Hirota Keiji 廣田圭司

… Alternative Names

HIROTA Keiji 廣田圭司

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Researcher Number	90631250
Affiliation (Current)	2025: 京都大学, 医生物学研究所, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 京都大学, 医生物学研究所, 准教授 2016 – 2021: 京都大学, ウイルス・再生医科学研究所, 准教授 2015 – 2016: 京都大学, 再生医科学研究所, 准教授 2014: 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) 2013 – 2014: 大阪大学, 免疫学フロンティア研究センター, 特任准教授
Review Section/Research Field	Principal Investigator Immunology / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Pathology, Infection/Immunology, and related fields / Collagenous pathology/Allergology Except Principal Investigator Immunology
Keywords	Principal Investigator Th17 / IL-17 / Th17細胞 / 炎症性Tヘルパー細胞 / 自己免疫性関節炎 / 自己免疫疾患 / GM-CSF / サイトカイン / Th17 cells / SKGマウス … More / 炎症性サイトカイン / Tヘルパー細胞 / Foxp3 / IL-23 / 炎症性疾患 / Memory / メモリーT細胞 / Autoimmune disease / T helper cells / 自己免疫疾患モデル / ヘルパーT細胞 / 粘膜免疫 … More Except Principal Investigator 自己抗原 / ZAP-70 / 関節リウマチ / 自己免疫性関節炎 / SKG Less

The molecular basis of tissue inflammation mediated by Th17 cellsPrincipal Investigator
- Principal Investigator
  
  Hirota Keiji
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
Elucidation of immunological memory of inflammatory T helper cellsPrincipal Investigator
- Principal Investigator
  
  Hirota Keiji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pathology, Infection/Immunology, and related fields
- Research Institution
  Kyoto University
A molecular basis of inflammatory Th17 cells in autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  Hirota Keiji
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Molecular basis and therapeutic target for autoimmune arthritis
- Principal Investigator
  
  Sakaguchi Shimon
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Regulation of GM-CSF-producing Th cellsPrincipal Investigator
- Principal Investigator
  
  Hirota Keiji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kyoto University
  Osaka University
Molecular basis of mucosal immunity maintained by Th17 cellsPrincipal Investigator
- Principal Investigator
  
  HIROTA Keiji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition2024
- Author(s)
  Tokifuji Yukiko、Hayabuchi Hodaka、Sasaki Takashi、Hara-Chikuma Mariko、Hirota Keiji、Takahashi Hayato、Amagai Masayuki、Yoshimura Akihiko、Chikuma Shunsuke
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 1 Pages: 108646-108646
- DOI
  10.1016/j.isci.2023.108646
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19444, KAKENHI-PROJECT-22K19446, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H05044, KAKENHI-PROJECT-19H01026
[Journal Article] Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice2024
- Author(s)
  Ohara Daiya、Takeuchi Yusuke、Watanabe Hitomi、Lee Yoonha、Mukoyama Hiroki、Ohteki Toshiaki、Kondoh Gen、Hirota Keiji
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 221 Issue: 2
- DOI
  10.1084/jem.20230923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KJ1935, KAKENHI-PROJECT-19H01026
[Journal Article] Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity2024
- Author(s)
  Luca Domnica、Lee Sumin、Hirota Keiji、Okabe Yasutaka、Uehori Junji、Izawa Kazushi、Lanz Anna-Lisa、Sch?tte Verena、Sivri Burcu、Tsukamoto Yuta、Hauck Fabian、Behrendt Rayk、Roers Axel、Fujita Takashi、Nishikomori Ryuta、Lee-Kirsch Min Ae、Kato Hiroki
- Journal Title
  
  Science Advances
  
  Volume: 10 Issue: 9
- DOI
  10.1126/sciadv.adk0820
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01026
[Journal Article] Identification of Surface Markers and Functional Characterization of Myeloid Derived Suppressor Cell‐Like Adherent Cells2023
- Author(s)
  Co Soriano John Clyde、Tsutsumi Shiho、Ohara Daiya、Hirota Keiji、Kondoh Gen、Niwa Tatsuya、Taguchi Hideki、Kadonosono Tetsuya、Kizaka‐Kondoh Shinae
- Journal Title
  
  Advanced Biology
  
  Volume: 8 Issue: 3
- DOI
  10.1002/adbi.202300159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ1935, KAKENHI-PROJECT-19H01026
[Journal Article] Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease2022
- Author(s)
  Tanaka Atsushi、Maeda Shinji、Nomura Takashi、Llamas-Covarrubias Mara Anais、Tanaka Satoshi、Jin Lin、Lim Ee Lyn、Morikawa Hiromasa、Kitagawa Yohko、Akizuki Shuji、Ito Yoshinaga、Fujimori Chihiro、Hirota Keiji、et al、Sakaguchi Shimon
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 220 Issue: 2 Pages: 1-5
- DOI
  10.1084/jem.20220386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-20K16286, KAKENHI-PROJECT-23K24181, KAKENHI-PROJECT-22K20758
[Journal Article] Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model2022
- Author(s)
  Lee Sumin、Hirota Keiji、Schuette Verena、Fujita Takashi、Kato Hiroki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 629 Pages: 171-175
- DOI
  10.1016/j.bbrc.2022.09.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Journal Article] Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity2022
- Author(s)
  Shirakashi Mirei、Maruya Mikako、Hirota Keiji、Tsuruyama Tatsuaki、Matsuo Takashi、Watanabe Ryu、Murata Koichi、Tanaka Masao、Ito Hiromu、Yoshifuji Hajime、Ohmura Koichiro、Elewaut Dirk、Sakaguchi Shimon、Fagarasan Sidonia、Mimori Tsuneyo、Hashimoto Motomu
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 74 Issue: 4 Pages: 641-653
- DOI
  10.1002/art.42016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09298, KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-20K08773
[Journal Article] 炎症性Th17細胞による組織炎症の形成2021
- Author(s)
  廣田圭司
- Journal Title
  
  炎症と免疫
  
  Volume: 29 Pages: 15-17
- Data Source
  KAKENHI-PROJECT-19H01026
[Journal Article] 自己免疫疾患に関わるT細胞の制御因子2021
- Author(s)
  小原乃也、廣田圭司
- Journal Title
  
  創薬研究者・アカデミア研究者が知っておくべき最新の免疫学とその応用技術
  
  Volume: 1 Pages: 203-213
- Data Source
  KAKENHI-PROJECT-19H01026
[Journal Article] Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis.2021
- Author(s)
  Takeuchi Y, Ohara D, Watanabe H, Sakaguchi N, Sakaguchi S, Kondoh G, Morinobu A, Mimori T, Hirota K.
- Journal Title
  
  Sci Rep.
  
  Volume: 11 Issue: 1 Pages: 18679-18679
- DOI
  10.1038/s41598-021-98145-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01026
[Journal Article] Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells.2021
- Author(s)
  Kawakami R, Kitagawa Y, Chen KY, Arai M, Ohara D, Nakamura Y, Yasuda K, Osaki M, Mikami N, Lareau CA, Watanabe H, Kondoh G, Hirota K, Ohkura N, Sakaguchi S.
- Journal Title
  
  Immunity
  
  Volume: 54 Issue: 5 Pages: 947-961
- DOI
  10.1016/j.immuni.2021.04.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-20J20443, KAKENHI-PROJECT-20K16279
[Journal Article] 臨床医が知っておくべき免疫学のいま：PathogenicヘルパーT細胞と組織炎症2021
- Author(s)
  廣田圭司
- Journal Title
  
  別冊・医学のあゆみ
  
  Volume: 1 Pages: 48-53
- Data Source
  KAKENHI-PROJECT-19H01026
[Journal Article] Foxp3+ Regulatory T Cells Inhibit CCl4-Induced Liver Inflammation and Fibrosis by Regulating Tissue Cellular Immunity2020
- Author(s)
  1)Ikeno Y, Ohara D, Takeuchi Y, Watanabe H, Kondoh G, Taura K, Uemoto S, Hirota K
- Journal Title
  
  Front Immunol.
  
  Volume: 15 Pages: 584048-584048
- DOI
  10.3389/fimmu.2020.584048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01026
[Journal Article] Impaired T cell receptor signaling and development of T cell-mediated autoimmune arthritis.2020
- Author(s)
  Takeuchi Y, Hirota K, Sakaguchi S.
- Journal Title
  
  Immunol Rev.
  
  Volume: 294 Issue: 1 Pages: 164-176
- DOI
  10.1111/imr.12841
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-17K19553, KAKENHI-PROJECT-16H06295
[Journal Article] PathogenicヘルパーT細胞と組織炎症2020
- Author(s)
  廣田圭司
- Journal Title
  
  医学のあゆみ
  
  Volume: 274 Pages: 1214-9
- Data Source
  KAKENHI-PROJECT-19H01026
[Journal Article] Th17細胞による関節炎惹起と慢性炎症の維持機構2020
- Author(s)
  廣田圭司
- Journal Title
  
  リウマチ科
  
  Volume: 63 Pages: 603-9
- Data Source
  KAKENHI-PROJECT-19H01026
[Journal Article] Correction to: The pathogenicity of Th17 cells in autoimmune diseases2019
- Author(s)
  Yasuda Keiko、Takeuchi Yusuke、Hirota Keiji
- Journal Title
  
  Seminars in Immunopathology
  
  Volume: 41 Issue: 3 Pages: 299-299
- DOI
  10.1007/s00281-019-00746-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19553, KAKENHI-PROJECT-16H06233
[Journal Article] Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/192019
- Author(s)
  Akamatsu Masahiko、Mikami Norihisa、Ohkura Naganari、Kawakami Ryoji、Kitagawa Yohko、Sugimoto Atsushi、Hirota Keiji、Nakamura Naoto、Ujihara Satoru、Kurosaki Toshio、Hamaguchi Hisao、Harada Hironori、Xia Guliang、Morita Yoshiaki、Aramori Ichiro、Narumiya Shuh、Sakaguchi Shimon
- Journal Title
  
  Science Immunology
  
  Volume: 4 Issue: 40
- DOI
  10.1126/sciimmunol.aaw2707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-17K19553
[Journal Article] 自己免疫性関節炎の発症・慢性化の原因となる炎症ネットワークメカニズムの解明2019
- Author(s)
  廣田　圭司
- Journal Title
  
  医学のあゆみ
  
  Volume: 269 Pages: 603-604
- Data Source
  KAKENHI-PROJECT-17K19553
[Journal Article] The pathogenicity of Th17 cells in autoimmune diseases.2019
- Author(s)
  Yasuda K, Takeuchi Y, Hirota K.
- Journal Title
  
  Semin Immunopathol.
  
  Volume: 41 Issue: 3 Pages: 283-297
- DOI
  10.1007/s00281-019-00733-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-17K19553
[Journal Article] Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation2019
- Author(s)
  Yasuda Keiko、Kitagawa Yohko、Kawakami Ryoji、Isaka Yoshitaka、Watanabe Hitomi、Kondoh Gen、Kohwi-Shigematsu Terumi、Sakaguchi Shimon、Hirota Keiji
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 549-549
- DOI
  10.1038/s41467-019-08404-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553, KAKENHI-PROJECT-16H06233, KAKENHI-PROJECT-16H06295
[Journal Article] Synovial Tissue Inflammation Mediated by Autoimmune T Cells2019
- Author(s)
  Takeuchi Yusuke、Hirota Keiji、Sakaguchi Shimon
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 1989-1989
- DOI
  10.3389/fimmu.2019.01989
- NAID
  120006726173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-17K19553
[Journal Article] 自己免疫性関節炎を惹起するTh17細胞を起点とした炎症カスケード2019
- Author(s)
  廣田　圭司
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71 Pages: 1-7
- Data Source
  KAKENHI-PROJECT-17K19553
[Journal Article] Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection2019
- Author(s)
  Hojo Miki Arai、Masuda Kyoko、Hojo Hiroaki、Nagahata Yosuke、Yasuda Keiko、Ohara Daiya、Takeuchi Yusuke、Hirota Keiji、Suzuki Yutaka、Kawamoto Hiroshi、Kawaoka Shinpei
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 2603-2603
- DOI
  10.1038/s41467-019-10525-1
- NAID
  120006782209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06306, KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-17K19553, KAKENHI-PUBLICLY-18H04810, KAKENHI-PROJECT-18K15409
[Journal Article] 自己免疫性関節炎の発症・慢性化の原因となる炎症ネットワークメカニズムの解明2019
- Author(s)
  廣田　圭司
- Journal Title
  
  医学のあゆみ
  
  Volume: 269 Pages: 603-604
- Data Source
  KAKENHI-PROJECT-19H01026
[Journal Article] 自己免疫性関節炎を惹起するTh17細胞を起点とした炎症カスケード2019
- Author(s)
  廣田　圭司
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71 Pages: 1-7
- Data Source
  KAKENHI-PROJECT-16H06233
[Journal Article] Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis2018
- Author(s)
  Hirota Keiji、Hashimoto Motomu、Ito Yoshinaga、Matsuura Mayumi、Ito Hiromu、Tanaka Masao、Watanabe Hitomi、Kondoh Gen、Tanaka Atsushi、Yasuda Keiko、Kopf Manfred、Potocnik Alexandre J.、Stockinger Brigitta、Sakaguchi Noriko、Sakaguchi Shimon
- Journal Title
  
  Immunity
  
  Volume: 48 Issue: 6 Pages: 1220-1232
- DOI
  10.1016/j.immuni.2018.04.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-16H06233, KAKENHI-PROJECT-17K15723
[Journal Article] Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor2017
- Author(s)
  Miralles Marta、Eixarch Herena、Tejero Marcos、Costa Carme、Hirota Keiji、Casta?o A. Raul、Puig Meritxell、Stockinger Gitta、Montalban Xavier、Bosch Assumpci?、Espejo Carmen、Chillon Miguel
- Journal Title
  
  Neurotherapeutics
  
  Volume: 14 Issue: 4 Pages: 1095-1106
- DOI
  10.1007/s13311-017-0545-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553, KAKENHI-PROJECT-16H06233
[Journal Article] Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.2017
- Author(s)
  Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S.
- Journal Title
  
  Nat Immunol.
  
  Volume: 18(2) Issue: 2 Pages: 173-183
- DOI
  10.1038/ni.3646
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16H06233, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-16K14650, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-17H05805
[Journal Article] 「自己免疫性関節炎を惹起するヘルパーTサブセットと認識自己抗原」：慢性炎症性疾患の新たな展開2016
- Author(s)
  廣田　圭司
- Journal Title
  
  最新医学
  
  Volume: 71 Pages: 2320-2325
- Data Source
  KAKENHI-PROJECT-26670477
[Journal Article] 自己免疫性関節炎を惹起するヘルパーTサブセットと認識自己抗原2016
- Author(s)
  廣田圭司
- Journal Title
  
  最新医学
  
  Volume: 71 Pages: 2320-2325
- Data Source
  KAKENHI-PROJECT-16H06233
[Journal Article] Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine.2016
- Author(s)
  Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, and Takeda K
- Journal Title
  
  Arthritis Rheum
  
  Volume: 68 Issue: 11 Pages: 2646-2661
- DOI
  10.1002/art.39783
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02511, KAKENHI-PROJECT-16H06233, KAKENHI-PROJECT-15K15152, KAKENHI-PROJECT-26670477, KAKENHI-PROJECT-16K08838, KAKENHI-PROJECT-16K14650, KAKENHI-PROJECT-16H06295
[Journal Article] Th17細胞の機能制御と自己免疫疾患2015
- Author(s)
  廣田圭司
- Journal Title
  
  実験医学　増刊
  
  Volume: 33 Pages: 1877-1881
- Data Source
  KAKENHI-PROJECT-26670477
[Journal Article] Th17細胞の機能制御と自己免疫疾患2015
- Author(s)
  廣田　圭司
- Journal Title
  
  実験医学　増刊
  
  Volume: 33 Pages: 1877-1881
- Data Source
  KAKENHI-PROJECT-25713019
[Journal Article] 関節リウマチの病態形成に関与するT細胞クローンの同定と新規自己抗原RPL23A2015
- Author(s)
  廣田圭司、橋本求、坂口志文
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 45 Pages: 67-70
- Data Source
  KAKENHI-PROJECT-25713019
[Journal Article] 関節リウマチの病態形成に関与するT細胞クローンの同定と新規自己抗原RPL23A2015
- Author(s)
  廣田圭司、橋本求、坂口志文
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 45 Pages: 67-70
- Data Source
  KAKENHI-PROJECT-26670477
[Journal Article] Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease.2014
- Author(s)
  Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali D, Kappler J, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.
- Journal Title
  
  Science
  
  Volume: 346 Issue: 6207 Pages: 363-8
- DOI
  10.1126/science.1259077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25713019, KAKENHI-PROJECT-26290054, KAKENHI-PROJECT-26670192, KAKENHI-PROJECT-26670477, KAKENHI-PROJECT-26670581, KAKENHI-PROJECT-26860331
[Journal Article] Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease2014
- Author(s)
  Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.
- Journal Title
  
  Science
  
  Volume: 346 Pages: 363-368
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions.2014
- Author(s)
  2)Di Meglio P, Duarte JH, Ahlfors H, Owens ND, Li Y, Villanova F, Tosi I, Hirota K, Nestle FO, Mrowietz U, Gilchrist MJ, Stockinger B.
- Journal Title
  
  Immunity
  
  Volume: 40 Issue: 6 Pages: 989-1001
- DOI
  10.1016/j.immuni.2014.04.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25713019, KAKENHI-PROJECT-26670477
[Journal Article] Plasticity of TH17 cells in Peyer’s patches is responsible for the induction of T cell-dependent IgA responses.2013
- Author(s)
  Hirota, K., et al.
- Journal Title
  
  Nature Immunology
  
  Volume: 4 Pages: 372-379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25713019
[Presentation] Differential TCR affinities for self antigens between Treg and arthritogenic Th17 cells shape the functional imbalance that cause autoimmune arthritis2024
- Author(s)
  Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Gen Kondoh; Akio Morinobu; Keiji Hirota
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology, Chiba, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] Sequential Notch2 and retinoic acid signals license IL-23 expression by EpCAM+ DCIR2+ CD103- cDC2 in gut-associated lymphoid tissues2024
- Author(s)
  Daiya Ohara; Yusuke Takeuchi; Hitomi Watanabe; Yoonha Lee; Hiroki Mukoyama; Toshiaki Ohteki; Gen Kondoh; Keiji Hirota
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology, Chiba, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] Sequential Notch2 and retinoic acid signals liceNotch2 and retinoic acid signals induce IL-23 expression by EpCAM+ DCIR2+ cDC2s in gut-associated lymphoid tissues2024
- Author(s)
  Keiji Hirota
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology, Chiba, Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] Dysregulation of Treg homeostasis by ADAR1 deficiency and chronic MDA5 signaling2024
- Author(s)
  Luca D; Lee S; Hirota K; Okabe Y; Uehori J; Izawa K; Anna; Lanz L; Sch V; Sivri B; Tsukamoto Y; Hauck F; Behrend R; Roers A; Fujita T; Nishikomori R; Lee-Kirsch M; Kato H
- Organizer
  The 7th TOLL Conference, Rotterdam, Netherlands
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] GM-CSF-induced differentiation and activation of CCR2+ monocytes in inflamed joints exacerbates synovial inflammation in autoimmune arthritis2024
- Author(s)
  Hiroki Mukoyama; Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe, Gen; Kondoh; Akio Morinobu; Keiji Hirota
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology, Chiba, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] An IL-23 reporter strain reveals the developmental identity and functional regulations of the IL-23-producing gut cDC2s that mediate mucosal host defense against infectious pathogens2023
- Author(s)
  Ohara D; Takeuchi Y; Watanabe H; Lee Y; Mukoyama H; Ohteki T; Kondoh G; Hirota K
- Organizer
  11th Annual Meeting of the International Cytokine & Interferon Society, Athen, Greece
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] Differential TCR repertoire for joint self-antigens determines the functional balance between the regulatory T and arthritogenic T cells in T cell-mediated autoimmune arthritis2022
- Author(s)
  Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Gen Kondoh; Akio Morinobu; Keiji Hirota
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] Regulation and cell fate of CCR2 + inflammatory monocytes in the development of T cell-dependent autoimmune arthritis2022
- Author(s)
  Hiroki Mukoyama; Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Gen Kondoh; Akio Morinobu; Keiji Hirota
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] An Il23a-Venus reporter strain reveals the spatio-temporal regulation of IL-23- producing cDC2 subset in gut-associated lymphoid tissues2022
- Author(s)
  Daiya Ohara; Hitomi Watanabe; Yusuke Takeuchi; Yoonha LEE; Mukoyama Hiroki; Gen Kondoh; Keiji Hirota
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] Foxp3+ regulatory T cells suppress chronic inflammation and fibrosis in the liver by regulating tissue cellular immunity in CCl4-induced liver injury2021
- Author(s)
  Ohara D,Takeuchi Y,Watanabe H,Kondoh G, Hirota K.
- Organizer
  第50回　日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] 自己免疫性関節炎の滑膜組織炎症における炎症性細胞サブセットの役割2020
- Author(s)
  廣田　圭司
- Organizer
  第38回日本骨代謝学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] 関節炎モデルSKGマウスを用いた免疫学的解析2019
- Author(s)
  廣田　圭司
- Organizer
  第63回日本リウマチ学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] A crucial role of the conserved non-coding sequences Foxp3-CNS0 and -CNS3 in the lineage specification of thymic Foxp3+ regulatory T cells2019
- Author(s)
  Kawakami R, Kitagawa Y, Yasuda K, Mikami N, Ohkura N, Watanabe H, Chen K, Kondoh G, Hirota K, Sakaguchi S
- Organizer
  第48回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] Satb1 controls GM-CSF and PD-1 expression by pathogenic Th17 cells2019
- Author(s)
  Hirota K, Yasuda K, Kitagawa Y, Kawakami R, Watanabe H, Kondoh G, Sakaguchi S
- Organizer
  7th Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] Inflammatory cascade of autoimmune arthritis by Th17 cells and GM-CSF-producing ILCs2019
- Author(s)
  Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S
- Organizer
  Keystone symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] 胸腺における負の選択に特化した機能を持つゲノミックエンハンサーの同定と機能解析2019
- Author(s)
  北條未来、増田喬子、北条広朗、長畑洋佑、安田圭子、小原及也、竹内悠介、廣田圭司、鈴木穣、河本宏、河岡慎平
- Organizer
  Kyoto T Cell Conference 第29回学術集会
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Satb1 controls GM-CSF and PD-1 expression by pathogenic Th17 cells2019
- Author(s)
  Hirota K, Yasuda K, Kitagawa Y, Kawakami R, Watanabe H, Kondoh G, Sakaguchi S
- Organizer
  7th Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] 関節炎モデルSKGマウスを用いた免疫学的解析2019
- Author(s)
  廣田　圭司
- Organizer
  第63回日本リウマチ学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] 胸腺Treg分化におけるFoxp3-CNS0/CNS3領域の重要性2019
- Author(s)
  川上竜司、北川瑶子、Chen K、安田圭子、大倉永也、渡邊仁美、近藤玄、廣田圭司、坂口志文
- Organizer
  Kyoto T Cell Conference 第29回学術集会
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Inflammatory cascade of autoimmune arthritis by Th17 cells and GM-CSF-producing ILCs2019
- Author(s)
  Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S
- Organizer
  Keystone symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] A crucial role of the conserved non-coding sequences Foxp3-CNS0 and -CNS3 in the lineage specification of thymic Foxp3+ regulatory T cells2019
- Author(s)
  Kawakami R, Kitagawa Y, Yasuda K, Mikami N, Ohkura N, Watanabe H, Chen K, Kondoh G, Hirota K, Sakaguchi S
- Organizer
  第48回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] 胸腺Treg分化におけるFoxp3-CNS0/CNS3領域の重要性2019
- Author(s)
  川上竜司、北川瑶子、Chen K、安田圭子、大倉永也、渡邊仁美、近藤玄、廣田圭司、坂口志文
- Organizer
  Kyoto T Cell Conference 第29回学術集会
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] 胸腺における負の選択に特化した機能を持つゲノミックエンハンサーの同定と機能解析2019
- Author(s)
  北條未来、増田喬子、北条広朗、長畑洋佑、安田圭子、小原及也、竹内悠介、廣田圭司、鈴木穣、河本宏、河岡慎平
- Organizer
  Kyoto T Cell Conference 第29回学術集会
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] Gsdmd and Ripk3 are dispensable for the induction and chronic inflammation of SKG arthritis2019
- Author(s)
  Takeuchi Y, Watanabe H, Kondoh G, Sakaguchi N, Sakaguchi S, Hirota K
- Organizer
  第48回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Gsdmd and Ripk3 are dispensable for the induction and chronic inflammation of SKG arthritis2019
- Author(s)
  Takeuchi Y, Watanabe H, Kondoh G, Sakaguchi N, Sakaguchi S, Hirota K
- Organizer
  第48回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01026
[Presentation] An inflammatory cellular cascade of autoimmune Th17 cells, GM-CSF-producing synovial ILCs and stromal cells in the development of autoimmune arthritis2018
- Author(s)
  Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S
- Organizer
  Kyoto T cell Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] Epigenetic landscape of FOXP3 enhancer sites during thymic FOXP3+ TREG development of CNS0- and CNS3-deficient mice2018
- Author(s)
  Kawakami R, Kitagawa Y, Hirota K, Watanabe H, Kondoh G, Ohkura N, Sakaguchi S
- Organizer
  6th Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Autoimmune Th17 cells instruct ILC secretion of inflammatory GM-CSF to initiate and augment autoimmune arthritis2018
- Author(s)
  Keiji Hirota
- Organizer
  第47回日本免疫学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] Satb1-mediated regulation of GM-CSF and PD-1 in effector Th17 cells in experimental autoimmune encephalomyelitis2018
- Author(s)
  Yasuda K, Kitagawa Y, Kawakami R, Watanabe H, Kondoh G, Kohwi-Shigematsu T, Sakaguchi S, Hirota K
- Organizer
  第47回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] Epigenetic landscape of FOXP3 enhancer sites during thymic FOXP3+ TREG development of CNS0- and CNS3-deficient mice2018
- Author(s)
  Kawakami R, Kitagawa Y, Hirota K, Watanabe H, Kondoh G, Ohkura N, Sakaguchi S
- Organizer
  6th Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] A role of Ripk3 and Gsdmd in the development of autoimmune arthritis in SKG mice2018
- Author(s)
  Takeuchi Y, Watanabe H, Kondoh G, Sakaguchi N, Sakaguchi S, Mimori T, Hirota K
- Organizer
  第47回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] GM-CSF-producing synovial ILCs exacerbate Th17-mediated autoimmune arthritis2018
- Author(s)
  Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S
- Organizer
  The 3rd International Conference on Innate Lymphoid Cells
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] A role of Ripk3 and Gsdmd in the development of autoimmune arthritis in SKG mice2018
- Author(s)
  Takeuchi Y, Watanabe H, Kondoh G, Sakaguchi N, Sakaguchi S, Mimori T, Hirota K
- Organizer
  第47回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] GM-CSF-producing synovial ILCs exacerbate Th17-mediated autoimmune arthritis2018
- Author(s)
  Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S
- Organizer
  The 3rd International Conference on Innate Lymphoid Cells
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Satb1-mediated regulation of GM-CSF and PD-1 in pathogenic Th17 cells2018
- Author(s)
  Yasuda K, Kitagawa Y, Kawakami R, Isaka Y, Watanabe H, Kondoh G, Kohwi-Shigematsu T, Sakaguchi S, Hirota K
- Organizer
  6th Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Satb1-mediated regulation of GM-CSF and PD-1 in effector Th17 cells in experimental autoimmune encephalomyelitis2018
- Author(s)
  Yasuda K, Kitagawa Y, Kawakami R, Watanabe H, Kondoh G, Kohwi-Shigematsu T, Sakaguchi S, Hirota K
- Organizer
  第47回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Autoimmune arthritis mediated by inflammatory Th17 cells2018
- Author(s)
  Keiji Hirota
- Organizer
  25th East Asia Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Autoimmune arthritis mediated by inflammatory Th17 cells2018
- Author(s)
  Keiji Hirota
- Organizer
  25th East Asia Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] An inflammatory cellular cascade of autoimmune Th17 cells, GM-CSF-producing synovial ILCs and stromal cells in the development of autoimmune arthritis2018
- Author(s)
  Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S
- Organizer
  Kyoto T cell Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Satb1-mediated regulation of GM-CSF and PD-1 in pathogenic Th17 cells2018
- Author(s)
  Yasuda K, Kitagawa Y, Kawakami R, Isaka Y, Watanabe H, Kondoh G, Kohwi-Shigematsu T, Sakaguchi S, Hirota K
- Organizer
  6th Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] Autoimmune Th17 cells instruct ILC secretion of inflammatory GM-CSF to initiate and augment autoimmune arthritis2018
- Author(s)
  Keiji Hirota
- Organizer
  第47回日本免疫学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Satb1 controls the differentiation and terminal effector function of Th17 cells2017
- Author(s)
  Keiko Yasuda, Yohko Kitagawa, Shimon Sakaguchi, Keiji Hirota
- Organizer
  第46回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] An inflammatory cellular network of autoimmune Th17 cells, GM-CSF-producing ILCs and synoviocytes in the development of autoimmune arthritis2017
- Author(s)
  Keiji Hirota
- Organizer
  Keystone symposia, Immune Regulation in Autoimmunity and Cancer
- Place of Presentation
  Whistler, Canada
- Year and Date
  2017-03-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670477
[Presentation] Satb1 controls the differentiation and terminal effector function of Th17 cells2017
- Author(s)
  Keiko Yasuda, Yohko Kitagawa, Shimon Sakaguchi, Keiji Hirota
- Organizer
  第46回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Characterization of Innate lymphoid cells in gingiva of mice infected with Porphyromonas gingivalis2017
- Author(s)
  Ryoki Kobayashi, Yohei Watanabe, Noriko M Tsuji, Keiji Hirota, Tomoko Kurita-Ochiai
- Organizer
  第46回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19553
[Presentation] Characterization of Innate lymphoid cells in gingiva of mice infected with Porphyromonas gingivalis2017
- Author(s)
  Ryoki Kobayashi, Yohei Watanabe, Noriko M Tsuji, Keiji Hirota, Tomoko Kurita-Ochiai
- Organizer
  第46回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] An inflammatory cellular network of autoimmune Th17 cells, GM-CSF-producing ILCs and synoviocytes in the development of autoimmune arthritis2017
- Author(s)
  Keiji Hirota
- Organizer
  Keystone symposia, Immune Regulation in Autoimmunity and Cancer
- Place of Presentation
  Whistler, Canada
- Year and Date
  2017-03-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] Inflammatory circuit of Th17 cells, GM-CSF-producing fibroblast-like synoviocytes, and ILCs in the development of autoimmune arthritis2016
- Author(s)
  Keiji Hirota
- Organizer
  第16回　国際免疫学会
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06233
[Presentation] Inflammatory circuit of Th17 cells, GM-CSF-producing fibroblast-like synoviocytes, and ILCs in the development of autoimmune arthritis2016
- Author(s)
  Keiji Hirota
- Organizer
  第16回　国際免疫学会
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670477
[Presentation] Th17 cells orchestrate an inflammatory circuit in the development of autoimmune arthritis2016
- Author(s)
  Keiji Hirota
- Organizer
  World Immune Regulation Meeting X
- Place of Presentation
  Davos, Switzerland
- Year and Date
  2016-03-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25713019
[Presentation] Th17 cells orchestrate an inflammatory circuit in the development of autoimmune arthritis2016
- Author(s)
  Keiji Hirota
- Organizer
  World Immune Regulation Meeting X
- Place of Presentation
  Davos, Switzerland
- Year and Date
  2016-03-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670477
[Presentation] Generation of highly self-reactive T helper cells in SKG autoimmune arthritis2015
- Author(s)
  Keiji Hirota
- Organizer
  第１０回　研究所ネットワーク国際シンポジウム
- Place of Presentation
  北海道
- Year and Date
  2015-07-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25713019
[Presentation] Role of glucocorticoid-induced TNFR-related protein (GITR) ligand in effector function and Treg-mediated suppression2015
- Author(s)
  Yasuda Keiko, Nishioka Tomohisa, Hirota Keiji, Takeda Kiyoshi, Akira Shizuo, Sakaguchi Shimon
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Generation of highly self-reactive T helper cells in SKG autoimmune arthritis2015
- Author(s)
  Keiji Hirota
- Organizer
  第１０回　研究所ネットワーク国際シンポジウム
- Place of Presentation
  北海道
- Year and Date
  2015-07-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670477
[Presentation] Rheumatoid arthritis patients-derived gut microbiota induce Th17-mediated arthritis in SKG Mice2015
- Author(s)
  Maeda Yuichi, Umemoto Eiji, Matsushita Masato, Saeki Yukihiko, Ito Yoshinaga, Hirota Keiji, Sakaguchi Noriko, Kumanogo Atushi, Sakaguchi Shimon, Takeda Kiyoshi
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Th17 plasticity in homeostasis and inflammation2013
- Author(s)
  Keiji Hirota
- Organizer
  Joint Internatioal Symposium: JSICR-MMCB
- Place of Presentation
  Tokyo, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-25713019
[Presentation] Function and regulation of autoimmune T helper cells2013
- Author(s)
  Keiji Hirota
- Organizer
  The 3rd CSI/JSI/KAI Joint Symposium on Immunology
- Place of Presentation
  Pohang, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-25713019
[Presentation] 胸腺と末梢の制御性T細胞発生におけるSATB1の役割
- Author(s)
  北川瑤子、大倉永也、廣田圭司、安田佳子、谷内一郎、近藤元就、重松照美、坂口志文
- Organizer
  第24回Kyoto T Cell Conference
- Place of Presentation
  京都平安ホテル(京都）
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] T cell-dependent IgA responses by plastic Th17 cells
- Author(s)
  Keiji Hirota
- Organizer
  The American Association of Immunologists Annual Meeeting.
- Place of Presentation
  Pittsburgh, Pennsylvania, USA.
- Year and Date
  2014-05-02 – 2014-05-06
- Invited
- Data Source
  KAKENHI-PROJECT-26670477
[Presentation] T cell-dependent IgA responses by plastic Th17 cells
- Author(s)
  Keiji Hirota
- Organizer
  The American Association of Immunologists Annual Meeeting.
- Place of Presentation
  Pittsburgh, Pennsylvania, USA.
- Year and Date
  2014-05-02 – 2014-05-06
- Invited
- Data Source
  KAKENHI-PROJECT-25713019
[Presentation] The genome organizer Satb1 differentially controls thymic and peripheral development of regulatory T cells.
- Author(s)
  4.Kitagawa Yohko, Ohkura Naganari, Hirota Keiji, Adeegbe Olakunle, Yasada Keiko, Kondo Motonari, Taniuchi Ichiro, Kohwi-ShigematuTerumi, Sakaguchi Shimon
- Organizer
  第43回日本免疫学会総会・学術総会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26253030

1. Sakaguchi Shimon (30280770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. OHKURA Naganari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. NAKAMURA Shota

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 吉村昭彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 三上統久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 村田浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 鈴木穣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 竹田潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirota Keiji 廣田 圭司

HIROTA Keiji 廣田 圭司

Research Projects

Research Products

Co-Researchers

The molecular basis of tissue inflammation mediated by Th17 cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of immunological memory of inflammatory T helper cellsPrincipal Investigator

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A molecular basis of inflammatory Th17 cells in autoimmune diseasesPrincipal Investigator

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Molecular basis and therapeutic target for autoimmune arthritis

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Regulation of GM-CSF-producing Th cellsPrincipal Investigator

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Molecular basis of mucosal immunity maintained by Th17 cellsPrincipal Investigator

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[Journal Article] Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition2024

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[Journal Article] Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice2024

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[Journal Article] Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity2024

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[Journal Article] Identification of Surface Markers and Functional Characterization of Myeloid Derived Suppressor Cell‐Like Adherent Cells2023

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[Journal Article] Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease2022

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[Journal Article] Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model2022

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[Journal Article] Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity2022

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[Journal Article] 炎症性Th17細胞による組織炎症の形成2021

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Hirota Keiji 廣田圭司

HIROTA Keiji 廣田圭司