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Aoshima Keisuke  青島 圭佑

Researcher Number 90745069
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-2987-0793
Affiliation (Current) 2025: 北海道大学, 獣医学研究院, 講師
Affiliation (based on the past Project Information) *help 2023 – 2025: 北海道大学, 獣医学研究院, 講師
2017 – 2022: 北海道大学, 獣医学研究院, 助教
2016: 北海道大学, 獣医学研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 42020:Veterinary medical science-related
Except Principal Investigator
Basic Section 42020:Veterinary medical science-related / Veterinary medical science
Keywords
Principal Investigator
エピジェネティクス / 血管肉腫 / ヒストンメチル化 / イヌ / ヒストン脱メチル化 / がん代謝 / PDX / がん幹細胞 / 腫瘍 / 治療 … More / マウスモデル / ヒストンユビキチン化 / KDM2B / マウス … More
Except Principal Investigator
ウマ / ヘルペスウイルス / 遺伝子発現調節 / 神経細胞 / 潜伏感染 / レセプター Less
  • Research Projects

    (6 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (3 People)
  •  リンパ管形成因子に着目し,血管肉腫の病態を再定義するPrincipal Investigator

    • Principal Investigator
      青島 圭佑
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Hokkaido University
  •  Epigenetics for cancer metabolism regulation -elucidation of hemangiosarcoma pathogenesis and search for a novel therapeutic target -Principal Investigator

    • Principal Investigator
      青島 圭佑
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Hokkaido University
  •  Elucidation of control mechanisms of viral gene expression in equine herpesvirus type 1-infected neurons

    • Principal Investigator
      木村 享史
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Hokkaido University
  •  Epigenetics of Hemangiosarcoma - The Role of KDM2B and Generation of Hemangiosarcoma Mouse Model -Principal Investigator

    • Principal Investigator
      Aoshima Keisuke
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Hokkaido University
  •  Unveiling the epigenetic mechanism of cellular differentiation in undifferentiated canine hemangiosarcoma cellsPrincipal Investigator

    • Principal Investigator
      Aoshima Keisuke
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Hokkaido University
  •  Investigation of the mechanism of equine herpesvirus-1 latency using mice expressing a viral receptor

    • Principal Investigator
      Kimura Takashi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Veterinary medical science
    • Research Institution
      Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Current understanding of comparative pathology and prospective research approaches for canine hemangiosarcoma2024

    • Author(s)
      Suzuki Tamami、Henshaw Michael James、Yanagi Teruki、Aoshima Keisuke
    • Journal Title

      Research in Veterinary Science

      Volume: 167 Pages: 105120-105120

    • DOI

      10.1016/j.rvsc.2023.105120

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23KJ0056, KAKENHI-PROJECT-22K06020, KAKENHI-PROJECT-22K08397
  • [Journal Article] A point mutation in GPI-attachment signal peptide accelerates the development of prion disease2023

    • Author(s)
      Kobayashi Atsushi、Hirata Tetsuya、Shimazaki Taishi、Munesue Yoshiko、Aoshima Keisuke、Kimura Takashi、Nio-Kobayashi Junko、Hasebe Rie、Takeuchi Atsuko、Matsuura Yuichi、Kusumi Satoshi、Koga Daisuke、Iwasaki Yasushi、Kinoshita Taroh、Mohri Shirou、Kitamoto Tetsuyuki
    • Journal Title

      Acta Neuropathologica

      Volume: 145 Issue: 5 Pages: 637-650

    • DOI

      10.1007/s00401-023-02553-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07261, KAKENHI-PROJECT-21K07062, KAKENHI-PROJECT-22K07531, KAKENHI-PROJECT-22K15357, KAKENHI-PROJECT-21K06727, KAKENHI-PROJECT-21H02415, KAKENHI-PROJECT-23K23773
  • [Journal Article] Malignant oligoastrocytoma in the spinal cord of a cat2022

    • Author(s)
      Hasegawa D, Aoshima K, Sasaoka K, Kobayashi A, Takiguchi M, Kimura T
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 84 Issue: 9 Pages: 1277-1282

    • DOI

      10.1292/jvms.22-0144

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K23773
  • [Journal Article] Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages2022

    • Author(s)
      Gulay Kevin Christian M.、Aoshima Keisuke、Maekawa Naoya、Suzuki Tamami、Konnai Satoru、Kobayashi Atsushi、Kimura Takashi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 2124-2124

    • DOI

      10.1038/s41598-022-06203-w

    • NAID

      120007191780

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K15654, KAKENHI-PROJECT-19H03114
  • [Journal Article] Manipulating histone acetylation leads to antitumor effects in hemangiosarcoma cells2022

    • Author(s)
      Suzuki Tamami、Aoshima Keisuke、Yamazaki Jumpei、Kobayashi Atsushi、Kimura Takashi
    • Journal Title

      Veterinary and Comparative Oncology

      Volume: 20 Issue: 4 Pages: 805-816

    • DOI

      10.1111/vco.12840

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06020, KAKENHI-PROJECT-23K21264, KAKENHI-PROJECT-23K23773
  • [Journal Article] The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression2021

    • Author(s)
      Gulay Kevin Christian M.、Aoshima Keisuke、Kim Sangho、Kitaguchi Ryusei、Kobayashi Atsushi、Kimura Takashi
    • Journal Title

      Veterinary and Comparative Oncology

      Volume: - Issue: 2 Pages: 529-534

    • DOI

      10.1111/vco.12796

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K15654, KAKENHI-PROJECT-23K23773
  • [Journal Article] KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma2021

    • Author(s)
      Gulay Kevin Christian Montecillo、Aoshima Keisuke、Shibata Yuki、Yasui Hironobu、Yan Qin、Kobayashi Atsushi、Kimura Takashi
    • Journal Title

      Journal of Genetics and Genomics

      Volume: 48 Issue: 7 Pages: 618-630

    • DOI

      10.1016/j.jgg.2021.02.005

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15654, KAKENHI-PROJECT-20KK0250
  • [Journal Article] Susceptibility of rat immortalized neuronal cell line Rn33B expressing equine major histocompatibility class 1 to equine herpesvirus‐1 infection is differentiation dependent2020

    • Author(s)
      Minato Erina、Kobayashi Atsushi、Aoshima Keisuke、Fukushi Hideto、Kimura Takashi
    • Journal Title

      Microbiology and Immunology

      Volume: 64 Issue: 2 Pages: 123-132

    • DOI

      10.1111/1348-0421.12761

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02343
  • [Journal Article] A novel combination of prion strain co-occurrence in patients with sporadic Creutzfeldt-Jakob disease2019

    • Author(s)
      Kobayashi Atsushi、Iwasaki Yasushi、Takao Masaki、Saito Yuko、Iwaki Toru、Qi Zechen、Torimoto Ryouta、Shimazaki Taishi、Munesue Yoshiko、Isoda Norikazu、Sawa Hirofumi、Aoshima Keisuke、Kimura Takashi、Kondo Hinako、Mohri Shirou、Kitamoto Tetsuyuki
    • Journal Title

      The American Journal of Pathology

      Volume: 印刷中 Issue: 6 Pages: 1276-1283

    • DOI

      10.1016/j.ajpath.2019.02.012

    • NAID

      120006847766

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18K06506, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02738
  • [Journal Article] High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines2019

    • Author(s)
      Morita Atsuya、Aoshima Keisuke、Gulay Kevin Christian Montecillo、Onishi Shinichi、Shibata Yuki、Yasui Hironobu、Kobayashi Atsushi、Kimura Takashi
    • Journal Title

      Research in Veterinary Science

      Volume: 127 Pages: 1-10

    • DOI

      10.1016/j.rvsc.2019.09.011

    • NAID

      120006937029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18K14575
  • [Journal Article] Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models2019

    • Author(s)
      Kobayashi Atsushi、Qi Zechen、Shimazaki Taishi、Munesue Yoshiko、Miyamoto Tomomi、Isoda Norikazu、Sawa Hirofumi、Aoshima Keisuke、Kimura Takashi、Mohri Shirou、Kitamoto Tetsuyuki、Yamashita Tadashi、Miyoshi Ichiro
    • Journal Title

      The American Journal of Pathology

      Volume: 189 Issue: 3 Pages: 677-686

    • DOI

      10.1016/j.ajpath.2018.11.009

    • NAID

      120006770947

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-17K07129
  • [Journal Article] Exogenous Expression of Equine MHC Class I Molecules in Mice Increases Susceptibility to Equine Herpesvirus 1 Pulmonary Infection2019

    • Author(s)
      Minato Erina、Aoshima Keisuke、Kobayashi Atsushi、Ohnishi Naomi、Sasaki Nobuya、Kimura Takashi
    • Journal Title

      Veterinary Pathology

      Volume: 印刷中 Issue: 5 Pages: 703-710

    • DOI

      10.1177/0300985819834616

    • NAID

      120006781559

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-17K14999, KAKENHI-PROJECT-16H05022
  • [Journal Article] Notch2 signal is required for the maintenance of canine hemangiosarcoma cancer stem cell-like cells2018

    • Author(s)
      Aoshima Keisuke、Fukui Yuki、Gulay Kevin Christian Montecillo、Erdemsurakh Ochbayar、Morita Atsuya、Kobayashi Atsushi、Kimura Takashi
    • Journal Title

      BMC Veterinary Research

      Volume: 14 Issue: 1 Pages: 301-301

    • DOI

      10.1186/s12917-018-1624-8

    • NAID

      120006536948

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022
  • [Journal Article] Development of a quick bioassay for the evaluation of transmission properties of acquired prion diseases.2018

    • Author(s)
      Munesue Y, Shimazaki T, Qi Z, Isoda N, Sawa H, Aoshima K, Kimura T, Mohri S, Kitamoto T, Kobayashi A
    • Journal Title

      Neuroscience Letters

      Volume: 668 Pages: 43-47

    • DOI

      10.1016/j.neulet.2018.01.014

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-16K18790, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738
  • [Journal Article] Cellular atypia is negatively correlated with immunohistochemical reactivity of CD31 and vWF expression levels in canine hemangiosarcoma2018

    • Author(s)
      Maharani A, Aoshima K, Onishi S, Gulay KCM, Kobayashi A, Kimura T
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 2 Pages: 213-218

    • DOI

      10.1292/jvms.17-0561

    • NAID

      130006339614

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05022
  • [Journal Article] Use of Histone K-M Mutants for the Analysis of Transcriptional Regulation in Mouse Zygotes.2017

    • Author(s)
      Aoshima K, Kimura T, Okada Y
    • Journal Title

      Methods in Molecular Biology

      Volume: 1605 Pages: 259-270

    • DOI

      10.1007/978-1-4939-6988-3_18

    • ISBN
      9781493969869, 9781493969883
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05022
  • [Presentation] イヌ血管肉腫の病態解明に向けた次なる研究戦略-患者由来モデルとエピジェネティクス-2023

    • Author(s)
      青島圭佑
    • Organizer
      第166回 日本獣医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K06020
  • [Presentation] Analyses of Roles of Histone Lactylation and Glucose Metabolism in Canine Hemangiosarcoma2023

    • Author(s)
      Tamami Suzuki, Keisuke Aoshima, Jumpei Yamazaki, Hironobu Yasui, Kazuki Heishima, Takashi Kimura
    • Organizer
      International Society of Organoid Research (ISoOR) annual meeting 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06020
  • [Presentation] Canine Hemangiosarcoma: A Gateway to Comparative Oncology Advancements Benefiting Both Human and Veterinary Medicine2023

    • Author(s)
      Keisuke Aoshima
    • Organizer
      International Society of Organoid Research (ISoOR) annual meeting 2023
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06020
  • [Presentation] イヌ血管肉腫におけるヒストンラクチル化とグルタミン代謝の役割の解析2023

    • Author(s)
      鈴木玲海, 青島圭佑, 山崎淳平, 安井博宣, 平島一輝, 木村享史
    • Organizer
      第9回 がんと代謝研究会
    • Data Source
      KAKENHI-PROJECT-22K06020
  • [Presentation] イヌ血管肉腫におけるDNAメチル化異常とDNAメチル化阻害による抗腫瘍効果2023

    • Author(s)
      鹿又崚, 青島圭佑, 鈴木玲海, 山崎淳平, 木村享史
    • Organizer
      第166回 日本獣医学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K06020
  • [Presentation] イヌ血管肉腫におけるヒストンラクチル化およびグルタミン代謝の役割の解析2023

    • Author(s)
      鈴木玲海, 青島圭佑, 山崎淳平, 安井博宣, 平島一輝, 木村享史
    • Organizer
      第82回 日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K06020
  • [Presentation] Analyses of Histone Lactylation and Metabolism in Canine Hemangiosarcoma2022

    • Author(s)
      Tamami SUZUKI, Keisuke AOSHIMA, Jumpei YAMAZAKI, Atsushi KOBAYASHI, Takashi KIMURA
    • Organizer
      The 10th Sapporo Summer Seminar for One Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06020
  • [Presentation] ヒストンアセチル化の改変はイヌ血管肉腫細胞に抗腫瘍効果をもたらす2022

    • Author(s)
      鈴木 玲海 , 青島 圭佑 , 山崎 淳平 , 小林 篤史 , 木村 享史
    • Organizer
      第165回 日本獣医学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K06020
  • [Presentation] Immunohistochemical analysis of naturally occurring equine glanders using anti-BpaB antibody2020

    • Author(s)
      Ochbayar Erdemsurakh, 青島圭佑、小林篤史、木村享史
    • Organizer
      第7回日本獣医病理学専門家協会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05022
  • [Presentation] Histone lysine demethylase 2B regulates endothelial cell carcinogenesis by enhancing gene stability2020

    • Author(s)
      GULAY Kevin Christian Montecillo, Aoshima Keisuke, Kobayashi Atsushi, Kimura Takashi
    • Organizer
      8th Sapporo Summer Seminar of One Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15654
  • [Presentation] KDM2B promotes endothelial cell carcinogenesis by enhancing DNA damage repair through the ATM and c-FOS pathways2020

    • Author(s)
      Montecillo Gulay Kevin Christian、Aoshima Keisuke、Shibata Yuki、Yasui Hironobu、Yan Qin、Kobayashi Atsushi、Kimura Takashi
    • Organizer
      第6回北海道大学部局横断シンポジウム
    • Data Source
      KAKENHI-PROJECT-20K15654
  • [Presentation] The role of lysine-specific demethylase 2B (KDM2B) in endothelial cell carcinogenesis2019

    • Author(s)
      Kevin Christian Montecillo Gulay, keisuke Aoshima, Atsushi Kobayashi, Takashi Kimura
    • Organizer
      7th Sapporo Summer Symposium for One Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05022
  • [Presentation] Pathology of equine glanders in Mongolia2018

    • Author(s)
      Erdemsurakh O, Aoshima K, Kobayashi A, Kimura T
    • Organizer
      The 6th Sapporo Summer Symposium for One Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05022
  • [Presentation] Analysis of the KDM2B-mediated Regulation of the Growth, Development, and Maintenance of Canine Hemangiosarcoma.2018

    • Author(s)
      Gulay, K.C.M., Aoshima, K., Kobayashi, A., and Kimura, T.
    • Organizer
      The 6th SaSSOH seminar for One Health. Sapporo, Japan, 2018.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14575
  • [Presentation] Establishment of the in vitro model of EHV-1 latent infection2018

    • Author(s)
      Minato E, Aoshima K, Kobayashi A, Kimura T
    • Organizer
      The 6th Sapporo Summer Symposium for One Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05022
  • [Presentation] Analysis of the KDM2B-mediated Regulation of the Growth, Development, and Maintenance of Canine Hemangiosarcoma2018

    • Author(s)
      Gulay, K.C.M., Aoshima, K., Kobayashi, A., and Kimura, T.
    • Organizer
      第41回 日本分子生物学会,横浜
    • Data Source
      KAKENHI-PROJECT-18K14575
  • [Presentation] Studies on the difference in the susceptibility of avian fibroblast cell and neurons to DTMUV and JEV infection2018

    • Author(s)
      Kulprasertsri S, Kobayashi S, Aoshima K, Kobayashi A, Kimura T
    • Organizer
      The 6th Sapporo Summer Symposium for One Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05022
  • [Presentation] Analysis of the KDM2B-mediated regulation of the growth, development, and maintenance of canine hemangiosarcoma2018

    • Author(s)
      Gulay KCM, Aoshima K, Kobayashi A, Kimura T
    • Organizer
      The 6th Sapporo Summer Symposium for One Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05022
  • [Presentation] Studies on the difference in the susceptibility of duck neurons to DTMUV and JEV infection2017

    • Author(s)
      Sittinee Kulprasertsri, Shintaro Kobayashi, Keisuke Aoshima, Atsushi Kobayashi, Takashi Kimura
    • Organizer
      The 5th Sapporo Summer Seminar for One Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05022
  • [Presentation] Investigation of the mechanism of latent infection of equine herpesvirus-12017

    • Author(s)
      Erina Minato, Keisuke Aoshima, Atsushi Kobayashi, Takashi Kimura
    • Organizer
      The 5th Sapporo Summer Seminar for One Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05022
  • [Presentation] Pathology of equine glanders in Mongolia2017

    • Author(s)
      Ochbayar Erdemsurakh, Keisuke Aoshima, Atsushi Kobayashi, Takashi Kimura
    • Organizer
      The 5th Sapporo Summer Seminar for One Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05022
  • 1.  Kimura Takashi (90261338)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 2.  KOGA Daisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  小林 篤史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results

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