Nakanishi Hideyuki 中西秀之

Researcher Number	90722885
Other IDs
Affiliation (Current)	2025: 大阪大学, 感染症総合教育研究拠点, 特任講師(常勤) 2025: 東京科学大学, 総合研究院, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京医科歯科大学, 生体材料工学研究所, 助教 2019 – 2021: 東京医科歯科大学, 生体材料工学研究所, プロジェクト助教
Review Section/Research Field	Principal Investigator Basic Section 90120:Biomaterials-related
Keywords	Principal Investigator 翻訳 / 合成生物学 / 遺伝子治療 / mRNA医薬 / 核酸医薬 / mRNA / 受容体 / メッセンジャーRNA / 光遺伝学 / 翻訳制御 … More / 細胞選別 / 人工遺伝子回路 / 発現制御 / 遺伝子発現制御 Less

Signal-responsive translational control of mRNA drugsPrincipal Investigator
- Principal Investigator
  
  中西秀之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo Medical and Dental University
Optical regulation system of mRNA translation with spatiotemporal and cell-type specificityPrincipal Investigator
- Principal Investigator
  
  Nakanishi Hideyuki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2020 2019

All Journal Article Presentation Book Patent

[Book] mRNAの制御機構の解明と治療薬・ワクチンへの活用2023
- Author(s)
  中西秀之、他72名
- Total Pages
  411
- Publisher
  技術情報協会
- ISBN
  9784861049378
- Data Source
  KAKENHI-PROJECT-19K20696
[Book] 核酸科学ハンドブック（「第9章医科学 9.1 細胞システム制御」を担当）2020
- Author(s)
  中西秀之、齊藤博英
- Total Pages
  576
- Publisher
  講談社
- ISBN
  9784065207864
- Data Source
  KAKENHI-PROJECT-19K20696
[Book] 担当記事名: Endogenous Signal-Responsive Transgene Switch Systems for Visualization and Purification of Specific Cells, 書名: Medical Applications of iPS Cells2019
- Author(s)
  Nakanishi Hideyuki、Saito Hirohide
- Total Pages
  190
- Publisher
  Springer
- ISBN
  9789811336720
- Data Source
  KAKENHI-PROJECT-19K20696
[Journal Article] Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery2023
- Author(s)
  Du Xuan、Yada Erica、Terai Yuki、Takahashi Takuya、Nakanishi Hideyuki、Tanaka Hiroki、Akita Hidetaka、Itaka Keiji
- Journal Title
  
  Pharmaceutics
  
  Volume: 15 Issue: 9 Pages: 2291-2291
- DOI
  10.3390/pharmaceutics15092291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K11843
[Journal Article] mRNA医薬とmRNAワクチン2023
- Author(s)
  中西秀之，位髙啓史
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 340-347
- Data Source
  KAKENHI-PROJECT-19K20696
[Journal Article] RNA修飾による炎症回避が，効果的なmRNAワクチンの開発を可能にした2023
- Author(s)
  中西秀之, 位髙啓史
- Journal Title
  
  科学
  
  Volume: 93 Pages: 1065-1069
- Data Source
  KAKENHI-PROJECT-23K11843
[Journal Article] 細胞・臓器選択的な翻訳を可能にするmRNA医薬の設計2023
- Author(s)
  中西秀之
- Journal Title
  
  細胞
  
  Volume: 55 Pages: 876-880
- Data Source
  KAKENHI-PROJECT-23K11843
[Journal Article] Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA2023
- Author(s)
  Zhang Maorui、Fukushima Yuta、Nozaki Kosuke、Nakanishi Hideyuki、Deng Jia、Wakabayashi Noriyuki、Itaka Keiji
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 43 Issue: 1 Pages: 32-32
- DOI
  10.1186/s41232-023-00285-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K11843, KAKENHI-PROJECT-21K16603
[Journal Article] 細胞死誘導タンパク質をコードした合成mRNAによる選択的細胞除去2023
- Author(s)
  中西秀之, 位髙啓史
- Journal Title
  
  バイオマテリアル－生体材料－
  
  Volume: 41 Pages: 332-333
- Data Source
  KAKENHI-PROJECT-23K11843
[Journal Article] Development of Synthetic mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection2023
- Author(s)
  Kendall Free, Hideyuki Nakanishi, Keiji Itaka
- Journal Title
  
  Pharmaceutics
  
  Volume: 15 Issue: 1 Pages: 213-213
- DOI
  10.3390/pharmaceutics15010213
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20696
[Journal Article] mRNA医薬とmRNAワクチン2023
- Author(s)
  中西秀之, 位髙啓史
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 340-347
- Data Source
  KAKENHI-PROJECT-23K11843
[Journal Article] 指定された期間・細胞種において選択的に薬効を発揮するmRNA医薬のための翻訳制御技術2022
- Author(s)
  中西秀之，位髙啓史
- Journal Title
  
  Drug Delivery System
  
  Volume: 37 Pages: 209-220
- Data Source
  KAKENHI-PROJECT-19K20696
[Journal Article] mRNAワクチン・mRNA医薬は何を可能にするのか2022
- Author(s)
  中西秀之，位髙啓史
- Journal Title
  
  ファルマシア
  
  Volume: 58 Pages: 415-419
- Data Source
  KAKENHI-PROJECT-19K20696
[Journal Article] Synthetic mRNA for ex?vivo therapeutic applications2022
- Author(s)
  Nakanishi Hideyuki、Itaka Keiji
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 44 Pages: 100447-100447
- DOI
  10.1016/j.dmpk.2022.100447
- NAID
  210000173115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03776, KAKENHI-PROJECT-19K20696
[Journal Article] Versatile Design of Intracellular Protein-Responsive Translational Regulation System for Synthetic mRNA2022
- Author(s)
  Nakanishi Hideyuki、Saito Hirohide、Itaka Keiji
- Journal Title
  
  ACS Synthetic Biology
  
  Volume: 11 Issue: 3 Pages: 1077-1085
- DOI
  10.1021/acssynbio.1c00567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03776, KAKENHI-PROJECT-19K20696, KAKENHI-PROJECT-20H05626
[Journal Article] A protocol to construct RNA-protein devices for photochemical translational regulation of synthetic mRNAs in mammalian cells2022
- Author(s)
  Hideyuki Nakanishi, Tatsuyuki Yoshii, Shinya Tsukiji, Hirohide Saito
- Journal Title
  
  STAR Protocols
  
  Volume: 3 Issue: 2 Pages: 101451-101451
- DOI
  10.1016/j.xpro.2022.101451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20696, KAKENHI-PROJECT-20H05626
[Journal Article] Purification of Specific Cell Populations Differentiated from Stem Cells Using MicroRNA-Responsive Synthetic Messenger RNAs2021
- Author(s)
  Hideyuki Nakanishi, Hirohide Saito
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2312 Pages: 73-86
- DOI
  10.1007/978-1-0716-1441-9_5
- ISBN
  9781071614402, 9781071614419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K20696, KAKENHI-PROJECT-20H05626
[Journal Article] mRNA医薬・mRNAワクチンの基礎と応用2021
- Author(s)
  中西秀之, 位髙啓史
- Journal Title
  
  実験医学
  
  Volume: 39 Pages: 2693-2701
- Data Source
  KAKENHI-PROJECT-19K20696
[Journal Article] Light-controllable RNA-protein devices for translational regulation of synthetic mRNAs in mammalian cells2021
- Author(s)
  Hideyuki Nakanishi, Tatsuyuki Yoshii, Shunsuke Kawasaki, Karin Hayashi, Keita Tsutsui, Choji Oki, Shinya Tsukiji, Hirohide Saito
- Journal Title
  
  Cell Chemical Biology
  
  Volume: Online ahead of print Issue: 5 Pages: 662-674.e5
- DOI
  10.1016/j.chembiol.2021.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K20696, KAKENHI-PROJECT-15H05722, KAKENHI-PROJECT-20H05626
[Journal Article] Protein-Based Systems for Translational Regulation of Synthetic mRNAs in Mammalian Cells2021
- Author(s)
  Hideyuki Nakanishi
- Journal Title
  
  Life
  
  Volume: 11 Issue: 11 Pages: 1192-1192
- DOI
  10.3390/life11111192
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20696
[Journal Article] Caliciviral protein-based artificial translational activator for mammalian gene circuits with RNA-only delivery2020
- Author(s)
  Nakanishi Hideyuki、Saito Hirohide
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1297-1297
- DOI
  10.1038/s41467-020-15061-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K20696, KAKENHI-PROJECT-15H05722
[Journal Article] Mammalian gene circuits with biomolecule-responsive RNA devices2019
- Author(s)
  Nakanishi Hideyuki、Saito Hirohide
- Journal Title
  
  Current Opinion in Chemical Biology
  
  Volume: 52 Pages: 16-22
- DOI
  10.1016/j.cbpa.2019.04.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K20696, KAKENHI-PROJECT-15H05722
[Patent] ｍＲＮＡの翻訳制御システム2023
- Inventor(s)
  中西秀之、位髙啓史
- Industrial Property Rights Holder
  東京医科歯科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-108509
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K11843
[Patent] タンパク質の翻訳制御システム2021
- Inventor(s)
  中西秀之, 位髙啓史, 齊藤博英
- Industrial Property Rights Holder
  中西秀之, 位髙啓史, 齊藤博英
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-139141
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K20696
[Patent] 生細胞の選別システム2021
- Inventor(s)
  中西秀之, 位髙啓史
- Industrial Property Rights Holder
  中西秀之, 位髙啓史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-139166
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K20696
[Patent] タンパク質翻訳の制御システム2020
- Inventor(s)
  中西秀之, 齊藤博英
- Industrial Property Rights Holder
  中西秀之, 齊藤博英
- Industrial Property Rights Type
  特許
- Patent Publication Number
  2021-122189
- Filing Date
  2020
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-19K20696
[Patent] タンパク質翻訳の制御システム2020
- Inventor(s)
  中西秀之、齊藤博英
- Industrial Property Rights Holder
  中西秀之、齊藤博英
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-015891
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] 状況に応じた翻訳制御ならびに翻訳後制御が可能な新型mRNA医薬の開発2023
- Author(s)
  中西秀之
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K11843
[Presentation] Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA2023
- Author(s)
  MAORUI ZHANG, 福島雄大, 野崎浩佑, 中西秀之, 若林則幸, 位高啓史
- Organizer
  第44回日本炎症・再生医学会 2023年7月12日
- Data Source
  KAKENHI-PROJECT-23K11843
[Presentation] 生体内mRNAデリバリーのための脂質ナノ粒子とナノミセル型キャリアの包括的評価2023
- Author(s)
  Du Xuan, 矢田英理香, 寺井湧貴, 高橋拓也, 中西秀之, 田中浩揮, 秋田英万, 位高啓史
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K11843
[Presentation] Development of extracellular signal-responsive mRNA drugs for controlled translation2023
- Author(s)
  Hideyuki Nakanishi, Keiji Itaka
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-23K11843
[Presentation] Intracellular protein-responsive translational regulation system based on the conditional reconstitution of an artificial translational regulator protein2022
- Author(s)
  中西秀之,齊藤博英,位髙啓史
- Organizer
  10th International mRNA Health Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] Synthetic mRNA-based selective cell elimination systems utilizing conditional reconstitution of split proteins2022
- Author(s)
  中西秀之,Kendall Free,位髙啓史
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] mRNAによる選択的細胞除去システム：細胞内タンパクに応答した細胞除去因子再構成2022
- Author(s)
  ケンドル・フリー,中西秀之,位髙啓史
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] 細胞選択的なmRNA医薬翻訳制御のための、特定の細胞内タンパク質を検知できる人工翻訳制御因子の開発2022
- Author(s)
  中西秀之,齊藤博英,位髙啓史
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] 合成 mRNA を用いた細胞選別システム：細胞内タンパク質を標的とする機能制御2022
- Author(s)
  中西秀之,Kendall Free,位髙啓史
- Organizer
  第44回日本バイオマテリアル学会
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] タンパク質への翻訳を状況に応じて制御できる"スマートmRNA医薬"の開発2022
- Author(s)
  中西秀之,位髙啓史
- Organizer
  日本核酸医薬学会第7回年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] 翻訳を人為的にコントロール可能な“スマート mRNA 医薬”の開発2022
- Author(s)
  中西秀之
- Organizer
  CBI学会2022年大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection2021
- Author(s)
  Free Kendall, Hideyuki Nakanishi, Keiji Itaka
- Organizer
  9th International mRNA Health Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] 標的タンパク質を発現する細胞選択的にmRNAの翻訳を制御する技術の開発2021
- Author(s)
  中西秀之, 齊藤博英, 位髙啓史
- Organizer
  遺伝子・デリバリー研究会第20回シンポジウム
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] Conditional translational regulation of synthetic mRNAs by caliciviral VPg protein-based translational activator (CaVT)2020
- Author(s)
  Hideyuki Nakanishi, Keiji Itaka, Hirohide Saito
- Organizer
  Virtual 8th International mRNA Health Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20696
[Presentation] Artificial translational activator for regulation of synthetic mRNA-based mammalian gene circuits2019
- Author(s)
  Nakanishi Hideyuki、Saito Hirohide
- Organizer
  19th Symposium for Gene・Design and Delivery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20696

1. ITAKA Keiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nakanishi Hideyuki 中西 秀之

Research Projects

Research Products

Co-Researchers

Signal-responsive translational control of mRNA drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Optical regulation system of mRNA translation with spatiotemporal and cell-type specificityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] mRNAの制御機構の解明と治療薬・ワクチンへの活用2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 核酸科学ハンドブック（「第9章 医科学 9.1 細胞システム制御」を担当）2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 担当記事名: Endogenous Signal-Responsive Transgene Switch Systems for Visualization and Purification of Specific Cells, 書名: Medical Applications of iPS Cells2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] mRNA医薬とmRNAワクチン2023

Author(s)

Journal Title

Data Source

[Journal Article] RNA修飾による炎症回避が，効果的なmRNAワクチンの開発を可能にした2023

Author(s)

Journal Title

Data Source

[Journal Article] 細胞・臓器選択的な翻訳を可能にするmRNA医薬の設計2023

Author(s)

Journal Title

Data Source

[Journal Article] Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 細胞死誘導タンパク質をコードした合成mRNAによる選択的細胞除去2023

Author(s)

Journal Title

Data Source

[Journal Article] Development of Synthetic mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] mRNA医薬とmRNAワクチン2023

Author(s)

Journal Title

Data Source

[Journal Article] 指定された期間・細胞種において選択的に薬効を発揮するmRNA医薬のための翻訳制御技術2022

Author(s)

Journal Title

Data Source

[Journal Article] mRNAワクチン・mRNA医薬は何を可能にするのか2022

Author(s)

Journal Title

Data Source

[Journal Article] Synthetic mRNA for ex?vivo therapeutic applications2022

Author(s)

Journal Title

Nakanishi Hideyuki 中西秀之

[Book] 核酸科学ハンドブック（「第9章医科学 9.1 細胞システム制御」を担当）2020