fujita hiroaki 藤田宏明

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Fujita Hiroaki 藤田宏明

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Researcher Number	90738006
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定講師
Affiliation (based on the past Project Information) *help	2016 – 2023: 京都大学, 医学研究科, 助教 2015: 京都大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Complex systems / Basic Section 44010:Cell biology-related / General medical chemistry / Biological Sciences
Keywords	Principal Investigator 細胞死 / 鉄 / LUBAC / フェロトーシス / ユビキチン / 直鎖状ポリユビキチン鎖 / セレン / 直鎖状ユビキチン鎖 / 鉄依存性細胞死 / セレノシステイン … More / セレンタンパク質 / オートファジー / フェリチノファジー / 相分離 / NCOA4 / フェリチン / HOIL-1L / OTULIN / NF-kB / 数理モデル / NF-kBシグナル Less

鉄誘導性フェロトーシス惹起機構の解明Principal Investigator
- Principal Investigator
  
  藤田宏明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto University
鉄誘導性フェロトーシスを制御する新たな生命金属動態の解明Principal Investigator
- Principal Investigator
  
  藤田宏明
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
鉄濃度依存的なフェリチンのオートファジー経路選択性の解析Principal Investigator
- Principal Investigator
  
  藤田宏明
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
過剰鉄によるフェロトーシス惹起メカニズムの解明Principal Investigator
- Principal Investigator
  
  藤田宏明
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
Elucidation of the mechanisms of cell survival and death by linear ubiquitin chainsPrincipal Investigator
- Principal Investigator
  
  Fujita Hiroaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto University
細胞の生存と死を決定する制御システムの数理モデル化Principal Investigator
- Principal Investigator
  
  藤田宏明
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
Elucidation of cell death regulation mechanisms and physiological significance by HOIL-1LPrincipal Investigator
- Principal Investigator
  
  Fujita Hiroaki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Elucidating the mechanisms underlying linear ubiquitin chains-mediated cell death protectionPrincipal Investigator
- Principal Investigator
  
  Fujita Hiroaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] シグナリング研究20152015
- Author(s)
  藤田宏明、岩井一宏
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-15K19007
[Journal Article] Iron-induced NCOA4 condensation regulates ferritin fate and iron homeostasis2022
- Author(s)
  S. Kuno, H. Fujita, Y. Tanaka, Y. Ogra, and K. Iwai
- Journal Title
  
  EMBO reports
  
  Volume: e54278 Issue: 5
- DOI
  10.15252/embr.202154278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05319, KAKENHI-PROJECT-21H04920, KAKENHI-PROJECT-22K06222, KAKENHI-PUBLICLY-20H05505, KAKENHI-PUBLICLY-22H04810
[Journal Article] The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC2020
- Author(s)
  Fuseya Yasuhiro、Fujita Hiroaki、Kim Minsoo、Ohtake Fumiaki、Nishide Akira、Sasaki Katsuhiro、Saeki Yasushi、Tanaka Keiji、Takahashi Ryosuke、Iwai Kazuhiro
- Journal Title
  
  Nature Cell Biology
  
  Volume: 22 Issue: 6 Pages: 663-673
- DOI
  10.1038/s41556-020-0517-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16144, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19H00997, KAKENHI-PLANNED-18H05498, KAKENHI-PUBLICLY-20H05319, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-19K06635, KAKENHI-PUBLICLY-20H05505
[Journal Article] Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization2018
- Author(s)
  Fujita Hiroaki、Tokunaga Akira、Shimizu Satoshi、Whiting Amanda L.、Aguilar-Alonso Francisco、Takagi Kenji、Walinda Erik、Sasaki Yoshiteru、Shimokawa Taketo、Mizushima Tsunehiro、Ohki Izuru、Ariyoshi Mariko、Tochio Hidehito、Bernal Federico、Shirakawa Masahiro、Iwai Kazuhiro
- Journal Title
  
  Cell Reports
  
  Volume: 23 Issue: 4 Pages: 1192-1204
- DOI
  10.1016/j.celrep.2018.03.112
- NAID
  120006460107
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06969, KAKENHI-PROJECT-18K06083, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-17H06174, KAKENHI-PUBLICLY-17H06002, KAKENHI-PROJECT-17K15594
[Journal Article] Differential involvement of the NZF domains of SHARPIN and HOIL-1L in LUBAC-mediated cell death protection.2016
- Author(s)
  Shimizu S, Fujita H, Sasaki Y, Tsuruyama T, Fukuda K, Iwai K.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 01049-15 Issue: 10 Pages: 1569-1583
- DOI
  10.1128/mcb.01049-15
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19007, KAKENHI-PROJECT-14J01829, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019, KAKENHI-PROJECT-26460573
[Journal Article] Immunoblot Analysis of Linear Polyubiquitination of NEMO.2015
- Author(s)
  Sasaki, Y., Fujita, H., Nakai, M., and Iwai, K.
- Journal Title
  
  Methods in Molecular Biology, NF-kappaB Methods and Protocols
  
  Volume: 1280 Pages: 297-309
- DOI
  10.1007/978-1-4939-2422-6_17
- ISBN
  9781493924219, 9781493924226
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460573, KAKENHI-PROJECT-15K19007, KAKENHI-ORGANIZER-24112001
[Journal Article] Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex.2015
- Author(s)
  Morita D, Yamamoto Y, Mizutani T, Ishikawa T, Suzuki J, Igarashi T, Mori N, Shiina T, Inoko H, Fujita H, Iwai K, Tanaka Y, Mikami B, Sugita M,
- Journal Title
  
  Nat Commun.
  
  Volume: 7 Issue: 1 Pages: 10356-10356
- DOI
  10.1038/ncomms10356
- NAID
  120005743661
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19007, KAKENHI-PUBLICLY-15H01257, KAKENHI-PROJECT-26670483, KAKENHI-PROJECT-26860323, KAKENHI-PLANNED-24120006
[Presentation] 鉄依存性フェロトーシスの制御メカニズム解明2023
- Author(s)
  藤田宏明
- Organizer
  日本生化学会　シンポジウム
- Data Source
  KAKENHI-PUBLICLY-22H04810
[Presentation] 鉄依存性フェロトーシスの制御メカニズム解明2023
- Author(s)
  藤田宏明
- Organizer
  日本生化学会　シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06222
[Presentation] 鉄誘導性フェロトーシスの制御メカニズム解明2022
- Author(s)
  藤田宏明
- Organizer
  メタルバイオサイエンス学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06222
[Presentation] 鉄誘導性フェロトーシスの制御メカニズム解明2022
- Author(s)
  藤田宏明
- Organizer
  メタルバイオサイエンス研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04810
[Presentation] 鉄依存的なNCOA4の相分離によるフェリチンオートファジーの制御2021
- Author(s)
  藤田宏明、九野宗大、岩井一宏
- Organizer
  第14回オートファジー研究会
- Data Source
  KAKENHI-PUBLICLY-20H05319
[Presentation] 過剰鉄によるフェロトーシス制御因子の解明2021
- Author(s)
  藤田宏明
- Organizer
  第94回　日本生化学会大会　シンポジウム
- Data Source
  KAKENHI-PUBLICLY-20H05505
[Presentation] 鉄依存性フェロトーシスの制御機構の解明2021
- Author(s)
  藤田宏明
- Organizer
  生命金属科学　夏の合宿
- Data Source
  KAKENHI-PUBLICLY-20H05505
[Presentation] LUBAC安定化機構の解明と応用2019
- Author(s)
  藤田宏明
- Organizer
  医科研若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K15594
[Presentation] Mathematical modeling of biological systems that regulate cell survival and death2019
- Author(s)
  藤田宏明
- Organizer
  数理シグナル　第一回国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H06002
[Presentation] LUBAC安定化機構の解明と応用2019
- Author(s)
  藤田宏明
- Organizer
  東大医科研若手シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H06002
[Presentation] Novel insights into linear ubiquitin chain assembly complex formation2019
- Author(s)
  Hiroaki Fujita
- Organizer
  EMBO conference : The ubiquitin system: Biology, mechanisms and roles in disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06635
[Presentation] Crystal structure of trimeric LUBAC reveals essential role of a novel HOIL-1L-SHARPIN interaction in LUBAC formation and function2018
- Author(s)
  Fujita, H., Tokunaga A., Iwai, K.
- Organizer
  第40回日本分子生物学会　シンポジウム
- Data Source
  KAKENHI-PROJECT-17K15594
[Presentation] 細胞の生存と死を決定する制御システムの数理モデル化2018
- Author(s)
  藤田宏明
- Organizer
  第27回　がん転移学会　シンポジウム
- Data Source
  KAKENHI-PUBLICLY-17H06002
[Presentation] Crystal structure of trimeric LUBAC reveals essential role of a novel HOIL-1L-SHARPIN interaction in LUBAC formation and function2017
- Author(s)
  Fujita, H., Tokunaga A., Iwai, K.
- Organizer
  第40回日本分子生物学会　シンポジウム
- Data Source
  KAKENHI-PUBLICLY-17H06002
[Presentation] Novel insights into linear ubiquitin chain assembly complex formation2016
- Author(s)
  藤田宏明
- Organizer
  KEYSTONE SYMPOSIA
- Place of Presentation
  Whistler, British Columbia, Canada
- Year and Date
  2016-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19007
[Presentation] LUBAC安定化機構の解析からみえてきたHOIL-1L、SHARPINの機能的差異2015
- Author(s)
  藤田宏明
- Organizer
  シグナルネットワーク研究会
- Place of Presentation
  沖縄科学技術大学院大学
- Year and Date
  2015-06-19
- Data Source
  KAKENHI-PROJECT-15K19007
[Presentation] LUBACリガーゼ形成における相同性の高いHOIL-1L、SHARPINのUBLの機能的差異2015
- Author(s)
  藤田宏明
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K19007

1. 佐々木義輝

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# of Collaborated Products: 1 results
2. 大木出

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# of Collaborated Products: 1 results
3. 伏屋康寛

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# of Collaborated Products: 1 results

fujita hiroaki 藤田 宏明

Fujita Hiroaki 藤田 宏明

Research Projects

Research Products

Co-Researchers

鉄誘導性フェロトーシス惹起機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

鉄誘導性フェロトーシスを制御する新たな生命金属動態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

鉄濃度依存的なフェリチンのオートファジー経路選択性の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

過剰鉄によるフェロトーシス惹起メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms of cell survival and death by linear ubiquitin chainsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞の生存と死を決定する制御システムの数理モデル化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of cell death regulation mechanisms and physiological significance by HOIL-1LPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidating the mechanisms underlying linear ubiquitin chains-mediated cell death protectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] シグナリング研究20152015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Iron-induced NCOA4 condensation regulates ferritin fate and iron homeostasis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Differential involvement of the NZF domains of SHARPIN and HOIL-1L in LUBAC-mediated cell death protection.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunoblot Analysis of Linear Polyubiquitination of NEMO.2015

fujita hiroaki 藤田宏明

Fujita Hiroaki 藤田宏明

[Presentation] 鉄誘導性フェロトーシスの制御メカニズム解明2022

[Presentation] 鉄誘導性フェロトーシスの制御メカニズム解明2022