Kubo Toshio 久保寿夫

Researcher Number	90726928
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2023: 岡山大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related Except Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator 化学予防 / 肺癌 / 間質性肺炎 Except Principal Investigator 非小細胞肺癌 / 臨床呼吸器学 / 肺癌 / CDK4/6 / ROS1 / ALK / EGFR … More / RB / SHP2 / tolerance / 分子標的治療 / 遺伝子多型 / 高精細CT / 根治的化学放射線療法 / 局所進行肺癌 / 放射線肺炎 / 放射線肺臓炎 / 放射線治療 / レーザーマイクロダイセクション / Kinase遺伝子発現解析 / 次世代シーケンサー / 特発性肺線維症 / 肺線維症 / 内科 / EGFR肺癌 / 呼吸器の腫瘍 / 肺癌幹細胞 / 非小細胞癌 / 遺伝子改変マウスモデル / 癌幹細胞 / EGFR変異 Less

Development of lung cancer treatment targeting drug tolerance by SHP2.
- Principal Investigator
  
  Ichihara Eiki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Okayama University
Examination of radiation pneumonitis using ultra-high definition CT and gene polymorphism
- Principal Investigator
  
  勝井邦彰
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Okayama University
Development of a novel therapeutic strategy for lung cancer with interstitial pneumonia - from the viewpoint of chemoprevention -Principal Investigator
- Principal Investigator
  
  Kubo Toshio
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Okayama University
Comprehensive analysis of druggable tyrosine kinase in idiopathic interstitial pneumonia
- Principal Investigator
  
  Kiura Katsuyuiki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
Next generation lung cancer mice model for conquering cancer stem
- Principal Investigator
  
  Kiura Katsuyuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University

All 2024 2023 2022 2021 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery2024
- Author(s)
  Kubo Yujiro、Yamamoto Hiromasa、Matsubara Kei、Hashimoto Kohei、Tanaka Shin、Shien Kazuhiko、Suzawa Ken、Miyoshi Kentaroh、Okazaki Mikio、Sugimoto Seiichiro、Katsui Kuniaki、Hiraki Takao、Kiura Katsuyuki、Toyooka Shinichi
- Journal Title
  
  Surgery Today
  
  Volume: Online ahead of print. Issue: 9 Pages: 995-1004
- DOI
  10.1007/s00595-024-02816-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07996
[Journal Article] CDK4/6 signaling attenuates the effect of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer2023
- Author(s)
  Hara Naofumi、Ichihara Eiki、Kano Hirohisa、Ando Chihiro、Morita Ayako、Nishi Tatsuya、Okawa Sachi、Nakasuka Takamasa、Hirabae Atsuko、Abe Masaya、Asada Noboru、Ninomiya Kiichiro、Makimoto Go、Fujii Masanori、Kubo Toshio、Ohashi Kadoaki、Hotta Katsuyuki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Translational Lung Cancer Research
  
  Volume: 12 Issue: 10 Pages: 2098-2112
- DOI
  10.21037/tlcr-23-99
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08179, KAKENHI-PROJECT-22K19529, KAKENHI-PROJECT-23K24339
[Journal Article] Corrigendum to ‘Gefitinib induction followed by chemoradiotherapy in EGFR-mutant, locally advanced non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study’2022
- Author(s)
  Hotta K.、Saeki S.、Yamaguchi M.、Harada D.、Bessho A.、Tanaka K.、Inoue K.、Gemba K.、Shiojiri M.、Kato Y.、Ninomiya T.、Kubo T.、Kishimoto J.、Shioyama Y.、Katsui K.、Sasaki J.、Kiura K.、Sugio K.
- Journal Title
  
  ESMO Open
  
  Volume: 7 Issue: 4 Pages: 100532-100532
- DOI
  10.1016/j.esmoop.2022.100532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07996
[Journal Article] Gefitinib induction followed by chemoradiotherapy in EGFR-mutant, locally advanced non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study2021
- Author(s)
  Hotta K.、Saeki S.、Yamaguchi M.、Harada D.、Bessho A.、Tanaka K.、Inoue K.、Gemba K.、Shiojiri M.、Kato Y.、Ninomiya T.、Kubo T.、Kishimoto J.、Shioyama Y.、Katsui K.、Sasaki J.、Kiura K.、Sugio K.
- Journal Title
  
  ESMO Open
  
  Volume: 6 Issue: 4 Pages: 100191-100191
- DOI
  10.1016/j.esmoop.2021.100191
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07996, KAKENHI-PROJECT-20K08113
[Journal Article] Re-administration of osimertinib in osimertinib-acquired resistant non-small-cell lung cancer2019
- Author(s)
  Ichihara Eiki、Hotta Katsuyuki、Ninomiya Kiichiro、Kubo Toshio、Ohashi Kadoaki、Rai Kammei、Tanaka Hisaaki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Lung Cancer
  
  Volume: 132 Pages: 54-58
- DOI
  10.1016/j.lungcan.2019.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15925
[Journal Article] Phase 2 Study of Afatinib Alone or Combined With Bevacizumab in Chemonaive Patients With Advanced Non-Small-Cell Lung Cancer Harboring EGFR Mutations: AfaBev-CS Study Protocol.2019
- Author(s)
  Ninomiya T, Ishikawa N, Inoue K, Kubo T, Yasugi M, Shibayama T, Maeda T, Fujitaka K, Kodani M, Yokoyama T, Kuyama S, Ochi N, Ueda Y, Miyoshi S, Kozuki T, Amano Y, Kubota T, Sugimoto K, Bessho A, Ishii T, Watanabe K, Oze I, Hotta K, Kiura K.
- Journal Title
  
  Clin Lung Cancer.
  
  Volume: 29 Issue: 2 Pages: 134-138
- DOI
  10.1016/j.cllc.2018.10.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04830
[Journal Article] Influence of age on the efficacy of immune checkpoint inhibitors in advanced cancers: a systematic review and meta-analysis2019
- Author(s)
  Ninomiya Kiichiro、Oze Isao、Kato Yuka、Kubo Toshio、Ichihara Eiki、Rai Kammei、Ohashi Kadoaki、Kozuki Toshiyuki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki、Hotta Katsuyuki
- Journal Title
  
  Acta Oncologica
  
  Volume: 59 Issue: 3 Pages: 249-256
- DOI
  10.1080/0284186x.2019.1695062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15925
[Journal Article] Programmed cell death-ligand 1 expression and efficacy of cisplatin-based chemotherapy in lung cancer: A sub-analysis of data from the two Okayama Lung Cancer Study Group prospective feasibility studies2019
- Author(s)
  Nishii Kazuya、Hotta Katsuyuki、Ninomiya Kiichiro、Kato Yuka、Ichihara Eiki、Ohashi Kadoaki、Ninomiya Takashi、Kubo Toshio、Rai Kammei、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Respiratory Investigation
  
  Volume: 57 Issue: 5 Pages: 460-465
- DOI
  10.1016/j.resinv.2019.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15925
[Journal Article] Rapid and Long-term Response of Pulmonary Pleomorphic Carcinoma to Nivolumab2019
- Author(s)
  Senoo Satoru、Ninomiya Takashi、Makimoto Go、Nishii Kazuya、Kano Hirohisa、Watanabe Hiromi、Hata Yusuke、Kubo Toshio、Tanaka Takehiro、Hotta Katsuyuki、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 7 Pages: 985-989
- DOI
  10.2169/internalmedicine.0890-18
- NAID
  130007622179
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-04-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15925
[Journal Article] The effect and safety of immune checkpoint inhibitor rechallenge in non-small cell lung cancer2019
- Author(s)
  Watanabe Hiromi、Kubo Toshio、Ninomiya Kiichiro、Kudo Kenichiro、Minami Daisuke、Murakami Etsuko、Ochi Nobuaki、Ninomiya Takashi、Harada Daijiro、Yasugi Masayuki、Ichihara Eiki、Ohashi Kadoaki、Fujiwara Keiichi、Hotta Katsuyuki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 49 Issue: 8 Pages: 762-765
- DOI
  10.1093/jjco/hyz066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15925
[Journal Article] A phase I/II trial of weekly nab‐paclitaxel for pretreated non‐small‐cell lung cancer patients without epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangement2019
- Author(s)
  Harada Daijiro、Kozuki Toshiyuki、Nogami Naoyuki、Bessho Akihiro、Hosokawa Shinobu、Fukamatsu Nobuaki、Hotta Katsuyuki、Ohashi Kadoaki、Kubo Toshio、Yoshioka Hiroshige、Yokoyama Toshihide、Sone Naoyuki、Kuyama Shoichi、Kudo Kenichiro、Yasugi Masayuki、Takigawa Nagio、Oze Isao、Kiura Katsuyuki
- Journal Title
  
  Asia-Pacific Journal of Clinical Oncology
  
  Volume: 15 Issue: 4 Pages: 250-256
- DOI
  10.1111/ajco.13147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15925
[Journal Article] Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden.2019
- Author(s)
  Makimoto G, Ohashi K, Tomida S, Nishii K, Matsubara T, Kayatani H, Higo H, Ninomiya K, Sato A, Watanabe H, Kano H, Ninomiya T, Kubo T, Rai K, Ichihara E, Hotta K, Tabata M, Toyooka S, Takata M, Maeda Y, Kiura K.
- Journal Title
  
  J Thorac Oncol.
  
  Volume: 11 Issue: 11 Pages: 2009-2018
- DOI
  10.1016/j.jtho.2019.07.017
- NAID
  120006871852
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08625, KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-18K15925
[Journal Article] Chemoradiotherapy for locally advanced lung cancer patients with interstitial lung abnormalities2019
- Author(s)
  Higo Hisao、Kubo Toshio、Makimoto Satoko、Makimoto Go、Ihara Hiroki、Masaoka Yoshihisa、Ninomiya Takashi、Ichihara Eiki、Ohashi Kadoaki、Sato Akiko、Hotta Katsuyuki、Tabata Masahiro、Takigawa Nagio、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 49 Issue: 5 Pages: 458-464
- DOI
  10.1093/jjco/hyz016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15925
[Journal Article] Patients’ preferences and perceptions of lung cancer treatment decision making: results from Okayama lung cancer study group trial 14062019
- Author(s)
  Makimoto Go、Hotta Katsuyuki、Oze Isao、Ninomiya Kiichiro、Nakanishi Masamoto、Hara Naofumi、Kano Hirohisa、Watanabe Hiromi、Hata Yusuke、Nishii Kazuya、Nakasuka Takamasa、Itano Junko、Ninomiya Takashi、Kubo Toshio、Ohashi Kadoaki、Ichihara Eiki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Acta Oncologica
  
  Volume: 59 Issue: 3 Pages: 324-328
- DOI
  10.1080/0284186x.2019.1679880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15925
[Journal Article] A phase I trial of afatinib and bevacizumab in chemo-naive patients with advanced non-small-cell lung cancer harboring EGFR mutations: Okayama Lung Cancer Study Group Trial 1404.2018
- Author(s)
  Ninomiya T, Nogami N, Kozuki T, Harada D, Kubo T, Ohashi K, Kuyama S, Kudo K, Bessho A, Fukamatsu N, Fujimoto N, Aoe K, Shibayama T, Sugimoto K, Takigawa N, Hotta K, Kiura K.
- Journal Title
  
  Lung Cancer.
  
  Volume: 115 Pages: 103-108
- DOI
  10.1016/j.lungcan.2017.11.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19454, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458, KAKENHI-PROJECT-18K15925
[Journal Article] Clinical significance of repeat rebiopsy in detecting the EGFR T790M secondary mutation in patients with non-small cell lung cancer2018
- Author(s)
  Ichihara Eiki、Hotta Katsuyuki、Kubo Toshio、Higashionna Tsukasa、Ninomiya Kiichiro、Ohashi Kadoaki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 50 Pages: 29525-29531
- DOI
  10.18632/oncotarget.25705
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15925, KAKENHI-PROJECT-15H04830
[Journal Article] A Phase II Study of Trastuzumab Emtansine in HER2-Positive Non-Small Cell Lung Cancer2018
- Author(s)
  Hotta Katsuyuki、Aoe Keisuke、Kozuki Toshiyuki、Ohashi Kadoaki、Ninomiya Kiichiro、Ichihara Eiki、Kubo Toshio、Ninomiya Takashi、Chikamori Kenichi、Harada Daijiro、Nogami Naoyuki、Hirata Taizo、Hinotsu Shiro、Toyooka Shinichi、Kiura Katsuyuki
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 13 Issue: 2 Pages: 273-279
- DOI
  10.1016/j.jtho.2017.10.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458, KAKENHI-PROJECT-18K15925
[Journal Article] MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib2018
- Author(s)
  Ninomiya Kiichiro、Ohashi Kadoaki、Makimoto Go、Tomida Shuta、Higo Hisao、Kayatani Hiroe、Ninomiya Takashi、Kubo Toshio、Ichihara Eiki、Hotta Katsuyuki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1955-1955
- DOI
  10.1038/s41598-018-20326-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-16K19454, KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458, KAKENHI-PROJECT-18K15925
[Journal Article] Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutations.2018
- Author(s)
  Tamura T, Kato Y, Ohashi K, Ninomiya K, Makimoto G, Gotoda H, Kubo T, Ichihara E, Tanaka T, Ichimura K, Maeda Y, Hotta K, Kiura K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 495 Issue: 1 Pages: 360-367
- DOI
  10.1016/j.bbrc.2017.10.175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19454, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-26430163, KAKENHI-PROJECT-16K15458
[Journal Article] Study Protocol: Phase-Ib Trial of Nivolumab Combined With Metformin for Refractory/Recurrent Solid Tumors.2018
- Author(s)
  Kubo T, Ninomiya T, Hotta K, Kozuki T, Toyooka S, Okada H, Fujiwara T, Udono H, Kiura K.
- Journal Title
  
  Clin Lung Cancer.
  
  Volume: 19 Issue: 6 Pages: e861-e864
- DOI
  10.1016/j.cllc.2018.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19598, KAKENHI-PROJECT-18H04033, KAKENHI-PROJECT-15H04830
[Journal Article] Atezolizumab in Japanese Patients With Previously Treated Advanced Non?Small-Cell Lung Cancer: A Subgroup Analysis of the Phase 3 OAK Study2018
- Author(s)
  Hida Toyoaki、Kaji Reiko、Satouchi Miyako、Ikeda Norihiko、Horiike Atsushi、Nokihara Hiroshi、Seto Takashi、Kawakami Tomohisa、Nakagawa Shintaro、Kubo Toshio
- Journal Title
  
  Clinical Lung Cancer
  
  Volume: 19 Issue: 4 Pages: e405-e415
- DOI
  10.1016/j.cllc.2018.01.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15925
[Journal Article] Atezolizumab Treatment Beyond Progression in Advanced NSCLC: Results From the Randomized, Phase III OAK Study2018
- Author(s)
  Gandara David R.、von Pawel Joachim、Mazieres Julien、Sullivan Richard、Helland ?slaug、Han Ji-Youn、Ponce Aix Santiago、Rittmeyer Achim、Barlesi Fabrice、Kubo Toshio、Park Keunchil、Goldschmidt Jerome、Gandhi Mayank、Yun Cindy、Yu Wei、Matheny Christina、He Pei、Sandler Alan、Ballinger Marcus、Fehrenbacher Louis
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 13 Issue: 12 Pages: 1906-1918
- DOI
  10.1016/j.jtho.2018.08.2027
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15925
[Journal Article] Second primary cancer in survivors of locally advanced non-small cell lung cancer treated with concurrent chemoradiation followed by surgery2018
- Author(s)
  Makimoto Go、Kubo Toshio、Oze Isao、Ohashi Kadoaki、Hotta Katsuyuki、Tabata Masahiro、Soh Junichi、Toyooka Shinichi、Katsui Kuniaki、Takigawa Nagio、Tanimoto Mitsune、Kiura Katsuyuki
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 48 Issue: 3 Pages: 287-290
- DOI
  10.1093/jjco/hyy003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458, KAKENHI-PROJECT-18K15925
[Journal Article] Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions2018
- Author(s)
  Kato Yuka、Ninomiya Kiichiro、Ohashi Kadoaki、Tomida Shuta、Makimoto Go、Watanabe Hiromi、Kudo Kenichiro、Matsumoto Shingo、Umemura Shigeki、Goto Koichi、Ichihara Eiki、Ninomiya Takashi、Kubo Toshio、Sato Akiko、Hotta Katsuyuki、Tabata Masahiro、Toyooka Shinichi、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 10 Pages: 3149-3158
- DOI
  10.1111/cas.13752
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-18K15925, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K19454
[Journal Article] A phase II trial of carboplatin plus S-1 for elderly patients with advanced non-small-cell lung cancer with wild-type epidermal growth factor receptor: The Okayama Lung Cancer Study Group Trial 12022017
- Author(s)
  Kuyama Shoichi、Ochi Nobuaki、Bessho Akihiro、Hotta Katsuyuki、Ikeda Genyo、Kishino Daizo、Kubo Toshio、Harada Daijiro、Fujimoto Nobukazu、Nakanishi Masamoto、Umeno Takahiro、Okada Toshiaki、Chikamori Kenichi、Yamagishi Tomoko、Ohashi Kadoaki、Ichihara Eiki、Takigawa Nagio、Tanimoto Mitsune、Kiura Katsuyuki
- Journal Title
  
  Lung Cancer
  
  Volume: 112 Pages: 188-194
- DOI
  10.1016/j.lungcan.2017.08.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458
[Journal Article] Clinical characteristics of Japanese candidates for lung transplant for interstitial lung disease and risk factors for early death while on the waiting list2017
- Author(s)
  Higo Hisao、Kurosaki Takeshi、Ichihara Eiki、Kubo Toshio、Miyoshi Kentaroh、Otani Shinji、Sugimoto Seiichiro、Yamane Masaomi、Miyahara Nobuaki、Kiura Katsuyuki、Miyoshi Shinichiro、Oto Takahiro
- Journal Title
  
  Respiratory Investigation
  
  Volume: 55 Issue: 4 Pages: 264-269
- DOI
  10.1016/j.resinv.2017.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458
[Journal Article] Triplet therapy with afatinib, cetuximab, and bevacizumab induces deep remission in lung cancer cells harboring EGFR T790M in vivo.2017
- Author(s)
  Kudo K, Ohashi K, Makimoto G, Higo H, Kato Y, Kayatani H, Kurata Y, Takami Y, Minami D, Ninomiya T, Kubo T, Ichihara E, Sato A, Hotta K, Yoshino T, Tanimoto M, Kiura K.
- Journal Title
  
  Mol Oncol
  
  Volume: Epub Issue: 6 Pages: 670-681
- DOI
  10.1002/1878-0261.12063
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K19454, KAKENHI-PROJECT-16K15458
[Journal Article] Endobronchial ultrasound-guided transbronchial needle aspiration of hilar and mediastinal lymph nodes detected on 18F-fluorodeoxyglucose positron emission tomography/computed tomography2016
- Author(s)
  Minami D, Takigawa N, Oda N, Ninomiya T, Kubo T, Ohashi K, Sato A, Hotta K, Tabata M, Kaji M, Tanimoto M, Kiura K..
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 46 Issue: 6 Pages: 529-33
- DOI
  10.1093/jjco/hyw023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15458
[Journal Article] A phase II study of topotecan and cisplatin with sequential thoracic radiotherapy in elderly patients with small-cell lung cancer: Okayama Lung Cancer Study Group 0102.2016
- Author(s)
  Kubo T, Fujiwara K, Hotta K, Okada T, Kuyama S, Harita S, Ninomiya T, Kamei H, Hosokawa S, Bessho A, Maeda T, Kozuki T, Fujimoto N, Ninomiya K, Takemoto M, Kanazawa S, Takigawa N, Tabata M, Tanimoto M, Ueoka H, Kiura K.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 78 Issue: 4 Pages: 769-74
- DOI
  10.1007/s00280-016-3135-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15458
[Journal Article] Safety and discomfort during bronchoscopy performed under sedation with fentanyl and midazolam: a prospective study.2016
- Author(s)
  Minami D, Takigawa N, Watanabe H, Ninomiya T, Kubo T, Ohashi K, Sato A, Hotta K, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 46 Issue: 9 Pages: 871-4
- DOI
  10.1093/jjco/hyw083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15458
[Journal Article] Potential influence of being overweight on the development of hepatic dysfunction in Japanese patients with EGFR-mutated non-small cell lung cancer undergoing gefitinib monotherapy: the Okayama Lung Cancer Study Group experience.2016
- Author(s)
  Oda N, Hotta K, Yoshioka H, Kudo K, Ichihara E, Kato Y, Ninomiya K, Minami D, Ninomiya T, Kubo T, Ohashi K, Sato A, Takigawa N, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 78 Issue: 5 Pages: 941-47
- DOI
  10.1007/s00280-016-3146-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15458
[Journal Article] TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells2015
- Author(s)
  Otani H, Yamamoto H, Takaoka M, Sakaguchi M, Soh J, Jida M, Ueno T, Kubo T, Asano H, Tsukuda K, Kiura K, Hatakeyama S, Kawahara E, Naomoto Y, Miyoshi S, Toyooka S
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: e0129838-e0129838
- DOI
  10.1371/journal.pone.0129838
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14382, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-25293302, KAKENHI-PROJECT-26290039
[Presentation] 局所進行肺癌に対する集学的治療における末梢血好中球/リンパ球比（NLR）と放射線肺臓炎の関連2022
- Author(s)
  久保友次郎, 山本寛斉, 松原慧, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 勝井邦彰, 平木隆夫, 豊岡伸一
- Organizer
  第63回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07996
[Presentation] Updated analysis of a phase I trial of afatinib (Afa) and bevacizumab (Bev) in chemo-naive patients (pts) with advanced non-small-cell lung cancer (NSCLC) harboring EGFR-mutations: OLCSG1404.2019
- Author(s)
  Ninomiya T, Nogami N, Kozuki T, Harada D, Kubo T, Ohashi K, Kuyama S, Kudo K, Bessho A, Fujimoto N, Aoe K, Shibayama T, Minami D, Sugimoto K, Ochi N, Takigawa N, Hotta K, Kiura K.
- Organizer
  ESMO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15925
[Presentation] Phase II trial of carboplatin, nab-paclitaxel and bevacizumab for advanced non-squamous non-small cell lung cancer (CARNAVAL study; TORG1424/OLCSG1402).2019
- Author(s)
  Kubo T, Nogami N, Bessho A, Morita A, Ikeo S, Yokoyama T, Ishihara M, Honda T, Fujimoto N, Murakami S, Kaira K, Harada T, Nakamura K, Iwasawa S, Shimokawa T, Kiura K, Yamashita N, Okamoto H.
- Organizer
  ESMO Asia Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15925
[Presentation] Significant combination benefit of anti-VEGFR antibody and oncogene-targeted agents in EGFR or ALK mutant NSCLC cells.2019
- Author(s)
  Watanabe H, Ichihara E, Kayatani H, Higo G, Makimoto G, Kano H, Nishii K, Hara N, Ninomiya K, Kubo T, Ohashi K, Rai K, Hotta K, Tabata M, Maeda Y, Kiura K.
- Organizer
  AACR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15925
[Presentation] Novel Syngenic Lung Cancer Mouse Model Harboring EGFR Mutations2018
- Author(s)
  Kazuya Nishii, Kadoaki Ohashi, Hisao Higo, Kenichiro Kudo, Go Makimoto, Hiroe Kayatani, Hiromi Watanabe, Kiichiro Ninomiya, Takashi Ninomiya, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  The 6th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] The novel osimertinib resistant lung cancer mice model harboring EGFR mutations driven by the SP-C promoter2018
- Author(s)
  Kadoaki Ohashi, Hisao Higo, Go Makimoto, Kenichiro Kudo, Kazuya Nishii, Kiichiro Ninomiya, Hiroe Kayatani, Takashi Ninomiya, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Immune checkpoint inhibitor efficacy and safety in elderly non-small cell lung cancer patients.2018
- Author(s)
  Kubo T, Watanabe H, Ninomiya K, Kudo K, Minami D, Murakami D, Ochi N, Ninomiya T, Harada D, Yasugi M, Ichihara E, Ohashi K, Fujiwara K, Hotta K, Tabata M, Maeda Y, Kiura K
- Organizer
  ESMO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15925
[Presentation] Phase Ib trial of nivolumab combined with metformin for refractory/recurrent solid tumors.2018
- Author(s)
  Kubo T, Hotta K, Ninomiya T, Kato H, Horiguchi S, Takamoto A, Kozuki T, Nogami N, Ishii　H, Nishina T, Harada D, Toyooka S, Okada H, Fujiwara T, Udono H, Kiura K
- Organizer
  ASCO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15925
[Presentation] In vivo efficacy of triplet therapy with osimertinib, cetuximab and bevacizumab for lung cancer cells harboring EGFR T790M2018
- Author(s)
  Kazuya Nishii, Kadoaki Ohashi, Go Makimoto, Hisao Higo, Kiichiro Ninomiya, Hiroe Kayatani, Takashi Ninomiya, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Analysis of the Rapid Acquired Resistance of ALK-positive Lung Cancers to Alectinib: A Comprehensive Study Using Autopsied Specimens and Patient-derived Cell Lines2018
- Author(s)
  Go Makimoto, Kadoaki Ohashi, Kazuya Nishii, (Shuta Tomida), Hiroe Kayatani, Hisao Higo, Kiichiro Ninomiya, Hiromi Watanabe, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, (Sinichi Toyooka), Yoshinobu Maeda, Katsuyuki Kiura
- Organizer
  The 6th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Acquired resistance to the third-generation EGFR inhibitor ASP8273 is associated with MET or NRAS gene amplifications in preclinical models2017
- Author(s)
  Kiichiro Ninomiya, Kadoaki Ohashi, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Go Makimoto, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura.
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Clinical Characteristics of Japanese Candidates for Lung Transplant Due to Interstitial Lung Disease and Risk Factors for Early Death While on the Waiting List2017
- Author(s)
  Hisao Higo , Eiki Ichihara , Takeshi Kurosaki , Kentaroh Miyoshi , Toshio Kubo , Shinji Otani , Seiichiro Sugimoto , Masaomi Yamane , Nobuaki Miyahara , Katsuyuki Kiura , Takahiro Oto
- Organizer
  American Thoracic Society 2017 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] A comprehensive analysis of autopsied specimens and patient-derived cell lines in ALK-positive lung cancers with rapid acquired resistance to alectinib2017
- Author(s)
  Go Makimoto, Kadoaki Ohashi, Kazuya Nishii, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Kiichiro Ninomiya, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] A comprehensive analysis of autopsied specimens and patient-derived cell lines in ALK-positive lung cancers with rapid acquired resistance to alectinib2017
- Author(s)
  Go Makimoto, Kadoaki Ohashi, Kazuya Nishii, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Kiichiro Ninomiya, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15458
[Presentation] Clinical Characteristics of Japanese Candidates for Lung Transplant Due to Interstitial Lung Disease and Risk Factors for Early Death While on the Waiting List2017
- Author(s)
  Hisao Higo , Eiki Ichihara , Takeshi Kurosaki , Kentaroh Miyoshi , Toshio Kubo , Shinji Otani , Seiichiro Sugimoto , Masaomi Yamane , Nobuaki Miyahara , Katsuyuki Kiura , Takahiro Oto
- Organizer
  American Thoracic Society 2017 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15458
[Presentation] Acquired resistance to the third-generation EGFR inhibitor ASP8273 is associated with MET or NRAS gene amplifications in preclinical models2017
- Author(s)
  Kiichiro Ninomiya, Kadoaki Ohashi, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Go Makimoto, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura.
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15458
[Presentation] Abstract 250: Interleukin-6 as potential predictive marker for therapeutic effect of Gefitinib in patients with advanced non-small-cell lung cancer harboring EGFR mutations2016
- Author(s)
  Tomoki Tamura, Katsuyuki Hotta, Yuka Kato, Takehiro Tanaka, Kouichi Ichimura, Kadoaki Oohashi, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Second primary cancer in survivors of locally advanced NSCLC treated with concurrent chemoradiation followed by surgery.2016
- Author(s)
  Go Makimoto, Toshio Kubo, Yuka Kato, Takashi Ninomiya, Isao Oze, Kadoaki Ohashi, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Nagio Takigawa, Shinichi Toyooka, Kuniaki Katsui, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  2016 ASCO Annual Meeting
- Place of Presentation
  Chicago
- Year and Date
  2016-06-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15458
[Presentation] Abstract 5198: Combination effect of anti-VEGFR-2 antibody with erlotinib on EGFR mutant non-small cell lung cancer2016
- Author(s)
  Hiroe Kayatani, Kadoaki Ohashi, Takeshi Imao, Kenichiro Kudo, Yuka Kato, Takashi Ninomiya, Toshio Kubo, Akiko Sato, Ktsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Abstract 4667: pCR induced by triplet therapy with low-dose afatinib, cetuximab and bevcizumab in lung cancer cells harboring EGFR T790M2016
- Author(s)
  AKadoaki Ohashi, Kenichiro Kudo, Eiki Ichihara, Hiroe Kayatani, Hisao Higo, Yuka Kato, Yasuko Kurata, Daisuke Minami, Takashi Ninomiya, Toshio Kubo, Katsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Abstract 1889: AXL and EGFR signaling mediate resistance to Crizotinib in non-small cell lung cancer cells harboring the ROS1 fusion gene2016
- Author(s)
  Yuka Kato, Kadoaki Ohashi, Eiki Ichihara, Shuuta Tomida, Hiroe Kayatani, Kenichiro Kudo, Daisuke Minami, Takashi Ninomiya, Toshio Kubo, Toshiyuki Kozuki, Katsuyuki Hotta, Nagio Takigawa, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830

1. Kiura Katsuyuki (10243502)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
2. 大橋圭明 (60729193)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
3. Ichihara Eiki (40549705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 勝井邦彰 (30509419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 大川七子 (70803633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 吉尾浩太郎 (70623297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 杉山聡一 (50898567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Yoshida Tadashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Takata Minoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HIGO Hisao

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. Makimoto Go

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 冨田秀太

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 鵜殿平一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 阪口政清

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 豊岡伸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kubo Toshio 久保 寿夫

Research Projects

Research Products

Co-Researchers

Development of lung cancer treatment targeting drug tolerance by SHP2.

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Examination of radiation pneumonitis using ultra-high definition CT and gene polymorphism

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Development of a novel therapeutic strategy for lung cancer with interstitial pneumonia - from the viewpoint of chemoprevention -Principal Investigator

Principal Investigator

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Research Institution

Comprehensive analysis of druggable tyrosine kinase in idiopathic interstitial pneumonia

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Next generation lung cancer mice model for conquering cancer stem

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[Journal Article] Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery2024

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[Journal Article] CDK4/6 signaling attenuates the effect of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer2023

Author(s)

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[Journal Article] Corrigendum to ‘Gefitinib induction followed by chemoradiotherapy in EGFR-mutant, locally advanced non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study’2022

Author(s)

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[Journal Article] Gefitinib induction followed by chemoradiotherapy in EGFR-mutant, locally advanced non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study2021

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Data Source

[Journal Article] Re-administration of osimertinib in osimertinib-acquired resistant non-small-cell lung cancer2019

Author(s)

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[Journal Article] Phase 2 Study of Afatinib Alone or Combined With Bevacizumab in Chemonaive Patients With Advanced Non-Small-Cell Lung Cancer Harboring EGFR Mutations: AfaBev-CS Study Protocol.2019

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[Journal Article] Influence of age on the efficacy of immune checkpoint inhibitors in advanced cancers: a systematic review and meta-analysis2019

Author(s)

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[Journal Article] Programmed cell death-ligand 1 expression and efficacy of cisplatin-based chemotherapy in lung cancer: A sub-analysis of data from the two Okayama Lung Cancer Study Group prospective feasibility studies2019

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Data Source

[Journal Article] Rapid and Long-term Response of Pulmonary Pleomorphic Carcinoma to Nivolumab2019

Author(s)

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NAID

ISSN

Kubo Toshio 久保寿夫