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Sakurai Takeshi  櫻井 武

ORCIDConnect your ORCID iD *help
Researcher Number 90615717
Other IDs
Affiliation (Current) 2025: 京都大学, 医学研究科, 研究員
Affiliation (based on the past Project Information) *help 2020 – 2021: 京都大学, 医学研究科, 客員研究員
2016 – 2019: 京都大学, 医学研究科, 特定教授
2013 – 2015: 京都大学, 医学(系)研究科(研究院), 准教授
Review Section/Research Field
Principal Investigator
Basic / Social brain science / Biological Sciences / Basic Section 51030:Pathophysiologic neuroscience-related
Keywords
Principal Investigator
マウスモデル / 社会性行動 / 前頭前野 / 精神疾患 / 脳内炎症 / 思春期 / 社会性ストレス / 発達精神障害 / 認知機能 / ヒトゲノム解析 / 統合失調症
  • Research Projects

    (5 results)
  • Research Products

    (41 results)
  • Co-Researchers

    (5 People)
  •  Dimensional approaches to psychiatric disorders associated with circuit abnormalities induced by genetic and environmental insults combined with inflammation in the brainPrincipal Investigator

    • Principal Investigator
      Sakurai Takeshi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Kyoto University
  •  Analysis of neural circuitry and regulatory mechanisms of social behavior adjustment to social environmentPrincipal Investigator

    • Principal Investigator
      Sakurai Takeshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic / Social brain science
    • Research Institution
      Kyoto University
  •  精神疾患に関与する遺伝環境因子で前頭前野発達期に現れるマイクロエンドフェノタイプPrincipal Investigator

    • Principal Investigator
      櫻井 武
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  社会性行動の異常に関わる回路のマイクロエンドフェノタイプの解明Principal Investigator

    • Principal Investigator
      櫻井 武
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Analysis of schizophrenia pathogenesis using mouse models based on human genetics dataPrincipal Investigator

    • Principal Investigator
      Sakurai Takeshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic / Social brain science
    • Research Institution
      Kyoto University

All 2022 2020 2019 2018 2017 2015 2014 2013 Other

All Journal Article Presentation Book

  • [Book] Chapter in "Charney and Nestler’s Neurobiology of Mental Illness, 5th edition"2018

    • Author(s)
      Nao J. Gamo, Takeshi Sakurai, Hanna Jaaro-Peled, and Akira Sawa
    • Publisher
      Oxford University Press
    • ISBN
      9780190681425
    • Data Source
      KAKENHI-PROJECT-16K01948
  • [Book] ブレインサイエンスレビュー2014(分担執筆「社会性行動を担う遺伝子ネットワークの解析」の項)2014

    • Author(s)
      櫻井武
    • Total Pages
      290
    • Publisher
      クバプロ
    • Data Source
      KAKENHI-PUBLICLY-25116516
  • [Journal Article] social processes and social environment during development2022

    • Author(s)
      Sakurai Takeshi
    • Journal Title

      Seminars in Cell and Developmental Biology

      Volume: - Pages: 40-46

    • DOI

      10.1016/j.semcdb.2021.09.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03547
  • [Journal Article] LOCATION, LOCATION, LOCATION: Location of neuroinflammation is important for pathogenesis of schizophrenia2020

    • Author(s)
      Takeshi Sakurai
    • Journal Title

      Brain, Behavior, and Immunity

      Volume: 88 Pages: 842-843

    • DOI

      10.1016/j.bbi.2020.06.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03547
  • [Journal Article] From population to neuron: exploring common mediators for metabolic problems and mental illnesses2020

    • Author(s)
      Takayanagi Yoichiro、Ishizuka Koko、Laursen Thomas M.、Yukitake Hiroshi、Yang Kun、Cascella Nicola G.、Ueda Shuhei、Sumitomo Akiko、Narita Zui、Horiuchi Yasue、Niwa Minae、Taguchi Akiko、White Morris F.、Eaton William W.、Mortensen Preben B.、Sakurai Takeshi、Sawa Akira
    • Journal Title

      Molecular Psychiatry

      Volume: - Issue: 8 Pages: 3931-3942

    • DOI

      10.1038/s41380-020-00939-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15929, KAKENHI-PROJECT-19H03547, KAKENHI-PROJECT-19K22835, KAKENHI-PROJECT-20H04137
  • [Journal Article] Editorial for “What can clinical findings tell us about the neurobiology of schizophrenia? Revisited”2019

    • Author(s)
      Sakurai Takeshi、Sawa Akira
    • Journal Title

      Neurobiology of Disease

      Volume: 131 Pages: 104521-104521

    • DOI

      10.1016/j.nbd.2019.104521

    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03547
  • [Journal Article] A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson’s disease and schizophrenia2018

    • Author(s)
      Sumitomo Akiko、Horike Kouta、Hirai Kazuko、Butcher Nancy、Boot Erik、Sakurai Takeshi、Nucifora Frederick C.、Bassett Anne S.、Sawa Akira、Tomoda Toshifumi
    • Journal Title

      Science Advances

      Volume: 4 Issue: 8

    • DOI

      10.1126/sciadv.aar6637

    • NAID

      120006510283

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01948
  • [Journal Article] 神経回路形成に働く遺伝子群 シナプス形成2018

    • Author(s)
      櫻井武 谷口智彦 中村大和
    • Journal Title

      Clinical Neuroscience

      Volume: 36 Pages: 176-180

    • Data Source
      KAKENHI-PROJECT-16K01948
  • [Journal Article] Ulk2 controls cortical excitatory?inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons2018

    • Author(s)
      Sumitomo Akiko、Yukitake Hiroshi、Hirai Kazuko、Horike Kouta、Ueta Keisho、Chung Youjin、Warabi Eiji、Yanagawa Toru、Kitaoka Shiho、Furuyashiki Tomoyuki、Narumiya Shuh、Hirano Tomoo、Niwa Minae、Sibille Etienne、Hikida Takatoshi、Sakurai Takeshi、Ishizuka Koko、Sawa Akira、Tomoda Toshifumi
    • Journal Title

      Human Molecular Genetics

      Volume: 27 Issue: 18 Pages: 3165-3176

    • DOI

      10.1093/hmg/ddy219

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08593, KAKENHI-PROJECT-17K08781, KAKENHI-PLANNED-16H06568, KAKENHI-PUBLICLY-17H05572, KAKENHI-PUBLICLY-17H06057, KAKENHI-PROJECT-16H05132, KAKENHI-PROJECT-18H02526, KAKENHI-PROJECT-18H02542, KAKENHI-PROJECT-16K01948, KAKENHI-PROJECT-16K14579, KAKENHI-PROJECT-17K19457
  • [Journal Article] 脳神経回路と精神生物学:神経機能と心の根源を探る、2、神経回路と脳機能2018

    • Author(s)
      櫻井武、友田利文
    • Journal Title

      Clinical Calcium

      Volume: 28 Pages: 844-850

    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01948
  • [Journal Article] Neuronal cell adhesion molecule regulating neural systems underlying addiction2018

    • Author(s)
      Ishiguro Hiroki、Miyake Kunio、Tabata Koichi、Mochizuki Chiaki、Sakurai Takeshi、Onaivi Emmanuel S.
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 39 Issue: 1 Pages: 10-16

    • DOI

      10.1002/npr2.12038

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01948
  • [Journal Article] Cognitive functions associated with developing prefrontal cortex during adolescence and developmental neuropsychiatric disorders2018

    • Author(s)
      Sakurai Takeshi、Gamo Nao J.
    • Journal Title

      Neurobiology of Disease

      Volume: in press Pages: 104322-104322

    • DOI

      10.1016/j.nbd.2018.11.007

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01948, KAKENHI-PROJECT-19H03547
  • [Journal Article] Characterizing vulnerable brain areas and circuits in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches.2018

    • Author(s)
      Hui K, Katayama Y, Nakayama KI, Nomura J, Sakurai T.
    • Journal Title

      Neurosci. Biobehav. Rev.

      Volume: 印刷中 Pages: 30121-0

    • DOI

      10.1016/j.neubiorev.2018.08.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07119, KAKENHI-PROJECT-18K14822, KAKENHI-PROJECT-18H05215, KAKENHI-PROJECT-16K01948
  • [Journal Article] The roles of cell adhesion molecules in brain wiring and neuropsychiatric disorders.2017

    • Author(s)
      Takeshi Sakurai
    • Journal Title

      Molecular and Cellular Neuroscience

      Volume: in press Pages: 4-11

    • DOI

      10.1016/j.mcn.2016.08.005

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01285, KAKENHI-PROJECT-16K01948
  • [Journal Article] Ulk1 protects against ethanol-induced neuronal stress and cognitive deficits in object discrimination.2017

    • Author(s)
      Akiko Sumitomo, Keisho Ueta, Sayaka Mauchi, Kazuko Hirai, Kouta Horike, Takatoshi Hikida, Takeshi Sakurai, Akira Sawa, Toshifumi Tomoda
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 54-61

    • DOI

      10.1016/j.neures.2016.12.004

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01285, KAKENHI-PLANNED-16H06568, KAKENHI-PROJECT-15H04275, KAKENHI-PROJECT-16K01948, KAKENHI-PROJECT-16K14579
  • [Journal Article] Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in <b><i>Fez1</i></b>-Deficient Mice2017

    • Author(s)
      Sumitomo Akiko、Saka Ayumi、Ueta Keisho、Horike Kouta、Hirai Kazuko、Gamo Nao J.、Hikida Takatoshi、Nakayama Keiichi I.、Sawa Akira、Sakurai Takeshi、Tomoda Toshifumi
    • Journal Title

      Molecular Neuropsychiatry

      Volume: 3 Issue: 4 Pages: 223-233

    • DOI

      10.1159/000488081

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01948, KAKENHI-PROJECT-18H05215, KAKENHI-PLANNED-16H06568, KAKENHI-PROJECT-18H02542, KAKENHI-PROJECT-16K14579
  • [Journal Article] Circuitry-Based Human Neuroanatomy for the Next Generation in Psychiatry and Neuroscience2017

    • Author(s)
      Sakurai Takeshi
    • Journal Title

      Molecular Neuropsychiatry

      Volume: 3 Issue: 2 Pages: 92-96

    • DOI

      10.1159/000479514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K01948
  • [Journal Article] Valley of death: A proposal to build a “translational bridge” for the next generation.2017

    • Author(s)
      Nao J. Gamo, Michelle R. Birknow, Danielle Sullivan, Mari A. Kondo, Yasue Horiuchi, Takeshi Sakurai, Barbara S. Slusher, Akira Sawa.
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 1-4

    • DOI

      10.1016/j.neures.2016.11.003

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01285, KAKENHI-PROJECT-16K01948
  • [Journal Article] Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics2017

    • Author(s)
      Tomoda Toshifumi、Hikida Takatoshi、Sakurai Takeshi
    • Journal Title

      Neurotherapeutics

      Volume: 14 Issue: 3 Pages: 623-629

    • DOI

      10.1007/s13311-017-0556-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01948, KAKENHI-PROJECT-16K14579, KAKENHI-PLANNED-16H06568, KAKENHI-PROJECT-15H04275
  • [Journal Article] Sequence of molecular events during maturation of developing mouse prefrontal cortex2015

    • Author(s)
      Shuhei Ueda, Minae Niwa, Hiroyuki Hioki, Jaerin Sohh, Takeshi Kaneko, Akira Sawa, Takeshi Sakurai
    • Journal Title

      Molecular Neuropsychiatry

      Volume: NA

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25350987
  • [Journal Article] Sequence of molecular events during maturation of developing mouse prefrontal cortex.2015

    • Author(s)
      Ueda S, Niwa M, Hioki H, Sohn J, Kaneko T, Sawa A, *Sakurai T.
    • Journal Title

      Mol Neuropsychiatry

      Volume: 1 Issue: 2 Pages: 94-104

    • DOI

      10.1159/000430095

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14333, KAKENHI-PUBLICLY-15H01285, KAKENHI-PUBLICLY-15H01430, KAKENHI-PROJECT-25350987
  • [Journal Article] Converging models of schizophrenia - Network alterations of prefrontal cortex underlying impairments2015

    • Author(s)
      Takeshi Sakurai, Nao J. Gamo, Takatoshi Hikida, Sun-Hong Kim, Toshiya Murai, Toshifumi Tomoda, Akira Sawa
    • Journal Title

      Progress in Neurobiology

      Volume: 134 Pages: 178-201

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25350987
  • [Journal Article] Converging models of schizophrenia - Network alterations of prefrontal cortex underlying cognitive impairments2015

    • Author(s)
      Takeshi Sakurai, Nao J. Gamo, Takatoshi Hikida, Sun-Hong Kim, Toshiya Murai, Toshifumi Tomoda, Akira Sawa
    • Journal Title

      Progress in Neurobiology

      Volume: 134 Pages: 178-201

    • DOI

      10.1016/j.pneurobio.2015.09.010

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01285, KAKENHI-PLANNED-23120011, KAKENHI-PROJECT-15H04275
  • [Presentation] Development and function of mouse prefrontal cortex.2017

    • Author(s)
      Takeshi Sakurai, Yamato Nakamura
    • Organizer
      Cold Spring Harbor Meeting, “Wiring the brain”
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01948
  • [Presentation] Analysis of mouse models for psychiatric disorders with social behavior alterations.2017

    • Author(s)
      Takeshi Sakurai, Yamato Nakamura
    • Organizer
      Annual meeting of International Behavioral Neuroscience Society
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01948
  • [Presentation] Development and function of mouse prefrontal cortex2017

    • Author(s)
      Takeshi Sakurai, Yamato Nakamura
    • Organizer
      Cold spring harbor meeting, "wiring the brain"
    • Place of Presentation
      Cold spring harbor, New York, USA
    • Year and Date
      2017-04-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01285
  • [Presentation] Development and function of mouse prefrontal cortex2017

    • Author(s)
      Takeshi Sakurai, Yamato Nakamura
    • Organizer
      Cold spring harbor meeting, wiring the brain
    • Place of Presentation
      Cold spring harbor, New York, USA
    • Year and Date
      2017-04-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01948
  • [Presentation] Analysis of Gtf2i mutant mice exhibiting social behavioral abnormality2015

    • Author(s)
      Shuhei Ueda, Akira Sawa, Takeshi Sakurai
    • Organizer
      Annual meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01285
  • [Presentation] Analysis of Gtf2i mutant mice exhibiting abnormal social behaviors2015

    • Author(s)
      Shuhei Ueda, Akira Sawa, Takeshi Sakurai
    • Organizer
      日本神経科学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-25350987
  • [Presentation] Analysis of Gtf2i mutant mice exhibiting abnormal social behavior2015

    • Author(s)
      Shuhei Ueda, Akira Sawa, Takeshi Sakurai
    • Organizer
      Annual meeting of Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25350987
  • [Presentation] Analysis of Gtf2i mutant mice exhibiting social behavioral abnormality2015

    • Author(s)
      Shuhei Ueda, Akira Sawa, Takeshi Sakurai
    • Organizer
      日本神経科学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PUBLICLY-15H01285
  • [Presentation] 統合失調症の分子病態の理解を目的としたPTPRAノックアウトマウスおよびPTPRZトランスジェニックマウスの解析2014

    • Author(s)
      上田修平、澤明、櫻井武
    • Organizer
      日本統合失調症学会
    • Place of Presentation
      京都テルサ、京都
    • Data Source
      KAKENHI-PROJECT-25350987
  • [Presentation] 社会性行動に関わる神経回路の形成に関与するGtf2iの遺伝子改変マウスの解析2014

    • Author(s)
      櫻井武、澤明、上田修平
    • Organizer
      日本解剖学会総会
    • Place of Presentation
      自治医大キャンパス、栃木
    • Data Source
      KAKENHI-PUBLICLY-25116516
  • [Presentation] Genes involved in Williams-Beuren syndrome and autism spectrum disorders to study social behavior development2013

    • Author(s)
      Takeshi Sakurai
    • Organizer
      Cold Spring Harbor Laboratory meeting "Wiring the brain"
    • Place of Presentation
      Cold Spring Harbor, New York, USA
    • Data Source
      KAKENHI-PUBLICLY-25116516
  • [Presentation] Towards understanding pathogenesis of schizophrenia through analysis of PTPRA knockout mice and PTPRZ transgenic mice2013

    • Author(s)
      Takeshi Sakurai, Toshifumi Tomoda, Takatoshi Hikida, Akira Sawa
    • Organizer
      World Federation of Societies of Biological Psychiatry Congress
    • Place of Presentation
      京都国際会館、京都
    • Data Source
      KAKENHI-PROJECT-25350987
  • [Presentation] Prefrontal cortex as targets of developmental insults associated with developmental psychiatric disorders -mouse model analysis-

    • Author(s)
      Takeshi Sakurai, Shuhei Ueda, Minae Niwa, Akira Sawa
    • Organizer
      日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18 – 2015-03-20
    • Invited
    • Data Source
      KAKENHI-PROJECT-25350987
  • [Presentation] Developmental profiles of prefrontal cortex of normal and disease model mice

    • Author(s)
      Shuhei Ueda, Minae Niwa, Akira Sawa, Takeshi Sakurai
    • Organizer
      Cold Spring Harbor Meeting, Wiring the Brain
    • Place of Presentation
      Cold Spring Harbor, US
    • Year and Date
      2015-03-24 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-25350987
  • [Presentation] Genes involved in Williams-Beuren Syndrome and Autism Spectrum Disorders to study social behavior development

    • Author(s)
      Takeshi Sakurai, Shuhei Ueda
    • Organizer
      Society of Biological Psychiatry 2014 Annual Meeting
    • Place of Presentation
      New York, New York, USA
    • Year and Date
      2014-05-08 – 2014-05-10
    • Data Source
      KAKENHI-PUBLICLY-25116516
  • [Presentation] Analysis of Gtf2i mutant mice exhibiting abnormal social behaviors

    • Author(s)
      Shuhei Ueda, Akira Sawa, Takeshi Sakurai
    • Organizer
      第38回日本神経科学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-28 – 2015-07-31
    • Data Source
      KAKENHI-PUBLICLY-25116516
  • [Presentation] Comprehensive gene expression profiling associated with the prefrontal circuit maturation

    • Author(s)
      Shuhei Ueda, Minae Niwa, Akira Sawa, Takeshi Sakurai
    • Organizer
      日本神経科学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-25350987
  • [Presentation] Comprehensive gene expression profiling associated with the prefrontal circuit maturation

    • Author(s)
      Shuhei Ueda, Minae Niwa, Akira Sawa, Takeshi Sakurai
    • Organizer
      Annual meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC, US
    • Year and Date
      2014-11-15 – 2014-11-19
    • Data Source
      KAKENHI-PROJECT-25350987
  • 1.  大槻 元 (60723278)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  KITAOKA Shiho
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  日置 寛之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  野村 淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  上田 修平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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