kokuho nariaki 國保成暁

Researcher Number	90595167
Affiliation (based on the past Project Information) *help	2018: 日本医科大学, 大学院医学研究科呼吸器内科学, 特別研究生 2018: 日本医科大学, 大学院医学研究科, 研究生 2017: 日本医科大学, 大学院医学研究科, 特別研究生 2016: 日本医科大学, 大学院医学研究科, ポストドクター 2015: 日本医科大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator バイオマーカー / 肺障害 / mTOR阻害薬 / 肺脂肪毒性 / 肺胞上皮傷害 / 肺胞サーファクタント / 上皮障害 / ｍTOR阻害薬 / 高脂血症 / 脂質異常症 … More / PPAR-γ / Pioglitazone / 脂質代謝ストレス / Temsirolimus / mTOR阻害薬肺障害 Less

Analyses of alveolar epithelial injury via lipid-related stress in mammalian target of rapamycin inhibitor-induced lung diseasePrincipal Investigator
- Principal Investigator
  
  kokuho nariaki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School

All 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Chronic Obstructive Pulmonary Disease2017
- Author(s)
  Kokuho N, Muro S, Azuma A
- Total Pages
  362
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K19433
[Book] Chronic Obstructive Pulmonary Disease, Germany2017
- Author(s)
  Kokuho N,Muro S,Azuma A
- Total Pages
  352
- Publisher
  Springer Book
- ISBN
  9789811008399
- Data Source
  KAKENHI-PROJECT-15K19433
[Book] びまん性肺疾患の分類と診断　病理診断と問題点　内科2016
- Author(s)
  寺崎泰弘, 國保成暁, 寺崎美佳, 功刀しのぶ
- Total Pages
  4
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-15K19433
[Book] 間質性肺炎の早期線維化巣におけるCanstatinの発現とその作用の解析2015
- Author(s)
  漆山博和, 寺崎泰弘, 山内康宏, 國保成暁, 寺崎美佳, 功刀しのぶ,
- Total Pages
  9
- Publisher
  厚生労働省難治性疾患政策研究事業
- Data Source
  KAKENHI-PROJECT-15K19433
[Journal Article] Analyses of alveolar epithelial injury via lipid-related stress in mammalian target of rapamycin inhibitor-induced lung disease.2019
- Author(s)
  Kokuho N, Terasaki Y, Kunugi S, Saito Y, Urushiyama H, Terasaki M, Hayashi H, Gemma A, Shimizu A.
- Journal Title
  
  Laboratory Investigation
  
  Volume: 2 Issue: 6 Pages: 853-865
- DOI
  10.1038/s41374-018-0158-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09630, KAKENHI-PROJECT-15K19433
[Journal Article] Prognostic Factors in the Acute Exacerbation of Idiopathic Pulmonary Fibrosis: A Retrospective Single-center Study2018
- Author(s)
  Atsumi K, Saito Y, Kuse N, Kobayashi K, Tanaka T, Kashiwada T, Inomata M, Kokuho N, Hayashi H, Kamio K, Fujita K, Abe S, Azuma A, Kubota K, Gemma A.
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 5 Pages: 655-661
- DOI
  10.2169/internalmedicine.9331-17
- NAID
  130006407627
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19433
[Journal Article] Localized pulmonary crystal-storing histiocytosis complicating pulmonary mucaosa-associated lymphoid tissue lymphoma presenting with multiple mass lesion.2017
- Author(s)
  Kokuho N, Terasaki Y, Kunugi S, Onda N, Urushiyama H, Terasaki M, Hino M, Gemma A, Hatori T, Shimizu A.
- Journal Title
  
  Human Pathology
  
  Volume: 印刷中 Pages: 180-186
- DOI
  10.1016/j.humpath.2016.10.028
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461203, KAKENHI-PROJECT-26461204, KAKENHI-PROJECT-17K09630, KAKENHI-PROJECT-15K19433
[Journal Article] Localized pulmonary crystal-storing histiocytosis complicating pulmonary mucosa-associated lymphoid tissue lymphoma presenting with multiple mass lesions.2017
- Author(s)
  Kokuho N, Terasaki Y, Kunugi S, Onda N, Urushiyama H, Terasaki M, Hino M, Gemma A, Hatori T, Shimizu A.
- Journal Title
  
  Hum Pathol
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19433
[Journal Article] XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts2017
- Author(s)
  Koichiro Kamio, Arata Azuma, Jiro Usuki, Kuniko Matsuda, Minoru Inomata, Nobuhiko Nishijima, Shioto Itakura, Hiroki Hayashi, Takeru Kashiwada, Nariaki Kokuho, Kenichiro Atsumi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe, Kaoru Kubota, Akihiko Gemma
- Journal Title
  
  Pulmonary Pharmacology & Therapeutics
  
  Volume: 44 Pages: 61-69
- DOI
  10.1016/j.pupt.2017.03.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461201, KAKENHI-PROJECT-26461202, KAKENHI-PROJECT-15K19433
[Journal Article] Role of canstatin in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts2016
- Author(s)
  Urushiyama H, Terasaki Y, Nagasaka S, Kokuho N, Terasaki M, Kunugi S, Mikami Y, Noguchi S, Horie M, Nagahama K, Yamauchi Y, Shimizu A, Nagase T
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 9 Pages: 12714-12722
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19433
[Journal Article] Pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis: a case report and literature review.2016
- Author(s)
  Kokuho N, Terasaki Y, Urushiyama H, Terasaki M, Kunugi S, Morimoto T, Azuma A, Usuda J, Gemma A, Eishi Y, Shimizu A.
- Journal Title
  
  Hum Pathol.
  
  Volume: 51 Pages: 57-63
- DOI
  10.1016/j.humpath.2015.12.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461203, KAKENHI-PROJECT-15K19433, KAKENHI-PROJECT-25461175, KAKENHI-PROJECT-26461204
[Journal Article] Nintedanib modulates surfactant protein-D expression in A549 human lung epithelial cells via the c-Jun N-terminal kinase-activator protein-1 pathway.2015
- Author(s)
  Kamio K, Usuki J, Azuma A, Matsuda K, Ishii T, Inomata M, Hayashi H, Kokuho N, Fujita K, Saito Y, Miya T, Gemma A.
- Journal Title
  
  Pulm Pharmacol Ther.
  
  Volume: 5539(15) Pages: 00036-00036
- DOI
  10.1016/j.pupt.2015.03.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-15K19433
[Presentation] The Analyses of Immunoglobulin Crystal Formation at Lung in Crystal Storing Histiosytosis and Crystalglobulinemia Syndrome2018
- Author(s)
  N. Kokuho, Y. Terasaki, K. Yusuke, S. Kunugi, M. Terasaki, Y. Takada, A. Gemma, A. Shimizu
- Organizer
  ATS Conference 2018, American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] The analyses of alveolar epithelial injury through the lipid metabolic stress in the mammalian target of rapamycin inhibitor induced lung disease2017
- Author(s)
  Nariaki Kokuho, Shinobu Kunugi, Yoshinobu Saito, Hirokazu Urushiyama, Mika Terasaki, Akihiko Gemma and Yasuhiro Terasaki
- Organizer
  ATS Conference 2017, American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] A case of sarcomatoid mesothelioma with osteosarcomatous elements of the pleura2016
- Author(s)
  Mika Terasaki, Yasuhiro Terasaki, Nariaki Kokuho, Shinobu Kunug, Kiyotaka Nagahama, Hirokazu Urushiyama, Yusuke Kajimoto, Akira Kajimoto
- Organizer
  American Thoracic Society: ATS Conference 2016
- Place of Presentation
  San fransisco, USA
- Year and Date
  2016-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] リウマチ肺モデルD1CCマウスの肺病変の病理形態学的に解析と高濃度水素分子(H2)水飲水の病変に対する効果2016
- Author(s)
  寺崎泰弘、國保成暁、漆山博和、寺崎美佳、功刀しのぶ、大澤郁朗、金沢智、清水章
- Organizer
  日本分子状水素医学生物学会　(第6回年会)
- Place of Presentation
  ワークピア横浜
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] 間質性肺炎の早期線維化巣におけるIV型コラーゲン由来血管新生抑制因子(canstatin)の産生とその機能についての解析2016
- Author(s)
  漆山博和, 寺﨑泰弘, 國保成暁, 功刀しのぶ, 山内康宏, 長瀬隆英
- Organizer
  日本呼吸器学会学術講演会（第56回）
- Place of Presentation
  京都国際会館
- Year and Date
  2016-04-08
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] 当院における抗ARS抗体陽性間質性肺炎の臨床病理学的検討2016
- Author(s)
  柏田建, 根井貴仁, 齋藤好信,中山幸治, 渥美健一郎, 林宏紀, 藤田和恵, 久保田馨, 吾妻安良太, 國保成暁, 功刀しのぶ, 寺崎泰弘, 弦間昭彦
- Organizer
  日本呼吸器学会学術講演会（第56回)
- Place of Presentation
  京都国際会館
- Year and Date
  2016-04-08
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] The process of development of lung fibrosis in the Rheumatoid Arthritis lung model and effect of H2 treatment in DICC mice.2016
- Author(s)
  Yasuhiro Terasaki, Nariaki Kokuho, Mika Terasaki, Shinobu Kunug, Hirokazu Urushiyama, Motoyo Maruyama, Toshio Akimoto, Saoshi Kanazawa
- Organizer
  American Thoracic Society: ATS Conference 2016
- Place of Presentation
  San fransisco, USA
- Year and Date
  2016-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] 特発性と骨髄移植後の弾性線維増生（PPFE型）肺線維症病変の病理学的特徴と弾性線維関連病態のUIP型病変との比較2016
- Author(s)
  寺崎泰弘、國保成暁、寺崎美佳、功刀しのぶ、桑原尚美、比島恒和、井上幸治、橋本潔、西岡安彦、清水章
- Organizer
  日本病理学会総会(第105回)
- Place of Presentation
  仙台国際センター会議棟
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] Localized pulmonary crystal-storing histiocytosis complicating pulmonary mucosa-associated lymphoid tissue lymphoma2016
- Author(s)
  Nariaki Kokuho, Yasuhiro Terasaki, Shinobu Kunug, Naomi Onda, Hirokazu Urushiyama, Mika Terasaki, Arata Azuma, Hino Mitunori, Akihiko Gemma
- Organizer
  American Thoracic Society: ATS Conference 2016
- Place of Presentation
  San fransisco, USA
- Year and Date
  2016-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] mTOR阻害薬肺障害における肺胞上皮での脂肪毒性障害の検討2016
- Author(s)
  國保成暁,　寺崎泰弘,　齋藤好信,　功刀しのぶ,　寺崎美佳,　弦間昭彦,　清水章
- Organizer
  日本医科大学医学会総会（第84回）
- Place of Presentation
  日本医科大学　橘桜会館
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] 肺MALTリンパ腫に合併した肺限局性crystal-storing histiocytosisの1例2016
- Author(s)
  國保成暁, 功刀しのぶ, 寺崎泰弘, 漆山博和, 寺崎美佳, 羽鳥努, 清水章
- Organizer
  日本病理学会（第105回)
- Place of Presentation
  仙台国際センター会議棟
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] 血液疾患に2次性肺胞蛋白症を呈した剖検肺2症例の検討2016
- Author(s)
  功刀しのぶ, 寺崎泰弘, 呉壮香, 許田典男, 國保成暁, 寺崎美佳, 清水章
- Organizer
  日本病理学会総会（第105回)
- Place of Presentation
  仙台国際センター会議棟
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] 間質性肺炎の早期線維化巣におけるIV型コラーゲンの沈着と線維芽細胞遊走についての解析.2015
- Author(s)
  漆山博和, 寺崎泰弘, 永坂真也, 國保成暁, 寺崎美佳, 功刀しのぶ, 清水章
- Organizer
  日本呼吸器学会総会（第55回）,
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] サルコイドーシス経過中に発症したMALTomaの1例2015
- Author(s)
  國保成暁, 漆山博和, 梶本雄介, 長濱清隆, 寺崎美佳, 功刀しのぶ, 益田幸成, 寺崎泰弘, 江石義信, 清水章
- Organizer
  日本病理学会総会（第104回）
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] リウマチ肺モデルD1CCマウスの肺病変の病理形態学的に解析と高濃度水素分子 (H2)水素水の病変に対する効果.2015
- Author(s)
  寺崎泰弘, 漆山博和, 國保成暁, 寺崎美佳, 功刀しのぶ, 金沢智, 清水章
- Organizer
  日本病理学会総会（第104回）,
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K19433
[Presentation] 破骨細胞様巨細胞を伴う子宮平滑筋肉腫の1例.2015
- Author(s)
  寺崎美佳, 寺崎泰弘, 米山剛一, 長濱清隆, 若松恭子, 桑原尚美, 功刀しのぶ, 梶本雄介, 漆山博和, 國保茂暁, 竹下俊行, 清水章
- Organizer
  日本病理学会総会（第104回）,
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K19433

1. TERASAKI Mika

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. GENMA Akihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. MATSUDA Kuniko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 寺崎泰弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 漆山博和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 神尾孝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 吾妻安良太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

kokuho nariaki 國保 成暁

Research Projects

Research Products

Co-Researchers

Analyses of alveolar epithelial injury via lipid-related stress in mammalian target of rapamycin inhibitor-induced lung diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Chronic Obstructive Pulmonary Disease2017

Author(s)

Total Pages

Publisher

Data Source

[Book] Chronic Obstructive Pulmonary Disease, Germany2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] びまん性肺疾患の分類と診断 病理診断と問題点 内科2016

Author(s)

Total Pages

Publisher

Data Source

[Book] 間質性肺炎の早期線維化巣におけるCanstatinの発現とその作用の解析2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Analyses of alveolar epithelial injury via lipid-related stress in mammalian target of rapamycin inhibitor-induced lung disease.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic Factors in the Acute Exacerbation of Idiopathic Pulmonary Fibrosis: A Retrospective Single-center Study2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Localized pulmonary crystal-storing histiocytosis complicating pulmonary mucaosa-associated lymphoid tissue lymphoma presenting with multiple mass lesion.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Localized pulmonary crystal-storing histiocytosis complicating pulmonary mucosa-associated lymphoid tissue lymphoma presenting with multiple mass lesions.2017

Author(s)

Journal Title

Data Source

[Journal Article] XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of canstatin in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts2016

Author(s)

Journal Title

Data Source

[Journal Article] Pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis: a case report and literature review.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nintedanib modulates surfactant protein-D expression in A549 human lung epithelial cells via the c-Jun N-terminal kinase-activator protein-1 pathway.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] The Analyses of Immunoglobulin Crystal Formation at Lung in Crystal Storing Histiosytosis and Crystalglobulinemia Syndrome2018

Author(s)

Organizer

Data Source

[Presentation] The analyses of alveolar epithelial injury through the lipid metabolic stress in the mammalian target of rapamycin inhibitor induced lung disease2017

Author(s)

Organizer

Data Source

kokuho nariaki 國保成暁

[Book] びまん性肺疾患の分類と診断　病理診断と問題点　内科2016

[Presentation] 間質性肺炎の早期線維化巣におけるIV型コラーゲンの沈着と線維芽細胞遊走についての解析.2015