Hanada Kenji 花田賢二

Researcher Number	90632993
Other IDs
Affiliation (Current)	2025: 弘前大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 弘前大学, 医学部附属病院, 講師 2018 – 2021: 弘前大学, 医学部附属病院, 助教 2020: 弘前大学, 医学研究科, 客員研究員 2020: 弘前大学, 医学研究科, 講師
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator βアレスチン / 肺高血圧症 / 肺動脈性肺高血圧 / 冠攣縮性狭心症 Except Principal Investigator カルシウム / 冠攣縮 / 動物モデル / カルベジロール / 冠攣縮性狭心症 / カルモジュリンキナーゼ

肺高血圧症における新たな機序の解明：エンドセリン受容体におけるβアレスチンの役割Principal Investigator
- Principal Investigator
  
  花田賢二
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hirosaki University
カルシウム感受性亢進に着目した冠攣縮性狭心症の新規病態の解明と治療法の確立
- Principal Investigator
  
  富田泰史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hirosaki University
Role of calcium/calmodulin-dependent protein kinase II and development of new treatment strategy for coronary spastic angina
- Principal Investigator
  
  Tomita Hirofumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hirosaki University
A new mechanism of coronary spastic angina: Possible role of beta-arrestinPrincipal Investigator
- Principal Investigator
  
  Hanada Kenji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hirosaki University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Incidence, Predictors, and Outcome Associated With Ventricular Tachycardia or Fibrillation in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction2024
- Author(s)
  Hanada Kenji、Kinjo Takahiko、Yokoyama Hiroaki、Tsushima Michiko、Senoo Maiko、Ichikawa Hiroaki、Nishizaki Fumie、Shibutani Shuji、Yokota Takashi、Okumura Ken、Tomita Hirofumi
- Journal Title
  
  Circ J
  
  Volume: 88 Issue: 8 Pages: 1254-1264
- DOI
  10.1253/circj.CJ-23-0023
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2024-07-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08171
[Journal Article] Serial longitudinal changes of coronary calcified plaques with clear outer borders under intensive lipid management: insights from optical coherence tomography2023
- Author(s)
  Soma Takanobu、Yokoyama Hiroaki、Saito Kazumasa、Washima Shota、Tsushima Michiko、Senoo Maiko、Ichikawa Hiroaki、Nishizaki Fumie、Shibutani Shuji、Hanada Kenji、Tomita Hirofumi
- Journal Title
  
  Heart and Vessels
  
  Volume: 39 Issue: 5 Pages: 373-381
- DOI
  10.1007/s00380-023-02345-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08171
[Journal Article] Reduced Left Ventricular Ejection Fraction Is a Risk for Sudden Cardiac Death in the Early Period After Hospital Discharge in Patients With Acute Myocardial Infarction2022
- Author(s)
  Hanada K, Sasaki S, Seno M, Kimura Y, Ichikawa H, Nishizaki F, Yokoyama H, Yokota T, Okumura K, Tomita H.
- Journal Title
  
  Circ J
  
  Volume: 86 Issue: 10 Pages: 1490-1498
- DOI
  10.1253/circj.CJ-21-0999
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2022-09-22
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08530, KAKENHI-PROJECT-22K08171
[Journal Article] Rivaroxaban attenuates cardiac hypertrophy via inhibition of protease-activated receptor-2 signaling in renin-overexpressing hypertensive mice2021
- Author(s)
  Narita M, Hanada K, Kawamura Y, Ichikawa H, Sakai S, Yokono Y, Senoo M, Narita N, Shimada M, Osanai T, Okumura K, Tomita H.
- Journal Title
  
  Hypertension Research
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08530
[Journal Article] Rivaroxaban attenuates cardiac hypertrophy by inhibiting protease-activated receptor-2 signaling in renin-overexpressing hypertensive mice.2021
- Author(s)
  Narita M, Hanada K, Kawamura Y, Ichikawa H, Sakai S, Yokono Y, Senoo M, Narita N, Shimada M, Osanai T, Okumura K, Tomita H.
- Journal Title
  
  Hypertens Res
  
  Volume: 44 Issue: 10 Pages: 1261-1273
- DOI
  10.1038/s41440-021-00700-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08530
[Journal Article] Diltiazem inhibits coronary spasm via inhibition of Cav1.2 phosphorylation and protein kinase C activation in a mouse model of coronary spastic angina2021
- Author(s)
  Ishida Y, Kitayama K, Hanada K, Shibutani S, Nishizaki K, Kinjo T, Endo T, Suzuki A, Tateyama S, Nishizaki F, Sukekawa T, Tanaka M, Osanai T, Okumura K, Tomita H.
- Journal Title
  
  International Heart Journal
  
  Volume: -
- NAID
  130008069198
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08530
[Journal Article] Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice2020
- Author(s)
  Yokono Y, Hanada K, Narita M, Tatara Y, Kawamura Y, Miura N, Kitayama K, Nakata M, Nozaka M, Kato T, Kudo N, Tsushima M, Toyama Y, Itoh K, Tomita H.
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 9 Issue: 12
- DOI
  10.1161/jaha.119.015616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08530, KAKENHI-PROJECT-18K06106
[Journal Article] Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina2020
- Author(s)
  Kudo N, Hanada K, Kawamura Y, Nakata M, Nozaka M, Kitayama K, Miura N, Tanaka M, Osanai T, Tomita H.
- Journal Title
  
  Hirosaki Medical Journal
  
  Volume: 70 Pages: 139-147
- NAID
  130007818299
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08530
[Journal Article] IQGAP1 activates PLC‐δ1 by direct binding and moving along microtubule with DLC‐1 to cell surface2019
- Author(s)
  Tanaka Makoto、Osanai Tomohiro、Homma Yoshimi、Hanada Kenji、Okumura Ken、Tomita Hirofumi
- Journal Title
  
  FASEB BioAdvances
  
  Volume: 1 Issue: 8 Pages: 465-480
- DOI
  10.1096/fba.2019-00020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08530
[Presentation] Carvedilol suppresses coronary artery spasm in A-kinase anchoring protein 150 knockout mouse2024
- Author(s)
  金野佑基、花田賢二、岩崎俊浩、加藤和史、齋藤数正、相馬宇伸、和島将太、廣澤瞬、梅﨑仁志、澁谷修司、富田泰史
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08171
[Presentation] The beta-arrestin-biased agonist TRV023 ameliorates cardiac hypertrophy and fibrosis in hypertensive mouse model2024
- Author(s)
  和島将太、花田賢二、富田泰史
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08171
[Presentation] Differential roles of beta-arrestins in the endothelin receptor signaling: possible role in the pathogenesis of pulmonary arterial hypertension2024
- Author(s)
  加藤和史、三浦尚武、花田賢二、富田泰史
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08171
[Presentation] Possible association between lipoprotein-associated phospholipase A2 gene Val279Phe polymorphism and variant angina2024
- Author(s)
  岩崎俊浩、澁谷修司、相馬宇伸、齋藤数正、和島将太、加藤和史、金野佑基、花田賢二、横山公章、富田泰史
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08171
[Presentation] Induced pluripotent stem cell-derived vascular smooth muscle cells as an in vitro model of coronary spastic angina2024
- Author(s)
  Soma T, Shibutani S, Iwasaki T, Saito K, Washima S, Kato K, Konno Y, Umezaki H, Hirosawa S, Hanada K, Yokoyama H, Tomita H.
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08171
[Presentation] The Mutation in SUR2B Gene is not Involved in the Genetic Pathogenesis of Coronary Spastic Angina in Humans2023
- Author(s)
  澁谷修司、對馬迪子、妹尾麻衣子、市川博章、西崎史恵、花田賢二、横山公章、富田泰史
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08171
[Presentation] Possible Protective Effects of SCH79797, A Protease-Activated Receptor-1 Antagonist, on Renal Impairment in Renin-Overexpressing Hypertensive Mice2023
- Author(s)
  反町悠也、花田賢二、澁谷修司、齋藤数正、相馬宇伸、和島将太、岩崎俊浩、加藤和史、金野佑基、鹿内駿、酒井峻太郎、濱浦奨悟、山﨑堅、富田泰史
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08171
[Presentation] Renal Dysfunction is Associated with Coronary Calcification and Worse Clinical Outcomes in Patients with Acute Myocardial Infarction2023
- Author(s)
  横山公章、對馬迪子、妹尾麻衣子、市川博章、西崎史恵、澁谷修司、花田賢二、富田泰史
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08171
[Presentation] The effects of beta-arrestins on the endothelin receptor signaling: possible role in the pathogenesis of pulmonary arterial hypertension2023
- Author(s)
  加藤和史、花田賢二
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08119
[Presentation] Esaxerenone, a Novel Mineralocorticoid Receptor Blocker, Reduces Albuminuria and Urinary MCP-1 in Renin-overexpressing Hypertensive Mice with High Salt Intake2023
- Author(s)
  酒井峻太郎、澁谷修司、花田賢二、島田美智子、齋藤数正、相馬宇伸、和島将太、鹿内駿、反町悠也、濱浦奨悟、山﨑堅、富田泰史
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08171
[Presentation] Differential roles of beta-arrestins in the endothelin receptor signaling: possible role in the pathogenesis of pulmonary arterial hypertension2023
- Author(s)
  Kazufumi Kato, Naotake Miura, Kenji Hanada, Hirofumi Tomita
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08119
[Presentation] The β-arrestin Biased Agonist TRV120023 Ameliorates Cardiac Fibrosis to the Same Extent as Angiotensin Receptor Blocker in Hypertensive Mouse Model2023
- Author(s)
  和島将太、濱舘美里、花田賢二、齋藤数正、相馬宇伸、富田泰史
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08171
[Presentation] Possible protective effects of SCH79797, a protease-activated receptor-1 antagonist, on renal impairment in renin-overexpressing hypertensive mice2022
- Author(s)
  Sorimachi Y, Hanada K, Shimada M, Shikanai S, Sakai S, Hamaura S, Yamazaki K, Kitayama K, Nagawa D, Hamadate M, Miura N, Tomita H.
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08530
[Presentation] Genetic variants of DAG and IP3 signaling pathways involved in predisposition to severe cases of coronary spastic angina2022
- Author(s)
  Shibutani S, Yonekura M, Shikanai S, Nozaka M, Kawamura Y, Ichikawa H, Kasai S, Shimizu E, Hanada K, Yokoyama H, Yokota T, Higuma T, Yoshida Y, Imoto S, Okumura K, Itoh K, Tomita H.
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08530
[Presentation] Esaxerenone, a novel mineralocorticoid receptor blocker, reduces albuminuria in renin-overexpressing hypertensive mice with high salt intake2022
- Author(s)
  Sakai S, Hanada K, Shimada M, Shikanai S, Sorimachi Y, Hamaura S, Yamazaki K, Kitayama K, Nagawa D, Hamadate M, Miura N, Tomita H.
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08530
[Presentation] Possible protective effects of SGLT2 inhibitor empagliflozin on renal impairment in renin-overexpressing hypertensive transgenic mice2020
- Author(s)
  Kawamura Y, Hanada K, Shimada M, Sakai S, Sorimachi Y, Shikanai S, Hamaura S, Yamazaki K, Kitayama K, Nagawa D, Hamadate M, Miura N, Nozaka M, Nakata M, Osanai T, Tomita H.
- Organizer
  第85回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08530
[Presentation] p122RhoGAP/DLC-1 overexpression enhances intracellular calcium concentration via increase in calcium release from endoplasmic reticulum: a potential role for coronary spastic angina2020
- Author(s)
  Kimura Y, Yamada N , Hanada K, Ichikawa H, Tanaka M, Osanai T, Okumura K, Tomita H.
- Organizer
  第85回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08530
[Presentation] Effect of Non-selective β-adrenergic receptor blocker Carvedilol for Coronary Spasm2020
- Author(s)
  Nozaka M, Hanada K, Kawamura Y, Nakata M, Kitayama K, Nagawa D, Miura N, Hamadate M, Osanai T, Tomita H.
- Organizer
  第85回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08530
[Presentation] Carvedilol suppresses coronary spasm in A-kinase anchoring protein 150 knockout mice : a possible role of CaMKII in coronary spastic angina2020
- Author(s)
  Kitayama K, Nagawa D, Miura N, Hamadate M, Kawamura Y, Nakata M, Nozaka M, Hanada K, Tomita H.
- Organizer
  第85回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08530
[Presentation] Ca 拮抗薬の中断によって引き起こされた急性心筋梗塞、難治性の異型狭心症の一例2019
- Author(s)
  川村陽介、相馬宇伸、遠藤知秀、西崎史恵、花田賢二、横山公章、横田貴志、山田雅大、富田泰史
- Organizer
  第169回日本循環器学会東北地方会
- Data Source
  KAKENHI-PROJECT-19K08530
[Presentation] プロテアーゼ活性化受容体シグナル抑制による心保護作用の検討2019
- Author(s)
  横野良和、成田真人、花田賢二、島田美智子、田中真実、長内智宏、富田泰史
- Organizer
  第40回日本循環制御医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08530
[Presentation] β-Arrestin 1 Negatively Regulates Intracellular Calcium Concentration in Acetylcholine M3 Receptor: Its Possible Role in Coronary Spastic Angina2019
- Author(s)
  妹尾麻衣子、花田賢二、他
- Organizer
  第８３回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15875
[Presentation] Blockade of protease activated receptor-1 signaling attenuates cardiac hypertrophy and fibrosis in renin-overexpressing hypertensive mice2019
- Author(s)
  Yokono Y, Narita M, Kawamura Y, Kato T, Kudo N, Tsushima M, Toyama Y, Hanada K, Shimada M, Makoto T, Osanai T, Tomita H
- Organizer
  European Society of Cardiology (ESC) Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08530

1. Tomita Hirofumi (00431437)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results

Hanada Kenji 花田 賢二

Research Projects

Research Products

Co-Researchers

肺高血圧症における新たな機序の解明：エンドセリン受容体におけるβアレスチンの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

カルシウム感受性亢進に着目した冠攣縮性狭心症の新規病態の解明と治療法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of calcium/calmodulin-dependent protein kinase II and development of new treatment strategy for coronary spastic angina

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A new mechanism of coronary spastic angina: Possible role of beta-arrestinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Incidence, Predictors, and Outcome Associated With Ventricular Tachycardia or Fibrillation in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Serial longitudinal changes of coronary calcified plaques with clear outer borders under intensive lipid management: insights from optical coherence tomography2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduced Left Ventricular Ejection Fraction Is a Risk for Sudden Cardiac Death in the Early Period After Hospital Discharge in Patients With Acute Myocardial Infarction2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Rivaroxaban attenuates cardiac hypertrophy via inhibition of protease-activated receptor-2 signaling in renin-overexpressing hypertensive mice2021

Author(s)

Journal Title

Data Source

[Journal Article] Rivaroxaban attenuates cardiac hypertrophy by inhibiting protease-activated receptor-2 signaling in renin-overexpressing hypertensive mice.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diltiazem inhibits coronary spasm via inhibition of Cav1.2 phosphorylation and protein kinase C activation in a mouse model of coronary spastic angina2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] IQGAP1 activates PLC‐δ1 by direct binding and moving along microtubule with DLC‐1 to cell surface2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Carvedilol suppresses coronary artery spasm in A-kinase anchoring protein 150 knockout mouse2024

Author(s)

Hanada Kenji 花田賢二