Mizuno Tadahaya 水野忠快

… Alternative Names

MIZUNO Tadahaya 水野忠快

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Researcher Number	90736050
Other IDs	https://orcid.org/0000-0002-1638-602X
Affiliation (Current)	2024: 東京大学, 大学院薬学系研究科(薬学部), 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 助教 2014 – 2015: 東京大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 57060:Surgical dentistry-related / Basic Section 37030:Chemical biology-related / Medium-sized Section 62:Applied informatics and related fields / Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords	Principal Investigator RNA-seq / トランスクリプトーム / プロファイルデータ解析 / 炎症 / トランスポーター / 低分子化合物 / プロファイル / 毒性 / 化学物質 / 化合物 … More / deconvolution / 免疫細胞 / 肝機能障害 / ビッグデータ解析 / トランスクリプトミクス / 応答プロファイルデータ / アルツハイマー型認知症 / 遺伝子発現変動 / 末梢血単核球 / 疾患層別化 / マクロファージ / リソソーム / macrophages / inflammation / solute carrier / transporter / 転写制御 / 転写因子 / インフラマソーム / 炎症制御 / SLCトランスポーター … More Except Principal Investigator オルガノイド / OLSA / in silico プロファイリング / in silicoプロファイリング / 消化管幹細胞 / ヒト新鮮消化管 / 薬剤誘導性消化器毒性 / In situ 多層オミクス / 創薬標的 / リアルワールドデータ / 多層オミクス / 組織マイクロアレイ / 口腔がん / 創薬化学 / ケミカルバイオロジー / 潜在変数モデル / エピジェネティクス / テンソル分解 / 老化 / ニューロン / エピゲノム / 治療抵抗性 / 細胞間コミュニケーション / がん / チロシンキナーゼ阻害薬 / ミトコンドリア / 代謝リプログラミング / 分子標的薬 / がんヘテロジェナイティ / 医療創成 / 健康長寿 / ドラッグリポジショニング / 代謝物プロファイル解析 / メタボロミクス / 内在性代謝物 / ヒト由来試料 / 薬物相互作用 / 初代培養上皮細胞 / 内因性基質 / 薬物動態 / 吸収・分泌 / 薬物トランスポーター / スフェロイド / 薬物輸送 / in vitroモデル / 基質探索 / オーファントランスポーター / メタボロミクス解析 / 体内動態 / 基質同定 / 膜輸送 / トランスポーター / 大規模診療データベース / ハイスループットスクリーニング / 創薬 / SWATH / 中枢関門創薬 / 中枢関門(原因)仮説 / バリアーシステム生物学 / 血液脳関門 / 中枢関門 / iPS細胞由来肝細胞 / オミクスデータ解析 / 胆汁酸 / 肝内胆汁うっ滞 / 小児肝疾患 / プロファイルデータ解析法 / オミクスデータ / リート化合物最適化 / トランスクリプトームデータ / プロファイリング / リード化合物の最適化 / 天然物 / プロファイルデータ解析 / 潜在的作用 / 構造類似体 / リード化合物最適化 / プロファイル解析 Less

Construction of the novel evaluation systems and the methodologies for quantitative risk assessment of drug-induced intestinal toxicity
- Principal Investigator
  
  前田和哉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kitasato University
Mechanism of constituting a cancer cell population resistant to molecular-targeted drugs
- Principal Investigator
  
  青木重樹
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Chiba University
ニューロンの多階層エピジェネティクス情報の潜在変数モデルによる記憶の解明
- Principal Investigator
  
  岸雄介
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 62:Applied informatics and related fields
- Research Institution
  The University of Tokyo
Development of enzymomics platform for characterization of disease-related alterations of enzymatic activities
- Principal Investigator
  
  小松徹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  The University of Tokyo
In situ多層オミクスとリアルワールドデータ活用による口腔がん分子標的探索
- Principal Investigator
  
  本田一文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nippon Medical School
Establishment of various and comparable liver injury models with low molecular weight compoundsPrincipal Investigator
- Principal Investigator
  
  水野忠快
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
健康長寿社会の実現に資する革新的低コスト医療創製基盤の構築
- Principal Investigator
  
  林久允
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  The University of Tokyo
生物情報学、発生医学の活用による原因不明小児肝臓難病の病態発症分子基盤の解明
- Principal Investigator
  
  Hayashi Hisamitsu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Establishment of CNS barrier-targeted drug development based on generation of a new field, Barrier Systems Biology
- Principal Investigator
  
  Uchida Yasuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tohoku University
Development of methods to realize medical theapy by enhancing the function of ABC transporters
- Principal Investigator
  
  Hayashi Hisamitsu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
Pharmacokinetic study on transporters in the xenobiotic detoxification among the liver, small intestine and kidney
- Principal Investigator
  
  Kusuhara Hiroyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
Development of lead optimization method using novel profile data analysis method
- Principal Investigator
  
  Kusuhara Hiroyuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
establishment of a novel disease stratification method with response profile data analysis of peripheral blood mononuclear cellsPrincipal Investigator
- Principal Investigator
  
  Tadahaya Mizuno
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
Investigation of importance of an orphan transporter in inflammatory responsesPrincipal Investigator
- Principal Investigator
  
  MIZUNO Tadahaya
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Investigation of transporters as atherosclerosis modifiersPrincipal Investigator
- Principal Investigator
  
  Mizuno Tadahaya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2017

All Journal Article Presentation

[Journal Article] Characterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH method2023
- Author(s)
  Ishiguro H, Mizuno T, Uchida Y, Sato R, Sasaki H, Nemoto S, Terasaki T, Kusuhara H
- Journal Title
  
  NAR Genom Bioinform
  
  Volume: 5(1) Issue: 1
- DOI
  10.1093/nargab/lqad022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0446, KAKENHI-PROJECT-20H03399
[Journal Article] Decomposition Profile Data Analysis for Deep Understanding of Multiple Effects of Natural Products2021
- Author(s)
  Nemoto Shumpei、Morita Katsuhisa、Mizuno Tadahaya、Kusuhara Hiroyuki
- Journal Title
  
  Journal of Natural Products
  
  Volume: 84 Issue: 4 Pages: 1283-1293
- DOI
  10.1021/acs.jnatprod.0c01381
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22485
[Journal Article] Influence of food on pharmacokinetics and pharmacodynamics of 4-phenylbutyrate in patients with urea cycle disorders2021
- Author(s)
  Nakajima Yoko、Osaka Shuhei、Mizuno Tadahaya、Yokoi Katsuyuki、Nakano Satoshi、Hirai Saeko、Hiraoka Yuka、Miura Yoshiki、Suzuki Mitsuyoshi、Kusuhara Hiroyuki、Hayashi Hisamitsu
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 29 Pages: 100799-100799
- DOI
  10.1016/j.ymgmr.2021.100799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0172
[Journal Article] A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers2021
- Author(s)
  Osaka Shuhei、Nakano Satoshi、Mizuno Tadahaya、Hiraoka Yuka、Minowa Kei、Hirai Saeko、Mizutani Ayumu、Sabu Yusuke、Miura Yoshiki、Shimizu Toshiaki、Kusuhara Hiroyuki、Suzuki Mitsuyoshi、Hayashi Hisamitsu
- Journal Title
  
  Molecular Genetics and Metabolism
  
  Volume: 132 Issue: 4 Pages: 220-226
- DOI
  10.1016/j.ymgme.2021.02.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0172
[Journal Article] Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development2021
- Author(s)
  Mochizuki Tatsuki、Mizuno Tadahaya、Maeda Kazuya、Kusuhara Hiroyuki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 37 Pages: 100358-100358
- DOI
  10.1016/j.dmpk.2020.09.003
- NAID
  210000177785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03401, KAKENHI-PROJECT-20J14855
[Journal Article] Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor.2020
- Author(s)
  Morita K, Mizuno T, Kusuhara H.
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 13139-13139
- DOI
  10.1038/s41598-020-70140-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16407
[Journal Article] Decomposition Profile Data Analysis of Multiple Drug Effects Identifies Endoplasmic Reticulum Stress-Inducing Ability as an Unrecognized Factor2020
- Author(s)
  Katsuhisa Morita, Tadahaya Mizuno, Hiroyuki Kusuhara
- Journal Title
  
  Scientific Reports
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22485
[Journal Article] Interesting Properties of Profile Data Analysis in the Understanding and Utilization of the Effects of Drugs2020
- Author(s)
  Mizuno Tadahaya、Morita Katsuhisa、Kusuhara Hiroyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 10 Pages: 1435-1442
- DOI
  10.1248/bpb.b20-00301
- NAID
  130007920894
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22485, KAKENHI-PROJECT-19K16407
[Journal Article] GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages.2019
- Author(s)
  Maedera S, Mizuno T, Ishiguro H, Ito T, Soga T, Kusuhara H.
- Journal Title
  
  FEBS Letters
  
  Volume: 593 Issue: 2 Pages: 195-208
- DOI
  10.1002/1873-3468.13298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15499
[Presentation] Development of single-molecule enzyme activity-based protein profiling (SEAP) strategy for the detection of disease-related enzyme activities in blood samples2022
- Author(s)
  Toru Komatsu, Shingo Sakamoto, Tadahaya Mizuno, Kazufumi Honda, Rikiya Watanabe, Yasuteru Urano
- Organizer
  Redox Week 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23484
[Presentation] Development of single-molecule enzyme activity-based protein profiling (SEAP) strategy for the detection of disease-related enzyme activities in blood samples2022
- Author(s)
  Toru Komatsu, Shingo Sakamoto, Yu Kagami, Tadahaya Mizuno, Kazufumi Honda, Rikiya Watanabe, Yasuteru Urano
- Organizer
  International Chemical Biology Society Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23484
[Presentation] プロファイルデータ分離解析による天然物レシナミンの複合的作用の同定2021
- Author(s)
  根本駿平、森田勝久、水野忠快、楠原洋之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22485
[Presentation] プロファイルデータ分離解析による天然物誘導体シロシンゴピンのHDAC阻害作用の発見2021
- Author(s)
  森田勝久、水野忠快、楠原洋之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22485
[Presentation] ユビキチンリガーゼAIP4を介した細胞膜上ABCA1の発現調節機構の解析2021
- Author(s)
  守屋一輝、水野忠快、勝部彬、楠原洋之、林久允
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-20H03400
[Presentation] ユビキチンリガーゼAIP4を介した細胞膜上ABCA1の発現調節機構の解析2021
- Author(s)
  守屋一輝、水野忠快、勝部彬、楠原洋之、林久允
- Organizer
  第20回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20H03400
[Presentation] 腎有機カチオントランスポーターOCT2の発現調節を担う遺伝子変異および転写因子の探索2020
- Author(s)
  三宅健之、水野忠快、楠原洋之
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20H03401
[Presentation] リソソームに局在するトランスポーターSLC2A6の機能解析2017
- Author(s)
  伊藤拓也、水野忠快、楠原洋之
- Organizer
  第23回創剤フォーラム若手研究会
- Data Source
  KAKENHI-PROJECT-17K15499
[Presentation] オーファントランスポーターSLC2A6のリソソームに着目した機能解析2017
- Author(s)
  伊藤拓也、水野忠快、楠原洋之
- Organizer
  第39回生体膜シンポジウム
- Data Source
  KAKENHI-PROJECT-17K15499
[Presentation] Functional Analysis of Lysosomal Transporter SLC2A6 as an Orphan Transporter2017
- Author(s)
  伊藤拓也、水野忠快、楠原洋之
- Organizer
  第32回日本薬物動態学会
- Data Source
  KAKENHI-PROJECT-17K15499
[Presentation] The Analysis of an Orphan Transporter SLC2A62017
- Author(s)
  Tadahaya Mizuno, Takuya Ito, Shotaro Maedera, Hiromu Ishiguro, Hiroyuki Kusuhara
- Organizer
  KSAP 2017 Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15499
[Presentation] 炎症応答におけるリソソームトランスポーターSLC-Xのフェノタイプ解析2017
- Author(s)
  水野忠快、伊藤拓也、前寺正太郎、石黒拡、楠原洋之
- Organizer
  第12回トランスポーター研究会
- Data Source
  KAKENHI-PROJECT-17K15499

1. Hayashi Hisamitsu (10451858)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. Kusuhara Hiroyuki (00302612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 前田和哉 (00345258)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Uchida Yasuo (70583590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 戸川貴夫 (10792814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 今川和生 (40708509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 三枝大輔 (90545237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 青木重樹 (30728366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 梅澤啓太郎 (30505764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 岸雄介 (00645236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小松徹 (40599172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 本田一文 (10260936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 森泰昌 (00296708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小田竜也 (20282353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MAEDERA Shotaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. ISHIGURO Hiromu

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Mizuno Tadahaya 水野 忠快

MIZUNO Tadahaya 水野 忠快

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Establishment of various and comparable liver injury models with low molecular weight compoundsPrincipal Investigator

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establishment of a novel disease stratification method with response profile data analysis of peripheral blood mononuclear cellsPrincipal Investigator

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Investigation of importance of an orphan transporter in inflammatory responsesPrincipal Investigator

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Investigation of transporters as atherosclerosis modifiersPrincipal Investigator

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Mizuno Tadahaya 水野忠快

MIZUNO Tadahaya 水野忠快