Furuie Hiroki 古家宏樹

Researcher Number	90639105
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, 主席研究員
Affiliation (based on the past Project Information) *help	2024: 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 2018 – 2023: 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, 室長 2017: 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 10040:Experimental psychology-related / Experimental psychology Except Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 統合失調症 / ラット / NMDA受容体 / グルタミン酸 / MRI / 神経発達 / 動物モデル / ヒストンアセチル化 / GABA / ヒストン修飾 … More / グルタミン酸脱炭酸酵素 / ヒストン脱アセチル化酵素 / エピジェネティクス / 現実認識能力 / 表象媒介性味覚嫌悪条件づけ / 新生仔期NMDA受容体遮断 / 幻覚 / 精神疾患 / 発達障害 / 空間参照記憶 / 空間作業記憶 / プレパルス抑制 / 認知機能障害 / グルタミン酸NMDA受容体 / 神経発達障害 … More Except Principal Investigator リゾホスファチジン酸 / グルタミン酸 / PTSD / リルゾール / 恐怖記憶 / WDR3 / 統合失調症 / アストロサイト / 社会的敗北ストレス / ストレス / うつ病 / 行動学 / 薬理学 / 情動行動 / 不安 / うつ / りゾホスファチジン酸 / 創薬 / 抗うつ薬 / 不安性障害 / 曝露療法 / 心的外傷後ストレス障害 Less

新生仔期グルタミン酸NMDA受容体遮断が脳内ネットワーク形成に及ぼす影響の解明Principal Investigator
- Principal Investigator
  
  古家宏樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 10040:Experimental psychology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
恐怖記憶の処理過程に対するリルゾールの作用メカニズムの検討
- Principal Investigator
  
  山田美佐
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Center of Neurology and Psychiatry
The involvement of abnormal histone modification in schizophrenia-related behaviors in rodent modelsPrincipal Investigator
- Principal Investigator
  
  Furuie Hiroki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 10040:Experimental psychology-related
- Research Institution
  National Center of Neurology and Psychiatry
Role of the lysophosphatidic acid in the glutamatergic neurotransmission abnormality of schizophrenia
- Principal Investigator
  
  Yamada Mitsuhiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Center of Neurology and Psychiatry
Validation of representation-mediated taste aversion as an index of reality testing ability of an animal model of schizophrenia.Principal Investigator
- Principal Investigator
  
  Furuie Hiroki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 10040:Experimental psychology-related
- Research Institution
  National Center of Neurology and Psychiatry
The effects of fasudil on social defeat stress in mouse.
- Principal Investigator
  
  Yamada Misa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Center of Neurology and Psychiatry
Time-specific involvement of N-methyl-D-aspartate receptor in the development of schizophrenia-like behavior in ratsPrincipal Investigator
- Principal Investigator
  
  Furuie Hiroki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental psychology
- Research Institution
  National Center of Neurology and Psychiatry
Post-reexposure administration of riluzole attenuates the reconsolidation of conditioned fear memory in rats
- Principal Investigator
  
  Yamada Mitsuhiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Center of Neurology and Psychiatry
Development of novel antidepressants targetting lysophosphatidic-acid-signaling
- Principal Investigator
  
  Yamada Misa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  National Center of Neurology and Psychiatry

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] An emotional stress model using witnessing social defeat scenes in mice2023
- Author(s)
  中武優子、古家宏樹、山田光彦.
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 158 Issue: 1 Pages: 39-42
- DOI
  10.1254/fpj.22104
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K03136, KAKENHI-PROJECT-22K20328
[Journal Article] Characterization of a WD-repeat family protein WDR3 in the brain of WDR3 hetero knockout mice.2023
- Author(s)
  Tanabe-Kobayashi, Furuie, Misa Yamada, Mitsuhiko Yamada.
- Journal Title
  
  Brain Research
  
  Volume: 1800 Pages: 148188-148188
- DOI
  10.1016/j.brainres.2022.148188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K03136, KAKENHI-PROJECT-21K15756, KAKENHI-PROJECT-20K07936
[Journal Article] Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity2023
- Author(s)
  Hiroki Furuie#、Yuka Kimura#、Tatsuhiro Akaishi#、Misa Yamada、Yoshiki Miyasaka、Akiyoshi Saitoh、Norihiro Shibuya、Akiko Watanabe、Naoki Kusunose、Tomoji Mashimo、Takeo Yoshikawa、Mitsuhiko Yamada、Kazuho Abe、Hideo Kimura
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 1-19
- DOI
  10.1038/s41598-023-44877-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K11814, KAKENHI-PROJECT-23K06016, KAKENHI-PROJECT-19K06554, KAKENHI-PROJECT-21K03136, KAKENHI-PROJECT-23H00367
[Journal Article] Effects of riluzole on psychiatric disorders with anxiety or fear as primary symptoms: A systematic review.2023
- Author(s)
  Yoshitaka Kawashima, Misa Yamada, Hiroki Furuie, Hiroshi Kuniishi, Kie Akagi, Tomoko Kawashima, Takamasa Noda, Mitsuhiko Yamada
- Journal Title
  
  Neuropsychopharmacology reports
  
  Volume: 43 Issue: 3 Pages: 320-327
- DOI
  10.1002/npr2.12364
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07630, KAKENHI-PROJECT-21K03136, KAKENHI-PROJECT-23K27527
[Journal Article] Neonatal blockade of NR2A-containing but not NR2B-containing NMDA receptor induces spatial working memory deficits in adult rats2022
- Author(s)
  Furuie Hiroki、Yamada Mitsuhiko
- Journal Title
  
  Neuroscience Research
  
  Volume: 176 Pages: 57-65
- DOI
  10.1016/j.neures.2021.10.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K03136
[Journal Article] Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice.2020
- Author(s)
  Nakatake, Y., Furuie, H., Ukezono, M., Yamada, M., Yoshizawa, K., Yamada, M.
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 16881-16881
- DOI
  10.1038/s41598-020-73988-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08085
[Journal Article] The effects of emotional stress are not identical to those of physical stress in mice model of social defeat stress.2020
- Author(s)
  Nakatake, Y., Furuie, H., Yamada, M., Kuniishi, H., Ukezono, M., Yoshizawa, K., Yamada, M
- Journal Title
  
  Neurosci. Res.
  
  Volume: 158 Pages: 56-63
- DOI
  10.1016/j.neures.2019.10.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08085
[Presentation] 新生仔期MK-801投与ラットの社会的相互作用を障害する.2023
- Author(s)
  古家宏樹，中武優子
- Organizer
  第53回日本神経精神薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] Social facilitation of feeding behavior in a schizophrenia rat model.2023
- Author(s)
  Furuie H, Ukezono M, Okada T, Yamada M
- Organizer
  The 11th Congress pf the Asian Society for Child and Adolescent Psychiatry and Allid Professions (ASCAPAP) 2023,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] The effect of lesion in the anterior cungulate cortex on social facilitation in rat.2023
- Author(s)
  Ukezono M, Takano Y, Furuie H, Nakatake Y, Shirakawa Y, Sayuri H Egashira Y, Uono S, Takada M Okada T
- Organizer
  The 11th Congress pf the Asian Society for Child and Adolescent Psychiatry and Allid Professions (ASCAPAP) 2023,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] The involvement of the oxytocin signaling in the transmission of social stress in mice.2023
- Author(s)
  Nakatake Y, Furuie H, Inoue YU, Inoue T, Yoshizawa K, Yamada M
- Organizer
  Society for Neuroscience Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] Subchoronic treatment with MK-801 during neonatal period decreased social interaction in adult rats.2023
- Author(s)
  Furuie H, Nakatake Y
- Organizer
  Society for Neuroscience Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] Developmental stage-specific involvement of NMDA receptor hypofunction in risk formation for psychiatric disorders.2022
- Author(s)
  Furuie H, Yamada M.
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] NMDA型グルタミン酸受容体遮断はラットのSense of Agencyを減衰させる.2022
- Author(s)
  寺尾真実、古家宏樹、山田光彦、澤幸祐.
- Organizer
  日本心理学会第86回大会
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] A psychosocial stress model using withnessing social defeat scenes.2022
- Author(s)
  Nakatake Y, Furuie H, Inoue-Ueno Y, Inoue T, Yosizawa K, Hosino M, Yamada M
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] NMDA受容体NR2Aサブユニットのラット新生仔期における機能阻害は空間作業記憶の発達を障害する.2022
- Author(s)
  山田光彦、古家宏樹.
- Organizer
  第118回日本精神神経学会学術総会、第118回日本精神神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] 視覚情報を利用したマウスの新規ストレスモデル.2022
- Author(s)
  中武優子、古家宏樹、請園正敏、山田美佐、吉澤一巳、山田光彦.
- Organizer
  BPCNPNPPP
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] 新生仔期NMDA 受容体慢性遮断はラットの食餌行動の社会的促進を障害する.2022
- Author(s)
  古家宏樹、請園正敏、岡田俊、山田光彦.
- Organizer
  第40回日本生理心理学会大会
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] Neonatal blockade of NR2A-containing NMDA receptor induces schizophrenia-related behaviors in adult rats.2022
- Author(s)
  Furuie H, Yamada M
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] Reduced expression of NMDA receptors (NR2A and NR2B) in the hippocampus of WD repeat domain 3 gene hetero knockout mice2021
- Author(s)
  小林桃子、古家宏樹、三輪秀樹、山田美佐、山田光彦
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07936
[Presentation] 社会的敗北場面の動画を用いた新規ストレスモデルマウスの開発2021
- Author(s)
  中武優子、古家宏樹、請園正敏、山田美佐、吉澤一巳、山田光彦
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08085
[Presentation] The oxytocin signaling in the anterior insular cortex mediates the emotional contagion in mice.2021
- Author(s)
  中武優子, 古家宏樹, 吉澤一巳, 山田光彦
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] 不安を主症状とする精神疾患に対するRiluzoleの効果：システマティックレビューによる検討.2021
- Author(s)
  山田光彦, 川島義高, 山田美佐, 古家宏樹, 國石洋, 立花良之, 野田隆政
- Organizer
  第42回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K03136
[Presentation] ROCK阻害剤であるファスジルは社会的敗北ストレスによるマウスの行動変化を予防する2020
- Author(s)
  中武優子、山田美佐、古家宏樹、吉澤一巳、山田光彦
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08085
[Presentation] A ROCK inhibitor, fasudil, suppressed behavioral changes induced by physical stress, but not by emotional stress in mice social defeat stress model.2019
- Author(s)
  Nakatake, Y., Yamada, M., Furuie, H., Yoshizawa, K., Yamada. M.
- Organizer
  6th Asian College of Neuropsychopharmacology (AsCNP) Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08085
[Presentation] ROCK阻害剤であるファスジルは社会的敗北ストレスによるマウスの行動変化を予防する2019
- Author(s)
  中武優子、山田美佐、古家宏樹、吉澤一巳、山田光彦
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K10201
[Presentation] Chronic social defeat stress induces social avoidance and changes the plasma cytokines levels in mice.2018
- Author(s)
  Nakatake, Y., Ukezono, M., Furuie, H., Kuniishi, H., Yamada, M., Yoshizawa, K., Yamada. M.
- Organizer
  Neuroscience Meeting
- Data Source
  KAKENHI-PROJECT-16K10201
[Presentation] 新生仔期ラットへのNR2A選択的拮抗薬慢性投与は成体期に統合失調症様行動異常を引き起こす2018
- Author(s)
  古家宏樹, 國石洋, 山田光彦
- Organizer
  第28回日本臨床精神神経薬理学会第48回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-17K13965
[Presentation] Emotional and physical stress exerts different effects on behavior and immune system in mice2018
- Author(s)
  中武優子、古家宏樹、國石洋、山田美佐、吉澤一巳、山田光彦
- Organizer
  第28回日本臨床精神神経薬理学会、第48回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-16K10201
[Presentation] Witnessing the defeat of a conspecific induces social avoidance in mice2018
- Author(s)
  Nakatake, Y., Ukezono, M., Furuie, H., Kuniishi, H., Yamada, M., Yoshizawa, K., Yamada. M.
- Organizer
  Asia Pacific Regional Congress of Biological Psychiatry
- Data Source
  KAKENHI-PROJECT-16K10201
[Presentation] リルゾールは恐怖条件づけ文脈学習課題において遠隔恐怖記憶を減弱する2018
- Author(s)
  古家宏樹、赤木希衣、山田美佐、岡淳一郎、山田光彦
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K07125
[Presentation] Neonatal blockade of NR2A-containing NMDA receptors induces schizophrenia-like behavior in adult rats.2018
- Author(s)
  Hiroki Furuie, Hiroshi Kuniishi, Mitsuhiko Yamada
- Organizer
  Society for Neuroscience 48th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13965
[Presentation] 不安を主症状とする精神疾患に対するRiluzoleの効果についての検討：システマティックレビュー2018
- Author(s)
  川島義高、山田美佐、古家宏樹、國石洋、野田隆政、山田光彦
- Organizer
  第28回日本臨床精神神経薬理学会、第48回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-17K07125
[Presentation] Chronic MK-801 treatment during the second, but not the third, postnatal week causes severe deficits in spatial working memory in adult rats.2017
- Author(s)
  Furuie H, Yamada K, Ichitani, Y
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K13965
[Presentation] 心理的ストレスに焦点を当てた社会的敗北ストレス負荷マウスモデルの確立：構成概念妥当性の高い新規の慢性ストレスモデルの提案2017
- Author(s)
  中武優子、請園正敏、古家宏樹、國石洋、山田美佐、吉澤一巳、山田光彦
- Organizer
  第36 回躁うつ病の薬理・生化学的研究懇話会
- Data Source
  KAKENHI-PROJECT-16K10201
[Presentation] 心理的ストレスに特化した慢性ストレスモデルの確立2017
- Author(s)
  中武優子、　請園正敏、　古家宏樹、　國石洋、　山田美佐、　吉澤一巳、　山田光彦
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-16K10201
[Presentation] 新生仔期MK-801の投与時期の違いが空間参照記憶および作業記憶に及ぼす影響2017
- Author(s)
  古家宏樹・山田一夫・一谷幸男
- Organizer
  日本動物行動関連学会2017
- Data Source
  KAKENHI-PROJECT-17K13965

1. Yamada Mitsuhiko (60240040)

# of Collaborated Projects: 6 results

# of Collaborated Products: 28 results
2. Yamada Misa (10384182)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
3. 三輪秀樹 (80468488)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
4. 斎藤顕宜 (00366832)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 國石洋 (60805034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 領家梨恵 (10737464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 釣木澤朋和 (10716210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 赤石樹泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Furuie Hiroki 古家 宏樹

Research Projects

Research Products

Co-Researchers

新生仔期グルタミン酸NMDA受容体遮断が脳内ネットワーク形成に及ぼす影響の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

恐怖記憶の処理過程に対するリルゾールの作用メカニズムの検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The involvement of abnormal histone modification in schizophrenia-related behaviors in rodent modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of the lysophosphatidic acid in the glutamatergic neurotransmission abnormality of schizophrenia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Validation of representation-mediated taste aversion as an index of reality testing ability of an animal model of schizophrenia.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effects of fasudil on social defeat stress in mouse.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Time-specific involvement of N-methyl-D-aspartate receptor in the development of schizophrenia-like behavior in ratsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Post-reexposure administration of riluzole attenuates the reconsolidation of conditioned fear memory in rats

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel antidepressants targetting lysophosphatidic-acid-signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An emotional stress model using witnessing social defeat scenes in mice2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Characterization of a WD-repeat family protein WDR3 in the brain of WDR3 hetero knockout mice.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of riluzole on psychiatric disorders with anxiety or fear as primary symptoms: A systematic review.2023

Author(s)

Journal Title

DOI

Data Source

Furuie Hiroki 古家宏樹