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Kanemoto Soshi  金本 聡自

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KANEMOTO Soshi  金本 聡自

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Researcher Number 90611913
Affiliation (Current) 2025: 広島大学, 医系科学研究科(医), 准教授
Affiliation (based on the past Project Information) *help 2018 – 2019: 旭川医科大学, 医学部, 准教授
2017: 広島大学, 医歯薬保健学研究科(医), 講師
2015 – 2016: 広島大学, 医歯薬保健学研究院(医), 講師
2013 – 2014: 広島大学, 医歯薬保健学研究院, 助教
Review Section/Research Field
Principal Investigator
Orthopaedic surgery / Pediatrics
Keywords
Principal Investigator
小胞体 / 破骨細胞 / イズロン酸-2-スルファターゼ / 小胞体関連分解 / ライソゾーム病 / ムコ多糖症 / 小胞体膜局在転写因子 / 樹状細胞 / 小胞体ストレス / 関節リウマチ / 細胞融合 / 分化 / 転写因子
  • Research Projects

    (3 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (8 People)
  •  The role of the endoplasmic reticulum in Mucopolysaccharidosis type IIPrincipal Investigator

    • Principal Investigator
      Kanemoto Soshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Asahikawa Medical College
      Hiroshima University
  •  Role of Endoplasmic reticulum stress response in rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      Kanemoto Soshi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Hiroshima University
  •  Luman, an ER membrane-bound transcription factor, is involved in osteoclastogenesisPrincipal Investigator

    • Principal Investigator
      KANEMOTO Soshi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Hiroshima University

All 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells.2019

    • Author(s)
      Maeoka Y, Wu Y, Okamoto T, Kanemoto S, Guo XP, Saito A, Asada R, Matsuhisa K, Masaki T, Imaizumi K, Kaneko M.
    • Journal Title

      J Biol Chem.

      Volume: 294 Issue: 1 Pages: 101-115

    • DOI

      10.1074/jbc.ra118.002896

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10052, KAKENHI-PROJECT-18K06685, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06416, KAKENHI-PROJECT-17H01424, KAKENHI-PROJECT-18H06105, KAKENHI-PROJECT-17K15599
  • [Journal Article] Pathological changes in mice with long term cuprizone administration2019

    • Author(s)
      Nomura T, Bando Y, Nakazawa H, Kanemoto S, Yoshida S.
    • Journal Title

      Neurochemistry International

      Volume: 126 Pages: 229-238

    • DOI

      10.1016/j.neuint.2019.03.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07023, KAKENHI-PROJECT-17K10052, KAKENHI-PROJECT-17K07087
  • [Journal Article] Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II.2018

    • Author(s)
      Osaki Y, Saito A, Kanemoto S, Kaneko M, Matsuhisa K, Asada R, Masaki T, Orii K, Fukao T, Tomatsu S, Imaizumi K
    • Journal Title

      Cell Death Dis.

      Volume: 9 Issue: 8 Pages: 808-808

    • DOI

      10.1038/s41419-018-0871-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10052, KAKENHI-PROJECT-18K06685, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06416, KAKENHI-PROJECT-17H01424, KAKENHI-PROJECT-17K15599
  • [Journal Article] Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury.2018

    • Author(s)
      Ohtake Y, Matsuhisa K, Kaneko M, Kanemoto S, Asada R, Imaizumi K, Saito A.
    • Journal Title

      Neuroscience

      Volume: 375 Pages: 34-48

    • DOI

      10.1016/j.neuroscience.2018.02.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10052, KAKENHI-PROJECT-17K15599, KAKENHI-PLANNED-17H06416, KAKENHI-PROJECT-17H06891, KAKENHI-PROJECT-18K06685, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H01424
  • [Journal Article] Endoplasmic reticulum stress and diseases2018

    • Author(s)
      金本聡自、今泉和則
    • Journal Title

      生化学

      Volume: 90 Issue: 1 Pages: 51-59

    • DOI

      10.14952/SEIKAGAKU.2018.900051

    • ISSN
      0037-1017
    • Year and Date
      2018-02-25
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-17K10052
  • [Journal Article] Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma.2018

    • Author(s)
      Saito A, Cai L, Matsuhisa K, Ohtake Y, Kaneko M, Kanemoto S, Asada R, Imaizumi K.
    • Journal Title

      Journal of Neurochemistry

      Volume: 144 Issue: 1 Pages: 35-49

    • DOI

      10.1111/jnc.14221

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10052, KAKENHI-PROJECT-17K15599, KAKENHI-PLANNED-17H06416, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H01424
  • [Journal Article] Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.2018

    • Author(s)
      Wu Y, Guo XP, Kanemoto S, Maeoka Y, Saito A, Asada R, Matsuhisa K, Ohtake Y, Imaizumi K, Kaneko M.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 1 Pages: e0190407-e0190407

    • DOI

      10.1371/journal.pone.0190407

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10052, KAKENHI-PROJECT-17K15599, KAKENHI-PLANNED-17H06416, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H01424
  • [Journal Article] ER Stress and Disease: Toward Prevention and Treatment2017

    • Author(s)
      Kaneko M, Imaizumi K, Saito A, Kanemoto S, Asada R, Matsuhisa K, Ohtake Y.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 9 Pages: 1337-1343

    • DOI

      10.1248/bpb.b17-00342

    • NAID

      130006038767

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10052, KAKENHI-PROJECT-17K15599
  • [Journal Article] The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression2016

    • Author(s)
      Cui X, Cui M, Asada R, Kanemoto S, Saito A, Matsuhisa K, Kaneko M, Imaizumi K
    • Journal Title

      Scientific reports

      Volume: 6 Issue: 1 Pages: 37310-37310

    • DOI

      10.1038/srep37310

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K21706, KAKENHI-PROJECT-15K19516, KAKENHI-PROJECT-15K20001
  • [Journal Article] The physiological roles of ER stress transducer BBF2H7/CREB3L2 and its potential as a target of disease therapy.2016

    • Author(s)
      Matsuhisa K, Saito A, Asada R, Kanemoto S, Kaneko M, Imaizumi K
    • Journal Title

      Medical Research Archives

      Volume: 4 Pages: 3-3

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K20001
  • [Journal Article] Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation2016

    • Author(s)
      Kaneko M, Iwase I, Yamasaki Y, Takai T, Wu Y, Kanemoto S, Matsuhisa K, Asada R, Okuma Y, Watanabe T, Imaizumi K, Nomura Y.
    • Journal Title

      Scientific reports

      Volume: 6 Issue: 1 Pages: 30955-30955

    • DOI

      10.1038/srep30955

    • NAID

      120006796544

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K21706, KAKENHI-PROJECT-15K20001
  • [Journal Article] Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress2016

    • Author(s)
      Kanemoto S, Nitani R, Murakami T, Kaneko M, Asada R, Matsuhisa K, Saito A, Imaizumi K
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 480 Issue: 2 Pages: 166-172

    • DOI

      10.1016/j.bbrc.2016.10.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K21706, KAKENHI-PROJECT-15K15067, KAKENHI-PROJECT-15K19516, KAKENHI-PROJECT-15K20001
  • [Journal Article] Promotion of cancer cell proliferation by cleaved and secreted luminal domains of ER stress transducer BBF2H7.2015

    • Author(s)
      Iwamoto H, Matsuhisa K, Saito A, Kanemoto S, Asada R, Hino K, Takai T, Cui M, Cui X, Kaneko M, Arihiro K, Sugiyama K, Kurisu K, Matsubara A, Imaizumi K.
    • Journal Title

      Plos One

      Volume: 10 Issue: 5 Pages: 1-17

    • DOI

      10.1371/journal.pone.0125982

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24659678, KAKENHI-PROJECT-15K19516, KAKENHI-PROJECT-15K20001, KAKENHI-PROJECT-25251014, KAKENHI-PROJECT-13J00677, KAKENHI-PROJECT-15K18377
  • [Journal Article] Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization.2015

    • Author(s)
      Kanemoto S, Kobayashi Y, Yamashita T, Miyamoto T, Cui M, Asada R, Cui X, Hino K, Kaneko M, Takai T, Matsuhisa K, Takahashi N, Imaizumi K.
    • Journal Title

      J Cell Sci

      Volume: 128 Pages: 4353-4365

    • DOI

      10.1242/jcs.176057

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-15K19516, KAKENHI-PROJECT-15K20001, KAKENHI-PROJECT-25221310, KAKENHI-PROJECT-25251014, KAKENHI-PROJECT-13J00677, KAKENHI-PROJECT-26670814, KAKENHI-PROJECT-15K18377, KAKENHI-PROJECT-15K21706
  • [Journal Article] IRE1a-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes.2015

    • Author(s)
      Asada R, Kanemoto S, Matsuhisa K, Hino K, Cui M, Cui X, Kaneko M, Imaizumi K.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 16580-16580

    • DOI

      10.1038/srep16580

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15067, KAKENHI-PROJECT-15K19516, KAKENHI-PROJECT-15K20001, KAKENHI-PROJECT-25251014, KAKENHI-PROJECT-13J00677, KAKENHI-PROJECT-15K21706
  • [Journal Article] 増大特集 細胞シグナル操作法 Ⅱ.機能からみたシグナル操作法 2.タンパク質の一生 小胞体ストレス応答2015

    • Author(s)
      金本聡自、今泉和則
    • Journal Title

      生体の科学

      Volume: 66 Issue: 5 Pages: 492-493

    • DOI

      10.11477/mf.2425200323

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2015-10-15
    • Data Source
      KAKENHI-PROJECT-15K20001
  • [Journal Article] OASIS modulates hypoxia pathway activity to regulate bone angiogenesis.2015

    • Author(s)
      Min Cui, Soshi Kanemoto, Xiang Cui, Masayuki Kaneko, Rie Asada, Koji Matsuhisa, Keiji Tanimoto, Yuki Yoshimoto, Chisa Shukunami, Kazunori Imaizumi.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 16455-16455

    • DOI

      10.1038/srep16455

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K11252, KAKENHI-PROJECT-15K19516, KAKENHI-PROJECT-15K20001, KAKENHI-PROJECT-25251014, KAKENHI-PROJECT-13J00677, KAKENHI-PROJECT-26293395, KAKENHI-PROJECT-15K21706
  • [Journal Article] Targeting the endoplasmic reticulum in prion disease treatment: breakthroughs and challenges.2015

    • Author(s)
      Kanemoto S.
    • Journal Title

      Research and Reports in Biochemistry

      Volume: 5 Pages: 31-38

    • DOI

      10.2147/rrbc.s74357

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25861324, KAKENHI-PROJECT-15K20001
  • [Journal Article] Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2.2014

    • Author(s)
      Saito A, Kanemoto S, Zhang Y, Asada R, Hino K, Imaizumi K.
    • Journal Title

      Molecular Cell

      Volume: 53 Issue: 1 Pages: 127-139

    • DOI

      10.1016/j.molcel.2013.11.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J00677, KAKENHI-PROJECT-24659678, KAKENHI-PROJECT-24689058, KAKENHI-PROJECT-25251014, KAKENHI-PROJECT-25650069, KAKENHI-PROJECT-25861324, KAKENHI-PROJECT-26860191
  • [Journal Article] Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice.2014

    • Author(s)
      Hino K, Saito A, Asada R, Kanemoto S, Imaizumi K.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 2 Pages: e88048-e88048

    • DOI

      10.1371/journal.pone.0088048

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J00677, KAKENHI-PROJECT-24659678, KAKENHI-PROJECT-24689058, KAKENHI-PROJECT-25251014, KAKENHI-PROJECT-25650069, KAKENHI-PROJECT-25861324
  • [Journal Article] Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the ER Stress Transducer BBF2H7/CREB3L2 in Chondrocytes.2014

    • Author(s)
      Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, Cui M, Cui X, Imaizumi K.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289 Issue: 20 Pages: 13810-13820

    • DOI

      10.1074/jbc.m113.543322

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J00677, KAKENHI-PROJECT-24659678, KAKENHI-PROJECT-24689058, KAKENHI-PROJECT-25251014, KAKENHI-PROJECT-25650069, KAKENHI-PROJECT-25861324
  • [Journal Article] Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice.2014

    • Author(s)
      Kanemoto S, Griffin J, Markham-Coultes K, Aubert I, Tandon A, George-Hyslop PS, Fraser PE.
    • Journal Title

      Neuroscience

      Volume: 261 Pages: 52-9

    • DOI

      10.1016/j.neuroscience.2013.12.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25861324
  • [Presentation] 小胞体関連分解によるムコ多糖症原因分子イズロン酸-2-スルファターゼの活性化抑制機構2017

    • Author(s)
      尾﨑陽介、金本聡自、齋藤敦、今泉和則
    • Organizer
      日本生化学会 中国・四国支部会
    • Data Source
      KAKENHI-PROJECT-17K10052
  • [Presentation] 新たな小胞体ストレス応答経路―――多胞体形成-エキソソーム分泌2016

    • Author(s)
      金本聡自、今泉和則
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K20001
  • [Presentation] 小胞体ストレス条件下で増加する多胞体(Multivesicular body)形成機構の解明と生理的意義の検討2016

    • Author(s)
      金本聡自、今泉和則
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-15K20001
  • [Presentation] 破骨細胞の多核化に関与する小胞体膜局在転写因子Lumanは樹状細胞の抗原提示能を制御する2016

    • Author(s)
      金本聡自、崔旻、今泉和則
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-15K20001
  • [Presentation] 神経系細胞における小胞体ストレス依存的多胞体(Multivesicular body)形成機構2016

    • Author(s)
      金本聡自、今泉和則
    • Organizer
      第59回日本神経化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-08
    • Data Source
      KAKENHI-PROJECT-15K20001
  • [Presentation] 樹状細胞における小胞体局在転写因子Lumanの機能解析2015

    • Author(s)
      金本聡自、崔旻、今泉和則
    • Organizer
      日本骨免疫学会
    • Place of Presentation
      宮古島
    • Year and Date
      2015-06-30
    • Data Source
      KAKENHI-PROJECT-15K20001
  • [Presentation] 小胞体ストレスによる多胞体(multivesicular body)形成とエクソソーム分泌2015

    • Author(s)
      金本聡自、松久幸司、崔旻、仁谷亮太、村岡賢、田原栄俊、今泉和則
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K20001
  • [Presentation] Multivesicular body is formed after endoplasmic reticulum stress2015

    • Author(s)
      Soshi Kanemoto, Koji Matsuhisa, Min Cui, Kazunori Imaizumi
    • Organizer
      日本神経化学会
    • Place of Presentation
      埼玉
    • Year and Date
      2015-09-11
    • Data Source
      KAKENHI-PROJECT-15K20001
  • [Presentation] 小胞体膜局在転写因子Lumanと破骨細胞融合因子DC-STAMPの結合による破骨細胞分化制御機構2015

    • Author(s)
      金本聡自、小林泰浩、山下照仁、宮本健史、高橋直之、今泉和則
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-23
    • Data Source
      KAKENHI-PROJECT-15K20001
  • [Presentation] 小胞体ストレスセンサーLumanは破骨細胞分化制御に関与する2013

    • Author(s)
      金本聡自、齋藤敦、小林 泰浩、山下 照仁、宮本健史、高橋 直之、今泉和則
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-25861324
  • [Presentation] Luman, an ER stress transducer, is involved in osteoclastogenesis through the regulation of DC-STAMP expression.2013

    • Author(s)
      Soshi Kanemoto, Atsushi Saito, Yasuhiro Kobayashi, Teruhito Yamashita, Takeshi Miyamoto, Naoyuki Takahashi, Kazunori Imaizumi
    • Organizer
      The 23rd ANZBMS Annual Scientific Meeting
    • Place of Presentation
      Melbourne, Australia
    • Data Source
      KAKENHI-PROJECT-25861324
  • [Presentation] 小胞体膜局在転写因子Lumanは破骨細胞分化制御に関与する

    • Author(s)
      金本聡自、小林 泰浩、山下 照仁、宮本健史、高橋 直之、今泉和則
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-07-24 – 2014-07-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-25861324
  • [Presentation] 小胞体膜局在転写因子Lumanによる破骨細胞分化制御機構の解明

    • Author(s)
      金本聡自、小林 泰浩、山下 照仁、宮本健史、高橋 直之、今泉和則
    • Organizer
      日本生化学会
    • Place of Presentation
      京都市
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25861324
  • [Presentation] Luman, an ER membrane-bound transcription factor, is involved in osteoclastogenesis

    • Author(s)
      Soshi Kanemoto, Yasuhiro Kobayashi, Teruhito Yamashita, Takeshi Miyamoto, Naoyuki Takahashi, Kazunori Imaizumi
    • Organizer
      Bone Biology Forum
    • Place of Presentation
      静岡県裾野市
    • Year and Date
      2014-08-22 – 2014-08-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-25861324
  • 1.  SAITO Atsushi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  山下 照仁
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    # of Collaborated Products: 1 results
  • 3.  金子 雅幸
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    # of Collaborated Products: 3 results
  • 4.  今泉 和則
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    # of Collaborated Products: 1 results
  • 5.  谷本 圭司
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    # of Collaborated Products: 1 results
  • 6.  板東 良雄
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    # of Collaborated Products: 1 results
  • 7.  野村 太一
    # of Collaborated Projects: 0 results
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  • 8.  吉田 成孝
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    # of Collaborated Products: 1 results

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