HIRAI Noriko 平井理子

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Hirai Noriko 平井理子

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Researcher Number	90596272
Other IDs	https://orcid.org/0000-0002-5175-0800
Affiliation (Current)	2025: 旭川医科大学, 医学部, 客員助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 旭川医科大学, 大学病院, 客員助教 2018 – 2021: 旭川医科大学, 大学病院, 特任助教 2020: 旭川医科大学, 大学病院, その他
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator シグナル伝達 / タンパク質 / 遺伝子 / 肺がん / がん / 代謝 / EML4-ALK融合遺伝子 / 蛋白質相互作用 / 蛋白多量体乖離 / EML4-ALK … More / 分子標的薬 / 単量体 / ペプチド / 非小細胞肺癌 / RAS/RAF / ペプチド創薬 / ALK / EML4 / ドライバー遺伝子 / 肺癌 / 治療 … More Except Principal Investigator 融合遺伝子 / 肺癌 / 薬剤耐性 / ドライバー遺伝子変異 / ドライバー遺伝子 / MET遺伝子のエクソン14欠失変異 / 遺伝子解析 / SMARCA4 / ナノポアシーケンシング / METエクソン14欠損 / ゲノム構造異常 / がんゲノム Less

肺癌タンパク多量体化阻害ペプチドの実用化を目指した安定性と細胞内デリバリーの探究Principal Investigator
- Principal Investigator
  
  平井理子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Asahikawa Medical College
獲得耐性後の癌融合蛋白に対する多量体化阻害ペプチドの改良と応用Principal Investigator
- Principal Investigator
  
  平井理子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Asahikawa Medical College
Study on the mechanism of oncogene activation by structural variants in cancer genome
- Principal Investigator
  
  佐々木高明
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Asahikawa Medical College
Monomerization of dimerized oncogenic fusion proteins by mimetic peptides as cancer treatmentsPrincipal Investigator
- Principal Investigator
  
  Hirai Noriko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Asahikawa Medical College

All 2021 2020 2019

All Journal Article Presentation

[Journal Article] A stealth antigen SPESP1, which is epigenetically silenced in tumors, is a suitable target for cancer immunotherapy2021
- Author(s)
  Kosaka Akemi,Yajima Yuki,Hatayama Mayumi,Ikuta Katsuya,Sasaki Takaaki,Hirai Noriko,Ohkuri Takayuki
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 7 Pages: 2705-2713
- DOI
  10.1111/cas.14973
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15300, KAKENHI-PROJECT-20K07367
[Journal Article] Cyclin-dependent kinase 4 upregulation mediates acquired resistance of dabrafenib plus trametinib in BRAF V600E-mutated lung cancer2021
- Author(s)
  Hirai Noriko、Hatanaka Yutaka、Hatanaka Kanako C.、Uno Yuji、Chiba Shin-Ichi、Umekage Yasuhiro、Minami Yoshinori、Okumura Shunsuke、Ohsaki Yoshinobu、Sasaki Takaaki
- Journal Title
  
  Translational Lung Cancer Research
  
  Volume: 10 Issue: 9 Pages: 3737-3744
- DOI
  10.21037/tlcr-21-415
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15300, KAKENHI-PROJECT-21K07189
[Journal Article] A 47-Year-Old Woman with Pulmonary Nodules and Facial Hemispasms2020
- Author(s)
  Noriko H, Kensuke O, Mishie T, Yoshinobu O.
- Journal Title
  
  CHEST
  
  Volume: 158 Issue: 4 Pages: e197-e204
- DOI
  10.1016/j.chest.2020.03.078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06980, KAKENHI-PROJECT-18K15300
[Journal Article] Monomerization of ALK Fusion Proteins as a Therapeutic Strategy in ALK-Rearranged Non-small Cell Lung Cancers2020
- Author(s)
  Hirai Noriko、Sasaki Takaaki、Okumura Shunsuke、Minami Yoshinori、Chiba Shinichi、Ohsaki Yoshinobu
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 10 Pages: 419-428
- DOI
  10.3389/fonc.2020.00419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15300, KAKENHI-PROJECT-18K08132
[Journal Article] Novel ALK-specific mRNA in situ hybridization assay for non-small-cell lung carcinoma2020
- Author(s)
  Hirai Noriko、Sasaki Takaaki、Okumura Shunsuke、Sado Masatoshi、Akiyama Naoko、Kitada Masahiro、Takei Hidehiro、Ohsaki Yoshinobu
- Journal Title
  
  Translational Lung Cancer Research
  
  Volume: 9 Issue: 2 Pages: 257-268
- DOI
  10.21037/tlcr.2020.03.04
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15300
[Journal Article] Acute eosinophilic pneumonia following inhalation of turpentine oil: A case report2020
- Author(s)
  Umekage Yasuhiro、Okumura Shunsuke、Tenma Toshiyuki、Kazebayashi Yoshihiro、Hirai Noriko、Minami Yoshinori、Doshita Kazushi、Sasaki Takaaki、Yamamoto Yasushi、Ohsaki Yoshinobu
- Journal Title
  
  Respiratory Medicine Case Reports
  
  Volume: 31 Pages: 101143-101143
- DOI
  10.1016/j.rmcr.2020.101143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15300
[Presentation] CDK4 copy number gain in BRAF V600E-mutated non-small cell lung cancers resistant to dabrafenib plus trametinib2021
- Author(s)
  Noriko Hirai
- Organizer
  AACR Annual Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15300
[Presentation] CDK4 copy number gain in BRAF V600E-mutated non-small cell lung cancers resistant to dabrafenib plus trametinib2021
- Author(s)
  Noriko Hirai, Takaaki Sasaki, Shinichi Chiba, Yuji Uno, Hidehiro Takei
- Organizer
  American Association for Cnacer Research Annual Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15300
[Presentation] coiled-coilを標的としたEML4-ALK融合蛋白の単量体化がもたらす抗腫瘍効果の検討2020
- Author(s)
  平井　理子、佐々木　高明、大崎　能伸
- Organizer
  第60回日本肺癌学会総会
- Data Source
  KAKENHI-PROJECT-18K15300
[Presentation] Tissue biopsy vs Liquid biopsy　ALK耐性遺伝子変異に対するLiquid biopsyの試み2020
- Author(s)
  佐々木　高明、吉田　遼平、平井　理子、梅影　泰寛、天満　紀之、南　幸範、奥村　俊介、大崎　能伸
- Organizer
  第42回日本呼吸器内視鏡学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15300
[Presentation] 気管支擦過ブラシ洗浄液を用いた肺がん遺伝子変異解析の有用性2020
- Author(s)
  佐々木　高明、平井　理子、堂下　和志、梅影　泰寛、天満　紀之、吉田　遼平、風林　佳大、南　幸範、奥村　俊介、山本　泰司、長内　忍、大崎　能伸
- Organizer
  第42回日本呼吸器内視鏡学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15300
[Presentation] Monomerization of ALK Fusion Proteins as a Therapeutic Strategy in ALK Rearranged Cancers2019
- Author(s)
  Noriko Hirai
- Organizer
  AACR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15300
[Presentation] Monomerization of ALK Fusion Proteins as a Therapeutic Strategy in ALK Rearranged Cancers2019
- Author(s)
  Noriko Hirai
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15300
[Presentation] coiled-coilを標的としたEML4-ALK融合蛋白の単量体化がもたらす抗腫瘍効果の検討2019
- Author(s)
  平井　理子
- Organizer
  第60回日本肺癌学会総会
- Data Source
  KAKENHI-PROJECT-18K15300

1. 佐々木高明 (70516997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 水上裕輔 (30400089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIRAI Noriko 平井 理子

Hirai Noriko 平井 理子

Research Projects

Research Products

Co-Researchers

肺癌タンパク多量体化阻害ペプチドの実用化を目指した安定性と細胞内デリバリーの探究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

獲得耐性後の癌融合蛋白に対する多量体化阻害ペプチドの改良と応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the mechanism of oncogene activation by structural variants in cancer genome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Monomerization of dimerized oncogenic fusion proteins by mimetic peptides as cancer treatmentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A stealth antigen SPESP1, which is epigenetically silenced in tumors, is a suitable target for cancer immunotherapy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclin-dependent kinase 4 upregulation mediates acquired resistance of dabrafenib plus trametinib in BRAF V600E-mutated lung cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A 47-Year-Old Woman with Pulmonary Nodules and Facial Hemispasms2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Monomerization of ALK Fusion Proteins as a Therapeutic Strategy in ALK-Rearranged Non-small Cell Lung Cancers2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel ALK-specific mRNA in situ hybridization assay for non-small-cell lung carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acute eosinophilic pneumonia following inhalation of turpentine oil: A case report2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] CDK4 copy number gain in BRAF V600E-mutated non-small cell lung cancers resistant to dabrafenib plus trametinib2021

Author(s)

Organizer

Data Source

[Presentation] CDK4 copy number gain in BRAF V600E-mutated non-small cell lung cancers resistant to dabrafenib plus trametinib2021

Author(s)

Organizer

Data Source

[Presentation] coiled-coilを標的としたEML4-ALK融合蛋白の単量体化がもたらす抗腫瘍効果の検討2020

Author(s)

Organizer

Data Source

[Presentation] Tissue biopsy vs Liquid biopsy ALK耐性遺伝子変異に対するLiquid biopsyの試み2020

Author(s)

Organizer

Data Source

[Presentation] 気管支擦過ブラシ洗浄液を用いた肺がん遺伝子変異解析の有用性2020

Author(s)

Organizer

Data Source

[Presentation] Monomerization of ALK Fusion Proteins as a Therapeutic Strategy in ALK Rearranged Cancers2019

HIRAI Noriko 平井理子

Hirai Noriko 平井理子

[Presentation] Tissue biopsy vs Liquid biopsy　ALK耐性遺伝子変異に対するLiquid biopsyの試み2020