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yasukawa takehiro  安川 武宏

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YASUKAWA TAKEHIRO  安川 武宏

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Researcher Number 90646720
Other IDs
Affiliation (Current) 2025: 順天堂大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 順天堂大学, 医学部, 准教授
2016 – 2019: 九州大学, 医学研究院, 助教
2015: 九州大学, 大学院医学研究院, 助教
2014 – 2015: 九州大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Genetics/Chromosome dynamics / Molecular biology
Except Principal Investigator
Basic Section 49020:Human pathology-related / Basic Section 55020:Digestive surgery-related / Laboratory medicine
Keywords
Principal Investigator
がん / がん微小環境 / ミトコンドリアDNA / ミトコンドリアDNA / がん抑制 / 線維芽細胞 / ミトコンドリア / CAFs / がん関連線維芽細胞 / 間質 … More / ミトコンドリアトランスファー / 癌微小環境 / 核酸 / DNAメチル化修飾 / DNA複製因子 … More
Except Principal Investigator
αシニクレイン / 虫垂 / パーキンソン病 / 癌微小環境 / エストロゲン / 卵巣癌 / Maspin / 膵癌モデルマウス / 微小環境 / 前がん病変 / 浸潤性膵管癌 / p32ノックアウトマウス / TFAM発現マウス / ミトコンドリアゲノム / ミトコンドリア / ミトコンドリアプロテアーゼ / マイトファジー / 臨床検査 / ミトコンドリアDNA / プロテオーム / メタボローム / ミトコンドリア病 Less
  • Research Projects

    (8 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (16 People)
  •  膵前癌病変の微小環境形成機転の解明とマウスモデルへの展開

    • Principal Investigator
      福村 由紀
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Juntendo University
  •  エストロゲンシグナルを介した癌微小環境制御による卵巣癌治療戦略

    • Principal Investigator
      佐伯 春美
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Juntendo University
  •  癌抑制能をもつ線維芽細胞の同定と、癌抑制能力の分子機序の探索・治療応用への展開Principal Investigator

    • Principal Investigator
      安川 武宏
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Juntendo University
  •  虫垂切除がパーキンソン病に与える影響に関する機構解明

    • Principal Investigator
      福永 哲
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Juntendo University
  •  癌関連線維芽細胞CAFsによるミトコンドリアを介した多面的な癌悪性化機構の解明Principal Investigator

    • Principal Investigator
      安川 武宏
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Juntendo University
  •  Epigenetic features of mammalian mitochondrial DNAPrincipal Investigator

    • Principal Investigator
      Yasukawa Takehiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Genetics/Chromosome dynamics
    • Research Institution
      Kyushu University
  •  Search for protein factors involved in mammalian mtDNA replicationPrincipal Investigator

    • Principal Investigator
      Yasukawa Takehiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Molecular biology
    • Research Institution
      Kyushu University
  •  Biomarkers in blood for mitochondrial abnormality

    • Principal Investigator
      Kang Dongchon
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] Methods in Molecular Biology "Assessing TFAM binding to human mitochondrial DNA" 分担執筆2022

    • Author(s)
      Yasukawa Takehiro、Kang Dongchon
    • Publisher
      Humana Press
    • Data Source
      KAKENHI-PROJECT-21K07127
  • [Book] 医学のあゆみ 「ミトコンドリアゲノムの複製と維持機構」分担執筆2022

    • Author(s)
      安川 武宏、康 東天
    • Publisher
      医歯薬出版株式会社
    • Data Source
      KAKENHI-PROJECT-21K07127
  • [Book] ミトコンドリアダイナミクス 第4章第3節 「ミトコンドリアゲノムの複製・維持」 分担執筆2021

    • Author(s)
      安川 武宏
    • Total Pages
      458
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860437466
    • Data Source
      KAKENHI-PROJECT-21K07127
  • [Book] Epigenetic features of mitochondrial DNA (a chapter in The Human Mitochondrial Genome), in press2020

    • Author(s)
      Yasukawa, T., Matsuda, S., Kang D.
    • Total Pages
      15
    • Publisher
      Academic Press
    • ISBN
      9780128196564
    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Journal Article] Increased <scp>RUNX3</scp> expression mediates tumor‐promoting ability of human breast cancer‐associated fibroblasts2023

    • Author(s)
      Koyama Yu、Okazaki Hiroya、Shi Yang、Mezawa Yoshihiro、Wang Zixu、Sakimoto Mizuki、Ishizuka Akane、Ito Yasuhiko、Koyama Takumi、Daigo Yataro、Takano Atsushi、Miyagi Yohei、Yokose Tomoyuki、Yamashita Toshinari、Sugahara Keisuke、Hino Okio、Yang Liying、Maruyama Reo、Katakura Akira、Yasukawa Takehiro、Orimo Akira
    • Journal Title

      Cancer Medicine

      Volume: 12 Issue: 17 Pages: 18062-18077

    • DOI

      10.1002/cam4.6421

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K17217, KAKENHI-PROJECT-23K14603, KAKENHI-PROJECT-21K07127, KAKENHI-PROJECT-22K20837, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K27506
  • [Journal Article] Assessing TFAM Binding to Human Mitochondrial DNA2023

    • Author(s)
      Yasukawa Takehiro、Kang Dongchon
    • Journal Title

      Methods in Molecular Biology

      Volume: 2615 Pages: 139-151

    • DOI

      10.1007/978-1-0716-2922-2_11

    • ISBN
      9781071629215, 9781071629222
    • Data Source
      KAKENHI-PROJECT-21K07127
  • [Journal Article] ミトコンドリアDNAの複製・維持機構と関連疾患2022

    • Author(s)
      安川 武宏、康 東天
    • Journal Title

      医学のあゆみ

      Volume: 281 Pages: 1121-1127

    • Data Source
      KAKENHI-PROJECT-21K07127
  • [Journal Article] TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication2022

    • Author(s)
      Inatomi Teppei、Matsuda Shigeru、Ishiuchi Takashi、Do Yura、Nakayama Masunari、Abe Shusaku、Kasho Kazutoshi、Wanrooij Sjoerd、Nakada Kazuto、Ichiyanagi Kenji、Sasaki Hiroyuki、Yasukawa Takehiro、Kang Dongchon
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 1869 Issue: 1 Pages: 119167-119167

    • DOI

      10.1016/j.bbamcr.2021.119167

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05756, KAKENHI-PROJECT-21K07127, KAKENHI-PROJECT-21K20640, KAKENHI-PROJECT-20H00530
  • [Journal Article] Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation2022

    • Author(s)
      Tani Haruna、Ishikawa Kaori、Tamashiro Hiroaki、Ogasawara Emi、Yasukawa Takehiro、Matsuda Shigeru、Shimizu Akinori、Kang Dongchon、Hayashi Jun-Ichi、Wei Fan-Yan、Nakada Kazuto
    • Journal Title

      Nucleic Acids Research

      Volume: 50 Issue: 16 Pages: 9382-9396

    • DOI

      10.1093/nar/gkac699

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07127, KAKENHI-PLANNED-21H05265, KAKENHI-PROJECT-22KJ0156, KAKENHI-PUBLICLY-21H00225, KAKENHI-PROJECT-23K21370, KAKENHI-PROJECT-23K23801
  • [Journal Article] Mitochondria metabolomics reveals a role of β-nicotinamide mononucleotide metabolism in mitochondrial DNA replication2021

    • Author(s)
      Nomiyama Tomoko、Setoyama Daiki、Yasukawa Takehiro、Kang Dongchon
    • Journal Title

      The Journal of Biochemistry

      Volume: 171 Issue: 3 Pages: 325-338

    • DOI

      10.1093/jb/mvab136

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-21K07127
  • [Journal Article] ミトコンドリアゲノムの複製・維持機構2019

    • Author(s)
      安川 武宏、康 東天
    • Journal Title

      実験医学

      Volume: 37 Pages: 24-30

    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Journal Article] An overview of mammalian mitochondrial DNA replication mechanisms2018

    • Author(s)
      Yasukawa Takehiro、Kang Dongchon
    • Journal Title

      The Journal of Biochemistry

      Volume: 164 Issue: 3 Pages: 183-193

    • DOI

      10.1093/jb/mvy058

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Journal Article] Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA2018

    • Author(s)
      Matsuda, S., *Yasukawa, T., Sakaguchi, Y., Ichiyanagi, K., Unoki, M., Gotoh, K., Fukuda, K., Sasaki, H., Suzuki, T. and Kang, D.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 5801-5801

    • DOI

      10.1038/s41598-018-24251-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26220205, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-17K07504, KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-18H05272
  • [Journal Article] ミトコンドリアDNAのユニークな複製メカニズム2017

    • Author(s)
      安川 武宏
    • Journal Title

      医学のあゆみ

      Volume: 260 Pages: 5-10

    • Data Source
      KAKENHI-PROJECT-26840011
  • [Journal Article] Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria2016

    • Author(s)
      Akman, G., Desai, R., Bailey, L.J., Yasukawa, T., Dalla Rosa, I., Durigon, R., Holmes, J.B., Moss, C.F., Mennuni, M., Houlden, H., Crouch, R.J., Hanna, M.G., Pitceathly, R.D., Spinazzola, A., Holt, I.J.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 113 Issue: 30

    • DOI

      10.1073/pnas.1600537113

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26840011
  • [Journal Article] Suppression of mitochondrial transcription initiation complexes changes the balance of replication intermediates of mitochondrial DNA and reduces 7S DNA in cultured human cells2016

    • Author(s)
      Jianhua Qu, Takehiro Yasukawa, Dongchon Kang
    • Journal Title

      The Journal of Biochemistry

      Volume: N/A Issue: 1 Pages: 49-57

    • DOI

      10.1093/jb/mvw010

    • NAID

      40020880721

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26840011, KAKENHI-PROJECT-25253041
  • [Presentation] Investigation of aberrant LEF1 expression in tumor-promoting cancer-associated fibroblasts2023

    • Author(s)
      H Okazazki, Y Shi, M Sakimoto, Y Koyama, Z Wang, A Isizuka, Y Mezawa, K Kajino, A Katakura, T Yasukawa, A Orimo
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K07127
  • [Presentation] Mechanism of mammalian mitochondrial DNA replication2023

    • Author(s)
      T Yasukawa, S Matsuda, Y Do, M Nakayama, T Inatomi, T Ishiuchi, K Nakada, K Ichiyanagi, H Sasaki, D Kang
    • Organizer
      第22回日本ミトコンドリア学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07127
  • [Presentation] ヒトミトコンドリアDNAの転写-複製調節メカニズム2021

    • Author(s)
      安川 武宏、松田 盛、中山 益成、石内 崇士、都 由羅、中田 和人、一柳 健司、佐々木 裕之、康 東天
    • Organizer
      第44回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07127
  • [Presentation] Epigenetic feature of mitochondrial DNA2019

    • Author(s)
      Takehiro Yasukawa, Shigeru Matsuda, Yuriko Sakaguchi, Kenji Ichiyanagi, Motoko Unoki, Kazuhito Gotoh, Kei Fukuda, Hiroyuki Sasaki, Tsutomu Suzuki, Dongchon Kang
    • Organizer
      The 16th Conference of Asian Society for Mitochondrial Research and Medicine & The 19th Conference of Japanese Society of Mitochondrial Research and Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Presentation] 複雑でユニークなミトコンドリアDNA複製メカニズム2019

    • Author(s)
      安川 武宏、松田 盛、稲冨 鉄平、都 由羅、阿部 周策、石内 崇士、中田 和人、 一柳 健司、佐々木 裕之、康 東天
    • Organizer
      第42回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Presentation] Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA2019

    • Author(s)
      Takehiro Yasukawa, Shigeru Matsuda, Yuriko Sakaguchi, Kenji Ichiyanagi, Motoko Unoki, Kazuhito Gotoh, Kei Fukuda, Hiroyuki Sasaki, Tsutomu Suzuki, Dongchon Kang
    • Organizer
      United Mitochondrial Disease Foundation (UMDF) Mitochondrial Medicine 2019 Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Presentation] 哺乳動物ミトコンドリアDNA複製開始メカニズムの研究2019

    • Author(s)
      安川 武宏、松田 盛、稲冨 鉄平、都 由羅、阿部 周策、石内 崇士、中田 和人、 一柳 健司、佐々木 裕之、康 東天
    • Organizer
      第25回DNA複製・組換え・修復ワークショップ
    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Presentation] Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA2018

    • Author(s)
      Yasukawa T, Matsuda S, Sakaguchi Y, Ichiyanagi K, Unoki M, Gotoh K, Fukuda K, Sasaki H, Suzuki T, Kang D
    • Organizer
      YoungMito2018, The 1st International Mitochondrial Meeting for Young Scientists
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Presentation] 哺乳動物ミトコンドリアゲノムのDNAメチル化修飾の検討2018

    • Author(s)
      安川 武宏, 松田 盛, 坂口 裕理子, 一柳 健司, 鵜木 元香, 後藤 和人, 福田 渓, 佐々木 裕之, 鈴木 勉, 康 東天
    • Organizer
      第18回日本ミトコンドリア学会年会
    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Presentation] 酸化ストレスの起点としてのミトコンドリアとミトコンドリアゲノムの複製2018

    • Author(s)
      安川 武宏, 康 東天
    • Organizer
      第41回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Presentation] Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA ~ Does cytosine modification occur to mtDNA?2018

    • Author(s)
      Matsuda S, Yasukawa T, Sakaguchi Y, Ichiyanagi K, Unoki M, Gotoh K, Fukuda K, Sasaki H, Suzuki T, Kang D
    • Organizer
      YoungMito2018, The 1st international mitochondrial meeting for Young Scientists
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07504
  • [Presentation] ミトコンドリアDNAメチル化修飾の解析~ミトコンドリアゲノムにエピジェネティクスは存在するのか2016

    • Author(s)
      安川 武宏、松田盛、坂口裕理子、鵜木元香、後藤和人、福田渓、一柳健司、鈴木勉、佐々木裕之、康東天
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2016-11-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-26840011
  • [Presentation] 高等脊椎動物ミトコンドリアDNAの複製機構2016

    • Author(s)
      安川 武宏
    • Organizer
      日本遺伝学会第88回大会
    • Place of Presentation
      日本大学国際関係学部三島駅北口校舎(静岡県)
    • Year and Date
      2016-09-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-26840011
  • [Presentation] Initiation of mtDNA replication in human mitochondria & role of 7S DNA2015

    • Author(s)
      Jianhua Qu, Takehiro Yasukawa, Yuji Komorita, Dongchon Kang
    • Organizer
      日本・フィンランドの若手研究者によるミトコンドリア最前線
    • Place of Presentation
      フィンランド国ヘルシンキ市
    • Year and Date
      2015-10-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26840011
  • 1.  福村 由紀 (90407312)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  Kang Dongchon (80214716)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  UCHIUMI TAKESHI (80253798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  MATSUSHIMA YUICI (20571342)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  SHINYA TAKAZAKI (90435149)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  仲程 純 (30926548)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  佐伯 春美 (20535603)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  岩澤 卓弥 (70906297)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  藤野 一成 (40543666)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  福永 哲 (20245731)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  李 賢哲 (30758321)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  折田 創 (50465069)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  波田野 琢 (60338390)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  小山 侑
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  鈴木 勉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  石内 崇士
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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