IHARA Tatsuya 井原達矢

Researcher Number	90622407
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 医学研究員
Affiliation (based on the past Project Information) *help	2023: 山梨大学, 大学院総合研究部, 医学研究員 2022: 山梨大学, 医学部, 医学研究員 2021: 山梨大学, 大学院総合研究部, 講師 2019 – 2020: 山梨大学, 大学院総合研究部, 助教 2017: 山梨大学, 大学院総合研究部, 助教 2015: 山梨大学, 医学部附属病院, 診療助教
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related Except Principal Investigator Urology / Basic Section 56030:Urology-related
Keywords	Principal Investigator 線維化 / Hippo-Yapシグナル伝達系 / 低活動膀胱 / 膀胱線維化 / 低酸素ストレス / 概日リズム障害 / 時計遺伝子 / 睡眠時無呼吸症候群 / 夜間頻尿 Except Principal Investigator 過活動膀胱 … More / 下部尿路機能障害 / 時計遺伝子 / 機械センサー / 下部尿路機能 / ミトコンドリア / 排尿筋低活動 / 下部尿路症状 / 低活動膀胱 / 膀胱機能 / 一酸化窒素 / アルギニン / シトルリン / 慢性虚血 / 動的恒常性 / 排尿機能学 / ＴＲＰチャネル / 夜間頻尿 / 時計遺伝子異常 / P2Y6受容体欠損マウス / 発症機序 / 動的恒常性破綻 / 複雑系ネットワーク / metabolomics / noctrunal polyuria / clock gene / nocturia / Biomarker / Metabolomics / Mechanosensor / Clock genes / Lower urinary tract / Piezo / TRPイオンチャネル / ATP / 小胞型トランスポータ / 難治性 / 小胞型トランスポーター / 難治性下部尿路機能障害 Less

relationship between Hippo-Yap circuit activity and hypoactive bladder leading to fibrosis of the bladder.Principal Investigator
- Principal Investigator
  
  Ihara Tatsuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Yamanashi
The effect of Arginine/Citrulline administration on detrusor underactivity
- Principal Investigator
  
  MITSUI Takahiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Yamanashi
Sleep apnea syndrome induces clock gene abnormalities and causes nocturia in the mice bladderPrincipal Investigator
- Principal Investigator
  
  IHARA Tatsuya
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Yamanashi
Studies on lower urinary tract dysfunction pathogenesis by complex systems network and dynamic homeostasis collapse
- Principal Investigator
  
  TAKEDA Masayuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  University of Yamanashi
Research on vesicular type transporter and refractory lower urinary tract dysfunction
- Principal Investigator
  
  TAKEDA Masayuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Urology
- Research Institution
  University of Yamanashi

All 2023 2022 2021 2019 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] G protein-coupled receptor 55 activated by palmitoylethanolamide is associated with the development of nocturia associated with circadian rhythm disorders2023
- Author(s)
  Ihara Tatsuya、Shinozaki Youichi、Shigetomi Eiji、Danjo Yosuke、Tsuchiya Sachiko、Kanda Mie、Kamiyama Manabu、Takeda Masayuki、Koizumi Schuichi、Mitsui Takahiko
- Journal Title
  
  Life Sciences
  
  Volume: 332 Pages: 122072-122072
- DOI
  10.1016/j.lfs.2023.122072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0366, KAKENHI-PROJECT-22K07368, KAKENHI-PROJECT-21K09417
[Journal Article] The prevalence and predictive factors of nocturnal polyuria in Japanese patients with nocturia: a multicentral retrospective cohort study2023
- Author(s)
  Iinuma Koji、Nishino Yoshinori、Matsuoka Kanako、Ihara Tatsuya、Makabe Shunta、Tanji Ryo、Harigane Yuki、Ishida Kenichiro、Tamaki Masayoshi、Yokoi Shigeaki、Hoshino Hiroki、Yuhara Kazuya、Yamada Toru、Kubota Yasuaki、Miwa Kousei、Kikuchi Mina、Kojima Yoshiyuki、Mitsui Takahiko、Koie Takuya
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 18128-18135
- DOI
  10.1038/s41598-023-45311-z
- Data Source
  KAKENHI-PROJECT-21K09417, KAKENHI-PROJECT-23K24475
[Journal Article] Effects of fatty acid metabolites on nocturia2022
- Author(s)
  106.Ihara T, Shimura H, Tsuchiya S, Kanda M, Kira S, Sawada N, Takeda M, Mitsui T, Shigetomi E, Shinozaki Y, Koizumi S
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 3050-3050
- DOI
  10.1038/s41598-022-07096-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09417, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786
[Journal Article] Mirabegron for overactive bladder in frail patients 80 years or over (HOKUTO study)2022
- Author(s)
  105.Nakagomi H., Mitsui T, Shimura H, Ihara T, Kira S, Sawada N, Takeda M
- Journal Title
  
  BMC Urology
  
  Volume: 22 Issue: 1 Pages: 40-40
- DOI
  10.1186/s12894-022-00989-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09417
[Journal Article] Different effects of GsMTx4 on nocturia associated with the circadian clock and Piezo1 expression in mice2021
- Author(s)
  Tatsuya Ihara, Takahiko Mitsui, Hiroshi Shimura, SachikoTsuchiya, Mie Kanda, Satoru Kira, Hiroshi Nakagomi, Norifumi Sawada, Manabu Kamiyama, Eiji Shigetomi, Yoichi Shinozaki, Schuichi Koizumi, Masayuki Takeda
- Journal Title
  
  Life Sciences
  
  Volume: 278 Pages: 119555-119555
- DOI
  10.1016/j.lfs.2021.119555
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18579, KAKENHI-PROJECT-21K09417, KAKENHI-PROJECT-21K19309, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786
[Journal Article] Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia.2019
- Author(s)
  Ihara T, Nakamura Y, Mitsui T, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Koizumi S, Takeda M.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 10069-10069
- DOI
  10.1038/s41598-019-46517-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06481, KAKENHI-PUBLICLY-18H05121, KAKENHI-PROJECT-17K11175, KAKENHI-PROJECT-16H04669, KAKENHI-PUBLICLY-19H04746, KAKENHI-PROJECT-19K18579
[Journal Article] Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa.2017
- Author(s)
  5.Ihara T, Mitsui T, Nakamura Y, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Andersson KE, Nakao A, Takeda M, Koizumi S
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 1 Pages: e0168234-e0168234
- DOI
  10.1371/journal.pone.0168234
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04864, KAKENHI-PROJECT-15K15524, KAKENHI-PROJECT-26860380, KAKENHI-PROJECT-16K11042, KAKENHI-PROJECT-15H04972
[Journal Article] The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells2017
- Author(s)
  Ihara Tatsuya、Mitsui Takahiko、Nakamura Yuki、Kanda Mie、Tsuchiya Sachiko、Kira Satoru、Nakagomi Hiroshi、Sawada Norifumi、Hirayama Yuri、Shibata Keisuke、Shigetomi Eiji、Shinozaki Yoichi、Yoshiyama Mitsuharu、Nakao Atsuhito、Takeda Masayuki、Koizumi Schuichi
- Journal Title
  
  Neurourology and Urodynamics
  
  Volume: 37 Issue: 3 Pages: 942-951
- DOI
  10.1002/nau.23400
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11175, KAKENHI-PLANNED-25117003, KAKENHI-PROJECT-15H04972, KAKENHI-PROJECT-17K09032, KAKENHI-PROJECT-18K06481, KAKENHI-PROJECT-16K11042
[Journal Article] The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria.2016
- Author(s)
  Ihara, T., Mitsui, T., Nakamura, Y., Kira, S., Miyamoto, T., Nakagomi, H., Sawada, N., Hirayama, Y., Shibata, K., Shigetomi, E., Shinozaki, Y., Yoshiyama, M., Nakao, A., *Takeda, M. *Koizumi, S.
- Journal Title
  
  Neurourology and Urodynamics
  
  Volume: 36 Issue: 4 Pages: 1034-1038
- DOI
  10.1002/nau.23062
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04669, KAKENHI-PROJECT-26860380, KAKENHI-PROJECT-16K11042, KAKENHI-PROJECT-15H04972
[Patent] 特許第7031104号2021
- Inventor(s)
  吉良聡、井原達矢、三井貴彦、武田正之、中込宙史、橋本由佳
- Industrial Property Rights Holder
  国立大学法人　山梨大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Acquisition Date
  2022
- Data Source
  KAKENHI-PROJECT-21K09417
[Patent] 睡眠期頻尿のモデル、評価方法2017
- Inventor(s)
  井原達矢
- Industrial Property Rights Holder
  井原達矢
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15H04972
[Presentation] Inhibition of Piezo1 in bladder urothelium: A potential therapy for overactive bladder2015
- Author(s)
  Tatsuya Miyamoto, Hiroshi Nakagomi, Tatsuya Ihara ,Satoru Kira, Tsutomu Mochizuki, Makoto Tominaga, Masayuki Takeda
- Organizer
  29th Annual EAU Congress
- Place of Presentation
  Stockholm(Sweden)
- Year and Date
  2015-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04972

1. SAWADA Norifumi (70402055)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. TAKEDA Masayuki (80197318)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. ZAKOJI Hidenori (60345717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MIYAMOTO Tatsuya (80456459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YOSHIYAMA Mitsuharu (20422694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KIRA Satoru (10530115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. MITSUI Takahiko (90421966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 小泉修一 (10280752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 富永真琴 (90260041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. SHIGETOMI Eiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. SHINOZAKI Youichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. NAKAMURA Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 中尾篤人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IHARA Tatsuya 井原 達矢

Research Projects

Research Products

Co-Researchers

relationship between Hippo-Yap circuit activity and hypoactive bladder leading to fibrosis of the bladder.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effect of Arginine/Citrulline administration on detrusor underactivity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Sleep apnea syndrome induces clock gene abnormalities and causes nocturia in the mice bladderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on lower urinary tract dysfunction pathogenesis by complex systems network and dynamic homeostasis collapse

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on vesicular type transporter and refractory lower urinary tract dysfunction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] G protein-coupled receptor 55 activated by palmitoylethanolamide is associated with the development of nocturia associated with circadian rhythm disorders2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The prevalence and predictive factors of nocturnal polyuria in Japanese patients with nocturia: a multicentral retrospective cohort study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of fatty acid metabolites on nocturia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mirabegron for overactive bladder in frail patients 80 years or over (HOKUTO study)2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different effects of GsMTx4 on nocturia associated with the circadian clock and Piezo1 expression in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria.2016

Author(s)

Journal Title

DOI

Data Source

[Patent] 特許第7031104号2021

IHARA Tatsuya 井原達矢