WATARI Kosuke 渡公佑

Researcher Number	90596834
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2019: 九州大学, 薬学研究院, 准教授 2015: 九州大学, 薬学研究科(研究院), 准教授 2013 – 2014: 九州大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Tumor biology
Keywords	Principal Investigator VEGF / 血管内皮細胞 / マクロファージ / 血管新生 / NDRG1 / カルシウム / 血管内皮 / PLCγ / VEGFR2 / 破骨細胞 / M-CSF / がん

Novel anti-tumor angiogenesis therapeutic strategy by targeting VEGF signaling pathway through N-myc downstream regulated gene 1 (NDRG1)Principal Investigator
- Principal Investigator
  
  Watari Kosuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kyushu University
Novel anti-angiogenic cancer therapeutic strategy by targeting differentiated macrophage lineage cells through N-myc downstream regulated gene 1 (NDRG1)Principal Investigator
- Principal Investigator
  
  WATARI Kosuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyushu University
Role of NDRG1 in tumor angiogenesis through activation of tumor-associated macrophages and vascular endothelial cells.Principal Investigator
- Principal Investigator
  
  WATARI Kosuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyushu University

All 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 血管新生・血流正常化を標的としたがん治療．最新がん薬物療法学-がん薬物療法の最新知見-．2014
- Author(s)
  渡公佑、小野眞弓．
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-25830083
[Journal Article] NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells2020
- Author(s)
  Watari Kosuke、Shibata Tomohiro、Fujita Hideaki、Shinoda Ai、Murakami Yuichi、Abe Hideyuki、Kawahara Akihiko、Ito Hiroshi、Akiba Jun、Yoshida Shigeo、Kuwano Michihiko、Ono Mayumi
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 107-107
- DOI
  10.1038/s42003-020-0829-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07169, KAKENHI-PROJECT-18K09450, KAKENHI-PROJECT-19K16449
[Journal Article] Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma2020
- Author(s)
  Ito Hiroshi、Watari Kosuke、Shibata Tomohiro、Miyamoto Tomofumi、Murakami Yuichi、Nakahara Yukiko、Izumi Hiroto、Wakimoto Hiroaki、Kuwano Michihiko、Abe Tatsuya、Ono Mayumi
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 2 Pages: 234-248
- DOI
  10.1158/0008-5472.can-19-0438
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16449, KAKENHI-PROJECT-19K16804, KAKENHI-PROJECT-17K07169, KAKENHI-PROJECT-18K08998
[Journal Article] Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.2016
- Author(s)
  Watari K, Shibata T, Nabeshima H, Shinoda A, Fukunaga Y, Kawahara A, Karasuyama K, Fukushi J, Iwamoto Y, Kuwano M, Ono M.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 19470-19470
- DOI
  10.1038/srep19470
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18411
[Journal Article] Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages.2014
- Author(s)
  Watari, K., Shibata, T., Kawahara, A., Sata, K., Nabeshima, H., Shinoda, A., Abe, H., Azuma, K., Murakami, Y., Izumi, H., Takahashi, T., Kage, M., Kuwano, M., Ono, M.
- Journal Title
  
  PLoS ONE
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25830083
[Journal Article] Tumor-derived Interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages2014
- Author(s)
  Watari K, Shibata T, Kawahara A, Sata K, Nabeshima H, Shinoda A, Abe H, Azuma K, Murakami Y, Izumi, H, Takahashi T, Kage M, Kuwano M, Ono M.
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 6 Pages: e99568-e99568
- DOI
  10.1371/journal.pone.0099568
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22134005, KAKENHI-PROJECT-23300350, KAKENHI-PROJECT-25830083, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25250017
[Journal Article] N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells2013
- Author(s)
  Murakami, Y., Watari, K., Ono, M, et al. 計11名
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 35 Pages: 25025-25037
- DOI
  10.1074/jbc.m113.472068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300350, KAKENHI-PROJECT-23790425, KAKENHI-PROJECT-24650646, KAKENHI-PROJECT-25830083
[Presentation] N-myc downstream regulated gene 1 (NDRG1) is indispensable for VEGF-A-induced tumor angiogenesis through PLCγ/ERK signaling activation in vascular endothelial cells2019
- Author(s)
  Kosuke Watari, Tomohiro Shibata, Ai Shinoda, Hideyuki Abe, Akihiko Kawahara, Yuichi Murakami, Eiji Oki, Jun Akiba, Yoshihiko Maehara, Michihiko Kuwano, Mayumi Ono
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] 血管内皮細胞のNDRG1はPLCγ1を介してVEGFR2/ERKシグナルを特異的に活性化し、VEGF誘導の血管新生を促進する2019
- Author(s)
  渡公佑, 柴田智博, 篠田あい, 藤田英明, 河原明彦, 村上雄一, 桑野信彦, 小野眞弓
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] 血管内皮細胞のNDRG1はPLCγ1活性を介してVEGF誘導の血管新生を特異的に制御し、がん血管新生抑制治療の新しい標的となる2019
- Author(s)
  渡公佑, 柴田智博, 河原明彦, 村上雄一, 桑野信彦, 小野眞弓
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] NDRG1 is indispensable for VEGF-A-induced tumor angiogenesis by PLCγ/ERK signal activation in vascular endothelial cells2019
- Author(s)
  Kosuke Watari, Tomohiro Shibata, Hiroshi Nabeshima, Akihiko Kawahara, Yuichi Murakami, Michihiko Kuwano, Mayumi Ono
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] 血管内皮細胞におけるNDRG1はVEGFR2/PLCγ1シグナルを制御し、がん血管新生と転移を亢進する2019
- Author(s)
  渡公佑, 柴田智博, 村上雄一, 桑野信彦, 小野眞弓
- Organizer
  第28回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] 血管内皮細胞におけるNDRG1はVEGFR2/PLCγ1シグナルを制御し、がん血管新生と転移を亢進する2018
- Author(s)
  渡公佑、柴田智博、村上雄一、桑野信彦、小野眞弓
- Organizer
  第27回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] 血管内皮細胞におけるNDRG1はVEGF-A誘導のPLCγ/ERKシグナルを活性化し、がん血管新生を促進する2018
- Author(s)
  渡公佑、柴田智博、鍋島弘嗣、河原明彦、村上雄一、桑野信彦、小野眞弓
- Organizer
  第77回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] 血管内皮細胞のNDRG1はPLCγ1活性を介してVEGF誘導の血管新生を特異的に制御し、がん血管新生抑制治療の新しい標的となる2018
- Author(s)
  渡公佑、柴田智博、河原明彦、村上雄一、桑野信彦、小野眞弓
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] NDRG1による血管内皮VEGF/VEGFR2シグナルの特異的制御－がん血管新生標的治療の創出を目指して2017
- Author(s)
  渡公佑、柴田智博、河原明彦、村上雄一、桑野信彦、小野眞弓
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] NDRG1は血管内皮細胞におけるVEGF/VEGFR2シグナルを特異的に活性化しがん血管新生と転移を促進する2017
- Author(s)
  渡公佑、柴田智博、鍋島弘嗣、河原明彦、村上雄一、桑野信彦、小野眞弓
- Organizer
  第76回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] NDRG1はがん血管新生と転移を亢進する―血管内皮細胞VEGF/VEGFR2シグナル活性の新しい制御2017
- Author(s)
  渡公佑、柴田智博、村上雄一、桑野信彦、小野眞弓
- Organizer
  第26回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K07169
[Presentation] NDRG1はがん血管新生と転移を亢進する―マクロファージの分化と成熟化を介して2016
- Author(s)
  渡公佑、柴田智博、村上雄一、小野眞弓
- Organizer
  第25回日本がん転移学会学術集会・総会
- Place of Presentation
  鳥取県米子市
- Year and Date
  2016-07-21
- Data Source
  KAKENHI-PROJECT-15K18411
[Presentation] NDRG1は血管内皮細胞におけるVEGF/VEGFR2シグナル活性を介してがん血管新生を促進する2016
- Author(s)
  渡公佑、柴田智博、鍋島弘嗣、河原明彦、村上雄一、桑野信彦、小野眞弓
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K18411
[Presentation] NDRG1による血管内皮細胞のVEGF/VEGFR2シグナルの特異的な制御－がん血管新生阻害剤の新規標的因子2016
- Author(s)
  渡公佑、柴田智博、河原明彦、村上雄一、鹿毛政義、小野眞弓
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  大分県別府市
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15K18411
[Presentation] NDRG1 はマクロファージの成熟と活性化を介してがん血管新生の重要な鍵をにぎる2015
- Author(s)
  渡公佑, 柴田　智博, 鍋島　弘嗣, 篠田　あい, 河原　明彦, 福士純一, 村上　雄一, 桑野信彦, 小野眞弓
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K18411
[Presentation] NDRG1 は血管内皮細胞 VEGF-A/VEGFR2 シグナルを介してがん血管新生と転移を促進する2015
- Author(s)
  渡公佑, 柴田　智博, 村上　雄一, 桑野　信彦, 小野眞弓
- Organizer
  第24回日本がん転移学会学術集会・総会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-15K18411
[Presentation] Novel anti-angiogenic cancer therapeutic strategy by targeting differentiated macrophage lineage cells through N-myc downstream regulated gene 1 (NDRG1)2015
- Author(s)
  K. Watari, T. Shibata, H. Nabeshima, A. Shinoda, Y. Fukunaga, A. Kawahara, K. Karasuyama, J. Fukushi, Y. Murakami, M. Kuwano, M. Ono
- Organizer
  AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  アメリカ　ボストン
- Year and Date
  2015-11-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18411
[Presentation] オクタヒドロナフタレン誘導体AMF-26はVEGF受容体の膜発現とNF-κBシグナルを阻害することによりがん血管新生を抑制する.2014
- Author(s)
  渡　公佑、中村　真美代、古野　綾奈、柴田　智博、村上　雄一、桑野　信彦、小野　眞弓
- Organizer
  文科省新学術領域研究・がん支援「化学療法基盤支援活動」第3回シンポジウム
- Place of Presentation
  沖縄県名護市
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PROJECT-25830083
[Presentation] N-myc downstream regulated gene-1(NDRG1)は血管内皮細胞の機能に関与し、がん血管新生に重要な役割を果たす.2013
- Author(s)
  篠田　あい、渡　公佑、鍋島　弘嗣、柴田　智博、小野　眞弓
- Organizer
  第30回日本薬学会九州支部大会
- Place of Presentation
  長崎県佐世保市
- Data Source
  KAKENHI-PROJECT-25830083
[Presentation] N-myc Downstream Regulated Gene-1(NDRG1)はマクロファージの機能化と成熟化に関与し腫瘍血管新生に影響する.2013
- Author(s)
  鍋島　弘嗣、渡　公佑、篠田　あい、柴田　智博、小野　眞弓
- Organizer
  第30回日本薬学会九州支部大会
- Place of Presentation
  長崎県佐世保市
- Data Source
  KAKENHI-PROJECT-25830083
[Presentation] NDRG1 はマクロファージの修飾を介してがん血管新生を誘導する－NDRG1 deficiency suppresses tumor angiogenesis through interference of macrophage activation2013
- Author(s)
  渡　公佑、鍋島　弘嗣、福永　裕一、柴田　智博、篠田　あい、河原　明彦、村上　雄一、鹿毛　政義、桑野　信彦、小野　眞弓
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-25830083
[Presentation] がん血管新生はN-myc downstream regulated gene-1(NDRG1)によって特異的に制御される.2013
- Author(s)
  渡　公佑、柴田　智博、村上　雄一、桑野　信彦、小野　眞弓
- Organizer
  第22回日本がん転移学会学術集会・総会
- Place of Presentation
  長野県松本市
- Data Source
  KAKENHI-PROJECT-25830083
[Presentation] N-myc downstream regulated gene 1 (NDRG1) as a novel anti-angiogenic and therapeutic target for VEGF/VEGF receptor signaling by vascular endothelial cells.
- Author(s)
  Kosuke Watari, Ai Shinoda, Tomohiro Shibata, Akihiko Kawahara, Takahito Nakama, Shigeo Yoshida, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono.
- Organizer
  26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics.
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-11-18 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-25830083
[Presentation] 宿主NDRG1はマクロファージの分化と成熟を制御し、がん血管新生と転移の鍵をにぎる
- Author(s)
  渡　公佑, 柴田　智博, 村上　雄一, 桑野　信彦, 小野　眞弓
- Organizer
  第23回日本がん転移学会芸術集会・総会
- Place of Presentation
  石川県金沢市
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25830083
[Presentation] Tumor-derived interleukin-1 promotes lymphangiogenesis, and lymph node metastasis through activation of M2-type macrophages by lung cancer cells.
- Author(s)
  Kosuke Watari, Tomohiro Shibata, Akihiko Kawahara, Yuichi Murakami, Hiroshi Nabeshima, Ai Shinoda, Koichi Azuma, Hiroto Izumi, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono.
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, CA
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25830083
[Presentation] NDRG1 欠失変異は血管内皮細胞の機能とVEGF 依存性血管新生を特異的に抑制する
- Author(s)
  渡　公佑, 篠田あい, 鍋島弘嗣, 柴田智博, 河原　明彦, 村上　雄一, 鹿毛政義, 桑野　信彦, 小野　眞弓
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25830083
[Presentation] N-myc downstream regulated gene 1 (NDRG1)は血管内皮細胞のVEGF-Aシグナルに関与し、がん血管新生を制御する
- Author(s)
  篠田あい, 渡公佑, 柴田智博, 桑野信彦, 小野眞弓
- Organizer
  第31回日本薬学会九州支部大会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2014-12-06 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-25830083

1. 小野真弓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 高橋隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 柴田智博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WATARI Kosuke 渡 公佑

Research Projects

Research Products

Co-Researchers

Novel anti-tumor angiogenesis therapeutic strategy by targeting VEGF signaling pathway through N-myc downstream regulated gene 1 (NDRG1)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel anti-angiogenic cancer therapeutic strategy by targeting differentiated macrophage lineage cells through N-myc downstream regulated gene 1 (NDRG1)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of NDRG1 in tumor angiogenesis through activation of tumor-associated macrophages and vascular endothelial cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 血管新生・血流正常化を標的としたがん治療．最新がん薬物療法学-がん薬物療法の最新知見-．2014

Author(s)

Publisher

Data Source

[Journal Article] NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages.2014

Author(s)

Journal Title

Data Source

[Journal Article] Tumor-derived Interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] N-myc downstream regulated gene 1 (NDRG1) is indispensable for VEGF-A-induced tumor angiogenesis through PLCγ/ERK signaling activation in vascular endothelial cells2019

Author(s)

Organizer

Data Source

[Presentation] 血管内皮細胞のNDRG1はPLCγ1を介してVEGFR2/ERKシグナルを特異的に活性化し、VEGF誘導の血管新生を促進する2019

Author(s)

Organizer

Data Source

[Presentation] 血管内皮細胞のNDRG1はPLCγ1活性を介してVEGF誘導の血管新生を特異的に制御し、がん血管新生抑制治療の新しい標的となる2019

Author(s)

Organizer

Data Source

[Presentation] NDRG1 is indispensable for VEGF-A-induced tumor angiogenesis by PLCγ/ERK signal activation in vascular endothelial cells2019

Author(s)

Organizer

Data Source

[Presentation] 血管内皮細胞におけるNDRG1はVEGFR2/PLCγ1シグナルを制御し、がん血管新生と転移を亢進する2019

Author(s)

Organizer

Data Source

[Presentation] 血管内皮細胞におけるNDRG1はVEGFR2/PLCγ1シグナルを制御し、がん血管新生と転移を亢進する2018

Author(s)

Organizer

Data Source

[Presentation] 血管内皮細胞におけるNDRG1はVEGF-A誘導のPLCγ/ERKシグナルを活性化し、がん血管新生を促進する2018

WATARI Kosuke 渡公佑