SHIMIZU Satoshi 清水聡

Researcher Number	90623041
Affiliation (based on the past Project Information) *help	2012 – 2013: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Gastroenterology
Keywords	Principal Investigator 細胞死 / 肝癌

The impact of chemotherapy on innate immune system and cell death signaling in liver cancer.Principal Investigator
- Principal Investigator
  
  SHIMIZU Satoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University

All 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Sorafenib enhances proteasome inhibitor-induced cell death via inactivation of Akt and stress-activated protein kinases2014
- Author(s)
  Honma Y, Shimizu S, Takehara T, Harada M
- Journal Title
  
  J Gastroenterol
  
  Volume: 49 Pages: 517-526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790694
[Journal Article] Sorafenib enhances proteasome inhibitor-induced cell death via inactivation of Akt and stress-activated protein kinases.2014
- Author(s)
  Honma Y, Shimizu S, Takehara T, Harada M.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 49 Issue: 3 Pages: 517-526
- DOI
  10.1007/s00535-013-0796-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790694, KAKENHI-PROJECT-26461026
[Journal Article] The Bcl-2 homology 3 (BH3)-only proteins Bim and Bid are functionally active and restrained by anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) family proteins in healthy liver.2013
- Author(s)
  [1] Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 42 Pages: 30009-30018
- DOI
  10.1074/jbc.m112.443093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390197, KAKENHI-PROJECT-24590970, KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694, KAKENHI-PROJECT-25460994
[Journal Article] The Bcl-2 Homology Domain 3 (BH3)-only Proteins Bim and Bid Are Functionally Active and Restrained by Anti-apoptotic Bcl-2 Family Proteins in Healthy Liver2013
- Author(s)
  Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Pages: 30009-30018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790694
[Journal Article] Valine, the branched-chain amino acid, suppresses hepatitis C virus RNA replication but promotes infectious particle formation2013
- Author(s)
  Ishida H, Kato T, Takehana K, Tatsumi T, Hosui A, Nawa T, Kodama T, Shimizu S, Hikita H, Hiramatsu N, Kanto T, Hayashi N, Takehara T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 437 Issue: 1 Pages: 127-33
- DOI
  10.1016/j.bbrc.2013.06.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694, KAKENHI-PROJECT-25460994
[Journal Article] The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice2013
- Author(s)
  Aketa H, Tatsumi T, Kohga K, Tsunematsu H, Aono S, Shimizu S, Kodama T, Nawa T, Shigekawa M, Hikita H, Sakamori R, Hosui A, Miyagi T, Hiramatsu N, Kanto T, Hayashi N, Takehara T
- Journal Title
  
  Int J Cancer
  
  Volume: 133 Pages: 1126-1134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790694
[Journal Article] The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice2013
- Author(s)
  Aketa H, Tatsumi T, Kohga K, Tsunematsu H, Aono S, Shimizu S, Kodama T, Nawa T, Shigekawa M, Hikita H, Sakamori R, Hosui A, Miyagi T, Hiramatsu N, Kanto T, Hayashi N, Takehara T
- Journal Title
  
  Int J Cancer
  
  Volume: 133 Issue: 5 Pages: 1126-34
- DOI
  10.1002/ijc.28118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694, KAKENHI-PROJECT-25460994
[Journal Article] Carbamazepine promotes liver regeneration and survival in mice.2013
- Author(s)
  Kawaguchi T, Kodama T, Hikita H, Tanaka S, Shigekawa M, Nawa T, Shimizu S, Li W, Miyagi T, Hiramatsu N, Tatsumi T, Takehara T.
- Journal Title
  
  J Hepatol.
  
  Volume: 59 Issue: 6 Pages: 1239-1245
- DOI
  10.1016/j.jhep.2013.07.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790694, KAKENHI-PROJECT-25460994
[Journal Article] Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma.2012
- Author(s)
  Kohga K, Tatsumi T, Tsunematsu H, Aono S, Shimizu S, Kodama T, Hikita H, Yamamoto M, Oze T, Aketa H, Hosui A, Miyagi T, Ishida H, Hiramatsu N, Kanto T, Hayashi N, Takehara T.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 61 Pages: 1425-1432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790694
[Journal Article] Pancreatitis STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction2012
- Author(s)
  Shigekawa M, Tatsumi T, et al.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 181 Issue: 6 Pages: 2105-2113
- DOI
  10.1016/j.ajpath.2012.08.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24659364, KAKENHI-PROJECT-24790694
[Journal Article] Interferon-α suppresses hepatitis B virus enhancer II activity via the protein kinase C pathway2012
- Author(s)
  Nawa T, Tatsumi T, et al.
- Journal Title
  
  Virology
  
  Volume: 432 Issue: 2 Pages: 452-459
- DOI
  10.1016/j.virol.2012.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694
[Journal Article] Bak deficiency inhibits liver carcinogenesis : A causal link between apoptosis and carcinogenesis2012
- Author(s)
  Hikita H, Takehara T, et al
- Journal Title
  
  Journal of Hepatology
  
  Volume: (印刷中) Issue: 1 Pages: 92-100
- DOI
  10.1016/j.jhep.2012.01.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659188, KAKENHI-PROJECT-23390197, KAKENHI-PROJECT-24590970, KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24790694
[Journal Article] Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.2012
- Author(s)
  Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T.
- Journal Title
  
  Cell Death Differ.
  
  Volume: 19(11) Issue: 11 Pages: 1856-1869
- DOI
  10.1038/cdd.2012.88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591416, KAKENHI-PROJECT-24590973, KAKENHI-PROJECT-24591422, KAKENHI-PROJECT-24790694
[Journal Article] Inhibition of autophagy potentiates the anti-tumor effect of the multi-kinase inhibitor sorafenib in hepatocellular carcinoma2012
- Author(s)
  Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
- Journal Title
  
  Int J Cancer
  
  Volume: 131 Pages: 548-557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] The crosstalk between apoptosis and autophagy in the pathogenesis of non-alcoholic fatty liver disease2013
- Author(s)
  Satoshi Tanaka, Hayato Hikita, Tasuku Nakabori, Yoshinobu Saito, Satoshi Shimizu, Wei Li, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  The 64th Annual Meeting of the American Association for the study of Liver Disease
- Place of Presentation
  Washington, USA
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] 肝細胞癌におけるCD26分子発現の意義2013
- Author(s)
  川口司、疋田隼人、巽智秀、田中聡司、青野悟志、向井香織、清水聡、宮城琢也、友國晃、永野浩昭、土岐祐一郎、森正樹、竹原徹郎
- Organizer
  第49回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] Hepatitis C virus infection reduces chemo-sensitivity of the hepatocellular carcinoma cells through enhancing cancer stem cell characters.2013
- Author(s)
  Takatoshi Nawa, Tomohide Tatsumi, Akira Nishio, Seiichi Tawara, Yoshiki Ohnishi, Satoshi Aono, Satoshi Shimizu, Hayato Hikita, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara
- Organizer
  The 64th Annual Meeting of the American Association for the study of Liver Disease.
- Place of Presentation
  Washington D.C.
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] 進行肝細胞癌においてSTAT3シグナルは有用な治療ターゲットとなりうる2013
- Author(s)
  重川稔、疋田隼人、巽智秀、岩橋潔、池澤賢治、清水聡、阪森亮太郎、宮城琢也、平松直樹、竹原徹郎
- Organizer
  第４９回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] 大腸癌細胞のp53欠損は間質細胞進展に寄与する2013
- Author(s)
  林義人、辻井正彦、赤坂智史、重川稔、清水聡、疋田隼人、阪森亮太郎、新崎信一郎、宮城琢也、巽智秀、竹原徹郎
- Organizer
  第72回癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] 肝細胞癌におけるCD26分子発現の意義2013
- Author(s)
  川口司、疋田隼人、巽智秀、田中聡司、青野悟志、向井香織、清水　聡、宮城琢也、友國晃、永野浩昭、土岐祐一郎、森　正樹、竹原徹郎
- Organizer
  第４９回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] Hepatitis C virus infection reduces chemo-sensitivity of the hepatocellular carcinoma cells through enhancing cancer stem cell characters2013
- Author(s)
  Takatoshi Nawa, Tomohide Tatsumi, Akira Nishio, Seiichi Tawara, Yoshiki Ohnishi, Satoshi Aono, Satoshi Shimizu, Hayato Hikita, Ryotaro Sakamori, Takuya Miyagi, Naoki Hiramatsu, Tetsuo Takehara
- Organizer
  The 64th Annual Meeting of the American Association for the study of Liver Disease
- Place of Presentation
  Washington, USA
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] Ras経路が活性化されている進行肝細胞癌におけるSTAT3シグナルの意義2013
- Author(s)
  重川稔、疋田隼人、巽智秀、齋藤義修、清水聡、林義人、阪森亮太郎、宮城琢也、辻井正彦、竹原徹郎
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] 大腸癌細胞のp53欠損は間質細胞進展に寄与する2013
- Author(s)
  林義人、辻井正彦、赤坂智史、重川稔、清水聡、疋田隼人、阪森亮太郎、新崎信一郎、宮城琢也、巽智秀、竹原徹郎
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] IFN治療がC型肝炎の肝メチル化に与える影響について2012
- Author(s)
  清水聡、巽智秀、小玉尚宏、疋田隼人、宮城琢也、竹原徹郎
- Organizer
  第71回癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] The impact of interferon therapy for chronic hepatitis C on methylation status in the liver2012
- Author(s)
  Satoshi Shimizu, Tsugiko Oze, Minoru Shigekawa, Takahiro Kodama, Hayato Hikita, Takuya Miyagi, Atsushi Hosui, Harumasa Yoshihara, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  DDW2012
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] The impact of interferon therapy for chronic hepatitis C on methylation status in the liver.
- Author(s)
  Satoshi Shimizu, Tsugiko Oze, Minoru Shigekawa, Takahiro Kodama, Hayato Hikita, Takuya Miyagi, Atsushi Hosui, Harumasa Yoshihara, Tomohide Tatsumi, Tetsuo Takehara
- Organizer
  DDW 2012
- Place of Presentation
  San Diego, CA, United States
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] C型肝炎における肝メチル化の定量的評価
- Author(s)
  清水聡、小瀬嗣子、巽智秀、甲賀啓介、小玉尚宏、疋田隼人、宮城琢也、法水淳、吉原治正、竹原徹郎
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  ホテル日航金沢、金沢、日本
- Data Source
  KAKENHI-PROJECT-24790694
[Presentation] The impact of interferon therapy for chronic hepatitis C on methylation status in the liver.
- Author(s)
  Satoshi Shimizu, Tomohide Tatsumi, Takahiro Kodama, Hayato Hikita, Takuya Miyagi, Tetsuo Takehara
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌、札幌、日本
- Data Source
  KAKENHI-PROJECT-24790694

1. HIKITA Hayato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. TANAKA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. NAWA Takatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. TADOKORO Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. MIYAGI Takuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. AONO Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 竹原徹郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 巽智秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
9. 冨山佳昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMIZU Satoshi 清水 聡

Research Projects

Research Products

Co-Researchers

The impact of chemotherapy on innate immune system and cell death signaling in liver cancer.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sorafenib enhances proteasome inhibitor-induced cell death via inactivation of Akt and stress-activated protein kinases2014

Author(s)

Journal Title

Data Source

[Journal Article] Sorafenib enhances proteasome inhibitor-induced cell death via inactivation of Akt and stress-activated protein kinases.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Bcl-2 homology 3 (BH3)-only proteins Bim and Bid are functionally active and restrained by anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) family proteins in healthy liver.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Bcl-2 Homology Domain 3 (BH3)-only Proteins Bim and Bid Are Functionally Active and Restrained by Anti-apoptotic Bcl-2 Family Proteins in Healthy Liver2013

Author(s)

Journal Title

Data Source

[Journal Article] Valine, the branched-chain amino acid, suppresses hepatitis C virus RNA replication but promotes infectious particle formation2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice2013

Author(s)

Journal Title

Data Source

[Journal Article] The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Carbamazepine promotes liver regeneration and survival in mice.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma.2012

Author(s)

Journal Title

Data Source

[Journal Article] Pancreatitis STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interferon-α suppresses hepatitis B virus enhancer II activity via the protein kinase C pathway2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bak deficiency inhibits liver carcinogenesis : A causal link between apoptosis and carcinogenesis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of autophagy potentiates the anti-tumor effect of the multi-kinase inhibitor sorafenib in hepatocellular carcinoma2012

Author(s)

Journal Title

Data Source

[Presentation] The crosstalk between apoptosis and autophagy in the pathogenesis of non-alcoholic fatty liver disease2013

Author(s)

Organizer

Place of Presentation

Data Source

SHIMIZU Satoshi 清水聡