Otsuka Nao 大塚菜緒

… Alternative Names

大塚菜緒オオツカナオ

OTSUKA Nao 大塚菜緒

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Researcher Number	90596610
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所細菌第二部, 室長
Affiliation (based on the past Project Information) *help	2019 – 2023: 国立感染症研究所, 細菌第二部, 主任研究官 2016 – 2017: 国立感染症研究所, 細菌第二部, 主任研究官 2014 – 2015: 国立感染症研究所, その他部局等, 研究員 2014: 国立感染症研究所, その他部局等, 主任研究官 2013: 国立感染症研究所, 細菌第二部, 主任研究官
Review Section/Research Field	Principal Investigator Bacteriology (including mycology) / Basic Section 49050:Bacteriology-related
Keywords	Principal Investigator fimbriae / 百日咳菌 / mechanism / gene expression / Bordetella pertussis / RisA / Bordetella perturssis / 線毛 / 自己凝集 / 遺伝子発現 / 発現 / 発現機構

The regulation mechanisms of B. pertussis fimbriae gene expressionPrincipal Investigator
- Principal Investigator
  
  大塚菜緒
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Institute of Infectious Diseases
Fim3-mediated autoagglutination of Bordetella pertussisPrincipal Investigator
- Principal Investigator
  
  Otsuka Nao
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Institute of Infectious Diseases
Bordetella pertussis fimbriae are regulated by BvgAS system and Pfim structurePrincipal Investigator
- Principal Investigator
  
  OTSUKA Nao
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Institute of Infectious Diseases

All 2023 2022 2021 2020 2019 2017 2016 2015 2013 Other

All Journal Article Presentation Book

[Book] 感染炎症免疫2015
- Author(s)
  大塚菜緒、蒲地一成
- Total Pages
  11
- Publisher
  鳥居薬品株式会社
- Data Source
  KAKENHI-PROJECT-15K19101
[Book] 化学療法の領域　2013年増刊号(Vol.29 S-1)：細菌感染症８．百日咳2013
- Author(s)
  大塚菜緒、蒲地一成
- Total Pages
  9
- Publisher
  医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-25860328
[Journal Article] Fim3-dependent autoagglutination of Bordetella pertussis2023
- Author(s)
  Otsuka Nao、Koide Kentaro、Goto Masataka、Kamachi Kazunari、Kenri Tsuyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 7629-7629
- DOI
  10.1038/s41598-023-34672-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07572
[Journal Article] The First Reported Case of Bordetella pertussis Bacteremia in a Patient With Human Immunodeficiency Virus Infection.2022
- Author(s)
  Wakimoto Y, Otsuka N, Yanagawa Y, Koide K, Kamachi K, Shibayama K, Teruya K, Kikuchi Y, Oka S.
- Journal Title
  
  Open Forum Infect Dis.
  
  Volume: 9 Issue: 3
- DOI
  10.1093/ofid/ofac020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07520, KAKENHI-PROJECT-19K07572
[Journal Article] Rapid and simple SNP genotyping for Bordetella pertussis epidemic strain MT27 based on a multiplexed single-base extension assay2021
- Author(s)
  Kamachi K, Yao SM, Chiang CS, Koide K, Otsuka N, Shibayama K.
- Journal Title
  
  Scientific Report
  
  Volume: 11 Issue: 1 Pages: 4823-4823
- DOI
  10.1038/s41598-021-84409-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07572
[Journal Article] Macrolide-Resistant Bordetella pertussis, Vietnam, 2016-20172020
- Author(s)
  Kamachi Kazunari、Duong Hong T.、Dang Anh D.、Hai T.、Do Do、Koide Kentaro、Otsuka Nao、Shibayama Keigo、Hoang Ha Thi Thu
- Journal Title
  
  Emerging Infectious Diseases
  
  Volume: 26 Issue: 10 Pages: 2511-2513
- DOI
  10.3201/eid2610.201035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07572
[Journal Article] Age-related differences in antibody avidities to pertussis toxin and filamentous hemagglutinin in a healthy Japanese population2019
- Author(s)
  Fumimoto Rei、Otsuka Nao、Sunagawa Tomimasa、Tanaka-Taya Keiko、Kamiya Hajime、Kamachi Kazunari
- Journal Title
  
  Vaccine
  
  Volume: 37 Issue: 18 Pages: 2463-2469
- DOI
  10.1016/j.vaccine.2019.03.055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07572
[Journal Article] Seroprevalence of IgA and IgM antibodies to Bordetella pertussis in healthy Japanese donors: Assessment for the serological diagnosis of pertussis2019
- Author(s)
  Fumimoto Rei、Otsuka Nao、Kamiya Hajime、Sunagawa Tomimasa、Tanaka-Taya Keiko、Kamachi Kazunari、Shibayama Keigo
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 7 Pages: e0219255-e0219255
- DOI
  10.1371/journal.pone.0219255
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07572
[Journal Article] A novel multilocus variable-number tandem repeat analysis for Bordetella parapertussis2019
- Author(s)
  Kamachi Kazunari、Otsuka Nao、Fumimoto Rei、Ozawa Kensuke、Yao Shu-Man、Chiang Chuen-Sheue、Luu Laurence Don Wai、Lan Ruiting、Shibayama Keigo、Watanabe Mineo
- Journal Title
  
  Journal of Medical Microbiology
  
  Volume: 68 Issue: 11 Pages: 1671-1676
- DOI
  10.1099/jmm.0.001095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07572
[Journal Article] The length of poly(C) stretch in the Bordetella pertussis Pfim3 promoter determines the vag or vrg function of the fim3 gene2017
- Author(s)
  Otsuka N, Guiso N, Bouchez V
- Journal Title
  
  Microbiology
  
  Volume: 163 Issue: 9 Pages: 1364-1368
- DOI
  10.1099/mic.0.000514
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19101
[Journal Article] A Novel IgM-capture enzyme-linked immunosorbent assay using recombinant Vag8 fusion protein for the accurate and early diagnosis of Bordetella pertussis infection2016
- Author(s)
  Otsuka N, Gotoh K, Nishimura N, Ozaki T, Nakamura Y, Haga K, Yamazaki M, Gondaira F, Okada K, Miyaji Y, Toyoizumi-Ajisaka H, Shibayama K, Arakawa Y, Kamachi K.
- Journal Title
  
  Microbiol Immunol.
  
  Volume: 60 Issue: 5 Pages: 326-333
- DOI
  10.1111/1348-0421.12378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19101
[Journal Article] Molecular epidemiology of Bordetella pertussis in the Philippines in 2012-20142015
- Author(s)
  Galit SR, Otsuka N, Furuse Y, et al.
- Journal Title
  
  Int J Infect Dis
  
  Volume: 35 Pages: 24-26
- DOI
  10.1016/j.ijid.2015.04.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860328
[Journal Article] Genetic analysis of Bordetella pertussis isolates from the 2008-2010 pertussis epidemic in Japan2013
- Author(s)
  Miyaji Y, Otsuka N, Toyoizumi-Ajisaka H, Shibayama K, Kamachi K
- Journal Title
  
  PLoS One
  
  Volume: (8)10 Issue: 10 Pages: e77165-e77165
- DOI
  10.1371/journal.pone.0077165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860328
[Presentation] 百日咳菌FHA欠損株に対するMALDI-TOF MSの菌種同定精度2023
- Author(s)
  大塚菜緒、松井真理、神谷元
- Organizer
  第97回日本感染症学会総会・学術講演会第71回日本化学療法学会学術集会合同学会
- Data Source
  KAKENHI-PROJECT-19K07572
[Presentation] Molecular prevalence of Fim3-highly producible sequence in Bordetella pertussis2020
- Author(s)
  大塚菜緒、文元礼、蒲地一成、柴山恵吾
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K07572
[Presentation] Seroplevalence of anti-Bordetella pertussis IgA and IgM in Japanese healthy people.2019
- Author(s)
  Rei Fumimoto, Nao Otsuka, Hajime Kamiya, Tomimasa Sunagawa, Keiko Tanaka-Taya, Kazunari Kamachi, Keigo Shibayama.
- Organizer
  12th International Bordetella symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07572
[Presentation] Fim3-mediated autoagglutination in Bordetella pertussis2019
- Author(s)
  Nao Otsuka, Rei Fumimoto, Keigo Shibayama, Kazunari Kamachi
- Organizer
  12th International Bordetella symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07572
[Presentation] Fimbriae-mediated autoagglutination of Bordetella pertussis2016
- Author(s)
  大塚菜緒、平松征洋、蒲地一成、柴山恵吾
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-15K19101
[Presentation] 国立感染症研究所・細菌第二部における業務と薬学の関わり2015
- Author(s)
  大塚菜緒
- Organizer
  第27回微生物シンポジウム
- Place of Presentation
  岡山県：就実大学
- Year and Date
  2015-09-05
- Invited
- Data Source
  KAKENHI-PROJECT-15K19101
[Presentation] Bordetella pertussis fimbriae are regulated by BvgAS system and Pfim structure
- Author(s)
  Nao Otsuka, Valerie Bouchez, Keigo Shibayama, Kazunari Kamachi, Nicole Guiso
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜県岐阜市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25860328

1. 照屋勝治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Otsuka Nao 大塚 菜緒

大塚 菜緒 オオツカ ナオ

OTSUKA Nao 大塚 菜緒

Research Projects

Research Products

Co-Researchers

The regulation mechanisms of B. pertussis fimbriae gene expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fim3-mediated autoagglutination of Bordetella pertussisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Bordetella pertussis fimbriae are regulated by BvgAS system and Pfim structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 感染 炎症 免疫2015

Author(s)

Total Pages

Publisher

Data Source

[Book] 化学療法の領域 2013年 増刊号(Vol.29 S-1)：細菌感染症 ８．百日咳2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Fim3-dependent autoagglutination of Bordetella pertussis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The First Reported Case of Bordetella pertussis Bacteremia in a Patient With Human Immunodeficiency Virus Infection.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid and simple SNP genotyping for Bordetella pertussis epidemic strain MT27 based on a multiplexed single-base extension assay2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrolide-Resistant Bordetella pertussis, Vietnam, 2016-20172020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Age-related differences in antibody avidities to pertussis toxin and filamentous hemagglutinin in a healthy Japanese population2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Seroprevalence of IgA and IgM antibodies to Bordetella pertussis in healthy Japanese donors: Assessment for the serological diagnosis of pertussis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel multilocus variable-number tandem repeat analysis for Bordetella parapertussis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The length of poly(C) stretch in the Bordetella pertussis Pfim3 promoter determines the vag or vrg function of the fim3 gene2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Novel IgM-capture enzyme-linked immunosorbent assay using recombinant Vag8 fusion protein for the accurate and early diagnosis of Bordetella pertussis infection2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular epidemiology of Bordetella pertussis in the Philippines in 2012-20142015

Otsuka Nao 大塚菜緒

大塚菜緒オオツカナオ

OTSUKA Nao 大塚菜緒

[Book] 感染炎症免疫2015

[Book] 化学療法の領域　2013年増刊号(Vol.29 S-1)：細菌感染症８．百日咳2013