Akiyama Tomohito 秋山智人

… Alternative Names

秋山智人アキヤマトモヒト

AKIYAMA Tomohito 秋山智人

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Researcher Number	90710319
Affiliation (Current)	2025: 昭和医科大学, 歯学部, 兼任講師
Affiliation (based on the past Project Information) *help	2017: 昭和大学, 歯学部, 助教 2013 – 2014: 昭和大学, 歯学部, 助教
Review Section/Research Field	Principal Investigator Prosthodontics/ Dental materials science and Except Principal Investigator Prosthodontics/ Dental materials science and / Functional basic dentistry
Keywords	Principal Investigator gingipain / OPG / p.gingivalis / P.gingivalis / protease / periodontitis / Porphyromonas gingivalis Except Principal Investigator iPS細胞 / 化合物ライブラリー / セロトニン神経系 … More / 5-HT2A受容体 / HTR2A / セロトニン / iPSC / 遺伝子多型 / セロトニン2A受容体 / 睡眠時ブラキシズム / 疾患特異的iPS細胞 / タンパク質分解酵素 / 骨 / ジンジパイン / 骨代謝 / プロテアーゼ / 破骨細胞 / 歯周病 Less

Development of disease-modifying drugs for sleep bruxism using iPS cell
- Principal Investigator
  
  Baba Kazuyoshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Showa University
A basic research aimed to develop nevel preventive and therapeutic measures for alveolar bone loss in periodontitisPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Tomohito
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Showa University
The role of lysine-specific gingipain in inflammatory bone loss in periodontitis.
- Principal Investigator
  
  MIYAMOTO Yoichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University

All 2014 2013 2012

All Journal Article Presentation

[Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor and interleukin-1 but suppresses that by interleukin-17: Importance of proteolytic degradation of osteoprotegerin by lysine gingipain.2014
- Author(s)
  Tomohito Akiyama, Yoichi Miyamoto, Kentaro Yoshimura, Atsushi Yamada, Masamichi Takami, Tetsuo Suzawa, Marie Hoshino, Takahisa Imamura, Chie Akiyama, Rika Yasuhara, Kenji Mishima, Toshifumi Maruyama, Chikara Kohda, Kazuo Tanaka, Jan Potempa, Hisataka Yasuda, Kazuyoshi Baba, Ryutaro Kamijo.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 289 Issue: 22 Pages: 1-35
- DOI
  10.1074/jbc.m113.520510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591876, KAKENHI-PROJECT-23592748, KAKENHI-PROJECT-24592813, KAKENHI-PROJECT-24592815, KAKENHI-PROJECT-24592817, KAKENHI-PROJECT-24659830, KAKENHI-PROJECT-24791983, KAKENHI-PROJECT-25460498, KAKENHI-PROJECT-26293398, KAKENHI-PROJECT-26461928, KAKENHI-PROJECT-26670813, KAKENHI-PROJECT-26861558
[Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.2014
- Author(s)
  Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R
- Journal Title
  
  The Journal Of Biological Chemistry
  
  Volume: 289 Pages: 15621-15630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25893241
[Journal Article] Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes2013
- Author(s)
  Maruyama T, Miyamoto Y, Yamamoto G, Yamada A, Yoshimura K, Suzawa T, Takami M, Akiyama T, Hoshino M, Iwasa F, Ikumi N, Tachikawa T, Mishima K, Baba K, Kamijo R
- Journal Title
  
  PLoS ONE
  
  Volume: Vol.8 Issue: 2 Pages: e56984-e56984
- DOI
  10.1371/journal.pone.0056984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390426, KAKENHI-PROJECT-23592718, KAKENHI-PROJECT-23592748, KAKENHI-PROJECT-24592813, KAKENHI-PROJECT-24592815, KAKENHI-PROJECT-24592817, KAKENHI-PROJECT-24659830, KAKENHI-PROJECT-24791985, KAKENHI-PROJECT-25462874
[Presentation] 歯周病原菌の毒素による破骨細胞分化の促進.2014
- Author(s)
  秋山智人，安原理佳，宮本洋一，今村隆寿，馬場一美，美島健二，上條竜太郎
- Organizer
  第14回東京骨関節フォーラム
- Place of Presentation
  東京
- Year and Date
  2014-07-19
- Data Source
  KAKENHI-PROJECT-24592817
[Presentation] 歯周病原菌由来リシン特異的ジンジパインはオステオプロテゲリンを優先的に分解しTNF-αおよびIL-1βによる破骨細胞分化を促進する．2012
- Author(s)
  秋山智人，宮本洋一，山田篤，高見正道，吉村健太郎，星野真理江，宮本尚，槇宏太郎，馬場一美，上條竜太郎
- Organizer
  第54回歯科基礎医学会学術大会・総会
- Place of Presentation
  郡山
- Data Source
  KAKENHI-PROJECT-24592817
[Presentation] Monocarboxylate transporter-1はBMP-2刺激後のSmad1のリン酸化に関与することで骨芽細胞分化を正に制御する．2012
- Author(s)
  吉村健太郎，宮本洋一，星野真理江，秋山智人，塚崎雅之，山田　篤，高見正道，須澤徹夫，馬場一美，上條竜太郎
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592817
[Presentation] Importance of proteolytic degradation of osteoprotegerin by lysine-specific gingipain in periodontal osteoclastogenesis.2012
- Author(s)
  Akiyama T, Miyamoto Y, Yamada A, Takami M, Yasuhara R, Yoshimura K, Hoshino M, Maruyama T, Mishima K, Baba K, Kamijo R
- Organizer
  ASBMR 2012 Annual Meeting
- Place of Presentation
  Minneapolis, MN, USA
- Data Source
  KAKENHI-PROJECT-24592817

1. MIYAMOTO Yoichi (20295132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. TAKAMI Masamichi (80307058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. IMAMURA Takahisa (20176499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Baba Kazuyoshi (80251536)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKABA Masayuki (30384192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ABE Yuka (80614156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YOSHIDA Yuya (60783298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TOZAWA Yurie (70783356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 美島健二 (50275343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 赤松和土 (60338184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 田中準一 (40710166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 松本貴志 (00635039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 菅沼岳史 (10196694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKAMURA Hirotaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAZATO Yukari

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAKAI Kento

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田中和生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 上條竜太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akiyama Tomohito 秋山 智人

秋山 智人 アキヤマ トモヒト

AKIYAMA Tomohito 秋山 智人

Research Projects

Research Products

Co-Researchers

Development of disease-modifying drugs for sleep bruxism using iPS cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A basic research aimed to develop nevel preventive and therapeutic measures for alveolar bone loss in periodontitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of lysine-specific gingipain in inflammatory bone loss in periodontitis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor and interleukin-1 but suppresses that by interleukin-17: Importance of proteolytic degradation of osteoprotegerin by lysine gingipain.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.2014

Author(s)

Journal Title

Data Source

[Journal Article] Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] 歯周病原菌の毒素による破骨細胞分化の促進.2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 歯周病原菌由来リシン特異的ジンジパインはオステオプロテゲリンを優先的に分解しTNF-αおよびIL-1βによる破骨細胞分化を促進する．2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Monocarboxylate transporter-1はBMP-2刺激後のSmad1のリン酸化に関与することで骨芽細胞分化を正に制御する．2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Importance of proteolytic degradation of osteoprotegerin by lysine-specific gingipain in periodontal osteoclastogenesis.2012

Author(s)

Organizer

Place of Presentation

Data Source

Akiyama Tomohito 秋山智人

秋山智人アキヤマトモヒト

AKIYAMA Tomohito 秋山智人