Takagi Kenji 高木賢治

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TAKAGI Kenji 高木賢治

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Researcher Number	90647322
Other IDs
Affiliation (Current)	2025: 津山工業高等専門学校, 総合理工学科, 准教授
Affiliation (based on the past Project Information) *help	2021: 津山工業高等専門学校, 総合理工学科, 准教授 2019 – 2020: 津山工業高等専門学校, 総合理工学科, 講師 2018: 大阪大学, 蛋白質研究所, 特任研究員 2013 – 2014: 兵庫県立大学, 生命理学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Functional biochemistry
Keywords	Principal Investigator プロテアソーム / X線結晶構造解析 / ゲル内結晶化 / タンパク質分解酵素 / 分子集合 / 細胞内タンパク質分解

Development of a proteasome regulator with a new mechanism of action using the in-gel crystallization methodPrincipal Investigator
- Principal Investigator
  
  Takagi Kenji
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Tsuyama National College of Technology
  Osaka University
Structural analysis of proteasome and PI31, a regulator of the activity and the molecular assembly of proteasome.Principal Investigator
- Principal Investigator
  
  TAKAGI Kenji
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  University of Hyogo

All 2022 2019 2018 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] Autophagy : Mechanisms of Regulation of p62 in Autophagy and Implications for Health and Diseases2013
- Author(s)
  Kenji Takagi, Tsunehiro Mizushima
- Publisher
  Academic press
- Data Source
  KAKENHI-PROJECT-25870631
[Book] プロテアソーム複合体形成シャペロンの構造と作用機構2013
- Author(s)
  高木賢治, 水島恒裕
- Publisher
  生化学
- Data Source
  KAKENHI-PROJECT-25870631
[Journal Article] Active site structure of the <i>Shigella flexneri</i> effector OspI2022
- Author(s)
  Nishide Akira、Takagi Kenji、Kim Minsoo、Mizushima Tsunehiro
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2022.02.15.480433
- Open Access
- Data Source
  KAKENHI-PROJECT-18K14637, KAKENHI-PROJECT-20H03198
[Journal Article] N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function.2015
- Author(s)
  Yashiroda H, Toda Y, Otsu S, Takagi K, Mizushima T, Murata S.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 35(1) Issue: 1 Pages: 141-52
- DOI
  10.1128/mcb.00582-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570208, KAKENHI-PROJECT-25870631, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-26000014
[Journal Article] Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition2014
- Author(s)
  Kim M et. al
- Journal Title
  
  Cells
  
  Volume: 3 Issue: 3 Pages: 848-864
- DOI
  10.3390/cells3030848
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13F03405, KAKENHI-PROJECT-14J10879, KAKENHI-PROJECT-23000012, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24370049, KAKENHI-PUBLICLY-25112506, KAKENHI-PUBLICLY-25121711, KAKENHI-PROJECT-25870631
[Journal Article] Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.2014
- Author(s)
  Lystad, AH., Ichimura, Y., Takagi, K., Yang, Y., Pankiv, S., Kanegae, Y., Kageyama, S., Suzuki, M., Saito, I., Mizushima,T., *Komatsu, M., *Simonsen, A.
- Journal Title
  
  EMBO Rep.
  
  Volume: 15 Issue: 5 Pages: 557-565
- DOI
  10.1002/embr.201338003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631, KAKENHI-PROJECT-26670221, KAKENHI-PROJECT-26860224
[Journal Article] Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation2014
- Author(s)
  Takagi, K., Saeki, Y., Yashiroda, H., Yagi, H., Kaiho, A., Murata, S., Yamane, T., Tanaka, K., Mizushima, T. and Kato, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 450 Issue: 2 Pages: 1110-1114
- DOI
  10.1016/j.bbrc.2014.06.119
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-24570208, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-25870631, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26293018
[Journal Article] Kinetic, Thermodynamic and Structural Characterizations of Association between Nrf2-DLGex Degron and Keap1.2014
- Author(s)
  Fukutomi, T., Takagi, K., Mizushima, T., Ohuchi, N., and Yamamoto, M.
- Journal Title
  
  Moll Cell Biol.
  
  Volume: 34 Issue: 5 Pages: 832-846
- DOI
  10.1128/mcb.01191-13
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25870631
[Journal Article] Structural basis for the recognition of Ubcl3 by the Shigell a flexneri effector OspI2013
- Author(s)
  Nishide A, et. al
- Journal Title
  
  J Mol Bio.
  
  Volume: 425 Issue: 15 Pages: 2623-2631
- DOI
  10.1016/j.jmb.2013.02.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13F03405, KAKENHI-PROJECT-23000012, KAKENHI-PROJECT-23689027, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24370049, KAKENHI-PUBLICLY-25112506, KAKENHI-PUBLICLY-25121711, KAKENHI-PROJECT-25870631
[Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013
- Author(s)
  Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
- Journal Title
  
  Mol Cell
  
  Volume: 51 Issue: 5 Pages: 618-631
- DOI
  10.1016/j.molcel.2013.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-23247034, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790332, KAKENHI-PROJECT-24790967, KAKENHI-PLANNED-25111002, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631
[Presentation] 赤痢菌エフェクターIpaH1.4/2.5基質認識ドメインのX線結晶構造解析2019
- Author(s)
  Keito Hiragi, Kenji Takagi, Akira Nishide, Kim Minsoo, Tsunehiro Mizushima
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K14637
[Presentation] 薬剤スクリーニングの効率化を目指した蛋白質結晶の高圧凍結とハイドロゲル結晶化とのハイブリッド法の開発2018
- Author(s)
  東浦彰史, 高木賢治, 中川敦史, 杉山成
- Organizer
  平成30年度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-18K14637
[Presentation] プロテアソーム形成シャペロンNas2によるRptサブユニットのHbYXモチーフ認識機構2018
- Author(s)
  田本和宏, 藤岡美季彦, 高木賢治, 水島恒裕
- Organizer
  日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-18K14637
[Presentation] 薬剤スクリーニングの効率化を目指した蛋白質結晶の高圧凍結とハイドロゲル結晶化とのハイブリッド法の開発2018
- Author(s)
  東浦彰史, 高木賢治, 中川敦史, 杉山成
- Organizer
  第16回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Data Source
  KAKENHI-PROJECT-18K14637
[Presentation] 脱アミド化Ubc13の構造解析による赤痢菌感染機構の考察2013
- Author(s)
  高木　賢治, 西出　旭, Kim Minsoo, 笹川　千尋, 水島　恒裕
- Organizer
  新学術領域研究「ユビキチン制御」平成25年度第2回領域会議
- Place of Presentation
  熱海ニューフジヤホテル（静岡県熱海市）
- Data Source
  KAKENHI-PROJECT-25870631
[Presentation] Structural basis for specific recognition of Rpt1 by proteasome-dedicated chaperone Hsm32013
- Author(s)
  Kenji Takagi, Sangwoo Kim, Yasushi Saeki, Keiji Tanaka, Koichi Kato, Tsunehiro Mizushima
- Organizer
  第35回内藤コンファレンス　"The Ubiquitin-Proteasome System: From BasicMechanisms to Pathophysiological Roles"
- Place of Presentation
  シャトレーゼ　ガトーキングダム　サッポロ（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-25870631
[Presentation] 赤痢菌エフェクターIpaH9.8基質認識ドメインのX線結晶構造解析
- Author(s)
  高木賢治、Kim Minsoo、笹川千尋、水島恒裕
- Organizer
  新学術領域研究「ユビキチンネオバイオロジー」平成26年度領域班会議
- Place of Presentation
  ホテルたつき（愛知県蒲郡市）
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-25870631
[Presentation] Structure and substrate recognition mechanism of IpaH9.8 LRR
- Author(s)
  Kenji Takagi, Akira Nishide, Tsunehiro Mizushima
- Organizer
  Symposium for young ubiquitin researchers ina Japan "New Era in the Ubiquitin Research"
- Place of Presentation
  国際高等研究所（京都府木津川市）
- Year and Date
  2014-11-11 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25870631
[Presentation] 赤痢菌エフェクターIpaH9.8基質認識ドメインのX線結晶構造解析
- Author(s)
  高木賢治、水島恒裕
- Organizer
  日本結晶学会平成26年度年会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2014-11-01 – 2014-11-03
- Data Source
  KAKENHI-PROJECT-25870631

1. KIM Minsoo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. SAEKI Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 八代田英樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 小松雅明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 水島恒裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 田中啓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takagi Kenji 高木 賢治

TAKAGI Kenji 高木 賢治

Research Projects

Research Products

Co-Researchers

Development of a proteasome regulator with a new mechanism of action using the in-gel crystallization methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural analysis of proteasome and PI31, a regulator of the activity and the molecular assembly of proteasome.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Autophagy : Mechanisms of Regulation of p62 in Autophagy and Implications for Health and Diseases2013

Author(s)

Publisher

Data Source

[Book] プロテアソーム複合体形成シャペロンの構造と作用機構2013

Author(s)

Publisher

Data Source

[Journal Article] Active site structure of the <i>Shigella flexneri</i> effector OspI2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kinetic, Thermodynamic and Structural Characterizations of Association between Nrf2-DLGex Degron and Keap1.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis for the recognition of Ubcl3 by the Shigell a flexneri effector OspI2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] 赤痢菌エフェクターIpaH1.4/2.5基質認識ドメインのX線結晶構造解析2019

Author(s)

Organizer

Data Source

[Presentation] 薬剤スクリーニングの効率化を目指した蛋白質結晶の高圧凍結とハイドロゲル結晶化とのハイブリッド法の開発2018

Author(s)

Organizer

Data Source

[Presentation] プロテアソーム形成シャペロンNas2によるRptサブユニットのHbYXモチーフ認識機構2018

Author(s)

Organizer

Data Source

[Presentation] 薬剤スクリーニングの効率化を目指した蛋白質結晶の高圧凍結とハイドロゲル結晶化とのハイブリッド法の開発2018

Author(s)

Organizer

Takagi Kenji 高木賢治

TAKAGI Kenji 高木賢治