Tomita Yusuke 冨田雄介

Researcher Number	90648619
Other IDs
Affiliation (Current)	2025: 熊本大学, 病院, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 熊本大学, 病院, 講師 2018 – 2023: 熊本大学, 大学院生命科学研究部(医), 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator がん免疫療法 / 肺癌 / dysbiosis / T細胞 / 免疫チェックポイント阻害剤 / 腸内細菌叢 / 腫瘍免疫 / 酪酸菌 / プロバイオティクス / CBM588 … More / T 細胞 / 末梢血単核球細胞（PBMC） / PD-L1 / PD-1 / SARS-CoV-2 / COVID-19 / 腫瘍抗原 / PDー1 / 腫瘍免疫微小環境 / がん免疫 / 腸内細菌 / 免疫療法 / 肺がん … More Except Principal Investigator 炎症 / PD-1阻害療法 / irAE実験モデル / マクロファージ / 免疫老化 / 有害事象 / PD-1阻害 / PD-1 / 個体老化 / T細胞 / 免疫関連有害事象 / がん免疫療法 Less

Development of a new combinational therapy with immune checkpoint blockade and live biotherapeutic products for advanced lung cancerPrincipal Investigator
- Principal Investigator
  
  冨田雄介
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kumamoto University
Development of irAE management strategy based on immuno-senescence, and novel cancer immunotherapy balancing augmented anti-tumor immunity and decreased risk of adverse events
- Principal Investigator
  
  Tsukamoto Hirotake
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyoto University
Clinical research on cancer immunotherapy combining the evasion of tumor immunosuppression and active immunity for advanced lung cancerPrincipal Investigator
- Principal Investigator
  
  Tomita Yusuke
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kumamoto University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations2023
- Author(s)
  Tomiya Y, Sakata S, Imamura K, Iyama S, Jodai T, et al.
- Journal Title
  
  Cancers
  
  Volume: 16 Issue: 1 Pages: 47-47
- DOI
  10.3390/cancers16010047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16449, KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-22K08256, KAKENHI-PROJECT-21K08494, KAKENHI-PROJECT-18K15928, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-23K24139
[Journal Article] Aging-associated and CD4 T-cell-dependent ectopic CXCL13 activation predisposes to anti?PD-1 therapy-induced adverse events2022
- Author(s)
  Tsukamoto Hirotake、Komohara Yoshihiro、Tomita Yusuke、Miura Yuji、Motoshima Takanobu、Imamura Kosuke、Kimura Toshiki、Ikeda Tokunori、Fujiwara Yukio、Yano Hiromu、Kamba Tomomi、Sakagami Takuro、Oshiumi Hiroyuki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 29
- DOI
  10.1073/pnas.2205378119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08541, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-20K09560
[Journal Article] Statistical Concern Regarding the Relationship of Change in Mucus Plug Score with Airflow Over Time2022
- Author(s)
  Ikeda Tokunori、Tomita Yusuke
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine
  
  Volume: 206 Issue: 10 Pages: 1299-1299
- DOI
  10.1164/rccm.202207-1273le
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08256
[Journal Article] Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer2022
- Author(s)
  Imamura Kosuke、Tomita Yusuke、Sato Ryo、Ikeda Tokunori、Iyama Shinji、Jodai Takayuki、Takahashi Misako、Takaki Akira、Akaike Kimitaka、Hamada Shohei、Sakata Shinya、Saruwatari Koichi、Saeki Sho、Ikeda Koei、Suzuki Makoto、Sakagami Takuro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 22 Pages: 13723-13723
- DOI
  10.3390/ijms232213723
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08256, KAKENHI-PROJECT-18K15928, KAKENHI-PROJECT-20K16449
[Journal Article] Clostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitors2022
- Author(s)
  Tomita Yusuke、Goto Yoshihiko、Sakata Shinya、Imamura Kosuke、Minemura Ayaka、Oka Kentaro、Hayashi Atsushi、Jodai Takayuki、Akaike Kimitaka、Anai Moriyasu、Hamada Shohei、Iyama Shinji、Saruwatari Koichi、Saeki Sho、Takahashi Motomichi、Ikeda Tokunori、Sakagami Takuro
- Journal Title
  
  OncoImmunology
  
  Volume: 11 Issue: 1 Pages: 2081010-2081010
- DOI
  10.1080/2162402x.2022.2081010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08256, KAKENHI-PROJECT-18K15928, KAKENHI-PROJECT-20K16449
[Journal Article] In small cell lung cancer patients treated with RRx-001, a downregulator of CD47, decreased expression of PD-L1 on circulating tumor cells significantly correlates with clinical benefit2021
- Author(s)
  Tomita Yusuke、Oronsky Bryan、Abrouk Nacer、Cabrales Pedro、Reid Tony R.、Lee Min-Jung、Yuno Akira、Baker Jonathan、Lee Sunmin、Trepel Jane B.
- Journal Title
  
  Translational Lung Cancer Research
  
  Volume: 10 Issue: 1 Pages: 274-278
- DOI
  10.21037/tlcr-20-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15928
[Journal Article] Association of Probiotic Clostridium butyricum Therapy with Survival and Response to Immune Checkpoint Blockade in Patients with Lung Cancer2020
- Author(s)
  Tomita Yusuke、Ikeda Tokunori、Sakata Shinya、Saruwatari Koichi、Sato Ryo、Iyama Shinji、Jodai Takayuki、Akaike Kimitaka、Ishizuka Shiho、Saeki Sho、Sakagami Takuro
- Journal Title
  
  Cancer Immunology Research
  
  Volume: 8 Issue: 10 Pages: 1236-1242
- DOI
  10.1158/2326-6066.cir-20-0051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15928, KAKENHI-PROJECT-20K16449
[Journal Article] BCG vaccine may generate cross-reactive T cells against SARS-CoV-2: In silico analyses and a hypothesis2020
- Author(s)
  Tomita Yusuke、Sato Ryo、Ikeda Tokunori、Sakagami Takuro
- Journal Title
  
  Vaccine
  
  Volume: 38 Issue: 41 Pages: 6352-6356
- DOI
  10.1016/j.vaccine.2020.08.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15928
[Journal Article] Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma2020
- Author(s)
  Tashiro Takahiro、Imamura Kosuke、Tomita Yusuke、Tamanoi Daisuke、Takaki Akira、Sugahara Kazuaki、Sato Ryo、Saruwatari Koichi、Sakata Shinya、Inaba Megumi、Ushijima Sunao、Hirata Naomi、Sakagami Takuro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 24 Pages: 9705-9705
- DOI
  10.3390/ijms21249705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15928
[Journal Article] Heterogeneous tumor‐immune microenvironments between primary and metastatic carcinoid tumors differentially respond to anti‐PD‐L1 antibody therapy2020
- Author(s)
  Sakata Shinya、Imamura Kosuke、Tajima Yuka、Masuda Yuiko、Sato Ryo、Yoshida Chieko、Okamoto Shinichiro、Saeki Sho、Tomita Yusuke、Sakagami Takuro
- Journal Title
  
  Thoracic Cancer
  
  Volume: 12 Issue: 3 Pages: 397-401
- DOI
  10.1111/1759-7714.13772
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15928, KAKENHI-PROJECT-20K16449
[Journal Article] Association between HLA gene polymorphisms and mortality of COVID‐19: An in silico analysis2020
- Author(s)
  Tomita Yusuke、Ikeda Tokunori、Sato Ryo、Sakagami Takuro
- Journal Title
  
  Immunity, Inflammation and Disease
  
  Volume: 8 Issue: 4 Pages: 684-694
- DOI
  10.1002/iid3.358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15928
[Journal Article] The Risks and Benefits of Immune Checkpoint Blockade in Anti-AChR Antibody-Seropositive Non-Small Cell Lung Cancer Patients2019
- Author(s)
  Saruwatari Koichi、Sato Ryo、Nakane Shunya、Sakata Shinya、Takamatsu Koutaro、Jodai Takayuki、Mito Remi、Horio Yuko、Saeki Sho、Tomita Yusuke、Sakagami Takuro
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 2 Pages: 140-140
- DOI
  10.3390/cancers11020140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15928
[Journal Article] Disorder of Coagulation-Fibrinolysis System: An Emerging Toxicity of Anti-PD-1/PD-L1 Monoclonal Antibodies2019
- Author(s)
  Sato Ryo、Imamura Kosuke、Sakata Shinya、Ikeda Tokunori、Horio Yuko、Iyama Shinji、Akaike Kimitaka、Hamada Shohei、Jodai Takayuki、Nakashima Kei、Ishizuka Shiho、Sato Nahoko、Saruwatari Koichi、Saeki Sho、Tomita Yusuke、Sakagami Takuro
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 8 Issue: 6 Pages: 762-762
- DOI
  10.3390/jcm8060762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15928
[Journal Article] Trousseau's syndrome triggered by an immune checkpoint blockade in a non-small cell lung cancer patient.2018
- Author(s)
  Yuko Horio Koutaro Takamatsu Daisuke Tamanoi Ryo Sato Koichi Saruwatari Tokunori Ikeda Shunya Nakane Makoto Nakajima Sho Saeki Hidenori Ichiyasu Kazuhiko Fujii Yusuke Tomita
- Journal Title
  
  European Journal of Immunology
  
  Volume: 48 Issue: 10 Pages: 1764-1767
- DOI
  10.1002/eji.201847645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15928
[Patent] ＣＤ４－ＣＤ８－Ｔ細胞を増殖および／または活性化させるための組成物2024
- Inventor(s)
  冨田雄介　本園千尋　坂上拓郎高橋志達　岡健太郎　林篤史
- Industrial Property Rights Holder
  冨田雄介　本園千尋　坂上拓郎高橋志達　岡健太郎　林篤史
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-22K08256
[Patent] ＣＤ４－ＣＤ８－Ｔ細胞を増殖および／または活性化させるための組成物2024
- Inventor(s)
  冨田雄介　本園千尋坂上拓郎高橋志達岡健太郎　林篤史
- Industrial Property Rights Holder
  冨田雄介　本園千尋坂上拓郎高橋志達岡健太郎　林篤史
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-18K15928
[Presentation] 腸内細菌叢を標的とした肺癌の治療戦略2024
- Author(s)
  坂田晋也, 冨田雄介, 坂上拓郎.
- Organizer
  第92回日本呼吸器学会・日本結核非結核性抗酸菌症学会九州支部春季学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08256
[Presentation] 腸内細菌叢を考慮した進行肺癌の治療2023
- Author(s)
  冨田雄介
- Organizer
  第 91 回日本呼吸器学会・日本結核非結核性抗酸菌症学会・日本サルコイドーシス肉芽腫性疾患学会九州支部秋季学術講演会
- Data Source
  KAKENHI-PROJECT-18K15928
[Presentation] がん免疫療法における腸内細菌の重要性2023
- Author(s)
  冨田雄介
- Organizer
  第82回九州山口薬学大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08256
[Presentation] がん免疫療法における腸内細菌の重要性2023
- Author(s)
  冨田雄介
- Organizer
  第82回九州山口薬学大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15928
[Presentation] 腸内細菌叢を考慮した進行肺癌の治療2023
- Author(s)
  冨田雄介
- Organizer
  第 91 回日本呼吸器学会・日本結核非結核性抗酸菌症学会・日本サルコイドーシス肉芽腫性疾患学会九州支部秋季学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08256
[Presentation] ILA合併肺癌の治療戦略：腸内細菌叢を考慮した進行肺癌の治療2022
- Author(s)
  冨田雄介
- Organizer
  第89 回日本呼吸器学会九州支部秋季学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08256
[Presentation] 腸内細菌叢を標的とする新たな肺癌治療戦略2022
- Author(s)
  冨田雄介
- Organizer
  第62回日本肺癌学会九州支部学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08256

1. 池田徳典 (00613530)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Tsukamoto Hirotake (10433020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. AWAI Hirotake

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 坂田晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tomita Yusuke 冨田 雄介

Research Projects

Research Products

Co-Researchers

Development of a new combinational therapy with immune checkpoint blockade and live biotherapeutic products for advanced lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of irAE management strategy based on immuno-senescence, and novel cancer immunotherapy balancing augmented anti-tumor immunity and decreased risk of adverse events

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinical research on cancer immunotherapy combining the evasion of tumor immunosuppression and active immunity for advanced lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aging-associated and CD4 T-cell-dependent ectopic CXCL13 activation predisposes to anti?PD-1 therapy-induced adverse events2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Statistical Concern Regarding the Relationship of Change in Mucus Plug Score with Airflow Over Time2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In small cell lung cancer patients treated with RRx-001, a downregulator of CD47, decreased expression of PD-L1 on circulating tumor cells significantly correlates with clinical benefit2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of Probiotic Clostridium butyricum Therapy with Survival and Response to Immune Checkpoint Blockade in Patients with Lung Cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BCG vaccine may generate cross-reactive T cells against SARS-CoV-2: In silico analyses and a hypothesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heterogeneous tumor‐immune microenvironments between primary and metastatic carcinoid tumors differentially respond to anti‐PD‐L1 antibody therapy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association between HLA gene polymorphisms and mortality of COVID‐19: An in silico analysis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Risks and Benefits of Immune Checkpoint Blockade in Anti-AChR Antibody-Seropositive Non-Small Cell Lung Cancer Patients2019

Author(s)

Journal Title

Tomita Yusuke 冨田雄介

[Presentation] 腸内細菌叢を考慮した進行肺癌の治療2023