SHIMAMURA Mika 嶋村美加

Researcher Number	90736406
Other IDs
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(医学系), 特任研究員
Affiliation (based on the past Project Information) *help	2025: 長崎大学, 医歯薬学総合研究科(医学系), 特任研究員 2016 – 2022: 長崎大学, 原爆後障害医療研究所, 助教 2015: 長崎大学, 原爆後障害医療研究所, 研究機関研究員
Review Section/Research Field	Principal Investigator Endocrinology / Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator 甲状腺癌 / 癌幹細胞 / 活性酸素 / 可塑性 Except Principal Investigator オートファジー / 放射線 / 癌 / PKCシグナル伝達経路 / 細胞死 / PKCシグナル伝達回路 … More / DNA二重鎖切断 / 酸化ストレス / 甲状腺ホルモン / TSH / アポトーシス / 甲状腺 / キナーゼ阻害剤 / 逆作動薬 / 遺伝子改変 / マウスモデル / インバースアゴニスト / TSH受容体 / 甲状腺がん Less

甲状腺癌マウスモデル・甲状腺癌オルガノイドを利用した予後を決定する微小環境の検討Principal Investigator
- Principal Investigator
  
  嶋村美加
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nagasaki University
Autophagy regulatory mechanisms in thyroid and significance for carcinogenesis
- Principal Investigator
  
  Kurashige Tomomi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Nagasaki University
Studies on thyorid cancer pathogenesis using mouse models
- Principal Investigator
  
  NAGAYAMA Yuji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Nagasaki University
Development of the new treatment for thyroid cancer by targeting the plasticity of the cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  SHIMAMURA Mika
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Nagasaki University
Studies on thyroid cancer stem cells: ALDH function analysis and plasticityPrincipal Investigator
- Principal Investigator
  
  SHIMAMURA Mika
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Nagasaki University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Characterization of metabolic reprogramming by metabolomics in the oncocytic thyroid cancer cell line XTC.UC1.2023
- Author(s)
  Kurashige T, Shimamura M, Hamada K, Matsuse M, Mitsutake N, Nagayama Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 149-160
- DOI
  10.1038/s41598-023-27461-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07668, KAKENHI-PROJECT-19K09028
[Journal Article] The Effect of Long-Term Inorganic Iodine on Intrathyroidal Iodothyronine Content and Gene Expression in Mice with Graves' Hyperthyroidism2023
- Author(s)
  Uchida Toyoyoshi、Shimamura Mika、Taka Hikari、Kaga Naoko、Miura Yoshiki、Nishida Yuya、Nagayama Yuji、Watada Hirotaka
- Journal Title
  
  Thyroid
  
  Volume: 33 Issue: 3 Pages: 330-337
- DOI
  10.1089/thy.2022.0496
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-19K11752
[Journal Article] Re-evaluation of the role of autophagy in thyroid cancer treatment2022
- Author(s)
  Kazakova D, Shimamura M, Kurashige T, Hamada K, Nagayama Y.
- Journal Title
  
  Endocr J
  
  Volume: 69 Issue: 7 Pages: 847-862
- DOI
  10.1507/endocrj.EJ22-0017
- NAID
  130008162464
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08888, KAKENHI-PROJECT-19K09028
[Journal Article] MIEAP and ATG5 are tumor suppressors in a mouse model of BRAFV600E-positive thyroid cancer2022
- Author(s)
  Hamada Koichiro、Kurashige Tomomi、Shimamura Mika、Arakawa Hirofumi、Nakamura Yasuyuki、Nagayama Yuji
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 13 Pages: 932754-932754
- DOI
  10.3389/fendo.2022.932754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19412, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-20K08888, KAKENHI-PROJECT-23K24169, KAKENHI-PROJECT-19K07655
[Journal Article] 甲状腺特異的オートファジーノックアウトマウスでは、濾胞上皮細胞死が誘導される2020
- Author(s)
  永山雄二 , 蔵重智美 , 中島康代 , 嶋村美加 , 松山睦美 , 中島正洋 , 山田正信
- Journal Title
  
  日本内分泌学会雑誌
  
  Volume: 95 Pages: 1335-1335
- Data Source
  KAKENHI-PROJECT-20K08888
[Journal Article] Re-evaluation of the effect of iodine on thyroid cell survival and function with PCCL3 and Nthy-ori 3-1 cells.2020
- Author(s)
  Kurashige T, Shimamura M, Nagayama Y.
- Journal Title
  
  Journal of Endocrine Society
  
  Volume: 4 (11) Issue: 11
- DOI
  10.1210/jendso/bvaa146
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09028
[Journal Article] Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors.2020
- Author(s)
  Mussazhanova Z, Shimamura M, Kurashige T, Ito M, Nakashima M, Nagayama Y
- Journal Title
  
  Cancer Sci.
  
  Volume: 111 Issue: 8 Pages: 2814-2823
- DOI
  10.1111/cas.14501
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-20K07424, KAKENHI-PROJECT-20K08886, KAKENHI-PROJECT-19KK0266
[Journal Article] Acceleration of BRAFV600E-mediated thyroid carcinogenesis by TGFβ signal deficiency.2020
- Author(s)
  Shimamura M, Kurashige T, Kuatov R, Nagayama Y.
- Journal Title
  
  Endocrine
  
  Volume: in press Issue: 3 Pages: 571-577
- DOI
  10.1007/s12020-020-02298-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-20K07424, KAKENHI-PROJECT-20K08886
[Journal Article] Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice2019
- Author(s)
  Kurashige Tomomi、Nakajima Yasuyo、Shimamura Mika、Matsuyama Mutsumi、Yamada Masanobu、Nakashima Masahiro、Nagayama Yuji
- Journal Title
  
  Endocrinology
  
  Volume: 160 Issue: 9 Pages: 2085-2092
- DOI
  10.1210/en.2019-00312
- NAID
  120006988409
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-17K00554
[Journal Article] Intracellular redox status controls spherogenicity, an in vitro cancer stem cell marker, in thyroid cancer cell lines2018
- Author(s)
  Shimamura Mika、Yamamoto Kazuo、Kurashige Tomomi、Nagayama Yuji
- Journal Title
  
  Experimental Cell Research
  
  Volume: 370 Issue: 2 Pages: 699-707
- DOI
  10.1016/j.yexcr.2018.07.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07235, KAKENHI-PROJECT-16K00548, KAKENHI-PROJECT-17K16167, KAKENHI-PROJECT-16H06276
[Journal Article] Aldehyde dehydrogenase activity plays no functional role in stem cell-like properties in anaplastic thyroid cancer cell lines.2017
- Author(s)
  Shimamura M, Kurashige T, Mitsutake N, Nagayama Y.
- Journal Title
  
  Endocrine
  
  Volume: 55 Issue: 3 Pages: 934-943
- DOI
  10.1007/s12020-016-1224-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-15K19535, KAKENHI-PROJECT-15K09437, KAKENHI-PROJECT-17K16167
[Presentation] MIEAP, ATG5は甲状腺がんの腫瘍抑制遺伝子である2022
- Author(s)
  濵田航一郎, 蔵重智美, 嶋村美加, 荒川博文, 中村康之, 永山雄二
- Organizer
  第65回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08888
[Presentation] MIEAP and ATG5 are tumor suppressors in a mouse model of thyroid cancer2022
- Author(s)
  濵田航一郎, 蔵重智美, 嶋村美加, 荒川博文, 中村康之, 永山雄二
- Organizer
  第6回放射線災害・医科学研究拠点国際シンポジウム
- Data Source
  KAKENHI-PROJECT-20K08888
[Presentation] 甲状腺オンコサイトーマにおけるmitochondria eating protein (MIEAP)の発現・機能2021
- Author(s)
  永山雄二、Mussazhanova Zhanna、嶋村美加、中島正洋
- Organizer
  第５回放射線災害・医科学研究拠点カンファランス
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09028
[Presentation] Intracellular redox status controls spherogenicity in thyroid cancer cells2018
- Author(s)
  嶋村美加蔵重智美　永山雄二
- Organizer
  第2回　放射線災害・医科学研究拠点国際シンポジウム
- Data Source
  KAKENHI-PROJECT-17K16167
[Presentation] 甲状腺癌幹細胞の特性の検討　～ROSを指標にして～2017
- Author(s)
  嶋村美加　永山雄二
- Organizer
  第2回　放射線災害・医科学研究拠点カンファランス
- Data Source
  KAKENHI-PROJECT-17K16167
[Presentation] Aldehyde Dehydrogenase Activity Plays No Role for Cancer stem-Like Properties in Anaplastic Thyroid Cancer Cell Lines2016
- Author(s)
  Shimamura M, Mitsutake N, Nagayama Y
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K19535

1. NAGAYAMA Yuji (30274632)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. Kurashige Tomomi (60568955)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. MATSUSE Michiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. TAKA Hikari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KAGA Naoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 中島正洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 山本一男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 荒川博文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 光武範吏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 伊東正博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMAMURA Mika 嶋村 美加

Research Projects

Research Products

Co-Researchers

甲状腺癌マウスモデル・甲状腺癌オルガノイドを利用した予後を決定する微小環境の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Autophagy regulatory mechanisms in thyroid and significance for carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on thyorid cancer pathogenesis using mouse models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the new treatment for thyroid cancer by targeting the plasticity of the cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on thyroid cancer stem cells: ALDH function analysis and plasticityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Characterization of metabolic reprogramming by metabolomics in the oncocytic thyroid cancer cell line XTC.UC1.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Effect of Long-Term Inorganic Iodine on Intrathyroidal Iodothyronine Content and Gene Expression in Mice with Graves' Hyperthyroidism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Re-evaluation of the role of autophagy in thyroid cancer treatment2022

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] MIEAP and ATG5 are tumor suppressors in a mouse model of BRAFV600E-positive thyroid cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 甲状腺特異的オートファジーノックアウトマウスでは、濾胞上皮細胞死が誘導される2020

Author(s)

Journal Title

Data Source

[Journal Article] Re-evaluation of the effect of iodine on thyroid cell survival and function with PCCL3 and Nthy-ori 3-1 cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acceleration of BRAFV600E-mediated thyroid carcinogenesis by TGFβ signal deficiency.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice2019

Author(s)

Journal Title

DOI

SHIMAMURA Mika 嶋村美加

[Presentation] 甲状腺癌幹細胞の特性の検討　～ROSを指標にして～2017