Mikawa Takumi 三河拓己

Researcher Number	90608051
Affiliation (Current)	2025: 京都大学, 医学研究科, 研究員
Affiliation (based on the past Project Information) *help	2021 – 2022: 京都大学, 医学研究科, 研究員 2015 – 2020: 京都大学, 医学研究科, 教務補佐員
Review Section/Research Field	Principal Investigator General internal medicine(including psychosomatic medicine) / Basic Section 52010:General internal medicine-related / Basic Section 44010:Cell biology-related
Keywords	Principal Investigator 解糖系代謝 / ホスホグリセリン酸ムターゼ / PGAM / 慢性炎症 / ガン / 発がん / 解糖系酵素 / 癌 / 発癌 / ガン化 … More / 炎症 / ワールブルグ効果 / Warburg効果 / 解糖系 / DNA損傷修復 Less

細胞老化の誘導する非細胞自律的な代謝・炎症制御機構の解明Principal Investigator
- Principal Investigator
  
  三河拓己
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto University
Metabolic mechanism for transcriptional induction of chronic inflammationPrincipal Investigator
- Principal Investigator
  
  MIKAWA Takumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kyoto University
The novel regulation pathway of glycolysis via PGAMPrincipal Investigator
- Principal Investigator
  
  Mikawa Takumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kyoto University
The analysis of conversion mechanism from ageing to tumorigenesis by the metabolic-remodeling of glycolysis.Principal Investigator
- Principal Investigator
  
  Mikawa Takumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kyoto University

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer2021
- Author(s)
  Itoyama R, Yasuda-Yoshihara N, Kitamura F, Yasuda T, Bu L, Yonemura A, Uchihara T, Arima K, Hu X, Jun Z, Okamoto Y, Akiyama T, Yamashita K, Nakao Y, Yusa T, Kitano Y, Higashi T, Miyata T, Imai K, Hayashi H, Yamashita Y, Mikawa T, Kondoh H, Baba H, Ishimoto T
- Journal Title
  
  Cancer Letters
  
  Volume: 523 Pages: 29-42
- DOI
  10.1016/j.canlet.2021.09.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07887, KAKENHI-PROJECT-20K16418, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-20K09038, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-21K16384, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-20K20658
[Journal Article] Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis2021
- Author(s)
  Mikawa T, Shibata E, Shimada M, Ito K, Ito T, Kanda H, Takubo K, Shimada A, Lleonart ME, Inagaki N, Yokode M, Kondoh H
- Journal Title
  
  PLoS One
  
  Volume: 16 Issue: 4 Pages: e0250856-e0250856
- DOI
  10.1371/journal.pone.0250856
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07887, KAKENHI-PROJECT-20K21616, KAKENHI-PROJECT-20K21621, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-20K20658
[Journal Article] Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis2020
- Author(s)
  Mikawa Takumi、Shibata Eri、Shimada Midori、Ito Ken、Ito Tomiko、Kanda Hiroaki、Takubo Keiyo、Lleonart Matilde E.、Inagaki Nobuya、Yokode Masayuki、Kondoh Hiroshi
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 7 Pages: 101306-101306
- DOI
  10.1016/j.isci.2020.101306
- NAID
  120006870881
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21503, KAKENHI-PROJECT-20K21616, KAKENHI-PROJECT-18H02681, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19K07887, KAKENHI-PROJECT-20K20658
[Journal Article] T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.2020
- Author(s)
  Toriyama K, Kuwahara M, Kondoh H, Mikawa T, Takemori N, Konishi A., Yorozuya T, Yamada T, Soga T., Shiraishi A, and Yamashita M.
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 1-13
- DOI
  10.1038/s42003-020-01122-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07680, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04948, KAKENHI-PROJECT-20H03504, KAKENHI-PROJECT-18K08409, KAKENHI-PROJECT-19K07887, KAKENHI-PROJECT-20K20658
[Journal Article] Senescence research from historical theory to future clinical application.2020
- Author(s)
  M Kameda, T Mikawa, M Yokode, N Inagaki, H Kondoh.
- Journal Title
  
  Geriatr. Gerontol. Int
  
  Volume: 21 Issue: 2 Pages: 125-130
- DOI
  10.1111/ggi.14121
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07887, KAKENHI-PROJECT-20K20658
[Journal Article] 解糖系酵素PGAMとストレス老化シグナル2016
- Author(s)
  近藤祥司、三河拓己、稲垣暢也
- Journal Title
  
  生化学
  
  Volume: 88-3 Pages: 296-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19283
[Journal Article] 細胞老化概論2～慢性炎症とSASPを中心に2016
- Author(s)
  近藤祥司、三河拓己、稲垣暢也
- Journal Title
  
  The Lung perspectives
  
  Volume: 24;3 Pages: 84-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19283
[Journal Article] 老化制御・抗加齢医学の現況と展望2016
- Author(s)
  近藤祥司、三河拓己、稲垣暢也
- Journal Title
  
  日本臨床
  
  Volume: 74:9 Pages: 1429-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19283
[Journal Article] 細胞老化概論1～テロメア依存性/非依存性からみた細胞老化2016
- Author(s)
  近藤祥司、三河拓己、稲垣暢也
- Journal Title
  
  The Lung perspectives
  
  Volume: 24;2 Pages: 87-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19283
[Journal Article] ガン代謝制御標的としてのPGAM2015
- Author(s)
  三河拓己、稲垣暢也、近藤祥司
- Journal Title
  
  実験医学
  
  Volume: 33巻 Pages: 1741-1745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19283
[Presentation] PGAMモデルマウスの解析2021
- Author(s)
  三河　拓己、近藤　祥司
- Organizer
  第63回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07887
[Presentation] 解糖系酵素PGAMとChk1による新規解糖系制御機構の解析2020
- Author(s)
  三河拓己、近藤祥司
- Organizer
  MBSJ2020
- Data Source
  KAKENHI-PROJECT-19K07887
[Presentation] 解糖系酵素PGAMによる新規解糖系制御機構2019
- Author(s)
  三河　拓己
- Organizer
  第30回日本老年医学会近畿地方会
- Data Source
  KAKENHI-PROJECT-19K07887
[Presentation] 解糖系代謝新規制御機構の解明2018
- Author(s)
  三河拓己、近藤祥司
- Organizer
  先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-17K15894
[Presentation] PGAMを介した解糖系新規制御機構の解析2018
- Author(s)
  三河拓己、伊藤健、横出正之、近藤祥司
- Organizer
  第60回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15894
[Presentation] 解糖系酵素PGAMによる解糖系制御機構の解析2018
- Author(s)
  三河拓己、伊藤健、稲垣暢也、横出正之、近藤祥司
- Organizer
  第41回日本分子生物学学会年会
- Data Source
  KAKENHI-PROJECT-17K15894
[Presentation] Metabolites in organismal ageing & Glycolysis in cellular senescence2017
- Author(s)
  近藤祥司、三河拓己
- Organizer
  Asian Society of Aging Research
- Invited
- Data Source
  KAKENHI-PROJECT-17K15894
[Presentation] PGAMを介した解糖系新規制御機構の解析2017
- Author(s)
  三河拓己、伊藤健、稲垣暢也、横出正之、近藤祥司
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K15894
[Presentation] PGAMを介した解糖系新規制御機構の解明2017
- Author(s)
  三河拓己、近藤祥司
- Organizer
  先端モデル支援プラットフォーム若手支援技術講習会
- Data Source
  KAKENHI-PROJECT-17K15894
[Presentation] Metabolites in organismal ageing & Glycolysis in cellular senescenc2017
- Author(s)
  近藤祥司、三河拓己
- Organizer
  International symposium in Kumamoto
- Invited
- Data Source
  KAKENHI-PROJECT-17K15894
[Presentation] 細胞老化からガン化への変遷に重要な解糖系酵素PGAM2016
- Author(s)
  三河拓己、伊藤健、村上逸雄、堀晃輔、稲垣暢也、近藤祥司
- Organizer
  第16回日本抗加齢医学総会
- Place of Presentation
  横浜
- Year and Date
  2016-06-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K19283
[Presentation] 解糖系酵素PGAMモデルマウスの解析2016
- Author(s)
  三河拓己、伊藤健、稲垣暢也、近藤祥司
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K19283
[Presentation] 解糖系酵素PGAMモデルマウスの解析2016
- Author(s)
  三河拓己、伊藤健、稲垣暢也、横出正之、近藤祥司
- Organizer
  第9回Symphony
- Place of Presentation
  東京
- Year and Date
  2016-09-18
- Data Source
  KAKENHI-PROJECT-15K19283
[Presentation] 老化シグナルによる解糖系酵素ＰＧＡMの転写後制御機構2015
- Author(s)
  近藤祥司、三河拓己
- Organizer
  第38回日本基礎老化学会大会
- Place of Presentation
  横浜
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-15K19283
[Presentation] ストレス老化シグナルによる解糖系ユビキチン化制御とその病態意義2015
- Author(s)
  三河拓己、近藤祥司
- Organizer
  第57回日本老年医学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-15K19283
[Presentation] PGAMモデルマウスの解析2015
- Author(s)
  三河拓己、伊藤健、堀晃輔、村上逸雄、稲垣暢也、横出正之、近藤祥司
- Organizer
  第8回Symphony
- Place of Presentation
  東京
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-15K19283
[Presentation] 解糖系酵素PGAMモデルマウスの解析2015
- Author(s)
  三河拓己、伊藤健、近藤祥司
- Organizer
  第26回　日本老年医学会近畿地方会
- Place of Presentation
  京都
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-15K19283
[Presentation] Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm22015
- Author(s)
  Mikawa T and Kondoh H
- Organizer
  The Controlling Cancer Summit
- Place of Presentation
  London, UK
- Year and Date
  2015-05-12
- Data Source
  KAKENHI-PROJECT-15K19283

1. KONDOH Hiroshi (80402890)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. SHIMADA Midori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 山田武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mikawa Takumi 三河 拓己

Research Projects

Research Products

Co-Researchers

細胞老化の誘導する非細胞自律的な代謝・炎症制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metabolic mechanism for transcriptional induction of chronic inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The novel regulation pathway of glycolysis via PGAMPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of conversion mechanism from ageing to tumorigenesis by the metabolic-remodeling of glycolysis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Senescence research from historical theory to future clinical application.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 解糖系酵素PGAMとストレス老化シグナル2016

Author(s)

Journal Title

Data Source

[Journal Article] 細胞老化概論2～慢性炎症とSASPを中心に2016

Author(s)

Journal Title

Data Source

[Journal Article] 老化制御・抗加齢医学の現況と展望2016

Author(s)

Journal Title

Data Source

[Journal Article] 細胞老化概論1～テロメア依存性/非依存性からみた細胞老化2016

Author(s)

Journal Title

Data Source

[Journal Article] ガン代謝制御標的としてのPGAM2015

Author(s)

Journal Title

Data Source

[Presentation] PGAMモデルマウスの解析2021

Author(s)

Organizer

Data Source

[Presentation] 解糖系酵素PGAMとChk1による新規解糖系制御機構の解析2020

Author(s)

Mikawa Takumi 三河拓己