SAKAGUTI MASAJI 阪口雅司

… Alternative Names

Sakaguchi Masaji 阪口雅司

Less

Researcher Number	90625774
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 助教
Affiliation (based on the past Project Information) *help	2023 – 2025: 熊本大学, 大学院生命科学研究部(医), 助教 2019 – 2021: 熊本大学, 大学院生命科学研究部(医), 助教 2018: 熊本大学, 医学部附属病院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 肥満 / インスリン抵抗性 / 糖尿病 / ミトコンドリア / 褐色脂肪組織 / 加齢 / 褐色脂肪 / ベージュ化 / 臓器連関 / インスリン受容体 … More / 2型糖尿病 / ２型糖尿病 / 再生 / インスリンシグナル … More Except Principal Investigator インスリン抵抗性 / 褐色脂肪組織 / 糖尿病 / ベージュ化 / サルコペニア / 骨格筋 / 核内移行 / Foxk1 / インスリン受容体 / ミトコンドリア / インスリンシグナル Less

加齢による褐色脂肪組織のインスリン抵抗性と機能不全の研究Principal Investigator
- Principal Investigator
  
  阪口雅司
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
褐色脂肪活性化因子による筋代謝調節機序の解明とバイオマーカーとしての意義
- Principal Investigator
  
  荒木栄一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
Elucidation of the Molecular Mechanisms of Interorgan Communication Factors Involved in Brown Adipose Tissue RegenerationPrincipal Investigator
- Principal Investigator
  
  Sakaguchi Masaji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
Analysis of the mechanism of nuclear co-localization of Insulin Receptor beta-Subunit and transcription factors FoxK1/2 and their target genes
- Principal Investigator
  
  Araki Eiichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kumamoto University
Search for the novel molecules involved in brown adipocyte activationPrincipal Investigator
- Principal Investigator
  
  Sakaguchi Masaji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University

All 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 医学の歩み2020
- Author(s)
  阪口雅司, 大久保侑馬, 岡川章太, 荒木栄一
- Total Pages
  4
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-18K16208
[Book] Medical Science Digest2020
- Author(s)
  1.阪口雅司, 大久保侑馬, 岡川章太, 荒木栄一
- Total Pages
  3
- Publisher
  ニュー・サイエンス社
- Data Source
  KAKENHI-PROJECT-18K16208
[Book] Diabetes Strategy2019
- Author(s)
  阪口雅司
- Total Pages
  6
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-18K16208
[Book] インスリン受容体異常症(A型，B型)2019
- Author(s)
  阪口雅司, 荒木栄一
- Total Pages
  7
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-18K16208
[Book] 臨床と研究2018
- Author(s)
  阪口雅司, 荒木栄一
- Total Pages
  8
- Publisher
  大道学館
- Data Source
  KAKENHI-PROJECT-18K16208
[Book] Diabetes Journal (糖尿病と代謝)2018
- Author(s)
  阪口雅司, 荒木栄一
- Total Pages
  3
- Publisher
  協和企画
- Data Source
  KAKENHI-PROJECT-18K16208
[Book] Islet Equality2018
- Author(s)
  阪口雅司
- Total Pages
  2
- Publisher
  メディカルレビュー社
- ISBN
- Data Source
  KAKENHI-PROJECT-18K16208
[Book] 糖尿病学20182018
- Author(s)
  阪口雅司, 荒木栄一
- Total Pages
  8
- Publisher
  診断と治療社
- ISBN
  9784787823472
- Data Source
  KAKENHI-PROJECT-18K16208
[Journal Article] The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis2021
- Author(s)
  Kondo T, Kitano S, Miyakawa N, Watanabe T, Goto R, Sato M, Hanatani S, Sakaguchi M, Igata M, Kawashima J, Motoshima H, Matsumura T, Araki E.
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 9 Pages: 1433-1442
- DOI
  10.2169/internalmedicine.6026-20
- NAID
  130008033306
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16208, KAKENHI-PROJECT-21K08533
[Journal Article] Inhibition of the PI 3-kinase pathway disrupts the unfolded protein response and reduces sensitivity to ER stress-dependent apoptosis.2020
- Author(s)
  Winnay JN, Solheim MH, Sakaguchi M, Njolstad PR, Kahn CR.
- Journal Title
  
  FASEB J.
  
  Volume: 34 Issue: 9 Pages: 12521-12532
- DOI
  10.1096/fj.202000892r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Journal Article] Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells2020
- Author(s)
  Gupta Manoj K.、Vethe Heidrun、Softic Samir、Rao Tata Nageswara、Wagh Vilas、Shirakawa Jun、Barsnes Harald、Vaudel Marc、Takatani Tomozumi、Kahraman Sevim、Sakaguchi Masaji、Martinez Rachael、Hu Jiang、Bj?rlykke Yngvild、Raeder Helge、Kulkarni Rohit N.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 15 Issue: 5 Pages: 1067-1079
- DOI
  10.1016/j.stemcr.2020.10.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08866, KAKENHI-PROJECT-18K16208
[Journal Article] Rapid and dramatic glucose‐lowering effect of bromocriptine in an inadequately controlled type2 diabetes patient with prolactinoma2020
- Author(s)
  Igata Motoyuki、Yagi Yoshitaka、Hanatani Satoko、Sakaguchi Masaji、Ishii Norio、Yoshinaga Kayo、Kawashima Junji、Motoshima Hiroyuki、Araki Eiichi
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 12 Issue: 4 Pages: 668-671
- DOI
  10.1111/jdi.13369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-18K16208
[Journal Article] Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism.2019
- Author(s)
  Li ME, Lauritzen HPMM, O'Neill BT, Wang CH, Cai W, Brandao BB, Sakaguchi M, Tao R, Hirshman MF, Softic S, Kahn CR.
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 3412-3412
- DOI
  10.1038/s41467-019-11265-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16208
[Journal Article] FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.2019
- Author(s)
  Sakaguchi M, Cai W, Wang CH, Cederquist CT, Damasio M, Homan EP, Batista T, Ramirez AK, Gupta MK, Steger M, Wewer Albrechtsen NJ, Singh SK, Araki E, Mann M, Enerback S, Kahn CR.
- Journal Title
  
  Nat Commun.
  
  Volume: 10 Issue: 1 Pages: 1582-1582
- DOI
  10.1038/s41467-019-09418-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208, KAKENHI-PROJECT-19K16691
[Journal Article] Mineralocorticoid Receptor May Regulate Glucose Homeostasis through the Induction of Interleukin-6 and Glucagon-Like peptide-1 in Pancreatic Islets2019
- Author(s)
  Goto Rieko、Kondo Tatsuya、Ono Kaoru、Kitano Sayaka、Miyakawa Nobukazu、Watanabe Takuro、Sakaguchi Masaji、Sato Miki、Igata Motoyuki、Kawashima Junji、Motoshima Hiroyuki、Matsumura Takeshi、Shimoda Seiya、Araki Eiichi
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 8 Issue: 5 Pages: 674-674
- DOI
  10.3390/jcm8050674
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09837, KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-18K16208, KAKENHI-PROJECT-17H04201, KAKENHI-PROJECT-17K09835
[Journal Article] TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism2019
- Author(s)
  Takahashi H, Alves C, Stanford K, Middelbeek R, Nigro P, Ryan R, Xue R, Sakaguchi M, Lynes M, So K, Mul J, Lee M. Y, Balan E, Pan H, Dreyfuss J, Hirshman M, Azhar M, Hannukainen J, Kalliokoski K, Nielsen S, Pedersen B, Kahn C.R, Tseng YH, Nuutila P, Goodyear L.
- Journal Title
  
  Nat Metab.
  
  Volume: 1 Issue: 2 Pages: 291-293
- DOI
  10.1038/s42255-018-0030-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Journal Article] Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo.2019
- Author(s)
  Batista TM, Garcia-Martin R, Cai W, Konishi M, O'Neill BT, Sakaguchi M, Kim JH, Jung DY, Kim JK, Kahn CR.
- Journal Title
  
  Cell Rep.
  
  Volume: 12 Issue: 12 Pages: 3429-3443
- DOI
  10.1016/j.celrep.2019.02.081
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Journal Article] Comparison of the efficacy and safety of once-daily insulin degludec/insulin aspart (IDegAsp) and long-acting second-generation basal insulin (insulin degludec and insulin glargine 300 units/mL) in insulin-naïve Japanese adults with type 2 diabetes: a pilot, randomized, controlled study2019
- Author(s)
  Shimoda Seiya、Sakamoto Wakana、Hokamura Ayaka、Matsuo Yasuto、Sekigami Taiji、Ichimori Shinji、Iwashita Shinsuke、Ishii Norio、Otsu Kae、Yoshimura Ryohei、Nishiyama Toshihiko、Sakaguchi Masaji、Nishida Kenro、Araki Eiichi
- Journal Title
  
  Endocr J
  
  Volume: 66 Issue: 8 Pages: 745-752
- DOI
  10.1507/endocrj.EJ19-0179
- NAID
  130007696455
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-18K16208, KAKENHI-PROJECT-17H04201, KAKENHI-PROJECT-17K09863
[Journal Article] 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.2019
- Author(s)
  Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Bluher M, Cypess AM, Kiebish MA, Spite M, Tseng YH.
- Journal Title
  
  Cell Metabolism
  
  Volume: 30 Issue: 4 Pages: 768-783
- DOI
  10.1016/j.cmet.2019.07.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16208
[Journal Article] Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes.2019
- Author(s)
  Ramirez AK, Dankel S, Cai W, Sakaguchi M, Kasif S, Kahn CR.
- Journal Title
  
  Mol Metab.
  
  Volume: 22 Pages: 21-36
- DOI
  10.1016/j.molmet.2019.01.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Journal Article] Impact of hepatic HSP72 on insulin signaling2019
- Author(s)
  Kitano Sayaka、Kondo Tatsuya、Matsuyama Rina、Ono Kaoru、Goto Rieko、Takaki Yuki、Hanatani Satoko、Sakaguchi Masaji、Igata Motoyuki、Kawashima Junji、Motoshima Hiroyuki、Matsumura Takeshi、Kai Hirofumi、Araki Eiichi
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: 316 Issue: 2 Pages: E305-E318
- DOI
  10.1152/ajpendo.00215.2018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09835, KAKENHI-PROJECT-18K16208, KAKENHI-PROJECT-16K09759, KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-17H04201
[Journal Article] Insulin regulates astrocyte gliotransmission and modulates behavior.2018
- Author(s)
  Cai W, Xue C, Sakaguchi M, Konishi M, Shirazian A, Ferris HA, Li ME, Yu R, Kleinridders A, Pothos EN, Kahn CR.
- Journal Title
  
  J Clin Invest.
  
  Volume: 128 Issue: 7 Pages: 2914-2926
- DOI
  10.1172/jci99366
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Journal Article] Identification of microRNA that represses IRS-1 expression in liver.2018
- Author(s)
  Ono K, Igata M, Kondo T, Kitano S, Takaki Y, Hanatani S, Sakaguchi M, Goto R, Senokuchi T, Kawashima J, Furukawa N, Motoshima H, Araki E
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 1 Pages: 0191553-0191553
- DOI
  10.1371/journal.pone.0191553
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09760, KAKENHI-PROJECT-15K09394, KAKENHI-PROJECT-15K15348, KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-18K16208, KAKENHI-PROJECT-17H04201, KAKENHI-PROJECT-16K09759, KAKENHI-PROJECT-16K09787
[Journal Article] Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions.2018
- Author(s)
  Altindis E, Cai W, Sakaguchi M, Zhang F, GuoXiao W, Liu F, De Meyts P, Gelfanov V, Pan H, DiMarchi R, Kahn CR.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 115 Issue: 10 Pages: 2461-2466
- DOI
  10.1073/pnas.1721117115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Presentation] Regulation of Phosphorylation Status in Insulin Signaling via α4 Is Necessary for Adipocyte Maintenance and Lipid Dynamics.2020
- Author(s)
  Sakaguchi M, Okagawa S, Okubo Y, Kitano S, Igata M, Kondo T, Araki E.
- Organizer
  The 80th ADA scientific meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Presentation] The essential role of the α4 for insulin signalling in metabolic regulation and maintenance of brown adipocyte.2020
- Author(s)
  Sakaguchi M, Okagawa S, Okubo Y, Igata M, Kondo T, Araki E.
- Organizer
  56th Annual Meetng of the European Association of the Study of Diabetes.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Presentation] 白色および褐色脂肪組織のインスリン抵抗性に関わる新規経路α4 の全身代謝制御の解析.2020
- Author(s)
  阪口雅司，岡川章太，大久保侑馬，北野さやか，井形元維，河島淳司，近藤龍也，荒木栄一
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K16208
[Presentation] FoxK1 and FoxK2 are positive regulators for IR and IGF1R signalling in cell proliferation and metabolism.2019
- Author(s)
  Sakaguchi M, Araki E, Mann M, Enerback S, Kahn CR
- Organizer
  55th Annual Meetng of the European Association of the Study of Diabetes.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Presentation] Molecular mechanism for adipose tissue dynamics2019
- Author(s)
  阪口雅司
- Organizer
  AASD-MDIA 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Presentation] Unique role of the α4 component for S6-kinase activity in Metabolic Regulation and anti- Apoptotic effect in Brown Adipose Tissue2019
- Author(s)
  Sakaguchi M, Okagawa S, Kondo T, Kitano S,Araki E.
- Organizer
  The 79th ADA scientific meeting,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Presentation] 脂肪細胞の機能を制御するインスリンシグナル伝達経路2018
- Author(s)
  阪口雅司, C Ronald Kahn, 荒木栄一
- Organizer
  第61回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K16208
[Presentation] FoxK1/K2 are new important components of IR and IGF1R signaling and control of cell proliferation and metabolism.2018
- Author(s)
  Sakaguchi M, Cai W, Wang C, Homan P. E, Batista T, Araki E, Kahn C. R.
- Organizer
  The 78th ADA scientific meeting,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16208
[Presentation] インスリン抵抗性下における白色及び褐色脂肪組織の維持及び再生2018
- Author(s)
  阪口雅司, C Ronald Kahn, 荒木栄一
- Organizer
  第61回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K16208
[Presentation] 脂肪組織のダイナミックス.2018
- Author(s)
  阪口雅司, 荒木栄一
- Organizer
  第56回日本糖尿病学会九州地方会
- Invited
- Data Source
  KAKENHI-PROJECT-18K16208

1. Araki Eiichi (10253733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 福田一起 (70884592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 近藤龍也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 後藤理英子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 白川純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 井形元維

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 松村剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAGUTI MASAJI 阪口 雅司

Sakaguchi Masaji 阪口 雅司

Research Projects

Research Products

Co-Researchers

加齢による褐色脂肪組織のインスリン抵抗性と機能不全の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

褐色脂肪活性化因子による筋代謝調節機序の解明とバイオマーカーとしての意義

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Molecular Mechanisms of Interorgan Communication Factors Involved in Brown Adipose Tissue RegenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanism of nuclear co-localization of Insulin Receptor beta-Subunit and transcription factors FoxK1/2 and their target genes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for the novel molecules involved in brown adipocyte activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 医学の歩み2020

Author(s)

Total Pages

Publisher

Data Source

[Book] Medical Science Digest2020

Author(s)

Total Pages

Publisher

Data Source

[Book] Diabetes Strategy2019

Author(s)

Total Pages

Publisher

Data Source

[Book] インスリン受容体異常症(A型，B型)2019

Author(s)

Total Pages

Publisher

Data Source

[Book] 臨床と研究2018

Author(s)

Total Pages

Publisher

Data Source

[Book] Diabetes Journal (糖尿病と代謝)2018

Author(s)

Total Pages

Publisher

Data Source

[Book] Islet Equality2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 糖尿病学20182018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis2021

Author(s)

Journal Title

SAKAGUTI MASAJI 阪口雅司

Sakaguchi Masaji 阪口雅司