ISONO Mayu 磯野真由

Researcher Number	90713511
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 薬学部(芝共立), 研究員
Affiliation (based on the past Project Information) *help	2024: 慶應義塾大学, 薬学部(芝共立), 研究員 2021 – 2022: 名古屋大学, 環境医学研究所, 客員研究者 2019 – 2020: 名古屋大学, 環境医学研究所, 特任助教 2018: 長崎大学, 原爆後障害医療研究所, 特任研究員 2016 – 2017: 公益財団法人佐々木研究所, 附属研究所, 研究員(移行) 2013 – 2015: 群馬大学, 重粒子線医学推進機構, 研究員
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related / Radiation science / Risk sciences of radiation and chemicals
Keywords	Principal Investigator DNA二本鎖切断修復 / DNA二本鎖切断 / DNA修復 / 放射線 / 炎症性サイトカイン / 転写 / RNAポリメラーゼ / ユビキチン化 / RNAポリメラーゼⅡ / ヒストン修飾 … More / DSB修復経路選択 / 53BP1 repositioning / DSB修復経路 / ATR活性 / 53BP1 / DSB修復 / 超高解像度顕微鏡 / ゲノム不安定性 / 染色体異常 / 重粒子線 / DNAクラスター損傷 / 細胞死 / 増殖 / 炭素線 / X線 / 神経膠芽種細胞 / アポトーシス / ネクローシス / 脳腫瘍細胞 / 神経幹細胞 Less

放射線照射により惹起される炎症性サイトカイン存在下でのDNA修復能の検討Principal Investigator
- Principal Investigator
  
  磯野真由
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Keio University
RNAポリメラーゼIIのDNA二本鎖切断修復機構への関与の解明Principal Investigator
- Principal Investigator
  
  磯野真由
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Nagoya University
Regulation of 53BP1 repositioning and foci formation during homologous recombinationPrincipal Investigator
- Principal Investigator
  
  ISONO Mayu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Nagoya University
  Nagasaki University
  Sasaki Foundation
Visualization of heavy-ion induced clustered DNA double strand break formation using super-resolution microscopyPrincipal Investigator
- Principal Investigator
  
  Isono Mayu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Sasaki Foundation
  Gunma University
The measurement of cell death in human neural stem cells and glioblastoma cellsPrincipal Investigator
- Principal Investigator
  
  ISONO Mayu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Radiation science
- Research Institution
  Gunma University

All 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] DNA Fragment Agarose Gel Electrophoresis for Chromatin Immunoprecipitation (ChIP)2020
- Author(s)
  Isono M, Hashimoto S.
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2119 Pages: 201-211
- DOI
  10.1007/978-1-0716-0323-9_17
- ISBN
  9781071603222, 9781071603239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K12821
[Journal Article] Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair2020
- Author(s)
  Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T
- Journal Title
  
  Cell
  
  Volume: 19 Issue: 6 Pages: 1228-1244
- DOI
  10.1016/j.cell.2020.02.010
- NAID
  120006871293
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K08508, KAKENHI-PROJECT-18K11639, KAKENHI-PROJECT-18K19585, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-18H03974, KAKENHI-PROJECT-17H01877, KAKENHI-PROJECT-18H03372, KAKENHI-PROJECT-16H06151, KAKENHI-PROJECT-17K12821, KAKENHI-PROJECT-19K21221
[Journal Article] DNA二本鎖切断修復経路を最適化する時空間的制御機構2018
- Author(s)
  磯野真由, 柴田淳史
- Journal Title
  
  放射線生物研究
  
  Volume: 53 Pages: 116-131
- NAID
  40021642264
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K12821
[Journal Article] BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation2017
- Author(s)
  Mayu Isono, Atsuko Niimi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano, Atsushi Shibata
- Journal Title
  
  Cell Reports
  
  Volume: 18 Issue: 2 Pages: 520-532
- DOI
  10.1016/j.celrep.2016.12.042
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02816, KAKENHI-PROJECT-16H04739, KAKENHI-PROJECT-16H05888, KAKENHI-PROJECT-26701005, KAKENHI-PROJECT-15K15449, KAKENHI-PROJECT-26650002, KAKENHI-PROJECT-26670549, KAKENHI-PROJECT-15K09988, KAKENHI-PROJECT-15K15447, KAKENHI-PLANNED-25116004, KAKENHI-PROJECT-26241014
[Journal Article] The EGFR mutation status affects the relative biological effectiveness of carbon-ion beams in non-small cell lung carcinoma cells.2015
- Author(s)
  Amornwichet N, Oike T, Shibata A, Nirodi CS, Ogiwara H, Makino H, Kimura Y, Hirota Y, Isono M, Yoshida Y, Ohno T, Kohno T, Nakano T.
- Journal Title
  
  Sci Rep.
  
  Volume: 11 Issue: 1 Pages: 11305-11305
- DOI
  10.1038/srep11305
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09988, KAKENHI-PROJECT-15K15449, KAKENHI-PROJECT-26670549, KAKENHI-PROJECT-26830122, KAKENHI-PROJECT-25861066, KAKENHI-PROJECT-24390288, KAKENHI-PROJECT-26701005
[Journal Article] Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells.2015
- Author(s)
  Isono M, Yoshida Y, Takahashi A, Oike T, Shibata A, Kubota Y, Kanai T, Ohno T, Nakano T.
- Journal Title
  
  J Radiat Res.
  
  Volume: 56 Issue: 5 Pages: 856-861
- DOI
  10.1093/jrr/rrv033
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09988, KAKENHI-PROJECT-15K15449, KAKENHI-PROJECT-26670549, KAKENHI-PROJECT-24390288, KAKENHI-PROJECT-26701005
[Journal Article] Carbon-ion beams induce production of an immune mediator protein, high mobility group box 1, at levels comparable with X-ray irradiation.2015
- Author(s)
  Yoshimoto Y, Oike T, Okonogi N, Suzuki Y, Ando K, Sato H, Noda SE, Isono M, Mimura K, Kono K, Nakano T.
- Journal Title
  
  Jornal of Radiation Research
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25893030
[Journal Article] Carbon-Ion Beam Irradiation Kills X-Ray-Resistant p53-Null Cancer Cells by Inducing Mitotic Catastrophe2014
- Author(s)
  Amornwichet N, Oike T, Shibata A, Ogiwara H, Tsuchiya N, Yamauchi M, Saitoh Y, Sekine R, Isono M, Yoshida Y, Ohno T, Kohno T, Nakano T
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 12 Pages: e115121-e115121
- DOI
  10.1371/journal.pone.0115121
- NAID
  120006986291
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-24791275, KAKENHI-PROJECT-25861066, KAKENHI-PROJECT-25893030, KAKENHI-PROJECT-26670549, KAKENHI-PROJECT-26701005, KAKENHI-PROJECT-26830122
[Journal Article] Nonhomologous end-joining repair plays a more important role than homologous recombination repair in defining radiosensitivity after exposure to high-LET radiation.2014
- Author(s)
  Takahashi A, Kubo M, Ma H, Nakagawa A, Yoshida Y, Isono M, Kanai T, Ohno T, Furusawa Y, Funayama T, Kobayashi Y, Nakano T.
- Journal Title
  
  Radiat Res.
  
  Volume: 182 Issue: 3 Pages: 338-344
- DOI
  10.1667/rr13782.1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791275, KAKENHI-PROJECT-25893030
[Presentation] ChIP-seqを利用したDNA損傷およびヌクレオチド除去修復のモニタリング.2019
- Author(s)
  原雄一郎, 中沢由華, 岡泰由, 小峯起, Diana van den Heuvel, 郭朝万, 大学保一, 磯野真由, 何予希, 嶋田繭子, 加藤香奈, 賈楠, 橋下悟, 小谷祐子, 三好由夏, 田中都, 祖父江顕, 光武範吏, 菅波孝祥, 増田章男, 大野欽司, 中田慎一郎, 真下知士, 山中宏二, Martijn S. Luijsterburg, 荻朋男.
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K12821
[Presentation] 転写共役ヌクレオチド除去修復機構に重要なRNAポリメラーゼユビキチン化部位の同定.2019
- Author(s)
  中沢由華, 原雄一郎, 岡泰由, 小峯起, Diana van den Heuvel, 郭朝万, 大学保一, 磯野真由, 何予希, 嶋田繭子, 加藤香奈, 賈楠, 橋下悟, 小谷祐子, 三好由夏, 田中都, 祖父江顕, 光武範吏, 菅波孝祥, 増田章男, 大野欽司, 中田慎一郎, 真下知士, 山中宏二, Martijn S. Luijsterburg, 荻朋男.
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K12821
[Presentation] 相同組換え修復への経路切り替えを促進する時空間的53BP1動態制御機構2018
- Author(s)
  磯野真由, 萩原慶彦, 佐藤浩央, 尾池貴洋, 西良太郎, 中田慎一郎, 中野隆史, 鈴木啓司, 柴田淳史
- Organizer
  日本放射線影響学会第61回大会
- Data Source
  KAKENHI-PROJECT-17K12821
[Presentation] 炭素イオン線誘発DNA二本鎖切断の修復経路選択における線エネルギー付与の効果2016
- Author(s)
  萩原慶彦，磯野真由，新美敦子，尾池貴洋，佐藤浩央，中野隆史，柴田淳史
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市, 神奈川県
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K15449
[Presentation] The effect of Linear Energy Transfer in DNA double strand break repair pathway choice in G2 cells2016
- Author(s)
  Yoshihiko Hagiwara, Atsuko Niimi, Mayu Isono, Takahiro Oike, Hiro Sato, Takashi Nakano and Atsushi Shibata
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  Matsue, Shimane, Japan
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15449
[Presentation] BRCA1 directs the repair pathway to homologous recombination　by promoting 53BP1 dephosphorylation2016
- Author(s)
  Mayu Isono, Atsuko Niimi, Yoshihiko Hagiwara, Ryotaro Nishi, Shinya Isobe,　Chikashi Obuse, Elena Petricci, Shinichiro Nakada, Takashi Nakano and Atsushi Shibata
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  Matsue, Shimane, Japan
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15449
[Presentation] The complexity of damage at the DNA break ends induces rapid DNA double strand break resection2015
- Author(s)
  磯野真由
- Organizer
  ICRR2015
- Place of Presentation
  国立京都国際会議場(京都市)
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15449
[Presentation] 増殖率と細胞死を指標としたヒト神経幹細胞と神経膠芽腫細胞におけるX線と炭素線の感受性2015
- Author(s)
  磯野真由、吉田由香里、八高知子、高橋昭久、尾池貴洋、柴田淳史、久保田佳樹、金井達明、大野達也、中野隆史
- Organizer
  第５回国際放射線神経生物学会
- Place of Presentation
  高崎シティーギャラリー（群馬県高崎市）
- Year and Date
  2015-02-21
- Invited
- Data Source
  KAKENHI-PROJECT-25893030
[Presentation] BRCA1によるDSB end resectionの時空間的制御2015
- Author(s)
  磯野真由
- Organizer
  第38回日本分子生物学会・第88回日本生化学会合同大会
- Place of Presentation
  神戸ポートピアホテル　本館 B1F 偕楽1(神戸市)
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K15449
[Presentation] Combination effect of carbon-ion beams and cell cycle regulation inhibitor on cell killing in lung cancer cells2014
- Author(s)
  H Ma, A Takahashi, M Kubo, A Nakagawa, Y Yoshida, M Isono, T Kanai, T Ohno, T Nakano
- Organizer
  The 53rd Annual Conference of the Particle Therapy Co-Operative Group
- Place of Presentation
  Shanghai International Convention Center, Shanghai, China.
- Data Source
  KAKENHI-PROJECT-25893030
[Presentation] 炭素線治療における放射線増感剤の標的候補としてのHRおよびNHEJ2014
- Author(s)
  久保誠, 高橋昭久, 馬洪玉, 中川彰子, 吉田由香里, 磯野真由, 金井達明, 大野達也, 中野隆史
- Organizer
  第16回癌治療増感研究シンポジウム
- Place of Presentation
  奈良文化会館, 奈良市, 奈良県
- Data Source
  KAKENHI-PROJECT-25893030
[Presentation] LET dependence of cell survival parameters in normal human skin cells2014
- Author(s)
  Y Yoshida, M Isono, K Mizohata, T Yakoh, K Ando, T Ohno, T Nakano, T Kanai
- Organizer
  The 53rd Annual Conference of the Particle Therapy Co-Operative Group
- Place of Presentation
  Shanghai International Convention Center, Shanghai, China.
- Data Source
  KAKENHI-PROJECT-25893030
[Presentation] ヒト肺がん細胞の炭素線治療における標的としての細胞周期調節2014
- Author(s)
  馬洪玉, 高橋昭久, 久保誠, 中川彰子, 吉田由香里, 磯野真由, 金井達明, 大野達也, 中野隆史
- Organizer
  第16回癌治療増感研究シンポジウム
- Place of Presentation
  奈良文化会館, 奈良市, 奈良県
- Data Source
  KAKENHI-PROJECT-25893030
[Presentation] Relation between sensitivity to carbon-ion beams and expression of cancer stem cell marker in melanoma cells2014
- Author(s)
  A Takahashi, A Nakagawa, H Ma,Y Yoshida, M Isono, T Kanai, T Ohno, T Nakano
- Organizer
  The 53rd Annual Conference of the Particle Therapy Co-Operative Group
- Place of Presentation
  Shanghai International Convention Center, Shanghai, China.
- Data Source
  KAKENHI-PROJECT-25893030
[Presentation] 放射線増感剤の標的候補としてのDNA二本鎖切断修復によるLET依存的感受性
- Author(s)
  久保誠, 高橋昭久, 馬洪玉, 中川彰子, 吉田由香里, 磯野真由, 古澤佳也, 小林泰彦, 舟山知夫, 金井達明, 大野達也, 中野隆史
- Organizer
  第4回国際放射線神経生物学会
- Place of Presentation
  高崎シティーギャラリー, 高崎市, 群馬県
- Data Source
  KAKENHI-PROJECT-25893030
[Presentation] ヒト肺がん細胞における細胞周期調節阻害剤MK-1775の炭素線増感効果
- Author(s)
  馬洪玉, 高橋昭久, 久保誠, 中川彰子, 吉田由香里, 磯野真由, 金井達明, 大野達也, 中野隆史
- Organizer
  第4回国際放射線神経生物学会
- Place of Presentation
  高崎シティーギャラリー, 高崎市, 群馬県
- Data Source
  KAKENHI-PROJECT-25893030
[Presentation] 相同組換え修復関連Rad51阻害剤B02による温熱増感効果
- Author(s)
  高橋昭久, 馬洪玉, 久保誠, 中川彰子, 小町麻由美, 磯野真由, 吉田由香里
- Organizer
  第18回関東・全身ハイパーサーミア研究会合同学術研究会
- Place of Presentation
  ホテルニューイタヤ, 宇都宮市, 栃木県
- Data Source
  KAKENHI-PROJECT-25893030
[Presentation] 神経幹細胞および神経膠芽腫細胞における増殖率を指標としたX線および炭素線の感受性
- Author(s)
  磯野真由、吉田由香里、八高知子、高橋昭久、尾池貴洋、柴田淳史、金井達明、大野達也、中野隆史
- Organizer
  日本放射線影響学会第５７回大会
- Place of Presentation
  鹿児島県民交流センター（鹿児島県鹿児島市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-25893030
[Presentation] 神経幹細胞と神経膠芽腫細胞の増殖率を指標とした放射線感受性
- Author(s)
  磯野真由, 吉田由香里, 八高知子, 高橋昭久, 大津昌弘, 中山孝, 井上順雄, 金井達明, 中野隆史
- Organizer
  第4回国際放射線神経生物学会
- Place of Presentation
  高崎シティーギャラリー, 高崎市, 群馬県
- Data Source
  KAKENHI-PROJECT-25893030

1. SHIBATA Atsushi (30707633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. YOSHIDA Yukari

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 荻原秀明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 河野隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 新美敦子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 増田章男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISONO Mayu 磯野 真由

Research Projects

Research Products

Co-Researchers

放射線照射により惹起される炎症性サイトカイン存在下でのDNA修復能の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RNAポリメラーゼIIのDNA二本鎖切断修復機構への関与の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of 53BP1 repositioning and foci formation during homologous recombinationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Visualization of heavy-ion induced clustered DNA double strand break formation using super-resolution microscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The measurement of cell death in human neural stem cells and glioblastoma cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] DNA Fragment Agarose Gel Electrophoresis for Chromatin Immunoprecipitation (ChIP)2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] DNA二本鎖切断修復経路を最適化する時空間的制御機構2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The EGFR mutation status affects the relative biological effectiveness of carbon-ion beams in non-small cell lung carcinoma cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Carbon-ion beams induce production of an immune mediator protein, high mobility group box 1, at levels comparable with X-ray irradiation.2015

Author(s)

Journal Title

Data Source

[Journal Article] Carbon-Ion Beam Irradiation Kills X-Ray-Resistant p53-Null Cancer Cells by Inducing Mitotic Catastrophe2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Nonhomologous end-joining repair plays a more important role than homologous recombination repair in defining radiosensitivity after exposure to high-LET radiation.2014

Author(s)

Journal Title

DOI

ISONO Mayu 磯野真由

[Presentation] BRCA1 directs the repair pathway to homologous recombination　by promoting 53BP1 dephosphorylation2016