NAGATA YASUNOBU 永田安伸

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Nagata Yasunobu 永田安伸

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Researcher Number	90739575
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, 講師 2025: 日本医科大学, 大学院医学研究科, 研究生
Affiliation (based on the past Project Information) *help	2024: 日本医科大学, 医学部, 講師 2021 – 2022: 日本医科大学, 医学部, 講師 2020: 日本医科大学, 医学部, 助教 2014 – 2015: 京都大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator 白血病 / 骨髄異形成症候群 / アポトーシス / BCL2阻害剤 / クローン構造 / クローン進化 / 次世代シーケンサー / 癌 / ゲノム / 再生不良性貧血 / 全エクソンシークエンス

BCL-2阻害剤抵抗性白血病における抗アポトーシス分子スイッチングの機序解明Principal Investigator
- Principal Investigator
  
  永田安伸
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nippon Medical School
Clarifying clonal architecture diversity of leukemia dervied from myelodysplastic syndromesPrincipal Investigator
- Principal Investigator
  
  Nagata Yasunobu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nippon Medical School
Integrated analysis of clonal evolution at early stage of myelodysplastic syndrome.Principal Investigator
- Principal Investigator
  
  Nagata Yasunobu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2016 2015 2014

All Journal Article Presentation Book

[Book] 血液内科　第85巻第1号骨髄異形成症候群の個別化予後予測モデル2022
- Author(s)
  永田安伸
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20K17412
[Journal Article] Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis with Central Nervous System Symptoms2023
- Author(s)
  Sakaguchi Masahiro、Nagata Yasunobu、Terasaki Yasuhiro、Takeyoshi Atsushi、Yasuda Shunichi、Honma Shunsuke、Kinoshita Ryosuke、Marumo Atsushi、Asayama Toshio、Yui Shunsuke、Wakita Satoshi、Okamoto Muneo、Kajimoto Yusuke、Inokuchi Koichi、Yamaguchi Hiroki
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 90 Issue: 1 Pages: 126-135
- DOI
  10.1272/jnms.JNMS.2023_90-105
- ISSN
  1345-4676, 1347-3409
- Year and Date
  2023-02-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17412, KAKENHI-PROJECT-20K08553
[Journal Article] Germ line <i>DDX41</i> mutations define a unique subtype of myeloid neoplasms2023
- Author(s)
  Makishima H, Saiki R, Nannya Y, (17人省略), Kon A, (28人省略), Maciejewski JP, Ogawa S.
- Journal Title
  
  Blood
  
  Volume: 141 Issue: 5 Pages: 534-549
- DOI
  10.1182/blood.2022018221
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08394, KAKENHI-PROJECT-22K08480, KAKENHI-PROJECT-22K16320, KAKENHI-PROJECT-19H01053, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-20H03712, KAKENHI-PROJECT-22KJ1756, KAKENHI-PROJECT-20K17412, KAKENHI-PROJECT-23K24079
[Journal Article] Safety and efficacy of high‐dose cytarabine MEAM therapy and other treatments for auto‐peripheral blood stem cell transplantation: A retrospective comparative study2022
- Author(s)
  Yui Shunsuke、Wakita Satoshi、Nagata Yasunobu、Omori Ikuko、Kinoshita Ryosuke、Takeyoshi Atsushi、Yasuda Shunichi、Honma Shunsuke、Nakayama Kazutaka、Hirakawa Tsuneaki、Arai Kunihito、Kitano Tomoaki、Okamoto Muneo、Inokuchi Koiti、Yamaguchi Hiroki
- Journal Title
  
  Asia-Pacific Journal of Clinical Oncology
  
  Volume: 19 Issue: 1 Pages: 136-148
- DOI
  10.1111/ajco.13780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17412
[Journal Article] Share Machine learning integrates genomic signatures for subclassification beyond primary and secondary acute myeloid leukemia.2021
- Author(s)
  Awada H, Durmaz A, Gurnari C, Kishtagari A, Meggendorfer M, Kerr CM, Kuzmanovic T, Durrani J, Shreve J, Nagata Y, Radivoyevitch T, Advani AS, Ravandi F, Carraway HE, Nazha A, Haferlach C, Saunthararajah Y, Scott J, Visconte V, Kantarjian H, Kadia T, Sekeres MA, Haferlach T, Maciejewski JP.
- Journal Title
  
  Blood
  
  Volume: 138(19) Issue: 19 Pages: 1885-1895
- DOI
  10.1182/blood.2020010603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17412
[Journal Article] A geno-clinical decision model for the diagnosis of myelodysplastic syndromes.2021
- Author(s)
  Radakovich N, Meggendorfer M, Malcovati L, Hilton CB, Sekeres MA, Shreve J, Rouphail Y, Walter W, Hutter S, Galli A, Pozzi S, Elena C, Padron E, Savona MR, Gerds AT, Mukherjee S, Nagata Y, Komrokji RS, Jha BK, Haferlach C, Maciejewski JP, Haferlach T, Nazha A.
- Journal Title
  
  Blood Advances
  
  Volume: 5(21) Issue: 21 Pages: 4361-4369
- DOI
  10.1182/bloodadvances.2021004755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17412
[Journal Article] Analysis of distinct SF3B1 hotspot mutations in relation to clinical phenotypes and response to therapy in myeloid neoplasia2020
- Author(s)
  Adema Vera、Khouri Jack、Ni Ying、Rogers Heesun J.、Awada Hassan、Nagata Yasunobu、Kuzmanovic Teodora、Advani Anjali S.、Gerds Aaron T.、Mukherjee Sudipto、Nazha Aziz、Saunthararajah Yogen、Madanat Yazan、Patel Bhumika J.、Sol Francesc、Nawrocki Steffan T.、Maciejewski Jaroslaw P.、Visconte Valeria、Carraway Hetty E.
- Journal Title
  
  Leukemia & Lymphoma
  
  Volume: 62 Issue: 3 Pages: 735-738
- DOI
  10.1080/10428194.2020.1839647
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17412
[Journal Article] Machine learning demonstrates that somatic mutations imprint invariant morphologic features in myelodysplastic syndromes2020
- Author(s)
  Nagata Yasunobu、Zhao Ran、Awada Hassan、Kerr Cassandra M.、Mirzaev Inom、Kongkiatkamon Sunisa、Nazha Aziz、Makishima Hideki、Radivoyevitch Tomas、Scott Jacob G.、Sekeres Mikkael A.、Hobbs Brian P.、Maciejewski Jaroslaw P.
- Journal Title
  
  Blood
  
  Volume: 136 Issue: 20 Pages: 2249-2262
- DOI
  10.1182/blood.2020005488
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17412, KAKENHI-PROJECT-19H01053
[Journal Article] Rare germline variant contributions to myeloid malignancy susceptibility2020
- Author(s)
  Li Samuel T.、Wang Janet、Wei Ruipeng、Shi Ruqi、Adema Vera、Nagata Yasunobu、Kerr Cassandra M.、Kuzmanovic Teodora、Przychodzen Bartlomiej、Sole Francesc、Maciejewski Jaroslaw P.、LaFramboise Thomas
- Journal Title
  
  Leukemia
  
  Volume: 34 Issue: 6 Pages: 1675-1678
- DOI
  10.1038/s41375-019-0701-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17412
[Journal Article] Variegated RHOA mutations in adult T-cell leukemia/lymphoma2016
- Author(s)
  Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, (9名), Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S
- Journal Title
  
  Blood
  
  Volume: 127 Issue: 5 Pages: 596-604
- DOI
  10.1182/blood-2015-06-644948
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-26893127, KAKENHI-PROJECT-14J03784, KAKENHI-PROJECT-26650029, KAKENHI-PROJECT-26290053, KAKENHI-PROJECT-26291038, KAKENHI-PROJECT-25461407, KAKENHI-PROJECT-23229001
[Journal Article] Complex molecular genetic abnormalities involving three or more genetic mutations are important prognostic factors for acute myeloid leukemia.2016
- Author(s)
  Wakita S, Yamaguchi H, Ueki T, Usuki K, Kurosawa S, Kobayashi Y, Kawata E, Tajika K, Gomi S, Koizumi M, Fujiwara Y, Yui S, Fukunaga K, Ryotokuji T, Hirakawa T, Arai K, Kitano T, Kosaka F, Tamai H, Nakayama K, Fukuda T, Inokuchi K
- Journal Title
  
  Leukemia
  
  Volume: 60 Issue: 22 Pages: 545-554
- DOI
  10.1182/blood-2015-05-646240
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461434, KAKENHI-PROJECT-26893127
[Journal Article] Genomon ITDetector: a tool for somatic internal tandem duplication detection from cancer genome sequencing data.2015
- Author(s)
  Chiba K, Shiraishi Y, Nagata Y, Yoshida K, Imoto S, Ogawa S, Miyano S.
- Journal Title
  
  Bioinformatics
  
  Volume: 31 Issue: 1 Pages: 116-118
- DOI
  10.1093/bioinformatics/btu593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26890016, KAKENHI-PROJECT-26893127, KAKENHI-PROJECT-25250017
[Journal Article] Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.2015
- Author(s)
  Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S.
- Journal Title
  
  N Engl J Med.
  
  Volume: 373 Issue: 1 Pages: 35-47
- DOI
  10.1056/nejmoa1414799
- NAID
  120005623244
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15360, KAKENHI-PLANNED-15H05909, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-15H06324, KAKENHI-PROJECT-26893127, KAKENHI-PROJECT-15J05178, KAKENHI-PROJECT-14F04419, KAKENHI-PROJECT-14J03784, KAKENHI-PROJECT-15K15361
[Journal Article] Integrated molecular analysis of adult T cell leukemia/lymphoma.2015
- Author(s)
  Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, et al.
- Journal Title
  
  Nat Genet.
  
  Volume: 47(11) Issue: 11 Pages: 1304-15
- DOI
  10.1038/ng.3415
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-15K09479, KAKENHI-PROJECT-15K09507, KAKENHI-PROJECT-26460554, KAKENHI-PROJECT-15K12139, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-25250020, KAKENHI-PROJECT-26893127, KAKENHI-PROJECT-25730173, KAKENHI-PROJECT-25860521, KAKENHI-PROJECT-25293219
[Journal Article] BRCC3 mutations in myeloid neoplasms.2015
- Author(s)
  Huang D, Nagata Y, Grossmann V, Radivoyevitch T, Yoshida K, Sekeres MA, Oakley K, Nguyen N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Miyano S, Haferlach C, Kern W, Haferlach T, Du Y, Ogawa S, Makishima H.
- Journal Title
  
  Haematologica
  
  Volume: 100(8) Pages: 1051-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893127
[Journal Article] Expressional changes of genes and miRNA in common megakaryocyte-erythroid progenitors from lower-risk myelodysplastic syndrome.2014
- Author(s)
  Maki K, Sasaki K, Nagata Y, Nagasawa F, Nakamura Y, Ogawa S, Mitani K.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 46(8) Issue: 4 Pages: 361-369
- DOI
  10.1007/s12185-014-1639-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26893127
[Journal Article] A robust molecular pattern for myelodysplastic syndromes in two independent cohorts investigated by next-generation sequencing can be revealed by comparative bioinformatic analyses.2014
- Author(s)
  Rose D, Kohlmann A, Nagata Y, Ogawa S, Haferlach C, Kern W, Schnittger S, Haferlach T.
- Journal Title
  
  British Journal of Haematology
  
  Volume: 167(2) Issue: 2 Pages: 278-281
- DOI
  10.1111/bjh.12971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26893127
[Presentation] The clinical and genetic features of Japanese de novo AML with IDH1/2 and SRSF2 mutations2022
- Author(s)
  Mika Iwakiri, Yasunobu Nagata, Jiadan Sheng, Atsushi Marumo, Satoshi Wakita, Junya Kuroda, Jiro Tadokoro, Shinya Kimura, Sayuri Motomura, Eriko Sato, Junya Kanda, Eri Kawata, Nobuhiko Uoshima, Shinichi Kako, Yoshinobu Kanda, Katsuhiro Shono, Atsushi Satake, Hiroki Yamaguchi
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17412
[Presentation] Clinical impact of IDH1/2 mutations in AML patients treated with Venetoclax2022
- Author(s)
  Jiadan Sheng, Yasunobu Nagata, Masahiro Sakaguchi, Kunihito Arai,　Junya Kuroda, Yuhei Nagao, Jiro Tadokoro, Hitoji Uchiyama, Shinya Kimura, Sayuri Motomura, Eriko Sato, Masao Ogata, Kenjiro Mitsuhashi, Jun Ando, Junya Kanda, Eri Kawata, Noriko Doki, Shinichiro Mori, Atsushi Satake, Hiroki Yamaguchi
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17412
[Presentation] 骨髄異形成症候群（MDS)288例における網羅的DNAメチル化解析と標的遺伝子異常との統合解析2015
- Author(s)
  Yasunobu Nagata
- Organizer
  第74回日本癌学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26893127
[Presentation] Landscape of DNA methylation and genetic profiles in 288 patients with myelodysplastic syndromes2015
- Author(s)
  Yasunobu Nagata
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2015-10-18
- Data Source
  KAKENHI-PROJECT-26893127
[Presentation] Novel Biological Effects and Distinct Patterns of Rhoa Mutations in Adult T-Cell Leukemia/Lymphoma and Angioimmunoblastic T Cell Lymphoma2014
- Author(s)
  Yasunobu Nagata
- Organizer
  56th ASH Annual Meeting and Exposition
- Place of Presentation
  ニューオリンズ
- Year and Date
  2014-12-07
- Data Source
  KAKENHI-PROJECT-26893127
[Presentation] Novel distributions and biological effects of RHOA mutations In Adult T-cell Leukemia/Lymphoma and other PTCLs2014
- Author(s)
  Yasunobu Nagata
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26893127
[Presentation] Distinct Pattrens of RHOA mutations in Adult Tcell Leukemia/Lymphoma and Per ipheral T-Cell Lymphomas2014
- Author(s)
  Yasunobu Nagata
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-26893127

1. 山口博樹 (90297937)

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2. YOSHIDA Yoshinori

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3. SHIRAISHI Yuichi

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4. 吉田健一

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5. 中尾真二

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6. 井元清哉

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7. 宮野悟

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8. 永江玄太

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9. 昆彩奈

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10. 玉井勇人

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11. 猪口孝一

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NAGATA YASUNOBU 永田 安伸

Nagata Yasunobu 永田 安伸

Research Projects

Research Products

Co-Researchers

BCL-2阻害剤抵抗性白血病における抗アポトーシス分子スイッチングの機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarifying clonal architecture diversity of leukemia dervied from myelodysplastic syndromesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated analysis of clonal evolution at early stage of myelodysplastic syndrome.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 血液内科 第85巻第1号 骨髄異形成症候群の個別化予後予測モデル2022

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis with Central Nervous System Symptoms2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Germ line <i>DDX41</i> mutations define a unique subtype of myeloid neoplasms2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Safety and efficacy of high‐dose cytarabine MEAM therapy and other treatments for auto‐peripheral blood stem cell transplantation: A retrospective comparative study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Share Machine learning integrates genomic signatures for subclassification beyond primary and secondary acute myeloid leukemia.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A geno-clinical decision model for the diagnosis of myelodysplastic syndromes.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of distinct SF3B1 hotspot mutations in relation to clinical phenotypes and response to therapy in myeloid neoplasia2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Machine learning demonstrates that somatic mutations imprint invariant morphologic features in myelodysplastic syndromes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rare germline variant contributions to myeloid malignancy susceptibility2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Variegated RHOA mutations in adult T-cell leukemia/lymphoma2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Complex molecular genetic abnormalities involving three or more genetic mutations are important prognostic factors for acute myeloid leukemia.2016

Author(s)

Journal Title

DOI

NAGATA YASUNOBU 永田安伸

Nagata Yasunobu 永田安伸

[Book] 血液内科　第85巻第1号骨髄異形成症候群の個別化予後予測モデル2022