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Ooe Kazuhiro  大江 一弘

ORCIDConnect your ORCID iD *help
Researcher Number 90610303
Other IDs
Affiliation (Current) 2025: 大阪大学, 放射線科学基盤機構附属ラジオアイソトープ総合センター, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 大阪大学, 放射線科学基盤機構附属ラジオアイソトープ総合センター, 准教授
2018 – 2021: 大阪大学, 医学部附属病院, 特任助教(常勤)
2015 – 2017: 新潟大学, 自然科学系, 助教
Review Section/Research Field
Principal Investigator
Basic Section 52040:Radiological sciences-related / Inorganic chemistry
Except Principal Investigator
Basic Section 52040:Radiological sciences-related / Radiation science
Keywords
Principal Investigator
ベータ線放出核種 / 加速器製造核種 / 核医学治療 / セラノスティクス / キレート配位子 / 溶媒抽出 / ラザホージウム / 超重元素
Except Principal Investigator
アスタチン / FAP … More / アルファ線 / 線維芽細胞活性化タンパク質 / 脱ハロゲン / α線 / ネオペンチル構造 / アスタチン-211 / PET / 癌関連線維芽細胞 / メラノコルチン-1受容体 / α-メラノサイト刺激ホルモン / ヨウ素-125 / 悪性黒色腫 / 核医学治療 / がん間質 / FAPI / がん関連線維芽細胞 / 核医学 / アルファ線治療 / 放射性医薬品 / ネオペンチル / 腫瘍低酸素領域 / 放射性ヨウ素 / ニトロイミダゾール / 腫瘍低酸素部位 / 標的α線治療 / O-15水 / バイオマーカー / 医薬品送達 / 腫瘍血流 / 放射線 / 抗がん剤治療 / O-15標識水 / 化学療法 / 腫瘍血流量 Less
  • Research Projects

    (8 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (20 People)
  •  Development of innovative alpha therapy targeting cancer-associated fibroblasts

    • Principal Investigator
      渡部 直史
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Osaka University
  •  悪性黒色腫の標的α線治療を指向するAt-211標識薬剤開発

    • Principal Investigator
      鈴木 博元
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Chiba University
  •  加速器製造可能な新規セラノスティクス核種の開発Principal Investigator

    • Principal Investigator
      大江 一弘
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Osaka University
  •  Development of accelerator produced radionuclides for radioisotope therapy applicationPrincipal Investigator

    • Principal Investigator
      Ooe Kazuhiro
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Osaka University
  •  Development of At-211-labeled agents targeting the tumor hypoxia region

    • Principal Investigator
      Suzuki Hiroyuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Chiba University
  •  Development of Nuclear Medicine Therapy targeting Cancer Stroma

    • Principal Investigator
      Watabe Tadashi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Osaka University
  •  Evaluation of anti-cancer drug delivery by means of positron emission tomography: a proposal for new strategy of cancer treatment

    • Principal Investigator
      Hatazawa Jun
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Radiation science
    • Research Institution
      Osaka University
  •  Study of complex formation of superheavy element, rutherfordium, with chelating agentsPrincipal Investigator

    • Principal Investigator
      Ooe Kazuhiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Inorganic chemistry
    • Research Institution
      Niigata University

All 2024 2023 2022 2021 2020 2019 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Neopentyl glycol-based radiohalogen-labeled amino acid derivatives for cancer radiotheranostics2024

    • Author(s)
      Kaizuka Yuta、Suzuki Hiroyuki、Watabe Tadashi、Ooe Kazuhiro、Toyoshima Atsushi、Takahashi Kazuhiro、Sawada Koichi、Iimori Takashi、Masuda Yoshitada、Uno Takashi、Kannaka Kento、Uehara Tomoya
    • Journal Title

      EJNMMI Radiopharmacy and Chemistry

      Volume: 9 Issue: 1 Pages: 17-17

    • DOI

      10.1186/s41181-024-00244-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23KJ0302, KAKENHI-PROJECT-22K07686
  • [Journal Article] Improvement of chemical separation method for theranostic radionuclide 141Ce2023

    • Author(s)
      K. Ooe, T. Watabe, Y. Shirakami, A. Nambu, H. Haba, J. Hatazawa
    • Journal Title

      RIKEN accelerator progress report

      Volume: 56 Pages: 153-153

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07717
  • [Journal Article] Fibroblast activation protein targeted therapy using [177Lu]FAPI-46 compared with [225Ac]FAPI-46 in a pancreatic cancer model2021

    • Author(s)
      Liu Yuwei、Watabe Tadashi、Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Naka Sadahiro、Ooe Kazuhiro、Toyoshima Atsushi、Nagata Kojiro、Haberkorn Uwe、Kratochwil Clemens、Shinohara Atsushi、Hatazawa Jun、Giesel Frederik
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 49 Issue: 3 Pages: 871-880

    • DOI

      10.1007/s00259-021-05554-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-21K07619, KAKENHI-PROJECT-19H03602, KAKENHI-PROJECT-23K21426
  • [Journal Article] Neopentyl Glycol as a Scaffold to Provide Radiohalogenated Theranostic Pairs of High In Vivo Stability2021

    • Author(s)
      Hiroyuki Suzuki, Yuta Kaizuka, Maho Tatsuta, Hiroshi Tanaka, Nana Washiya, Yoshifumi Shirakami, Kazuhiro Ooe, Atsushi Toyoshima, Tadashi Watabe, Takahiro Teramoto, Ichiro Sasaki, Shigeki Watanabe, Noriko S. Ishioka, Jun Hatazawa, Tomoya Uehara, Yasushi Arano
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 64 Issue: 21 Pages: 15846-15857

    • DOI

      10.1021/acs.jmedchem.1c01147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08222
  • [Journal Article] Preclinical Evaluation of Radiation-Induced Toxicity in Targeted Alpha Therapy Using [211At] NaAt in Mice: A Revisit2020

    • Author(s)
      Liu Yuwei、Watabe Tadashi、Kaneda-Nakashima Kazuko、Ooe Kazuhiro、Shirakami Yoshifumi、Toyoshima Atsushi、Shimosegawa Eku、Nakano Takashi、Shinohara Atsushi、Hatazawa Jun
    • Journal Title

      Translational Oncology

      Volume: 13 Issue: 4 Pages: 100757-100757

    • DOI

      10.1016/j.tranon.2020.100757

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-19H03602
  • [Journal Article] Enhancement of astatine-211 uptake via the sodium iodide symporter by the addition of ascorbic acid in targeted alpha therapy of thyroid cancer2019

    • Author(s)
      Watabe Tadashi、Kaneda-Nakashima Kazuko、Liu Yuwei、Shirakami Yoshifumi、Ooe Kazuhiro、Toyoshima Atsushi、Shimosegawa Eku、Fukuda Mitsuhiro、Shinohara Atsushi、Hatazawa Jun
    • Journal Title

      Journal of Nuclear Medicine

      Volume: - Issue: 9 Pages: 1-43

    • DOI

      10.2967/jnumed.118.222638

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-16K10277, KAKENHI-PROJECT-19H03602
  • [Journal Article] Theranostics Targeting Fibroblast Activation Protein in the Tumor Stroma: 64Cu- and 225Ac-Labeled FAPI-04 in Pancreatic Cancer Xenograft Mouse Models2019

    • Author(s)
      Watabe Tadashi、Liu Yuwei、Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Lindner Thomas、Ooe Kazuhiro、Toyoshima Atsushi、Nagata Kojiro、Shimosegawa Eku、Haberkorn Uwe、Kratochwil Clemens、Shinohara Atsushi、Giesel Frederik、Hatazawa Jun
    • Journal Title

      Journal of Nuclear Medicine

      Volume: 61 Issue: 4 Pages: 563-569

    • DOI

      10.2967/jnumed.119.233122

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07323, KAKENHI-PROJECT-19H03602
  • [Presentation] ネオペンチル基を標識部位とする211At標識αMSHペプチド薬剤の開発2023

    • Author(s)
      田中頌子、鈴木博元、山下紗葵、貝塚祐太、甘中健登、佐々木一郎、大島康宏、渡辺茂樹、大江一弘, 渡部直史、石岡典子, 上原知也
    • Organizer
      短寿命RI利用研究シンポジウム
    • Data Source
      KAKENHI-PROJECT-22K07686
  • [Presentation] Alpha-melanocyte stimulating hormone peptide analogs radiolabeled with At-211 via a neopentyl glycol scaffold2023

    • Author(s)
      Hiroyuki Suzuki, Saki Yamashita, Yuta Kaizuka, Kento Kannaka, Yasuhiro Ohshima, Ichiro Sasaki, Shigeki Watanabe, Kazuhiro Ooe, Tadashi Watabe, Noriko S. Ishioka, Tomoya Uehara
    • Organizer
      The 12th International Symposium on Targeted Alpha Therapy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07686
  • [Presentation] 核医学利用に向けたCe-141の加速器製造と分離精製の検討2022

    • Author(s)
      大江一弘、渡部直史、白神宜史、南部明弘、羽場宏光、畑澤順
    • Organizer
      日本放射化学会第66回討論会(2022)
    • Data Source
      KAKENHI-PROJECT-22K07717
  • [Presentation] Preparation of an astatine-211 aqueous solution by dry distillation and dissolution in pure water2021

    • Author(s)
      Kazuhiro Ooe, Atsushi Toyoshima, Takahiro Teramoto, Kojiro Nagata, Yuichiro Kadonaga, Akimitsu Kanda, Katsuyuki Tokoi, Sota Nakagawa, Tadashi Watabe, Yoshifumi Shirakami, Takashi Yoshimura, Atsushi Shinohara, and Jun Hatazawa
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2021 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08173
  • [Presentation] 乾式分離と純水を用いた溶解によるアスタチン211の分離精製2021

    • Author(s)
      大江一弘、豊嶋厚史、寺本高啓、永田光知郎、床井健運、中川創太、渡部 直史、白神宜史、吉村崇、篠原厚、畑澤順
    • Organizer
      第61回日本核医学会学術総会(2021)
    • Data Source
      KAKENHI-PROJECT-19K08173
  • [Presentation] Production and separation of theranostic radionuclide Ag-111 from Pd target2020

    • Author(s)
      Kazuhiro Ooe, Tadashi Watabe, Yoshifumi Shirakami, Daiki Mori, Takuya Yokokita, Yukiko Komori, Hiromitsu Haba and Jun Hatazawa
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging 2020 Annual Meeting (SNMMI 2020)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08173
  • [Presentation] 治療用核種Ag-111のPd標的からの加速器製造と分離精製2020

    • Author(s)
      大江一弘、渡部直史、白神宜史、森大輝、横北卓也、小森有希子、羽場宏光、畑澤順
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K08173
  • [Presentation] 核医学利用に向けたAg-111の加速器による製造と分離精製2020

    • Author(s)
      大江一弘、渡部直史、白神宜史、森大輝、横北卓也、小森有希子、羽場宏光、畑澤順
    • Organizer
      日本放射化学会第64回討論会(2020)
    • Data Source
      KAKENHI-PROJECT-19K08173
  • [Presentation] Radiotheranosticsに有用な放射性ヨウ素/アスタチン-211標識母体としてのネオペンチル誘導体の評価2019

    • Author(s)
      貝塚祐太、鈴木博元、龍田真帆、田中浩士、上原知也、白神宜史、大江一弘、渡辺茂樹、豊嶋厚史、渡部直史、石岡典子、畑澤順、荒野泰
    • Organizer
      第17回次世代を担う若手のためのフィジカル・ファーマフォーラム
    • Data Source
      KAKENHI-PROJECT-19K08222
  • [Presentation] Increased uptake of At-211 in thyroid gland by the preparation with ascorbic acid for targeted alpha therapy of thyroid cancer2019

    • Author(s)
      Kazuhiro Ooe, Tadashi Watabe, Kazuko Kaneda-Nakashima, Yuwei Liu, Yoshifumi Shirakami, Atsushi Toyoshima, Eku Shimosegawa, Mitsuhiro Fukuda, Atsushi Shinohara, Jun Hatazawa
    • Organizer
      The 11th International Symposium on Targeted-Alpha-Therapy (TAT11)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08173
  • [Presentation] Dissolution of dry distilled At-211 with non-toxic aqueous solutions2019

    • Author(s)
      Kazuhiro Ooe, Tadashi Watabe, Yoshifumi Shirakami, Soichiro Ichimura, Honoka Obata, Takumi Ikeda, Zi Jian Zhang, Kojiro Nagata, Atsushi Toyoshima, Takashi Yoshimura, Atsushi Shinohara, and Jun Hatazawa
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2019 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08173
  • [Presentation] Targeted alpha therapy of thyroid cancer: evaluation of [At-211]NaAt treatment in the xenograft model.2019

    • Author(s)
      Watabe T, Kaneda K, Liu Y, Shirakami Y, Ooe K, Toyoshima A, Shimosegawa E, Fukuda M, Shinohara A, Hatazawa
    • Organizer
      第59回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-19H03602
  • [Presentation] Determination of Rn-219 radioactivity in exhaled breath from patients treated with Ra-2232019

    • Author(s)
      Kazuhiro Ooe, Tadashi Watabe, Takashi Kamiya, Takashi Yoshimura, Makoto Hosono, Atsushi Shinohara, Jun Hatazawa
    • Organizer
      第59回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K08173
  • [Presentation] Radiohalogenated neopentyl derivatives: A novel scaffold for radioiodinated and astatinated compounds of high stability against in vivo dehalogenation2019

    • Author(s)
      Suzuki H, Tanaka H, Washiya N, Tatsuta M, Sato Y, Kaizuka Y, Watanabe S, Uehara T, Ishioka N, Shirakami Y, Ooe K, Toyoshima A, Watabe T, Hatazawa J, Arano A.
    • Organizer
      The 11th International Symposium on Targeted-Alpha-Therapy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08222
  • [Presentation] Theranostics targeting fibroblast activation protein in the tumor stroma: [64Cu] and [225Ac] labelled FAPI-04 in pancreatic cancer xenograft mice.2019

    • Author(s)
      Watabe T, Shirakami Y, Kaneda K, Liu Y, Lindner T, Ooe K, Toyoshima A, Naka S, Shimosegawa E, Haberkorn Uwe; Giesel F, Hatazawa J.
    • Organizer
      ヨーロッパ核医学会(EANM2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03602
  • [Presentation] Rfの同族元素Zr、Hfの2-フロイルトリフルオロアセトンを用いた溶媒抽出2017

    • Author(s)
      大江一弘、草刈駿、後藤真一、工藤久昭、羽場宏光、小森有希子
    • Organizer
      2017日本放射化学会年会・第61回放射化学討論会
    • Data Source
      KAKENHI-PROJECT-15K17830
  • [Presentation] Rfの同族元素Zr、Hfの4-イソプロピルトロポロンを用いた溶媒抽出挙動2016

    • Author(s)
      大江一弘、山田亮平、後藤真一、工藤久昭、羽場宏光、小森有希子
    • Organizer
      2016日本放射化学会年会・第60回放射化学討論会
    • Place of Presentation
      新潟大学(新潟県新潟市)
    • Year and Date
      2016-09-10
    • Data Source
      KAKENHI-PROJECT-15K17830
  • [Presentation] フローインジェクション分析法を利用した4族元素Zr, Hfのキレート抽出2016

    • Author(s)
      山田亮平、大江一弘、後藤真一、工藤久昭、羽場宏光、小森有希子
    • Organizer
      2016日本放射化学会年会・第60回放射化学討論会
    • Place of Presentation
      新潟大学(新潟県新潟市)
    • Year and Date
      2016-09-10
    • Data Source
      KAKENHI-PROJECT-15K17830
  • [Presentation] Liquid-liquid extraction behavior of zirconium and hafnium as homologs of element 104, rutherfordium using chelate extractants2015

    • Author(s)
      K. Ooe, A. Tanaka, R. Yamada, H. Kikunaga, M. Murakami, Y. Komori, H. Haba, S. Goto and H. Kudo
    • Organizer
      The 2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu. Hawaii, USA
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K17830
  • [Presentation] Rfの溶液化学実験に向けた同族元素Zr, HfのHDEHPによる溶媒抽出挙動2015

    • Author(s)
      山田亮平、大江一弘、村上昌史、羽場宏光、小森有希子、菊永英寿、後藤真一、工藤久昭
    • Organizer
      第59回放射化学討論会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-09-25
    • Data Source
      KAKENHI-PROJECT-15K17830
  • [Presentation] Solvent extraction behavior of Zr and Hf with chelate extractants for aqueous chemical studies of Rf2015

    • Author(s)
      K. Ooe, A. Tanaka, R. Yamada, H. Kikunaga, M. Murakami, Y. Komori, H. Haba, S. Goto and H. Kudo
    • Organizer
      The 5th International Conference on the Chemistry and Physics of the Transactinide Elements
    • Place of Presentation
      Urabandai, Fukushima, Japan
    • Year and Date
      2015-05-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K17830
  • 1.  Watabe Tadashi (90648932)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 2.  仲 定宏 (60599843)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 3.  Hatazawa Jun (70198745)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 4.  Suzuki Hiroyuki (00707648)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 5.  下瀬川 恵久 (30370258)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  佐々木 一郎 (60817477)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 7.  兼田 加珠子 (00533209)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 8.  白神 宜史 (00560400)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 9.  豊嶋 厚史 (40414578)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 10.  深瀬 浩一 (80192722)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  巽 光朗 (60397700)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  加藤 弘樹 (20448054)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  松永 恵子 (80727454)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  堀次 元気 (70646231)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  礒橋 佳也子 (50598604)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  篠原 厚 (60183050)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  福田 光宏 (60370467)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  白崎 謙次 (70447176)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  吉村 崇 (90323336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  樺山 一哉 (00399974)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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