Echigoya Yusuke 越後谷裕介

… Alternative Names

ECHIGOYA Yusuke 越後谷裕介

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Researcher Number	90609950
Other IDs
Affiliation (Current)	2025: 日本大学, 生物資源科学部, 准教授
Affiliation (based on the past Project Information) *help	2023: 日本大学, 生物資源科学部, 准教授 2019 – 2022: 日本大学, 生物資源科学部, 講師 2017 – 2018: 日本大学, 生物資源科学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 42020:Veterinary medical science-related / Experimental pathology
Keywords	Principal Investigator アンチセンス核酸 / 核酸医薬 / ウイルス / 日本脳炎 / モデル動物 / 老化 / CTGリピート / アンチセンス人工核酸 / 加齢 / 筋強直性ジストロフィー … More / 筋ジストロフィー / 抗ウイルス薬 / RNA / gapmer / ウイルスRNA / RNA分解 / RNAウイルス Less

筋強直性ジストロフィーの加齢性病態の解明とアンチセンス核酸療法の開発Principal Investigator
- Principal Investigator
  
  越後谷裕介
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Nihon University
Development of RNase H-mediated antiviral oligonucleotides.Principal Investigator
- Principal Investigator
  
  ECHIGOYA Yusuke
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Nihon University
RNA分解型アンチセンス核酸を用いた新たなウイルス治療法の開発Principal Investigator
- Principal Investigator
  
  越後谷裕介
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Experimental pathology
- Research Institution
  Nihon University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] CLINICAL NEUROSCIENCE Vol.41 2023年5月号核酸医薬と神経疾患「筋ジストロフィー」2023
- Author(s)
  越後谷裕介, 青木吉嗣
- Total Pages
  160
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21K06976
[Journal Article] Restoring Dystrophin Expression with Exon 44 and 53 Skipping in the DMD Gene in Immortalized Myotubes2023
- Author(s)
  Yusuke Echigoya, Toshifumi Yokota
- Journal Title
  
  Methods in Molecular Biology: Muscular Dystrophy Therapeutics
  
  Volume: 2587 Pages: 125-139
- DOI
  10.1007/978-1-0716-2772-3_7
- ISBN
  9781071627716, 9781071627723
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06976
[Journal Article] Antiviral Efficacy of RNase H-Dependent Gapmer Antisense Oligonucleotides against Japanese Encephalitis Virus.2023
- Author(s)
  Shunsuke Okamoto, Yusuke Echigoya (Corresponding), Ayaka Tago, Takao Segawa, Yukita Sato, Takuya Itou
- Journal Title
  
  International journal of molecular sciences
  
  Volume: 24(19) Issue: 19 Pages: 14846-14846
- DOI
  10.3390/ijms241914846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06976, KAKENHI-PROJECT-23K05386
[Journal Article] Development of DG9 peptide-conjugated single- and multi-exon skipping therapies for the treatment of Duchenne muscular dystrophy2022
- Author(s)
  Lim KRQ, Woo S, Melo D, Huang Y, Dzierlega K, Shah MNA, Aslesh T, Roshmi RR, Echigoya Y, Maruyama R, Moulton HM, Yokota T.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 119(9) Issue: 9
- DOI
  10.1073/pnas.2112546119
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14595, KAKENHI-PROJECT-21K06976
[Journal Article] DUX4 Transcript Knockdown with Antisense 2′-O-Methoxyethyl Gapmers for the Treatment of Facioscapulohumeral Muscular Dystrophy2021
- Author(s)
  Lim KRQ, Bittel A, Maruyama R, Echigoya Y, Nguyen Q, Huang Y, Dzierlega K, Zhang A, Chen YW, Yokota T.
- Journal Title
  
  Molecular Therapy
  
  Volume: 29 Issue: 2 Pages: 848-858
- DOI
  10.1016/j.ymthe.2020.10.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14595
[Journal Article] A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping2021
- Author(s)
  Echigoya Y, Trieu N, Duddy W, Moulton HM, Yin H, Partridge TA, Hoffman EP, Kornegay JN, Rohret FA, Rogers CS, Yokota T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 22(23) Issue: 23 Pages: 13065-13065
- DOI
  10.3390/ijms222313065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14595, KAKENHI-PROJECT-21K06976
[Journal Article] Inhibition of DUX4expression with antisense LNA gapmers as a therapy for facioscapulohumeral muscular dystrophy2020
- Author(s)
  Lim KRQ, Maruyama R, Echigoya Y, Nguyen Q, Zhang A, Khawaja H, Sen Chandra S, Jones T, Jones P, Chen YW, Yokota T.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 28 Pages: 16509-16515
- DOI
  10.1073/pnas.1909649117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14595
[Journal Article] Exons 45-55 Skipping Using Mutation-Tailored Cocktails of Antisense Morpholinos in the DMD Gene2019
- Author(s)
  Echigoya Yusuke、Lim Kenji Rowel Q.、Melo Dyanna、Bao Bo、Trieu Nhu、Mizobe Yoshitaka、Maruyama Rika、Mamchaoui Kamel、Tanihata Jun、Aoki Yoshitsugu、Takeda Shin’ichi、Mouly Vincent、Duddy William、Yokota Toshifumi
- Journal Title
  
  Molecular Therapy
  
  Volume: 27 Issue: 11 Pages: 2005-2017
- DOI
  10.1016/j.ymthe.2019.07.012
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14595
[Journal Article] ウイルス性疾患に対するアンチセンス核酸医薬品の開発現状と課題2019
- Author(s)
  越後谷裕介
- Journal Title
  
  Medical Science Digest-核酸医薬の最前線-
  
  Volume: 1 Pages: 8-9
- Data Source
  KAKENHI-PROJECT-18K14595
[Journal Article] Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes.2019
- Author(s)
  Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 520 Issue: 1 Pages: 179-185
- DOI
  10.1016/j.bbrc.2019.09.095
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02577, KAKENHI-PROJECT-18H02887, KAKENHI-PROJECT-18K15026, KAKENHI-PROJECT-18K14595
[Journal Article] Efficacy of Multi-exon Skipping Treatment in Duchenne Muscular Dystrophy Dog Model Neonates.2019
- Author(s)
  Lim KRQ*, Echigoya Y* (* equally contributed), Nagata T, Kuraoka M, Kobayashi M, Aoki Y, Partridge T, Maruyama R, Takeda S, Yokota T.
- Journal Title
  
  Molecular Therapy
  
  Volume: 27(1) Issue: 1 Pages: 76-86
- DOI
  10.1016/j.ymthe.2018.10.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14595, KAKENHI-PROJECT-16H05221
[Journal Article] Multiple Exon Skipping in the Duchenne Muscular Dystrophy Hot Spots: Prospects and Challenges2018
- Author(s)
  Echigoya Yusuke、Lim Kenji Rowel Q.、Nakamura Akinori、Yokota Toshifumi
- Journal Title
  
  Journal of Personalized Medicine
  
  Volume: 8 Issue: 4 Pages: 41-41
- DOI
  10.3390/jpm8040041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14595, KAKENHI-PROJECT-18H02577
[Journal Article] 核酸医薬開発における筋ジストロフィーモデル犬2018
- Author(s)
  越後谷裕介
- Journal Title
  
  LABIO21
  
  Volume: 71 Pages: 12-15
- Data Source
  KAKENHI-PROJECT-17H07142
[Presentation] 筋強直性ジストロフィー 1 型モデルマウスにおける筋強直の評価法の検討および血液生化学性状の解析2023
- Author(s)
  伊賀わか菜, 越後谷裕介(発表責任者), 佐藤雪太
- Organizer
  第166回日本獣医学会学術集会(日本実験動物医学会)
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] Inhibition of Japanese Encephalitis Virus Replication with RNase H-dependent Gapmer Antisense Oligonucleotides2023
- Author(s)
  Shunsuke OKAMOTO, Yusuke ECHIGOYA(Corresponding), Takao SEGAWA, Yukita SATO, Takuya ITOU
- Organizer
  第3回東アジア(韓国、中国[台湾]、日本)合同獣医学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] 筋強直性ジストロフィーモデルマウスの加齢病態解明とアンチセンス療法の開発2023
- Author(s)
  越後谷裕介, 中森雅之, 高橋正紀, 横田俊文, 青木吉嗣
- Organizer
  2023年度精神・神経疾患研究開発費2-6「疾患モデルを駆使した筋ジストロフィーの治療法開発」青木班研究班会議
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] Locked Nucleic Acid gapmers effectively inhibit the proliferation of Japanese encephalitis virus in a human neuroblastoma cell line2023
- Author(s)
  Shunsuke Okamoto, Yusuke Echigoya(Corresponding), Takao Segawa, Yukita Sato, Takuya Itou
- Organizer
  The 70th Annual Meeting of the Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] Locked nucleic acid (LNA) gapmerの日本脳炎ウイルス野外株に対する増殖抑制効果2023
- Author(s)
  田児彩佳, 岡本俊輔, 越後谷裕介(発表責任者), 伊藤琢也, 佐藤雪太
- Organizer
  第166回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] Evaluation of Urinary Titin Levels and Myotonic Discharges with Aging in a Myotonic Dystrophy Mouse Model2023
- Author(s)
  Yusuke ECHIGOYA(Corresponding), Yume SHINOHARA, Masato KITAGAWA, Yukita SATO
- Organizer
  第3回東アジア(韓国、中国[台湾]、日本)合同獣医学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] 筋強直性ジストロフィー1 型に対する筋指向性脂質付加 siRNA 医薬品の探索研究2023
- Author(s)
  峰岸かつら, 越後谷裕介, 木村公一, 本橋紀夫, 青木吉嗣
- Organizer
  2023年度精神・神経疾患研究開発費2-6「疾患モデルを駆使した筋ジストロフィーの治療法開発」青木班研究班会議
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] 筋強直性ジストロフィーモデルマウスにおける尿中タイチンおよびミオトニー放電の加齢性変化2022
- Author(s)
  篠原由夢、越後谷裕介、丸山順裕、北川勝人、佐藤雪太
- Organizer
  第165回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] 筋ジストロフィーモデル動物を用いた核酸医薬の研究開発2022
- Author(s)
  越後谷裕介
- Organizer
  第3回コンパニオンアニマルのゲノム医療研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] 日本脳炎ウイルス増殖抑制効果におけるRNA分解型アンチセンス核酸の塩基配列および修飾核酸の特異性2022
- Author(s)
  岡本俊輔、越後谷裕介、瀬川太雄、佐藤雪太、伊藤琢也
- Organizer
  第165回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] 筋ジストロフィーモデル動物の加齢病態に基づいたアンチセンス療法の開発2022
- Author(s)
  越後谷裕介、中森雅之、高橋正紀、横田俊文、青木吉嗣
- Organizer
  国立研究開発法人国立精神・神経医療研究センター精神・神経疾患研究開発費「疾患モデル動物を基盤とした筋ジストロフィーの新しい治療法開発」班　2022年度班会議
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] 筋ジストロフィーモデル動物の加齢病態に基づいたアンチセンス療法の開発2021
- Author(s)
  越後谷裕介, 中森雅之, 高橋正紀, 横田俊文, 青木吉嗣
- Organizer
  国立研究開発法人国立精神・神経医療研究センター精神・神経疾患研究開発費「疾患モデル動物を基盤とした筋ジストロフィーの新しい治療法開発」班　2021年度班会議
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] 日本脳炎ウイルスに増殖抑制効果を示すRNA構造阻害型アンチセンス人工核酸の開発2021
- Author(s)
  速水李誉、越後谷裕介、岡本俊輔、伊藤琢也、佐藤雪太
- Organizer
  第164回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K14595
[Presentation] RNA分解型アンチセンス人工核酸による日本脳炎ウイルス増殖抑制効果2021
- Author(s)
  岡本俊輔、越後谷裕介、瀬川太雄、佐藤雪太、伊藤琢也
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K14595
[Presentation] 日本脳炎ウイルスに増殖抑制効果を示すRNA構造阻害型アンチセンス人工核酸の開発2021
- Author(s)
  速水李誉、越後谷裕介、岡本俊輔、伊藤琢也、佐藤雪太
- Organizer
  第164回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] RNA分解型アンチセンス人工核酸による日本脳炎ウイルス増殖抑制効果2021
- Author(s)
  岡本俊輔、越後谷裕介、瀬川太雄、佐藤雪太、伊藤琢也
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06976
[Presentation] デュシェンヌ型筋ジストロフィーに対するアンチセンス核酸カクテル療法の開発2019
- Author(s)
  越後谷裕介
- Organizer
  日本筋学会第5回学術集会シンポジウム1「最新ゲノム解析による遺伝学的診断と運動器疾患の新たな治療戦略」
- Invited
- Data Source
  KAKENHI-PROJECT-18K14595

1. NAKAMURA Akinori

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2. 武田伸一

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3. 柴祐司

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4. 柴直子

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5. 宮崎大吾

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6. 青木吉嗣

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Echigoya Yusuke 越後谷 裕介

ECHIGOYA Yusuke 越後谷 裕介

Research Projects

Research Products

Co-Researchers

筋強直性ジストロフィーの加齢性病態の解明とアンチセンス核酸療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of RNase H-mediated antiviral oligonucleotides.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RNA分解型アンチセンス核酸を用いた新たなウイルス治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] CLINICAL NEUROSCIENCE Vol.41 2023年5月号 核酸医薬と神経疾患「筋ジストロフィー」2023

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Restoring Dystrophin Expression with Exon 44 and 53 Skipping in the DMD Gene in Immortalized Myotubes2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Antiviral Efficacy of RNase H-Dependent Gapmer Antisense Oligonucleotides against Japanese Encephalitis Virus.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of DG9 peptide-conjugated single- and multi-exon skipping therapies for the treatment of Duchenne muscular dystrophy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DUX4 Transcript Knockdown with Antisense 2′-O-Methoxyethyl Gapmers for the Treatment of Facioscapulohumeral Muscular Dystrophy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of DUX4expression with antisense LNA gapmers as a therapy for facioscapulohumeral muscular dystrophy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exons 45-55 Skipping Using Mutation-Tailored Cocktails of Antisense Morpholinos in the DMD Gene2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ウイルス性疾患に対するアンチセンス核酸医薬品の開発現状と課題2019

Author(s)

Journal Title

Data Source

[Journal Article] Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of Multi-exon Skipping Treatment in Duchenne Muscular Dystrophy Dog Model Neonates.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiple Exon Skipping in the Duchenne Muscular Dystrophy Hot Spots: Prospects and Challenges2018

Author(s)

Echigoya Yusuke 越後谷裕介

ECHIGOYA Yusuke 越後谷裕介

[Book] CLINICAL NEUROSCIENCE Vol.41 2023年5月号核酸医薬と神経疾患「筋ジストロフィー」2023