SHIMURA KAZUYA 志村和也

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SHIMURA Kazuya 志村和也

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Researcher Number	90613836
Other IDs
Affiliation (based on the past Project Information) *help	2021: 京都大学, ウイルス・再生医科学研究所, 特定講師 2016 – 2020: 京都大学, ウイルス・再生医科学研究所, 助教 2015: 京都大学, ウイルス研究所, 助教 2011 – 2013: 京都大学, ウイルス研究所, 助教
Review Section/Research Field	Principal Investigator Infectious disease medicine / Virology
Keywords	Principal Investigator HIV / 再活性化 / HIV-1 / 潜伏感染 / 細胞間感染 / 薬剤感受性 / 感染経路 / 抗ウイルス薬 / 耐性機序 / 融合阻害薬

HIV潜伏感染モデル細胞における再活性化動態に関する研究Principal Investigator
- Principal Investigator
  
  志村和也
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
Relationship between HIV entry pathway and drug resistancePrincipal Investigator
- Principal Investigator
  
  SHIMURA KAZUYA
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kyoto University
Impact of HIV infection pathway on the potency of antiviral agentsPrincipal Investigator
- Principal Investigator
  
  SHIMURA Kazuya
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
Identification of novel resistance mechanism of HIV-1 fusion inhibitorsPrincipal Investigator
- Principal Investigator
  
  SHIMURA Kazuya
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University

All 2021 2018 2017 2016 2015 2013 2012 2011

All Journal Article Presentation Patent

[Journal Article] Human retroviral antisense mRNAs are retained in the nuclei of infected cells for viral persistence.2021
- Author(s)
  Ma G, Yasunaga JI, Shimura K, Takemoto K, Watanabe M, Amano M, Nakata H, Liu B, Zuo X, Matsuoka M.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 118 Issue: 17
- DOI
  10.1073/pnas.2014783118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03689, KAKENHI-PROJECT-17K10016
[Journal Article] Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.2018
- Author(s)
  Mahgoub M, Yasunaga JI, Iwami S, Nakaoka S, Koizumi Y, Shimura K, Matsuoka M.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 115 Issue: 6 Pages: 529-538
- DOI
  10.1073/pnas.1715724115
- NAID
  120006697286
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KT0107, KAKENHI-PROJECT-16K05265, KAKENHI-PROJECT-17K07166, KAKENHI-PROJECT-16K13777, KAKENHI-PROJECT-17K19610, KAKENHI-PROJECT-16H04845, KAKENHI-PROJECT-16H05336, KAKENHI-PROJECT-26287025, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-26460554, KAKENHI-PROJECT-17K10016, KAKENHI-PROJECT-16KT0111, KAKENHI-PROJECT-15H05707
[Journal Article] Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread2015
- Author(s)
  Shimura K, Miyazato P, Oishi S, Fujii N, Matsuoka M.
- Journal Title
  
  Virology
  
  Volume: 484 Pages: 364-376
- DOI
  10.1016/j.virol.2015.06.029
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K21084
[Journal Article] HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strains.2013
- Author(s)
  Kazuki Shimane, KumiKawaji, Fusako Miyamoto, Shinya Oishi, Kentaro Watanabe, YasukoSakagami, Nobutaka Fujii, Kazuya Shimura, Masao Matsuoka, Mitsuo Kaku, Stefan Sarafianos, and Eiichi Kodama
- Journal Title
  
  Antimicrobal Agents and Chemotherapy
  
  Volume: 57 Issue: 8 Pages: 4035-4038
- DOI
  10.1128/aac.00237-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390254, KAKENHI-PROJECT-24791021
[Journal Article] Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 4041822013
- Author(s)
  Tsukasa Mizuhara, Shinya Oishi, Hiroaki Ohno, Kazuya Shimura, Masao Matsuoka, Nobutaka Fujii
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 21 Issue: 7 Pages: 2079-2087
- DOI
  10.1016/j.bmc.2013.01.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J01895, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24791021
[Journal Article] Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design.2013
- Author(s)
  Izumi K, Kawaji K, Miyamoto F, Shimane K, Shimura K, Sakagami Y, Hattori T, Watanabe K, Oishi S, Fujii N, Matsuoka M, Kaku M, Sarafianos SG, Kodama EN.
- Journal Title
  
  Int J Biochem Cell Biol.
  
  Volume: 45 Issue: 4 Pages: 908-915
- DOI
  10.1016/j.biocel.2013.01.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590636, KAKENHI-PROJECT-24390254, KAKENHI-PROJECT-24791021
[Journal Article] Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents2013
- Author(s)
  Mizuhara T, Kato T, Hirai A, Kurihara H, Shimada Y, Taniguchi M, Maeta M, Togami H, Shimura K, Matsuoka M, Okazaki S, Takeuchi T, Ohno H, Oishi S, Fujii N.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Issue: 16 Pages: 4557-4561
- DOI
  10.1016/j.bmcl.2013.06.026
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24791021
[Journal Article] Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents2013
- Author(s)
  Tognmi, H., Shimura, K., Okamoio, M., Yoshikawa, R., MiyazHwa, T., Matsuoka M.
- Journal Title
  
  Journal of Virology
  
  Volume: 87 Issue: 8 Pages: 4322-4329
- DOI
  10.1128/jvi.03208-12
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J05135, KAKENHI-PLANNED-22114003, KAKENHI-PROJECT-24300153, KAKENHI-PROJECT-24791021
[Journal Article] HIV膜融合阻害薬の開発と耐性獲得機序の解析、遺伝子医学MOOK2012
- Author(s)
  志村和也、松岡雅雄
- Journal Title
  
  ナノバイオ技術と最新創薬応用研究(メディカルドゥ)
  
  Volume: 20 Pages: 84-88
- URL
  http://www.medicaldo.co.jp/gene/mook.no20.html
- Data Source
  KAKENHI-PROJECT-23890091
[Journal Article] Structure-activity relationship study of pyrimido[1, 2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents.2012
- Author(s)
  Tsukasa Mizuhara, Shinya Oishi, Hiroaki Ohno, Kazuya Shimura, Masao Matsuoka, Nobutaka Fujii
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 20 Issue: 21 Pages: 6334-6441
- DOI
  10.1016/j.bmc.2012.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J01895, KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24791021
[Journal Article] Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles.2012
- Author(s)
  Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 10 Issue: 33 Pages: 6792-6802
- DOI
  10.1039/c2ob25904d
- NAID
  120005302103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-24791021
[Journal Article] CXCR4 stimulates macropinocytosis: implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV2012
- Author(s)
  Gen Tanaka, Ikuhiko Nakase, et al.
- Journal Title
  
  Chemistry & Biology
  
  Volume: 19 Issue: 11 Pages: 1437-1446
- DOI
  10.1016/j.chembiol.2012.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22121511, KAKENHI-PROJECT-23689007, KAKENHI-PROJECT-23790129, KAKENHI-PROJECT-24790099, KAKENHI-PROJECT-24791021
[Journal Article] HIV膜融合阻害薬の開発と耐性獲得機序の解析2012
- Author(s)
  志村和也、松岡雅雄
- Journal Title
  
  遺伝子医学MOOKナノバイオ技術と最新創薬応用研究
  
  Volume: 20 Pages: 84-88
- Data Source
  KAKENHI-PROJECT-23890091
[Patent] ピラゾール誘導体またはその塩ならびにそれらを含有する医薬組成物2013
- Inventor(s)
  加藤貴之, 平井敦, 松岡雅雄, 志村和也
- Industrial Property Rights Holder
  富士フイルム株式会社, 国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-092023
- Filing Date
  2013-04-25
- Data Source
  KAKENHI-PROJECT-24791021
[Presentation] HIV-1潜伏感染モデル細胞を用いた再活性化誘導機序の解析2017
- Author(s)
  志村和也、松岡雅雄
- Organizer
  第31回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10016
[Presentation] HIV-1潜伏感染モデル細胞を用いた再活性化誘導機序の解析2017
- Author(s)
  志村和也、松岡雅雄
- Organizer
  第31回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-15K21084
[Presentation] 蛍光HIV潜伏感染モデル細胞を用いた活性化誘導と抗HIV薬活性の評価2016
- Author(s)
  志村和也、松岡雅雄
- Organizer
  日本エイズ学会学術集会
- Place of Presentation
  かごしま県民交流センター
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-15K21084
[Presentation] 抗ウイルス薬感受性に対するHIV感染経路の影響2013
- Author(s)
  志村和也、大石真也、藤井信孝、松岡雅雄
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  市民会館崇城大学ホール・熊本市交際交流会館
- Data Source
  KAKENHI-PROJECT-24791021
[Presentation] 抗ウイルス薬感受性に対するHIV感染経路の影響2013
- Author(s)
  志村和也, 大石真也, 藤井信孝, 松岡雅雄
- Organizer
  第27回日本エイズ学会学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24791021
[Presentation] ニホンザルより検出されたSRV-4に対する抗HIV 薬の効果2012
- Author(s)
  戸上博昭, 志村和也, 宮沢孝幸, 松岡雅雄
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24791021
[Presentation] ニホンザルより検出されたSRV-4に対する抗HIV薬の効果2012
- Author(s)
  戸上博昭、志村和也、宮沢孝幸、松岡雅雄
- Organizer
  日本ウイルス学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24791021
[Presentation] 広範なスペクトルを有する新規抗HIV薬の同定とその開発2012
- Author(s)
  志村和也、水原司、大石真也、藤井信孝、松岡雅雄
- Organizer
  日本エイズ学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24791021
[Presentation] 広範なスペクトルを有する新規抗HIV 薬の同定とその開発2012
- Author(s)
  志村和也, 水原司, 大石真也, 藤井信孝, 松岡雅雄
- Organizer
  第26回に日本エイズ学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24791021
[Presentation] HIV-1膜融合阻害剤に対する新規耐性メカニズムの解析2011
- Author(s)
  志村和也
- Organizer
  第25回日本エイズ学会学術集会・総会
- Place of Presentation
  ハイアットリージェンシー東京(東京都)
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-23890091
[Presentation] HIV-1膜融合阻害剤に対する新規耐性メカニズムの解析2011
- Author(s)
  志村和也
- Organizer
  第25回日本エイズ学会学術集会・総会
- Place of Presentation
  ハイアットリージェンシー東京
- Data Source
  KAKENHI-PROJECT-23890091

1. NAKAOKA SHINJI

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 岩見真吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 児玉栄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 安永純一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 松岡雅雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 藤井信孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 大野浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 中瀬生彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMURA KAZUYA 志村 和也

SHIMURA Kazuya 志村 和也

Research Projects

Research Products

Co-Researchers

HIV潜伏感染モデル細胞における再活性化動態に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relationship between HIV entry pathway and drug resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Impact of HIV infection pathway on the potency of antiviral agentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of novel resistance mechanism of HIV-1 fusion inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Human retroviral antisense mRNAs are retained in the nuclei of infected cells for viral persistence.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strains.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 4041822013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HIV膜融合阻害薬の開発と耐性獲得機序の解析、遺伝子医学MOOK2012

Author(s)

Journal Title

URL

Data Source

[Journal Article] Structure-activity relationship study of pyrimido[1, 2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents.2012

Author(s)

Journal Title

DOI

Data Source

SHIMURA KAZUYA 志村和也

SHIMURA Kazuya 志村和也