Nomura Takao 野村尚生

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NOMURA Takao 野村尚生

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Researcher Number	90597840
Other IDs
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 特任講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 北海道大学, 薬学研究院, 特任講師 2016 – 2020: 北海道大学, 薬学研究院, 特任助教 2015: 慶應義塾大学, 理工学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Biomolecular chemistry Except Principal Investigator Transformative Research Areas, Section (II) / Functional biochemistry
Keywords	Principal Investigator 小胞体 / ミトコンドリア / 癌 / がんの分化 / がん幹細胞 / 幹細胞 / 機能解明 / 生体分子 / 薬学 / タンパク質間ネットワーク … More / がんの分子機構 / がん創薬 / 小胞体ストレス / 酸化還元 / 癌幹細胞 … More Except Principal Investigator 分子間相互作用解析 / 蛍光イメージング / 生物活性評価 / 化合物潜在空間 / ジスルフィド結合 / 金属シャペロン / 銅イオン / タンパク質 / 金属タンパク質 / 筋萎縮性側索硬化症 / タンパク質凝集 / SOD1 / タンパク質フォールディング / 神経変性疾患 / 銅シャペロン Less

Elucidation of the mechanism of cancer differentiation and drug discovery for novel cancer therapy using cancer stem cell lines derived from cancer cell linesPrincipal Investigator
- Principal Investigator
  
  野村尚生
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Hokkaido University
潜在空間を構成・検証する生物活性の時空間定量計測手法開発・応用
- Principal Investigator
  
  菊地和也
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Osaka University
Elucidation of protein networks for the mechanism of carcinogenesis through the oxidoreductase in the endoplasmic reticulumPrincipal Investigator
- Principal Investigator
  
  Nomura Takao
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Hokkaido University
Elucidation of oncogenic molecular mechanism mediated by redox regulatory enzyme based on novel inhibitorPrincipal Investigator
- Principal Investigator
  
  NOMURA Takao
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Hokkaido University
A mechanism regulating the copper acquisition by intracellular proteins
- Principal Investigator
  
  FURUKAWA YOSHIAKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Keio University

All 2020 2019 2018 2017 2016 2014

All Journal Article Presentation Patent

[Journal Article] The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein2020
- Author(s)
  Nakagawa Natsumi、Sakaguchi Shuya、Nomura Takao、Kamada Rui、Omichinski James G.、Sakaguchi Kazuyasu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 521 Issue: 3 Pages: 681-686
- DOI
  10.1016/j.bbrc.2019.10.130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05329
[Journal Article] Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells2018
- Author(s)
  Kakuguchi Wataru、Nomura Takao、Kitamura Tetsuya、Otsuguro Satoko、Matsushita Kazuhiro、Sakaitani Masahiro、Maenaka Katsumi、Tei Kanchu
- Journal Title
  
  Cancer Medicine
  
  Volume: 7 Issue: 12 Pages: 6269-6280
- DOI
  10.1002/cam4.1877
- NAID
  120006559018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05329, KAKENHI-PROJECT-18K17022
[Journal Article] A copper-deficient form of mutant cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis2018
- Author(s)
  Tokuda Eiichi、Nomura Takao、Ohara Shinji、Watanabe Seiji、Yamanaka Koji、Morisaki Yuta、Misawa Hidemi、Furukawa Yoshiaki
- Journal Title
  
  Biochimica et Biophysica Acta - Molecular Basis of Disease
  
  Volume: 印刷中 Issue: 6 Pages: 2119-2130
- DOI
  10.1016/j.bbadis.2018.03.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K16634, KAKENHI-PROJECT-18K05329, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K15077
[Journal Article] Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors2017
- Author(s)
  Matsumaru Takanori、Inai Makoto、Ishigami Kana、Iwamatsu Toshiki、Maita Hiroshi、Otsuguro Satoko、Nomura Takao、Matsuda Akira、Ichikawa Satoshi、Sakaitani Masahiro、Shuto Satoshi、Maenaka Katsumi、Kan Toshiyuki
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Issue: 10 Pages: 2144-2147
- DOI
  10.1016/j.bmcl.2017.03.055
- NAID
  120006628669
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15424, KAKENHI-PUBLICLY-16H01160, KAKENHI-PROJECT-17H03973, KAKENHI-PROJECT-16K16634
[Journal Article] Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRα immune cell receptor2017
- Author(s)
  Furukawa Atsushi、Kakita Kosuke、Yamada Tomoki、Ishizuka Mikihiro、Sakamoto Jiro、Hatori Nanao、Maeda Naoyoshi、Ohsaka Fumina、Saitoh Takashi、Nomura Takao、Kuroki Kimiko、Nambu Hisanori、Arase Hisashi、Matsunaga Shigeki、Anada Masahiro、Ose Toyoyuki、Hashimoto Shunichi、Maenaka Katsumi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 51 Pages: 21128-21136
- DOI
  10.1074/jbc.m117.799239
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08848, KAKENHI-PROJECT-15H02545, KAKENHI-PUBLICLY-17H05793, KAKENHI-PROJECT-16K15290, KAKENHI-PROJECT-16K16634
[Journal Article] Conformational Disorder of the Most Immature Cu,Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis2016
- Author(s)
  Yoshiaki Furukawa, Itsuki Anzai, Shuji Akiyama, Mizue Imai, Fatima Joy Consul Cruz, Tomohide Saio, Kenichi Nagasawa, Takao Nomura, and Koichiro Ishimori
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 291 Issue: 8 Pages: 4144-4155
- DOI
  10.1074/jbc.m115.683763
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14480, KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-25291028
[Journal Article] Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis2014
- Author(s)
  Nomura, T., Watanabe, S., Kaneko, K., Yamanaka, K., Nukina, N. & Furukawa, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Issue: 2 Pages: 1192-1202
- DOI
  10.1074/jbc.m113.516492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25291028
[Patent] 初代培養細胞を用いない株化細胞からの癌幹細胞の調製法2020
- Inventor(s)
  前仲勝実、野村尚生
- Industrial Property Rights Holder
  前仲勝実、野村尚生
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-097691
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K05329
[Presentation] 小胞体ストレス応答性酸化還元調節酵素を標的とした創薬スクリーニング2019
- Author(s)
  野村尚生、松丸尊紀、春山知樹、前田直良、奥村正樹、金村進吾、稲葉謙次、田村保明、前仲勝実
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K05329
[Presentation] Academia anti-cancer Drug Discovery targeted for ER-stress Responsive Enzyme2019
- Author(s)
  野村尚生、松丸尊紀、春山知樹、前田直良、奥村正樹、金村進吾、稲葉謙次、田村保明、前仲勝実
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K05329
[Presentation] HSV-1感染における糖ペプチドと免疫受容体PILRa相互作用解析2018
- Author(s)
  野村尚生、柿田浩輔、古川敦、穴田仁洋、橋下俊一、松永茂樹、齊藤貴士、前仲勝実
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-16K16634
[Presentation] ヒト単純ヘルペスウイルス由来糖ペプチドと免疫受容体PILRα相互作用解析2018
- Author(s)
  野村尚生、柿田浩輔、古川敦、穴田仁洋、橋下俊一、松永茂樹、齊藤貴士、前仲勝実
- Organizer
  第57回NMR討論会
- Data Source
  KAKENHI-PROJECT-18K05329
[Presentation] Binding Mechanism of Glycopeptide Derived from HSV-1 with Human Immune Receptor PILRa2018
- Author(s)
  野村尚生、柿田浩輔、古川敦、穴田仁洋、橋下俊一、松永茂樹、齊藤貴士、前仲勝実
- Organizer
  第10回国際ペプチドシンポジウム／第55回ペプチド討論会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05329
[Presentation] 免疫受容体PILRaと単純ヘルペスウイルス１型gB糖ペプチドの相互作用解析2018
- Author(s)
  野村尚生、柿田浩輔、古川敦、穴田仁洋、橋下俊一、松永茂樹、齊藤貴士、前仲勝実
- Organizer
  第１3回ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-18K05329
[Presentation] 抗がん剤を目指した若手研究者連携による創薬スクリーニング（口頭）2017
- Author(s)
  野村尚生、松丸尊紀、奥村正樹、稲葉謙次、田村保明、前仲勝実
- Organizer
  日本薬学会第137年会（仙台）
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2017-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-16K16634
[Presentation] Interaction Detail between Sugar Chain on HSV1 Glycoprotein with Immune Receptor PILRa2017
- Author(s)
  野村尚生、柿田浩輔、古川敦、穴田仁洋、橋下俊一、松永茂樹、齊藤貴士、前仲勝実
- Organizer
  第５４回日本ペプチド討論会
- Data Source
  KAKENHI-PROJECT-16K16634
[Presentation] Effect of Sugar Chain on Interaction of HSV1 Glycoprotein with Immune Receptor PILRa（ポスター）2016
- Author(s)
  Takao Nomura, Kosuke Kakita, Atsushi Furukawa, Masahiro Anada, Shunichi Hashimoto, Hisashi Arase, Takashi Saitoh, and Katsumi Maenaka
- Organizer
  第５３回　日本ペプチド討論会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16K16634
[Presentation] 小胞体ストレス応答性酸化還元調節酵素を標的とした抗癌剤スクリーニング（口頭）2016
- Author(s)
  野村尚生、鈴木華央、松丸尊紀、奥村正樹、稲葉謙次、田村保明、前仲勝実
- Organizer
  第11回ケミカルバイオロジー学会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K16634

1. FURUKAWA YOSHIAKI (40415287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 菊地和也 (70292951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 蓑島維文 (20600844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 松森信明 (50314357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MAEDA Naoyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山中智行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 貫名信行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 稲井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nomura Takao 野村 尚生

NOMURA Takao 野村 尚生

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of cancer differentiation and drug discovery for novel cancer therapy using cancer stem cell lines derived from cancer cell linesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

潜在空間を構成・検証する生物活性の時空間定量計測手法開発・応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of protein networks for the mechanism of carcinogenesis through the oxidoreductase in the endoplasmic reticulumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of oncogenic molecular mechanism mediated by redox regulatory enzyme based on novel inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A mechanism regulating the copper acquisition by intracellular proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A copper-deficient form of mutant cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRα immune cell receptor2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conformational Disorder of the Most Immature Cu,Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis2014

Author(s)

Journal Title

DOI

Data Source

[Patent] 初代培養細胞を用いない株化細胞からの癌幹細胞の調製法2020

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 小胞体ストレス応答性酸化還元調節酵素を標的とした創薬スクリーニング2019

Nomura Takao 野村尚生

NOMURA Takao 野村尚生