KIM HYUN 金玄

… Alternative Names

金玄キムヒュン

Kim Hyun 金玄

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Researcher Number	90648817
Other IDs	https://orcid.org/0000-0002-7439-5231
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所細菌第二部, 主任研究員
Affiliation (based on the past Project Information) *help	2017 – 2019: 国立感染症研究所, 細菌第二部, 主任研究官 2015: 国立感染症研究所, その他部局等, 主任研究官 2013 – 2015: 国立感染症研究所, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Bacteriology (including mycology)
Keywords	Principal Investigator 立体構造解析 / 結核菌 / 薬剤耐性 / X線結晶構造解析 / Catalase-peroxidase 活性 / KatG変異 / KatG / イソニアジド耐性 / 結核菌由来katG / 結晶構造解析 … More / Isoniazid-resistance / M.tuberculosis KatG / X線回折 / ニューキノロン / DNAジャイレース / X線回析 / 薬剤耐性菌 Less

Functional analysis and characterization of KatG mutations associated with isoniazid-resistant Mycobacterium tuberculosis and their crystal structuresPrincipal Investigator
- Principal Investigator
  
  KIM HYUN
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Institute of Infectious Diseases
Functional and structural analysis of DNA gyrase from Beijing strain M. tuberculosisPrincipal Investigator
- Principal Investigator
  
  Kim Hyun
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Institute of Infectious Diseases

All 2020 2019 2018 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] WQ-3810: A new fluoroquinolone with a high potential against fluoroquinolone-resistant Mycobacterium tuberculosis2020
- Author(s)
  Ouchi Yuki、Mukai Tetsu、Koide Kentaro、Yamaguchi Tomoyuki、Park Jong-Hoon、Kim Hyun、Yokoyama Kazumasa、Tamaru Aki、Gordon Stephen V.、Nakajima Chie、Suzuki Yasuhiko
- Journal Title
  
  Tuberculosis
  
  Volume: 120 Pages: 101891-101891
- DOI
  10.1016/j.tube.2019.101891
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15695
[Journal Article] WQ-3810 inhibits DNA gyrase activity in ofloxacin-resistant Mycobacterium leprae2020
- Author(s)
  Park Jong-Hoon、Yamaguchi Tomoyuki、Ouchi Yuki、Koide Kentaro、Mori Shigetarou、Kim Hyun、Mukai Tetsu、Nakajima Chie、Suzuki Yasuhiko
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 26 Issue: 4 Pages: 335-342
- DOI
  10.1016/j.jiac.2019.10.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15695
[Journal Article] DNA gyrase could be a crucial regulatory factor for growth and survival of Mycobacterium leprae2019
- Author(s)
  Kim Hyun、Fukutomi Yasuo、Nakajima Chie、Kim Youn Uck、Mori Shigetarou、Shibayama Keigo、Nakata Noboru、Suzuki Yasuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10815-10815
- DOI
  10.1038/s41598-019-47364-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15695
[Journal Article] Mutations in Genes Encoding Penicillin-Binding Proteins and Efflux Pumps Play a Role in β-Lactam Resistance in Helicobacter cinaedi2018
- Author(s)
  Emiko Rimbara, Shigetarou Mori, Hyun Kim, Masato Suzuki, Keigo Shibayama
- Journal Title
  
  ANTIMICROBIAL AGENS AND CHEMOTHERAPHY
  
  Volume: 62(2)
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15695
[Journal Article] Impact of mutations in DNA gyrase genes on quinolone resistance in Campylobacter jejuni2016
- Author(s)
  Ruchirada Changkwanyeun, Tomoyuki Yamaguchi, Siriporn Kongsoi, Kanjana Changkaew, Kazumasa Yokoyama, Hyun Kim, Orasa Suthienkul, Masaru Usui, Yutaka Tamura, Chie Nakajima and Yasuhiko Suzuki
- Journal Title
  
  Drug testing and analysis
  
  Volume: in press Issue: 10 Pages: 1071-1076
- DOI
  10.1002/dta.1937
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860329
[Journal Article] Purification and functional characterization of diadenosine 5', 5'''-P1,P4-tetraphosphate phosphorylases from Mycobacterium smegmatis and Mycobacterium avium.2015
- Author(s)
  Naoko Honda, Hyun Kim, Emiko Rimbara, Atsushi Kato, Keigo Shibayama, Shigetarou Mori
- Journal Title
  
  Protein Expression and Purification
  
  Volume: 112 Pages: 37-42
- DOI
  10.1016/j.pep.2015.04.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23790490, KAKENHI-PROJECT-24780088, KAKENHI-PROJECT-25860329, KAKENHI-PROJECT-15K07377
[Journal Article] Characterization of Campylobacter jejuni DNA gyrase as the target of quinolones2015
- Author(s)
  Ruchirada Changkwanyeun, Masaru Usui, Siriporn Kongsoi, Kazumasa Yokoyama, Hyun Kim, Orasa Suthienkul, Kanjana Changkaew, Chie Nakajima, Yutaka Tamura, Yasuhiko Suzuki
- Journal Title
  
  Journal of infection and chemotherpy
  
  Volume: 21;8 Issue: 8 Pages: 604-609
- DOI
  10.1016/j.jiac.2015.05.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860329
[Journal Article] What Hansen's disease research learned from tuberculosis research: from molecular biological aspect2014
- Author(s)
  Yasuhiko Suzuki, Tomoyuki Yamaguchi, Hyun Kim, Kazumasa Yokoyama, Chie, Nakayama
- Journal Title
  
  Nihon Hansenbyo Gakkai Zasshi
  
  Volume: 83;3 Pages: 21-27
- NAID
  130005169024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860329
[Journal Article] Functional analysis of the receptor binding domain of SARS coronavirus S1 region and its monoclonal antibody2014
- Author(s)
  Hyun Kim, Yeongjin Hong, Keigo Shibayama, Yasuhiko Suzuki, Nobutaka Wakamiya, Youn Uck Kim
- Journal Title
  
  Genes & Genomics
  
  Volume: 36;3 Issue: 3 Pages: 387-397
- DOI
  10.1007/s13258-014-0186-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860329, KAKENHI-PROJECT-26293124, KAKENHI-PROJECT-26670489
[Journal Article] Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide2014
- Author(s)
  Kim H, Shibayama K, Rimbara E, Mori S
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 6 Pages: 1-11
- DOI
  10.1371/journal.pone.0100062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24780088, KAKENHI-PROJECT-25860329
[Journal Article] Roles of Ala-149 in the catalytic activity of diadenosine tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv2014
- Author(s)
  Mori S, Kim H, Rimbara E, Arakawa Y, Shibayama K
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 79 Issue: 2 Pages: 236-238
- DOI
  10.1080/09168451.2014.973364
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24780088, KAKENHI-PROJECT-25860329
[Presentation] Antimicrobial resistance in Helicobacter cinaedi2020
- Author(s)
  Emiko Rimbara, Shigetarou Mori, Hyun Kim, Masato Suzuki, Keigo Shibayama
- Organizer
  第93回日本細菌学会・総会
- Data Source
  KAKENHI-PROJECT-17K15695
[Presentation] Crystal structure of a diadenosine tetraphosphate phosphorylase from Mycobacterium avium2020
- Author(s)
  森茂太郎，本田尚子，金玄，林原絵美子，柴山恵吾
- Organizer
  第93回日本細菌学会・総会
- Data Source
  KAKENHI-PROJECT-17K15695
[Presentation] BFF122 shows inhibitory activities against Mycobacterium tuberculosis and M. leprae DNA gyrases2020
- Author(s)
  Hyun Kim, Yumi Maeda, Emiko Rimbara, Keigo Shibayama, Toshiki Tamura, Shigetarou Mori
- Organizer
  第93回日本細菌学会・総会
- Data Source
  KAKENHI-PROJECT-17K15695
[Presentation] Transcriptomic change by knockout of genes involving DNA modifications in Helicobacter cineadi2019
- Author(s)
  Emiko Rimbara, Atsushi Toyoda, Shigetarou Mori, Hyun Kim, Keigo Shibayama
- Organizer
  第92回日本細菌学会・総会
- Data Source
  KAKENHI-PROJECT-17K15695
[Presentation] Functional analysis of M. leprae DNA gyrase and its role in bacterial growth and survival2019
- Author(s)
  Hyun Kim, Yasuo Fukutomi, Chie Nakajima, Youn Uck Kim, Shigetarou Mori, Keigo Shibayama, Naboru Nakata, Yasuhiko Suzuki
- Organizer
  第92回日本細菌学会・総会
- Data Source
  KAKENHI-PROJECT-17K15695
[Presentation] Functional analysis of KatG mutations associated with isoniazid-resistance in M. tuberculosis2018
- Author(s)
  Hyun Kim, Ruwen Jou, Shigetarou Mori, Emiko Rimbara, Keigo Shibayama
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K15695
[Presentation] Whole-genome phylogenetic analysis of Helicobacter cinaedi including isolates from nosocomial infection2018
- Author(s)
  Emiko Rimbara, Masato Suzuki, Koji Yahara, Shigetarou Mori, Hyun Kim, Keigo Shibayama
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K15695
[Presentation] Novel inhibitors of diadenosine tetraphosphate phosphorylase and their antituberculosis activity2016
- Author(s)
  Shigetarou Mori, Naoko Honda, Hyun Kim, Emiko Rimbara, and Keigo Shibayama
- Organizer
  第89回日本細菌学会
- Place of Presentation
  大阪市
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-25860329
[Presentation] Identification of katG gene mutations associated with isoniazid-resistant Mycobacterium tuberculosis2016
- Author(s)
  Hyun Kim, Shigetarou Mori, Ruwen Jou, Emiko Rimbara, Keigo Shibayama
- Organizer
  第89回日本細菌学会
- Place of Presentation
  大阪
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-25860329
[Presentation] katG遺伝子上で新たに見出された変異とイソニアジド耐性化との関連2016
- Author(s)
  金玄、森茂太郎、林原絵美子、柴山恵吾
- Organizer
  第89回日本ハンセン病学会・総会
- Place of Presentation
  群馬県
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-25860329
[Presentation] Clarification of Correlation Between Mutants DNA GyrA and Quinolone Resistance in M. tuberculosis2014
- Author(s)
  金　玄、横山和正、中島千絵、森茂太郎、柴山恵吾、鈴木定彦
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京都江戸川区（タワーホール船堀）
- Data Source
  KAKENHI-PROJECT-25860329
[Presentation] 結核菌DNAジャイレースにおけるキノロン耐性決定領域外に見出されたアミノ酸置換のキノロン剤耐性への影響2013
- Author(s)
  金　玄、横山和正、中島千絵、鈴木定彦
- Organizer
  第86回日本ハンセン病学会
- Place of Presentation
  大宮市（大宮ソニックシティ）
- Data Source
  KAKENHI-PROJECT-25860329
[Presentation] Clarification of Correlation Between Mutations on DNA Gyrase A subunit and Quinolone Resistance in Mycobacterium tuberculosis2013
- Author(s)
  金　玄、横山和正、中島千絵、鈴木定彦
- Organizer
  第86回日本ハンセン病学会
- Place of Presentation
  大宮市（大宮ソニックシティ）
- Data Source
  KAKENHI-PROJECT-25860329
[Presentation] Enzymatic activities of Quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv2013
- Author(s)
  金　玄、森茂太郎、林原恵美子、柴山恵吾
- Organizer
  Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC）
- Place of Presentation
  アメリカ・デンバー
- Data Source
  KAKENHI-PROJECT-25860329
[Presentation] Characterization of QAPRTase From M. tuberculosis H37Rv And Inhibition of Its Activity by Pyrazinamide
- Author(s)
  金玄, 森茂太郎, 林原絵美子,柴山恵吾
- Organizer
  第87回ハンセン病学会・総会
- Place of Presentation
  所沢市
- Year and Date
  2014-09-29 – 2014-09-30
- Data Source
  KAKENHI-PROJECT-25860329
[Presentation] nzymatic Activity of Quinolinic Acid Phosphoribosyltransferase From Mycobacterium tuberculosis H37Rv And Inhibition of Its Activity by Pyrazinamide
- Author(s)
  Hyun Kim, Shigetarou Mori, Emiko Rimbara, and Keigo Shibayama
- Organizer
  International Union of Microbiological Societies Congresses (IUMS)
- Place of Presentation
  カナダ・モントリオール
- Year and Date
  2014-07-27 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-25860329

1. 本田尚子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 森茂太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

KIM HYUN 金 玄

金 玄 キム ヒュン

Kim Hyun 金 玄

Research Projects

Research Products

Co-Researchers

Functional analysis and characterization of KatG mutations associated with isoniazid-resistant Mycobacterium tuberculosis and their crystal structuresPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional and structural analysis of DNA gyrase from Beijing strain M. tuberculosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] WQ-3810: A new fluoroquinolone with a high potential against fluoroquinolone-resistant Mycobacterium tuberculosis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] WQ-3810 inhibits DNA gyrase activity in ofloxacin-resistant Mycobacterium leprae2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA gyrase could be a crucial regulatory factor for growth and survival of Mycobacterium leprae2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutations in Genes Encoding Penicillin-Binding Proteins and Efflux Pumps Play a Role in β-Lactam Resistance in Helicobacter cinaedi2018

Author(s)

Journal Title

Data Source

[Journal Article] Impact of mutations in DNA gyrase genes on quinolone resistance in Campylobacter jejuni2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Purification and functional characterization of diadenosine 5', 5'''-P1,P4-tetraphosphate phosphorylases from Mycobacterium smegmatis and Mycobacterium avium.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of Campylobacter jejuni DNA gyrase as the target of quinolones2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] What Hansen's disease research learned from tuberculosis research: from molecular biological aspect2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Functional analysis of the receptor binding domain of SARS coronavirus S1 region and its monoclonal antibody2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of Ala-149 in the catalytic activity of diadenosine tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] Antimicrobial resistance in Helicobacter cinaedi2020

Author(s)

Organizer

Data Source

[Presentation] Crystal structure of a diadenosine tetraphosphate phosphorylase from Mycobacterium avium2020

Author(s)

Organizer

Data Source

KIM HYUN 金玄

金玄キムヒュン

Kim Hyun 金玄