Ohno Hirohisa 大野博久

Researcher Number	90612391
Other IDs
Affiliation (Current)	2025: 京都大学, iPS細胞研究所, 特定拠点助教
Affiliation (based on the past Project Information) *help	2020 – 2025: 京都大学, iPS細胞研究所, 特定拠点助教 2016 – 2018: 京都大学, iPS細胞研究所, 特定研究員
Review Section/Research Field	Principal Investigator Basic Section 90120:Biomaterials-related / Medium-sized Section 17:Earth and planetary science and related fields / Nanobioscience Except Principal Investigator Medium-sized Section 61:Human informatics and related fields / Broad Section J
Keywords	Principal Investigator 化学修飾 / 人工mRNA / 遺伝子治療 / RNA / RNAワールド / リボザイム / 5' キャップ / RNAワクチン / 5'キャップ / キャップ … More / mRNA / 蛋白質 / 核酸 / バイオテクノロジー / ナノバイオ / RNA-タンパク質複合体 / 細胞内局在 / 分子設計 / ナノ構造体 / 細胞運命制御 / 分子足場 / RNA-タンパク質相互作用 … More Except Principal Investigator 電子-分子インタフェイス / 大量生産 / 自己複製 / 人工細胞 / オートマター / 分子ロボティクス / 人工多細胞 Less

非天然型の構造を有する高機能RNAベクターの開発Principal Investigator
- Principal Investigator
  
  大野博久
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kyoto University
RNA分子の集合によるリボザイム活性発現モデルの構築Principal Investigator
- Principal Investigator
  
  大野博久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 17:Earth and planetary science and related fields
- Research Institution
  Kyoto University
Development of a highly functional artificial mRNA platform for the realization of mRNA medicinePrincipal Investigator
- Principal Investigator
  
  Ohno Hirohisa
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kyoto University
AutoMatter: Toward creation and expansion of programmable micro-active matter
- Principal Investigator
  
  野村慎一郎
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section J
- Research Institution
  Tohoku University
Creation and development of programmable dynamic microparticles "auto-matter"
- Principal Investigator
  
  野村慎一郎
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 61:Human informatics and related fields
- Research Institution
  Tohoku University
Spatial control of intracellular molecules by the RNA-protein nanostructurePrincipal Investigator
- Principal Investigator
  
  Ohno Hirohisa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nanobioscience
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

[Book] Molecular Robotics: An Introduction (S. Murata, Ed.), pp.249-2582022
- Author(s)
  H. Ohno, S. Komatsu, H. Saito
- Total Pages
  296
- Publisher
  Springer
- ISBN
  9789811939860
- Data Source
  KAKENHI-PROJECT-20K12644
[Book] Molecular Robotics: An Introduction2022
- Author(s)
  Satoshi Murata (Ed)（p.157-167をH. Ohno, C. Sawanobori, H. Saitoが執筆担当）
- Total Pages
  296
- Publisher
  Springer Nature Singapore
- Data Source
  KAKENHI-PROJECT-20H05701
[Book] Molecular Robotics: An Introduction2022
- Author(s)
  Satoshi Murata (Ed)（p. 249-258をH. Ohno, S. Komatsu, H. Saitoが執筆担当）
- Total Pages
  296
- Publisher
  Springer Nature Singapore
- Data Source
  KAKENHI-PROJECT-20H05701
[Book] 「翻訳，リボソーム」, 公益財団法人遺伝学普及会日本遺伝学会編「遺伝学の百科事典－継承と多様性の源」2021
- Author(s)
  大野博久, 齊藤博英
- Total Pages
  690
- Publisher
  丸善出版
- ISBN
  9784621306604
- Data Source
  KAKENHI-PROJECT-20H05701
[Book] 相分離生物学の全貌（現代化学増刊46) pp. 268-2732020
- Author(s)
  大野博久, 齊藤博英（編：白木　賢太郎）
- Total Pages
  400
- Publisher
  東京化学同人
- ISBN
  9784807913466
- Data Source
  KAKENHI-PROJECT-20H05701
[Journal Article] Synthetic circular RNA switches and circuits that control protein expression in mammalian cells2023
- Author(s)
  Kameda Shigetoshi、Ohno Hirohisa、Saito Hirohide
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 4 Pages: e24-e24
- DOI
  10.1093/nar/gkac1252
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12644, KAKENHI-PROJECT-20H05701, KAKENHI-PROJECT-22KJ1729, KAKENHI-PROJECT-20H05626
[Journal Article] Target-dependent RNA polymerase as universal platform for gene expression control in response to intracellular molecules2023
- Author(s)
  Komatsu Shodai、Ohno Hirohisa、Saito Hirohide
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 7256-7256
- DOI
  10.1038/s41467-023-42802-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12644, KAKENHI-PROJECT-20H05701
[Journal Article] Versatile strategy using vaccinia virus-capping enzyme to synthesize functional 5′ cap-modified mRNAs2023
- Author(s)
  Ohno Hirohisa、Akamine Sae、Mochizuki Megumi、Hayashi Karin、Akichika Shinichiro、Suzuki Tsutomu、Saito Hirohide
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 6 Pages: e34-e34
- DOI
  10.1093/nar/gkad019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12644, KAKENHI-PROJECT-20H05701, KAKENHI-PROJECT-20J30002, KAKENHI-PROJECT-20H05626, KAKENHI-PROJECT-18H05272
[Journal Article] RNA nanostructures and scaffolds for biotechnology applications2019
- Author(s)
  Ohno Hirohisa、Akamine Sae、Saito Hirohide
- Journal Title
  
  Current Opinion in Biotechnology
  
  Volume: 58 Pages: 53-61
- DOI
  10.1016/j.copbio.2018.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21117, KAKENHI-PLANNED-24104002, KAKENHI-PROJECT-15H05722
[Journal Article] Protein-driven RNA nanostructured devices that function in vitro and control mammalian cell fate.2017
- Author(s)
  Tomonori Shibata, Yoshihiko Fujita, Hirohisa Ohno, Yuki Suzuki, Karin Hayashi, Kaoru R. Komatsu, Shunsuke Kawasaki, Kumi Hidaka, Shin Yonehara, Hiroshi Sugiyama, Masayuki Endo and Hirohide Saito
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 540-540
- DOI
  10.1038/s41467-017-00459-x
- NAID
  120006346264
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21117, KAKENHI-PROJECT-16H06356, KAKENHI-PROJECT-15H02774, KAKENHI-PROJECT-15H03837, KAKENHI-PROJECT-15K13314, KAKENHI-PROJECT-16K14033, KAKENHI-PLANNED-24104002, KAKENHI-PROJECT-15H05722
[Journal Article] RNA/RNP Nanotechnology for Biological Applications2016
- Author(s)
  大野博久, 齊藤博英
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 56 Issue: 1 Pages: 023-026
- DOI
  10.2142/biophys.56.023
- NAID
  130005121648
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21117, KAKENHI-PROJECT-15H05722
[Journal Article] RNA and RNP as Building Blocks for Nanotechnology and Synthetic Biology.2016
- Author(s)
  Ohno, Hirohisa and Saito, Hirohide
- Journal Title
  
  Prog. Mol. Biol. Transl. Sci.
  
  Volume: 139 Pages: 165-185
- DOI
  10.1016/bs.pmbts.2015.12.004
- ISBN
  9780128045657
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05722, KAKENHI-PLANNED-24104002, KAKENHI-PROJECT-15H02774, KAKENHI-PROJECT-16K21117
[Patent] ＲＮＡのキャッピング方法、修飾ＲＮＡの製造方法、及び修飾ＲＮＡ2020
- Inventor(s)
  齊藤博英、大野博久、赤峰冴
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-20K12644
[Presentation] Designing RNP network structures for inducing um-scale molecular assembly2023
- Author(s)
  Kazuya Ankai, Hirohisa Ohno, Masahiro Takinoue, Yoshihiro Shimizu, Hirohide Saito and Shin-ichiro M. Nomura
- Organizer
  DNA29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Target-dependent RNA polymerase: Universal platform for controlling gene expression in response to intracellular molecules2023
- Author(s)
  Shodai Komatsu, Hirohisa Ohno, Hirohide Saito
- Organizer
  Winter Q-bio 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Protein splicing enables the high target-cell specificity of a synthetic circuit composed of multiple RNA switches2023
- Author(s)
  Itsuki Abe, Hirohisa Ohno, Hirohide Saito
- Organizer
  CiRA 2023 international symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Protein-splicing improves the target-specificity of RNA-based logic circuit2023
- Author(s)
  Itsuki abe, Hirohisa Ohno, Megumi Mochizuki, Karin Hayashi, Yoshihiko Fujita, Hirohide Saito
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] プロテインスプライシングによるRNA論理回路のターゲット特異性向上化2023
- Author(s)
  阿部一樹, 大野博久, 齊藤博英
- Organizer
  第2回生命分子科学研究会
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Protein splicingによるmicroRNA応答性スイッチのON/OFF比の向上2023
- Author(s)
  阿部一樹, 大野博久, 望月めぐみ, 林香倫, 齊藤博英
- Organizer
  「細胞を創る」研究会16.0
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] 酵素を用いたキャップ修飾mRNAの合成2023
- Author(s)
  大野博久, 赤峰冴, 齊藤博英
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-20K12644
[Presentation] Protein splicing enables the high target-cell specificity of a synthetic circuit composed of multiple RNA switches2023
- Author(s)
  Itsuki Abe, Hirohisa Ohno, Hirohide Saito
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] RNA origami structure made of RNA tertiary structural motif2023
- Author(s)
  Chisato Sawanobori, Hirohisa Ohno, Megumi Mochizuki, Hirohide Saito
- Organizer
  28th Annual Meeting of the RNA Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Strategic enhancement of RNA switch using split-intein for precise gene regulation2023
- Author(s)
  Itsuki Abe, Hirohisa Ohno, Hirohide Saito
- Organizer
  Winter Q-bio 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Protein splicing enables the high target-cell specificity of a synthetic circuit composed of multiple RNA switches2023
- Author(s)
  Itsuki Abe, Hirohisa Ohno, Hirohide Saito
- Organizer
  RNAフロンティアミーティング2023
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] 大腸菌リボソームは真核細胞の中で何をするのか？2023
- Author(s)
  大塚衆志, 大野博久,益田恵子, 清水義宏, 齊藤博英
- Organizer
  第18回無細胞生命科学研究会
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Building Stable RNA Origami Structures with Tertiary Structural Motifs and Modified Bases2023
- Author(s)
  Chisato Sawanobori, Hirohisa Ohno, Megumi Mochizuki, Hirohide Saito
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Designing RNP network structures for inducing um-scale molecular assembly2022
- Author(s)
  Kazuya Ankai, Hirohisa Ohno, Hirohide Saito, Shin-ichiro M. Nomura
- Organizer
  第23回日本RNA学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] RNA origami structure made of RNA tertiary structural motif2022
- Author(s)
  Chisato Sawanobori, Hirohisa Ohno, Megumi Mochizuki, Hirohide Saito
- Organizer
  第23回日本RNA学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Target-dependent RNA polymerase as a versatile biosensor platform2022
- Author(s)
  Shodai Komatsu, Hirohisa Ohno, Hirohide Saito
- Organizer
  CiRA Retreat 2021
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Synthetic Circular mRNA Engineering for Cell-Type-Specific Translational Regulation2022
- Author(s)
  Shigetoshi Kameda, Hirohisa Ohno, Hirohide Saito
- Organizer
  第23回日本RNA学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Programmable circular mRNA devices that enable superior stability and gene expression persistence2022
- Author(s)
  Shigetoshi Kameda, Hirohisa Ohno, Hirohide Saito
- Organizer
  日本核酸医薬学会第７回大会
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] RNA nanostructures using 3-dimensional RNA structures as a motif2022
- Author(s)
  Chisato Sawanobori, Hirohisa Ohno, Megumi Mochizuki, Hirohide Saito
- Organizer
  「細胞を創る」研究会15.0
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Programmable synthetic circular mRNA devices that ebnable superior stability and gene expression persistence2022
- Author(s)
  Shigetoshi Kameda, Hirohisa Ohno, Hirohide Saito
- Organizer
  CiRA 2022 International Symposium
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Programmable synthetic circular mRNA devices that can improve stability and gene expression persistence2021
- Author(s)
  Shigetoshi Kameda, Hirohisa Ohno, Hirohide Saito
- Organizer
  第22回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] 遺伝子発現の高持続性と生体分子応答性を併せ持つ人工環状mRNAの開発2021
- Author(s)
  亀田重賢、大野博久、齊藤博英
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H05701
[Presentation] Design of artificial RNA nanostructures using natural RNA structural motifs2019
- Author(s)
  Hirohisa Ohno, Hirohide Saito
- Organizer
  Gordon Research Conference RNA Nanotechnology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21117
[Presentation] pH依存型RNAロボット2019
- Author(s)
  加藤嘉崇、大野博久、齊藤博英
- Organizer
  第30回日本医学会総会
- Data Source
  KAKENHI-PROJECT-16K21117
[Presentation] RNA構造モチーフを利用した新規ナノ構造体の設計と構築2018
- Author(s)
  大野博久、宮里智博、齊藤博英
- Organizer
  「細胞を創る」研究会 11.0
- Data Source
  KAKENHI-PROJECT-16K21117
[Presentation] 天然のRNA構造モチーフを利用した人工RNAナノ構造体の設計2018
- Author(s)
  大野博久、宮里智博、齊藤博英
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K21117
[Presentation] リガンドに応答して構造変化を示すRNAナノ構造体の設計・構築2017
- Author(s)
  宮里智博、大野博久、齊藤博英
- Organizer
  「細胞を創る」研究会 10.0
- Data Source
  KAKENHI-PROJECT-16K21117
[Presentation] Synthetic RNA-protein nanostructured devices that function in vitro and in cells2017
- Author(s)
  Hirohide Saito and Hirohisa Ohno
- Organizer
  第55回生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K21117

1. 野村慎一郎 (50372446)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 瀧ノ上正浩 (20511249)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 清水義宏 (90401231)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 齊藤博英 (20423014)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
5. 岡夏央 (50401229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ENDO Masayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Mochizuki Megumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MIYAZATO Tomohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Ohno Hirohisa 大野 博久

Research Projects

Research Products

Co-Researchers

非天然型の構造を有する高機能RNAベクターの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RNA分子の集合によるリボザイム活性発現モデルの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a highly functional artificial mRNA platform for the realization of mRNA medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

AutoMatter: Toward creation and expansion of programmable micro-active matter

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creation and development of programmable dynamic microparticles "auto-matter"

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Spatial control of intracellular molecules by the RNA-protein nanostructurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Molecular Robotics: An Introduction (S. Murata, Ed.), pp.249-2582022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Molecular Robotics: An Introduction2022

Author(s)

Total Pages

Publisher

Data Source

[Book] Molecular Robotics: An Introduction2022

Author(s)

Total Pages

Publisher

Data Source

[Book] 「翻訳，リボソーム」, 公益財団法人 遺伝学普及会 日本遺伝学会 編 「遺伝学の百科事典－継承と多様性の源」2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 相分離生物学の全貌（現代化学増刊46) pp. 268-2732020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Synthetic circular RNA switches and circuits that control protein expression in mammalian cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Target-dependent RNA polymerase as universal platform for gene expression control in response to intracellular molecules2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Versatile strategy using vaccinia virus-capping enzyme to synthesize functional 5′ cap-modified mRNAs2023

Author(s)

Ohno Hirohisa 大野博久

[Book] 「翻訳，リボソーム」, 公益財団法人遺伝学普及会日本遺伝学会編「遺伝学の百科事典－継承と多様性の源」2021