KOYANAGI NAOTO 小柳直人

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Koyanagi Naoto 小柳直人

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Researcher Number	90738121
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 助教
Affiliation (based on the past Project Information) *help	2023: 東京大学, 医科学研究所, 助教 2022: 福島県立医科大学, 保健科学部, 助教 2018 – 2021: 東京大学, 医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related
Keywords	Principal Investigator HSV / 免疫回避 / 脳炎 / MHC-I / CTL / HSV-2 / 単純ヘルペスウイルス / NKG2Dリガンド / 感染制御 / 障害回避 / 回避機構 / NK細胞

単純ヘルペス脳炎発症機構の解明Principal Investigator
- Principal Investigator
  
  小柳直人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  The University of Tokyo
Novel CTL evasion mechanism of HSV-2Principal Investigator
- Principal Investigator
  
  Koyanagi Naoto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  The University of Tokyo
  Fukushima Medical University
Elucidation of NK cell evasion mechanism by herpes simplex virusPrincipal Investigator
- Principal Investigator
  
  Koyanagi Naoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  The University of Tokyo

All 2023 2022 2020 2018 Other

All Journal Article Presentation Other

[Journal Article] Role of the Arginine Cluster in the Disordered Domain of Herpes Simplex Virus 1 UL34 for the Recruitment of ESCRT-III for Viral Primary Envelopment2022
- Author(s)
  Arii Jun、Takeshima Kosuke、Maruzuru Yuhei、Koyanagi Naoto、Nakayama Yoshitaka、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
- Journal Title
  
  Journal of Virology
  
  Volume: 96 Issue: 2
- DOI
  10.1128/jvi.01704-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00417, KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-21K19370, KAKENHI-PROJECT-21K15447, KAKENHI-PROJECT-21K19498, KAKENHI-PUBLICLY-22H05584, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PROJECT-20H03496, KAKENHI-PUBLICLY-21H00338
[Journal Article] Phosphoregulation of a Conserved Herpesvirus Tegument Protein by a Virally Encoded Protein Kinase in Viral Pathogenicity and Potential Linkage between Its Evolution and Viral Phylogeny2020
- Author(s)
  Shibazaki Misato、Kato Akihisa、Takeshima Kosuke、Ito Jumpei、Suganami Mai、Koyanagi Naoto、Maruzuru Yuhei、Sato Kei、Kawaguchi Yasushi
- Journal Title
  
  Journal of Virology
  
  Volume: 94 Issue: 18 Pages: 1-4
- DOI
  10.1128/jvi.01055-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-19K22524, KAKENHI-PROJECT-20K15767, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PUBLICLY-19H04826, KAKENHI-PUBLICLY-20H04899, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-19J01713, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-20H03492, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] Role of the DNA Binding Activity of Herpes Simplex Virus 1 VP22 in Evading AIM2-Dependent Inflammasome Activation Induced by the Virus2020
- Author(s)
  Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Kawaguchi Yasushi
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 5
- DOI
  10.1128/jvi.02172-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-PLANNED-16H06433, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PUBLICLY-20H04899, KAKENHI-PUBLICLY-21H00338, KAKENHI-PROJECT-21K19498
[Journal Article] Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway2020
- Author(s)
  Watanabe Mizuki、Arii Jun、Takeshima Kosuke、Fukui Ayano、Shimojima Masayuki、Kozuka-Hata Hiroko、Oyama Masaaki、Minamitani Takeharu、Yasui Teruhito、Kubota Yuji、Takekawa Mutsuhiro、Kosugi Isao、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 3
- DOI
  10.1128/jvi.01413-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-ORGANIZER-16H06573, KAKENHI-PLANNED-16H06574, KAKENHI-PLANNED-16H06578, KAKENHI-PUBLICLY-19H05286, KAKENHI-PUBLICLY-19H05417, KAKENHI-PROJECT-18H02609, KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03496, KAKENHI-PUBLICLY-20H04899, KAKENHI-PUBLICLY-21H00338, KAKENHI-PROJECT-21H02692, KAKENHI-PROJECT-21K07816, KAKENHI-PROJECT-21K19498, KAKENHI-INTERNATIONAL-16K21739
[Journal Article] ESCRT-III controls nuclear envelope deformation induced by progerin2020
- Author(s)
  Arii Jun、Maeda Fumio、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 18877-18877
- DOI
  10.1038/s41598-020-75852-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07511, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PUBLICLY-19H05286, KAKENHI-PUBLICLY-19H05417, KAKENHI-PUBLICLY-20H04899, KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PROJECT-20H03496
[Journal Article] Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics2020
- Author(s)
  Kato Akihisa、Adachi Shungo、Kawano Shuichi、Takeshima Kousuke、Watanabe Mizuki、Kitazume Shinobu、Sato Ryota、Kusano Hideo、Koyanagi Naoto、Maruzuru Yuhei、Arii Jun、Hatta Tomohisa、Natsume Tohru、Kawaguchi Yasushi
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 4894-4894
- DOI
  10.1038/s41467-020-18718-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-19K22524, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PUBLICLY-20H04899, KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-19K21256, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PROJECT-19K16685, KAKENHI-PUBLICLY-21H00338, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] Evasion of the Cell-Mediated Immune Response by Alphaherpesviruses2020
- Author(s)
  Koyanagi Naoto、Kawaguchi Yasushi
- Journal Title
  
  Viruses
  
  Volume: 12 Issue: 12 Pages: 1354-1354
- DOI
  10.3390/v12121354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15164, KAKENHI-PROJECT-20H05692
[Journal Article] ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity.2018
- Author(s)
  Arii J, Watanabe M, Maeda F, Tokai-Nishizumi N, Chihara T, Miura M, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
- Journal Title
  
  Nat Commun.
  
  Volume: 9 Issue: 1 Pages: 3379-3379
- DOI
  10.1038/s41467-018-05889-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-17K19549, KAKENHI-PROJECT-18K15164, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-16K15280, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-19K21256
[Journal Article] Regulation of Herpes Simplex Virus 2 Protein Kinase UL13 by Phosphorylation and Its Role in Viral Pathogenesis.2018
- Author(s)
  Koyanagi N, Kato A, Takeshima K, Maruzuru Y, Kozuka-Hata H, Oyama M, Arii J, Kawaguchi Y.
- Journal Title
  
  J Virol.
  
  Volume: 92 Issue: 17
- DOI
  10.1128/jvi.00807-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-17K19549, KAKENHI-PROJECT-18K15164, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PLANNED-16H06578, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-19K21256
[Journal Article] Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity.2018
- Author(s)
  Kato A, Oda S, Watanabe M, Oyama M, Kozuka-Hata H, Koyanagi N, Maruzuru Y, Arii J, Kawaguchi Y.
- Journal Title
  
  J Virol.
  
  Volume: 92 Issue: 18
- DOI
  10.1128/jvi.01035-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-17K19549, KAKENHI-PROJECT-18K15164, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PLANNED-16H06578, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-19K21256, KAKENHI-ORGANIZER-15H05935
[Presentation] Regulatory mimicry of cyclin-dependent kinases by conserved herpesvirus protein kinases2023
- Author(s)
  Naoto Koyanagi, Akihisa Kato, Kosuke Takeshima, Yuhei Maruzuru and Yasushi Kawaguchi
- Organizer
  International Herpesvirus Workshop 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15447
[Presentation] Role of amino acid residues in the α-helix 9 of HSV-1 UL31 in its interaction with capsid proteins and nuclear egress2018
- Author(s)
  Kosuke Takeshima, Jun Arii, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
- Organizer
  43nd Annual International Herpesvirus Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15164
[Presentation] Primary Envelopment におけるHSV-1 UL31 α-helix 9 の役割2018
- Author(s)
  竹島功高，有井潤，丸鶴雄平，小柳直人，加藤哲久，川口寧
- Organizer
  第32回ヘルペスウイルス研究会
- Data Source
  KAKENHI-PROJECT-18K15164
[Presentation] αヘルペスウイルスの進化とUs3 リン酸化部位の獲得2018
- Author(s)
  柴崎美里，加藤哲久，竹島功高，丸鶴雄平，小柳直人，有井潤，川口寧
- Organizer
  第32回ヘルペスウイルス研究会
- Data Source
  KAKENHI-PROJECT-18K15164
[Presentation] HSV type-specific phosphorylation mediated by Us3 kinase: its role in viral pathogenesis and implication in evolution of herpesviruses2018
- Author(s)
  Misato Shibazaki，Akihisa Kato，Kosuke Takeshima，Naoto Koyanagi，Yuhei Maruzuru， Jun Arii，Yasushi Kawaguchi
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15164
[Presentation] Negative regulation of HSV-1 Us3 kinase by tyrosine phosphorylation and its role in viral replication and pathogenesis2018
- Author(s)
  Nami Kimura，Akihisa Kato，Yuhei Maruzuru，Naoto Koyanagi，Jun Arii，Yasushi Kawaguchi
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15164
[Presentation] A single amino acid substitution in HSV-1 UL31 at an inter-hexamer contact site abrogates primary envelopment and viral growth2018
- Author(s)
  Jun Arii，Kosuke Takeshima，Yuhei Maruzuru，Naoto Koyanagi，Akihisa Kato， Yasushi Kawaguchi
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15164
[Presentation] A single amino acid substitution in herpes simplex virus 1 UL31 at an inter-hexamer contact site abrogates primary envelopment and viral growth2018
- Author(s)
  Jun Arii, Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
- Organizer
  43nd Annual International Herpesvirus Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15164
[Presentation] Residues in α-helix 9 of HSV-1 UL31 is critical for interaction with UL25 and incorporation of capsid into vesicles in the perinuclear space2018
- Author(s)
  Kosuke Takeshima，Jun Arii，Yuhei Maruzuru，Naoto Koyanagi，Akihisa Kato， Yasushi Kawaguchi
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15164
[Presentation] A HSV-2 specific phosphorylation event mediated by Us3 kinase is involved in viral pathogenicity in mice following vaginal infection2018
- Author(s)
  Misato Shibazaki, Akihisa Kato, Naoto Koyanagi, Yuhei Maruzuru, Jun Arii, Yasushi Kawaguchi
- Organizer
  43nd Annual International Herpesvirus Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15164
[]

1. 有井潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 丸鶴雄平

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results

KOYANAGI NAOTO 小柳 直人

Koyanagi Naoto 小柳 直人

Research Projects

Research Products

Co-Researchers

単純ヘルペス脳炎発症機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel CTL evasion mechanism of HSV-2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of NK cell evasion mechanism by herpes simplex virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Role of the Arginine Cluster in the Disordered Domain of Herpes Simplex Virus 1 UL34 for the Recruitment of ESCRT-III for Viral Primary Envelopment2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphoregulation of a Conserved Herpesvirus Tegument Protein by a Virally Encoded Protein Kinase in Viral Pathogenicity and Potential Linkage between Its Evolution and Viral Phylogeny2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of the DNA Binding Activity of Herpes Simplex Virus 1 VP22 in Evading AIM2-Dependent Inflammasome Activation Induced by the Virus2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ESCRT-III controls nuclear envelope deformation induced by progerin2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evasion of the Cell-Mediated Immune Response by Alphaherpesviruses2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of Herpes Simplex Virus 2 Protein Kinase UL13 by Phosphorylation and Its Role in Viral Pathogenesis.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Regulatory mimicry of cyclin-dependent kinases by conserved herpesvirus protein kinases2023

Author(s)

Organizer

Data Source

[Presentation] Role of amino acid residues in the α-helix 9 of HSV-1 UL31 in its interaction with capsid proteins and nuclear egress2018

Author(s)

Organizer

KOYANAGI NAOTO 小柳直人

Koyanagi Naoto 小柳直人