YAMAWAKI KAORU 山脇芳

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Yamawaki Kaoru 山脇芳

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Researcher Number	90650622
Other IDs
Affiliation (Current)	2026: 新潟大学, 医歯学総合研究科, 客員研究員
Affiliation (based on the past Project Information) *help	2019 – 2024: 新潟大学, 医歯学総合病院, 助教 2018: 国立研究開発法人国立がん研究センター, 研究所, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator がん幹細胞 / 卵巣がん / ペントースリン酸経路 / プラチナ抵抗性 / 3次元培養 / NRF2 / G6PD / 3次元培養系 / 抗がん剤耐性 / 治療抵抗性 / 腹膜播種

3次元がん幹細胞培養系を用いた卵巣がん幹細胞のプラチナ抵抗性獲得機序の解明Principal Investigator
- Principal Investigator
  
  山脇芳
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Niigata University
Elucidation of the mechanism of chemoresistance in ovarian cancer stem cells based on the pentose phosphate pathway.Principal Investigator
- Principal Investigator
  
  Yamawaki Kaoru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Niigata University
Elucidation of the promotion mechanism of ovarian cancer peritoneal dissemination using a three-dimensional cancer stem cell culture systemPrincipal Investigator
- Principal Investigator
  
  Yamawaki Kaoru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Niigata University
  National Cancer Center Japan

All 2024 2023 2021 2019

All Journal Article Presentation Book

[Book] 患者由来がんモデルを用いたがん研究実践ガイド2019
- Author(s)
  山脇芳、大畑広和、岡本康司
- Total Pages
  294
- Publisher
  羊土社
- ISBN
  9784758122429
- Data Source
  KAKENHI-PROJECT-18K16786
[Journal Article] Glycolysis-mTORC1 crosstalk drives proliferation of patient-derived endometrial cancer spheroid cells with ALDH activity2024
- Author(s)
  Ueda Haruka、Ishiguro Tatsuya、Mori Yutaro、Yamawaki Kaoru、Okamoto Koji、Enomoto Takayuki、Yoshihara Kosuke
- Journal Title
  
  Cell Death Discovery
  
  Volume: 10 Issue: 1 Pages: 435-435
- DOI
  10.1038/s41420-024-02204-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09490, KAKENHI-PROJECT-22K09635, KAKENHI-PROJECT-23K08794, KAKENHI-PROJECT-24K12575
[Journal Article] Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1α and tumor progression of clear cell ovarian cancer2024
- Author(s)
  Yutaro Mori、Yoshie Okimoto、Hiroaki Sakai、Yusuke Kanda、Hirokazu Ohata、Daisuke Shiokawa、Mikiko Suzuki、Hiroshi Yoshida、Haruka Ueda、Tomoyuki Sekizuka、Ryo Tamura、Kaoru Yamawaki、Tatsuya Ishiguro、Yasushi Yatabe、Akinobu Hamada、Kosuke Yoshihara、Takayuki Enomoto、Koji Okamoto et al.
- Journal Title
  
  Cell Reports Medicine
  
  Volume: － Issue: 5 Pages: 101532-101532
- DOI
  10.1016/j.xcrm.2024.101532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21K09490, KAKENHI-PROJECT-22K07037, KAKENHI-PROJECT-22K09635, KAKENHI-PROJECT-23K27389, KAKENHI-PROJECT-23K08794, KAKENHI-PROJECT-24K10319, KAKENHI-PROJECT-24K19687
[Journal Article] 医薬品開発におけるがん患者由来非臨床モデル卵巣がんスフェロイド細胞を用いた抗がん剤奏効性の解析2024
- Author(s)
  山脇芳、岡本康司
- Journal Title
  
  Drug Delivery System (Drug Delivery System)
  
  Volume: 39 Pages: 165-173
- Data Source
  KAKENHI-PROJECT-23K08794
[Journal Article] SLFN11 is a <i>BRCA</i> Independent Biomarker for the Response to Platinum-Based Chemotherapy in High-Grade Serous Ovarian Cancer and Clear Cell Ovarian Carcinoma2023
- Author(s)
  Akashi Hidehiko、Yachida Nozomi、Ueda Haruka、Yamaguchi Manako、Yamawaki Kaoru、Tamura Ryo、Suda Kazuaki、Ishiguro Tatsuya、Adachi Sosuke、Nagase Yoshikazu、Ueda Yutaka、Ueda Masashi、Abiko Kaoru、Kagabu Masahiro、Baba Tsukasa、Nakaoka Hirofumi、Enomoto Takayuki、Murai Junko、Yoshihara Kosuke
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 23 Issue: 1 Pages: 106-116
- DOI
  10.1158/1535-7163.mct-23-0257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16431, KAKENHI-PROJECT-22K09635, KAKENHI-PROJECT-23K08794, KAKENHI-PROJECT-23K08859, KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-21K16810, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K27447, KAKENHI-PROJECT-23K27459
[Journal Article] Integrative analyses of gene expression and chemosensitivity of patient-derived ovarian cancer spheroids link G6PD-driven redox metabolism to cisplatin chemoresistance.2021
- Author(s)
  Yamawaki K, Mori Y Sakai H, Kanda Y, Shiokawa D, Ueda U, Ishiguro T, Yoshihara K, Nagasaka K, Onda T, Kato T, Kondo T, Enomoto T, *Okamoto K.
- Journal Title
  
  Cancer Lett.
  
  Volume: 521 Pages: 29-38
- DOI
  10.1016/j.canlet.2021.08.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03081, KAKENHI-PROJECT-19K09834, KAKENHI-PROJECT-20K16230, KAKENHI-PROJECT-20K18214
[Journal Article] MCM10 compensates for Myc‐induced DNA replication stress in breast cancer stem‐like cells2021
- Author(s)
  Murayama Takahiko、Takeuchi Yasuto、Li Mengjiao、Marcela Rojas‐Chaverra N.、Nishimura Tatsunori、Ikeda Kazuhiro、Horie‐Inoue Kuniko、Inoue Satoshi、Seki Masahide、Suzuki Yutaka、Sugano Sumio、Enomoto Takayuki、Tanabe Masahiko、Tada Kei‐ichiro、Okamoto Koji、Tojo Arinobu、Gotoh Noriko
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 3 Pages: 1209-1224
- DOI
  10.1111/cas.14776
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02679, KAKENHI-PROJECT-20H03734, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19K22557, KAKENHI-PUBLICLY-20H05029, KAKENHI-PROJECT-21H02761, KAKENHI-PROJECT-20K18214, KAKENHI-PROJECT-21K15501, KAKENHI-PROJECT-21H04719
[Presentation] 卵巣がんはグルコース-6-リン酸脱水素酵素の誘導によりシスプラチン抵抗性を獲得する。2019
- Author(s)
  山脇　芳、森　裕太郎、石黒　竜也、大畑　広和、榎本　隆之、岡本　康司
- Organizer
  第7回　がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-18K16786

1. YOSHIHARA Kousuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. TADA Keiichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 榎本隆之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 岡本康司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 加藤友康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 石黒竜也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 鈴木穣

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 浜田道昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 森宙史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 安彦郁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 東條有伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 後藤典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAWAKI KAORU 山脇 芳

Yamawaki Kaoru 山脇 芳

Research Projects

Research Products

Co-Researchers

3次元がん幹細胞培養系を用いた卵巣がん幹細胞のプラチナ抵抗性獲得機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of chemoresistance in ovarian cancer stem cells based on the pentose phosphate pathway.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the promotion mechanism of ovarian cancer peritoneal dissemination using a three-dimensional cancer stem cell culture systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 患者由来がんモデルを用いたがん研究実践ガイド2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Glycolysis-mTORC1 crosstalk drives proliferation of patient-derived endometrial cancer spheroid cells with ALDH activity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1α and tumor progression of clear cell ovarian cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 医薬品開発におけるがん患者由来非臨床モデル 卵巣がんスフェロイド細胞を用いた抗がん剤奏効性の解析2024

Author(s)

Journal Title

Data Source

[Journal Article] SLFN11 is a <i>BRCA</i> Independent Biomarker for the Response to Platinum-Based Chemotherapy in High-Grade Serous Ovarian Cancer and Clear Cell Ovarian Carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Integrative analyses of gene expression and chemosensitivity of patient-derived ovarian cancer spheroids link G6PD-driven redox metabolism to cisplatin chemoresistance.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MCM10 compensates for Myc‐induced DNA replication stress in breast cancer stem‐like cells2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 卵巣がんはグルコース-6-リン酸脱水素酵素の誘導によりシスプラチン抵抗性を獲得する。2019

Author(s)

Organizer

Data Source

YAMAWAKI KAORU 山脇芳

Yamawaki Kaoru 山脇芳

[Journal Article] 医薬品開発におけるがん患者由来非臨床モデル卵巣がんスフェロイド細胞を用いた抗がん剤奏効性の解析2024