-A1の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of ephrin-A1 in lung metastasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Endogenous TLR4 ligands in tumor metastasis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 血液内科2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Savior or not: ADAM17 inhibitors overcome radiotherapy-resistance in non-small cell lung cancer2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LINGO-1 Protein Interacts with the p75 Neurotrophin Receptor in Intracellular Membrane Compartments2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ZFC3H1, a Zinc Finger Protein, Modulates IL-8 Transcription by Binding with Celastramycin A, a Potential Immune Suppressor2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ADAM12-cleaved ephrin-A1 contributes to lung metastasis2014

Author(s)

Journal Title

Data Source

[Journal Article] がん転移における炎症と血管新生2014

Author(s)

Journal Title

Data Source

[Journal Article] ADAM12-cleaved ephrin-A1 contributes to lung metastasis.2014

Author(s)

Journal Title

DOI

Data Source

Ieguchi Katsuaki 家口勝昭

家口勝昭イエグチカツアキ

IEGUCHI Katsuaki 家口勝昭