yasukawa takehiro 安川武宏

… Alternative Names

YASUKAWA TAKEHIRO 安川武宏

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Researcher Number	90646720
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 順天堂大学, 医学部, 准教授 2016 – 2019: 九州大学, 医学研究院, 助教 2015: 九州大学, 大学院医学研究院, 助教 2014 – 2015: 九州大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Genetics/Chromosome dynamics / Molecular biology Except Principal Investigator Basic Section 49020:Human pathology-related / Basic Section 55020:Digestive surgery-related / Laboratory medicine
Keywords	Principal Investigator がん / がん微小環境 / ミトコンドリアＤＮＡ / ミトコンドリアDNA / がん抑制 / 線維芽細胞 / ミトコンドリア / CAFs / がん関連線維芽細胞 / 間質 … More / ミトコンドリアトランスファー / 癌微小環境 / 核酸 / ＤＮＡメチル化修飾 / DNA複製因子 … More Except Principal Investigator αシニクレイン / 虫垂 / パーキンソン病 / 癌微小環境 / エストロゲン / 卵巣癌 / Maspin / 膵癌モデルマウス / 微小環境 / 前がん病変 / 浸潤性膵管癌 / ｐ32ノックアウトマウス / TFAM発現マウス / ミトコンドリアゲノム / ミトコンドリア / ミトコンドリアプロテアーゼ / マイトファジー / 臨床検査 / ミトコンドリアDNA / プロテオーム / メタボローム / ミトコンドリア病 Less

膵前癌病変の微小環境形成機転の解明とマウスモデルへの展開
- Principal Investigator
  
  福村由紀
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Juntendo University
エストロゲンシグナルを介した癌微小環境制御による卵巣癌治療戦略
- Principal Investigator
  
  佐伯春美
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Juntendo University
癌抑制能をもつ線維芽細胞の同定と、癌抑制能力の分子機序の探索・治療応用への展開Principal Investigator
- Principal Investigator
  
  安川武宏
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Juntendo University
虫垂切除がパーキンソン病に与える影響に関する機構解明
- Principal Investigator
  
  福永哲
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Juntendo University
癌関連線維芽細胞CAFsによるミトコンドリアを介した多面的な癌悪性化機構の解明Principal Investigator
- Principal Investigator
  
  安川武宏
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Juntendo University
Epigenetic features of mammalian mitochondrial DNAPrincipal Investigator
- Principal Investigator
  
  Yasukawa Takehiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  Kyushu University
Search for protein factors involved in mammalian mtDNA replicationPrincipal Investigator
- Principal Investigator
  
  Yasukawa Takehiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kyushu University
Biomarkers in blood for mitochondrial abnormality
- Principal Investigator
  
  Kang Dongchon
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Methods in Molecular Biology "Assessing TFAM binding to human mitochondrial DNA" 分担執筆2022
- Author(s)
  Yasukawa Takehiro、Kang Dongchon
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-21K07127
[Book] 医学のあゆみ　「ミトコンドリアゲノムの複製と維持機構」分担執筆2022
- Author(s)
  安川武宏、康東天
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-21K07127
[Book] ミトコンドリアダイナミクス　第４章第３節　「ミトコンドリアゲノムの複製・維持」　分担執筆2021
- Author(s)
  安川武宏
- Total Pages
  458
- Publisher
  エヌ・ティー・エス
- ISBN
  9784860437466
- Data Source
  KAKENHI-PROJECT-21K07127
[Book] Epigenetic features of mitochondrial DNA (a chapter in The Human Mitochondrial Genome), in press2020
- Author(s)
  Yasukawa, T., Matsuda, S., Kang D.
- Total Pages
  15
- Publisher
  Academic Press
- ISBN
  9780128196564
- Data Source
  KAKENHI-PROJECT-17K07504
[Journal Article] Increased <scp>RUNX3</scp> expression mediates tumor‐promoting ability of human breast cancer‐associated fibroblasts2023
- Author(s)
  Koyama Yu、Okazaki Hiroya、Shi Yang、Mezawa Yoshihiro、Wang Zixu、Sakimoto Mizuki、Ishizuka Akane、Ito Yasuhiko、Koyama Takumi、Daigo Yataro、Takano Atsushi、Miyagi Yohei、Yokose Tomoyuki、Yamashita Toshinari、Sugahara Keisuke、Hino Okio、Yang Liying、Maruyama Reo、Katakura Akira、Yasukawa Takehiro、Orimo Akira
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 17 Pages: 18062-18077
- DOI
  10.1002/cam4.6421
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17217, KAKENHI-PROJECT-23K14603, KAKENHI-PROJECT-21K07127, KAKENHI-PROJECT-22K20837, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K27506
[Journal Article] Assessing TFAM Binding to Human Mitochondrial DNA2023
- Author(s)
  Yasukawa Takehiro、Kang Dongchon
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2615 Pages: 139-151
- DOI
  10.1007/978-1-0716-2922-2_11
- ISBN
  9781071629215, 9781071629222
- Data Source
  KAKENHI-PROJECT-21K07127
[Journal Article] ミトコンドリアDNAの複製・維持機構と関連疾患2022
- Author(s)
  安川武宏、康東天
- Journal Title
  
  医学のあゆみ
  
  Volume: 281 Pages: 1121-1127
- Data Source
  KAKENHI-PROJECT-21K07127
[Journal Article] TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication2022
- Author(s)
  Inatomi Teppei、Matsuda Shigeru、Ishiuchi Takashi、Do Yura、Nakayama Masunari、Abe Shusaku、Kasho Kazutoshi、Wanrooij Sjoerd、Nakada Kazuto、Ichiyanagi Kenji、Sasaki Hiroyuki、Yasukawa Takehiro、Kang Dongchon
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1869 Issue: 1 Pages: 119167-119167
- DOI
  10.1016/j.bbamcr.2021.119167
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05756, KAKENHI-PROJECT-21K07127, KAKENHI-PROJECT-21K20640, KAKENHI-PROJECT-20H00530
[Journal Article] Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation2022
- Author(s)
  Tani Haruna、Ishikawa Kaori、Tamashiro Hiroaki、Ogasawara Emi、Yasukawa Takehiro、Matsuda Shigeru、Shimizu Akinori、Kang Dongchon、Hayashi Jun-Ichi、Wei Fan-Yan、Nakada Kazuto
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 50 Issue: 16 Pages: 9382-9396
- DOI
  10.1093/nar/gkac699
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07127, KAKENHI-PLANNED-21H05265, KAKENHI-PROJECT-22KJ0156, KAKENHI-PUBLICLY-21H00225, KAKENHI-PROJECT-23K21370, KAKENHI-PROJECT-23K23801
[Journal Article] Mitochondria metabolomics reveals a role of β-nicotinamide mononucleotide metabolism in mitochondrial DNA replication2021
- Author(s)
  Nomiyama Tomoko、Setoyama Daiki、Yasukawa Takehiro、Kang Dongchon
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 171 Issue: 3 Pages: 325-338
- DOI
  10.1093/jb/mvab136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-21K07127
[Journal Article] ミトコンドリアゲノムの複製・維持機構2019
- Author(s)
  安川武宏、康東天
- Journal Title
  
  実験医学
  
  Volume: 37 Pages: 24-30
- Data Source
  KAKENHI-PROJECT-17K07504
[Journal Article] An overview of mammalian mitochondrial DNA replication mechanisms2018
- Author(s)
  Yasukawa Takehiro、Kang Dongchon
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 164 Issue: 3 Pages: 183-193
- DOI
  10.1093/jb/mvy058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07504
[Journal Article] Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA2018
- Author(s)
  Matsuda, S., *Yasukawa, T., Sakaguchi, Y., Ichiyanagi, K., Unoki, M., Gotoh, K., Fukuda, K., Sasaki, H., Suzuki, T. and Kang, D.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 5801-5801
- DOI
  10.1038/s41598-018-24251-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26220205, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-17K07504, KAKENHI-PLANNED-26113003, KAKENHI-PROJECT-18H05272
[Journal Article] ミトコンドリアDNAのユニークな複製メカニズム2017
- Author(s)
  安川武宏
- Journal Title
  
  医学のあゆみ
  
  Volume: 260 Pages: 5-10
- Data Source
  KAKENHI-PROJECT-26840011
[Journal Article] Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria2016
- Author(s)
  Akman, G., Desai, R., Bailey, L.J., Yasukawa, T., Dalla Rosa, I., Durigon, R., Holmes, J.B., Moss, C.F., Mennuni, M., Houlden, H., Crouch, R.J., Hanna, M.G., Pitceathly, R.D., Spinazzola, A., Holt, I.J.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 113 Issue: 30
- DOI
  10.1073/pnas.1600537113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840011
[Journal Article] Suppression of mitochondrial transcription initiation complexes changes the balance of replication intermediates of mitochondrial DNA and reduces 7S DNA in cultured human cells2016
- Author(s)
  Jianhua Qu, Takehiro Yasukawa, Dongchon Kang
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: N/A Issue: 1 Pages: 49-57
- DOI
  10.1093/jb/mvw010
- NAID
  40020880721
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26840011, KAKENHI-PROJECT-25253041
[Presentation] Investigation of aberrant LEF1 expression in tumor-promoting cancer-associated fibroblasts2023
- Author(s)
  H Okazazki, Y Shi, M Sakimoto, Y Koyama, Z Wang, A Isizuka, Y Mezawa, K Kajino, A Katakura, T Yasukawa, A Orimo
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07127
[Presentation] Mechanism of mammalian mitochondrial DNA replication2023
- Author(s)
  T Yasukawa, S Matsuda, Y Do, M Nakayama, T Inatomi, T Ishiuchi, K Nakada, K Ichiyanagi, H Sasaki, D Kang
- Organizer
  第22回日本ミトコンドリア学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07127
[Presentation] ヒトミトコンドリアDNAの転写-複製調節メカニズム2021
- Author(s)
  安川武宏、松田盛、中山益成、石内崇士、都由羅、中田和人、一柳健司、佐々木裕之、康東天
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07127
[Presentation] Epigenetic feature of mitochondrial DNA2019
- Author(s)
  Takehiro Yasukawa, Shigeru Matsuda, Yuriko Sakaguchi, Kenji Ichiyanagi, Motoko Unoki, Kazuhito Gotoh, Kei Fukuda, Hiroyuki Sasaki, Tsutomu Suzuki, Dongchon Kang
- Organizer
  The 16th Conference of Asian Society for Mitochondrial Research and Medicine & The 19th Conference of Japanese Society of Mitochondrial Research and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07504
[Presentation] 複雑でユニークなミトコンドリアDNA複製メカニズム2019
- Author(s)
  安川武宏、松田盛、稲冨鉄平、都由羅、阿部周策、石内崇士、中田和人、一柳健司、佐々木裕之、康東天
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07504
[Presentation] Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA2019
- Author(s)
  Takehiro Yasukawa, Shigeru Matsuda, Yuriko Sakaguchi, Kenji Ichiyanagi, Motoko Unoki, Kazuhito Gotoh, Kei Fukuda, Hiroyuki Sasaki, Tsutomu Suzuki, Dongchon Kang
- Organizer
  United Mitochondrial Disease Foundation (UMDF) Mitochondrial Medicine 2019 Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07504
[Presentation] 哺乳動物ミトコンドリアDNA複製開始メカニズムの研究2019
- Author(s)
  安川武宏、松田盛、稲冨鉄平、都由羅、阿部周策、石内崇士、中田和人、一柳健司、佐々木裕之、康東天
- Organizer
  第25回DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-17K07504
[Presentation] Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA2018
- Author(s)
  Yasukawa T, Matsuda S, Sakaguchi Y, Ichiyanagi K, Unoki M, Gotoh K, Fukuda K, Sasaki H, Suzuki T, Kang D
- Organizer
  YoungMito2018, The 1st International Mitochondrial Meeting for Young Scientists
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07504
[Presentation] 哺乳動物ミトコンドリアゲノムのDNAメチル化修飾の検討2018
- Author(s)
  安川武宏, 松田盛, 坂口裕理子, 一柳健司, 鵜木元香, 後藤和人, 福田渓, 佐々木裕之, 鈴木勉, 康東天
- Organizer
  第18回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-17K07504
[Presentation] 酸化ストレスの起点としてのミトコンドリアとミトコンドリアゲノムの複製2018
- Author(s)
  安川武宏, 康東天
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07504
[Presentation] Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA ~ Does cytosine modification occur to mtDNA?2018
- Author(s)
  Matsuda S, Yasukawa T, Sakaguchi Y, Ichiyanagi K, Unoki M, Gotoh K, Fukuda K, Sasaki H, Suzuki T, Kang D
- Organizer
  YoungMito2018, The 1st international mitochondrial meeting for Young Scientists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07504
[Presentation] ミトコンドリアDNAメチル化修飾の解析～ミトコンドリアゲノムにエピジェネティクスは存在するのか2016
- Author(s)
  安川武宏、松田盛、坂口裕理子、鵜木元香、後藤和人、福田渓、一柳健司、鈴木勉、佐々木裕之、康東天
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-26840011
[Presentation] 高等脊椎動物ミトコンドリアDNAの複製機構2016
- Author(s)
  安川武宏
- Organizer
  日本遺伝学会第88回大会
- Place of Presentation
  日本大学国際関係学部三島駅北口校舎（静岡県）
- Year and Date
  2016-09-07
- Invited
- Data Source
  KAKENHI-PROJECT-26840011
[Presentation] Initiation of mtDNA replication in human mitochondria & role of 7S DNA2015
- Author(s)
  Jianhua Qu, Takehiro Yasukawa, Yuji Komorita, Dongchon Kang
- Organizer
  日本・フィンランドの若手研究者によるミトコンドリア最前線
- Place of Presentation
  フィンランド国ヘルシンキ市
- Year and Date
  2015-10-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840011

1. 福村由紀 (90407312)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Kang Dongchon (80214716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. UCHIUMI TAKESHI (80253798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MATSUSHIMA YUICI (20571342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHINYA TAKAZAKI (90435149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 仲程純 (30926548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐伯春美 (20535603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岩澤卓弥 (70906297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 藤野一成 (40543666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 福永哲 (20245731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 李賢哲 (30758321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 折田創 (50465069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 波田野琢 (60338390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小山侑

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 鈴木勉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 石内崇士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

yasukawa takehiro 安川 武宏

YASUKAWA TAKEHIRO 安川 武宏

Research Projects

Research Products

Co-Researchers

膵前癌病変の微小環境形成機転の解明とマウスモデルへの展開

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エストロゲンシグナルを介した癌微小環境制御による卵巣癌治療戦略

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌抑制能をもつ線維芽細胞の同定と、癌抑制能力の分子機序の探索・治療応用への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

虫垂切除がパーキンソン病に与える影響に関する機構解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌関連線維芽細胞CAFsによるミトコンドリアを介した多面的な癌悪性化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic features of mammalian mitochondrial DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for protein factors involved in mammalian mtDNA replicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biomarkers in blood for mitochondrial abnormality

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Methods in Molecular Biology "Assessing TFAM binding to human mitochondrial DNA" 分担執筆2022

Author(s)

Publisher

Data Source

[Book] 医学のあゆみ 「ミトコンドリアゲノムの複製と維持機構」分担執筆2022

Author(s)

Publisher

Data Source

[Book] ミトコンドリアダイナミクス 第４章第３節 「ミトコンドリアゲノムの複製・維持」 分担執筆2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Epigenetic features of mitochondrial DNA (a chapter in The Human Mitochondrial Genome), in press2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Increased <scp>RUNX3</scp> expression mediates tumor‐promoting ability of human breast cancer‐associated fibroblasts2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Assessing TFAM Binding to Human Mitochondrial DNA2023

Author(s)

yasukawa takehiro 安川武宏

YASUKAWA TAKEHIRO 安川武宏

[Book] 医学のあゆみ　「ミトコンドリアゲノムの複製と維持機構」分担執筆2022

[Book] ミトコンドリアダイナミクス　第４章第３節　「ミトコンドリアゲノムの複製・維持」　分担執筆2021