Aoshima Keisuke 青島圭佑

Researcher Number	90745069
Other IDs	https://orcid.org/0000-0002-2987-0793
Affiliation (Current)	2024: 北海道大学, 獣医学研究院, 講師
Affiliation (based on the past Project Information) *help	2024: 北海道大学, 獣医学研究院, 講師 2017 – 2023: 北海道大学, 獣医学研究院, 助教 2016: 北海道大学, 獣医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related Except Principal Investigator Basic Section 42020:Veterinary medical science-related / Veterinary medical science
Keywords	Principal Investigator エピジェネティクス / 血管肉腫 / ヒストンメチル化 / イヌ / ヒストン脱メチル化 / がん代謝 / PDX / がん幹細胞 / 腫瘍 / 治療 … More / マウスモデル / ヒストンユビキチン化 / KDM2B / マウス … More Except Principal Investigator ウマ / ヘルペスウイルス / 遺伝子発現調節 / 神経細胞 / 潜伏感染 / レセプター Less

Epigenetics for cancer metabolism regulation -elucidation of hemangiosarcoma pathogenesis and search for a novel therapeutic target -Principal Investigator
- Principal Investigator
  
  青島圭佑
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Elucidation of control mechanisms of viral gene expression in equine herpesvirus type 1-infected neurons
- Principal Investigator
  
  木村享史
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Epigenetics of Hemangiosarcoma - The Role of KDM2B and Generation of Hemangiosarcoma Mouse Model -Principal Investigator
- Principal Investigator
  
  Aoshima Keisuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Unveiling the epigenetic mechanism of cellular differentiation in undifferentiated canine hemangiosarcoma cellsPrincipal Investigator
- Principal Investigator
  
  Aoshima Keisuke
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Investigation of the mechanism of equine herpesvirus-1 latency using mice expressing a viral receptor
- Principal Investigator
  
  Kimura Takashi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Malignant oligoastrocytoma in the spinal cord of a cat2022
- Author(s)
  Hasegawa D, Aoshima K, Sasaoka K, Kobayashi A, Takiguchi M, Kimura T
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 84 Issue: 9 Pages: 1277-1282
- DOI
  10.1292/jvms.22-0144
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K23773
[Journal Article] Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages2022
- Author(s)
  Gulay Kevin Christian M.、Aoshima Keisuke、Maekawa Naoya、Suzuki Tamami、Konnai Satoru、Kobayashi Atsushi、Kimura Takashi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 2124-2124
- DOI
  10.1038/s41598-022-06203-w
- NAID
  120007191780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15654, KAKENHI-PROJECT-19H03114
[Journal Article] Manipulating histone acetylation leads to antitumor effects in hemangiosarcoma cells2022
- Author(s)
  Suzuki Tamami、Aoshima Keisuke、Yamazaki Jumpei、Kobayashi Atsushi、Kimura Takashi
- Journal Title
  
  Veterinary and Comparative Oncology
  
  Volume: 20 Issue: 4 Pages: 805-816
- DOI
  10.1111/vco.12840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06020, KAKENHI-PROJECT-23K21264, KAKENHI-PROJECT-23K23773
[Journal Article] The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression2021
- Author(s)
  Gulay Kevin Christian M.、Aoshima Keisuke、Kim Sangho、Kitaguchi Ryusei、Kobayashi Atsushi、Kimura Takashi
- Journal Title
  
  Veterinary and Comparative Oncology
  
  Volume: - Issue: 2 Pages: 529-534
- DOI
  10.1111/vco.12796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15654, KAKENHI-PROJECT-23K23773
[Journal Article] KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma2021
- Author(s)
  Gulay Kevin Christian Montecillo、Aoshima Keisuke、Shibata Yuki、Yasui Hironobu、Yan Qin、Kobayashi Atsushi、Kimura Takashi
- Journal Title
  
  Journal of Genetics and Genomics
  
  Volume: 48 Issue: 7 Pages: 618-630
- DOI
  10.1016/j.jgg.2021.02.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15654, KAKENHI-PROJECT-20KK0250
[Journal Article] Susceptibility of rat immortalized neuronal cell line Rn33B expressing equine major histocompatibility class 1 to equine herpesvirus‐1 infection is differentiation dependent2020
- Author(s)
  Minato Erina、Kobayashi Atsushi、Aoshima Keisuke、Fukushi Hideto、Kimura Takashi
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 64 Issue: 2 Pages: 123-132
- DOI
  10.1111/1348-0421.12761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02343
[Journal Article] A novel combination of prion strain co-occurrence in patients with sporadic Creutzfeldt-Jakob disease2019
- Author(s)
  Kobayashi Atsushi、Iwasaki Yasushi、Takao Masaki、Saito Yuko、Iwaki Toru、Qi Zechen、Torimoto Ryouta、Shimazaki Taishi、Munesue Yoshiko、Isoda Norikazu、Sawa Hirofumi、Aoshima Keisuke、Kimura Takashi、Kondo Hinako、Mohri Shirou、Kitamoto Tetsuyuki
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 印刷中 Issue: 6 Pages: 1276-1283
- DOI
  10.1016/j.ajpath.2019.02.012
- NAID
  120006847766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18K06506, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02738
[Journal Article] High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines2019
- Author(s)
  Morita Atsuya、Aoshima Keisuke、Gulay Kevin Christian Montecillo、Onishi Shinichi、Shibata Yuki、Yasui Hironobu、Kobayashi Atsushi、Kimura Takashi
- Journal Title
  
  Research in Veterinary Science
  
  Volume: 127 Pages: 1-10
- DOI
  10.1016/j.rvsc.2019.09.011
- NAID
  120006937029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18K14575
[Journal Article] Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models2019
- Author(s)
  Kobayashi Atsushi、Qi Zechen、Shimazaki Taishi、Munesue Yoshiko、Miyamoto Tomomi、Isoda Norikazu、Sawa Hirofumi、Aoshima Keisuke、Kimura Takashi、Mohri Shirou、Kitamoto Tetsuyuki、Yamashita Tadashi、Miyoshi Ichiro
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 189 Issue: 3 Pages: 677-686
- DOI
  10.1016/j.ajpath.2018.11.009
- NAID
  120006770947
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-17K07129
[Journal Article] Exogenous Expression of Equine MHC Class I Molecules in Mice Increases Susceptibility to Equine Herpesvirus 1 Pulmonary Infection2019
- Author(s)
  Minato Erina、Aoshima Keisuke、Kobayashi Atsushi、Ohnishi Naomi、Sasaki Nobuya、Kimura Takashi
- Journal Title
  
  Veterinary Pathology
  
  Volume: 印刷中 Issue: 5 Pages: 703-710
- DOI
  10.1177/0300985819834616
- NAID
  120006781559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-17K14999, KAKENHI-PROJECT-16H05022
[Journal Article] Notch2 signal is required for the maintenance of canine hemangiosarcoma cancer stem cell-like cells2018
- Author(s)
  Aoshima Keisuke、Fukui Yuki、Gulay Kevin Christian Montecillo、Erdemsurakh Ochbayar、Morita Atsuya、Kobayashi Atsushi、Kimura Takashi
- Journal Title
  
  BMC Veterinary Research
  
  Volume: 14 Issue: 1 Pages: 301-301
- DOI
  10.1186/s12917-018-1624-8
- NAID
  120006536948
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022
[Journal Article] Development of a quick bioassay for the evaluation of transmission properties of acquired prion diseases.2018
- Author(s)
  Munesue Y, Shimazaki T, Qi Z, Isoda N, Sawa H, Aoshima K, Kimura T, Mohri S, Kitamoto T, Kobayashi A
- Journal Title
  
  Neuroscience Letters
  
  Volume: 668 Pages: 43-47
- DOI
  10.1016/j.neulet.2018.01.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-16K18790, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738
[Journal Article] Cellular atypia is negatively correlated with immunohistochemical reactivity of CD31 and vWF expression levels in canine hemangiosarcoma2018
- Author(s)
  Maharani A, Aoshima K, Onishi S, Gulay KCM, Kobayashi A, Kimura T
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 80 Issue: 2 Pages: 213-218
- DOI
  10.1292/jvms.17-0561
- NAID
  130006339614
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05022
[Journal Article] Use of Histone K-M Mutants for the Analysis of Transcriptional Regulation in Mouse Zygotes.2017
- Author(s)
  Aoshima K, Kimura T, Okada Y
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1605 Pages: 259-270
- DOI
  10.1007/978-1-4939-6988-3_18
- ISBN
  9781493969869, 9781493969883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05022
[Presentation] Analyses of Histone Lactylation and Metabolism in Canine Hemangiosarcoma2022
- Author(s)
  Tamami SUZUKI, Keisuke AOSHIMA, Jumpei YAMAZAKI, Atsushi KOBAYASHI, Takashi KIMURA
- Organizer
  The 10th Sapporo Summer Seminar for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06020
[Presentation] ヒストンアセチル化の改変はイヌ血管肉腫細胞に抗腫瘍効果をもたらす2022
- Author(s)
  鈴木玲海 , 青島圭佑 , 山崎淳平 , 小林篤史 , 木村享史
- Organizer
  第165回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K06020
[Presentation] Immunohistochemical analysis of naturally occurring equine glanders using anti-BpaB antibody2020
- Author(s)
  Ochbayar Erdemsurakh, 青島圭佑、小林篤史、木村享史
- Organizer
  第7回日本獣医病理学専門家協会学術集会
- Data Source
  KAKENHI-PROJECT-16H05022
[Presentation] Histone lysine demethylase 2B regulates endothelial cell carcinogenesis by enhancing gene stability2020
- Author(s)
  GULAY Kevin Christian Montecillo, Aoshima Keisuke, Kobayashi Atsushi, Kimura Takashi
- Organizer
  8th Sapporo Summer Seminar of One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15654
[Presentation] KDM2B promotes endothelial cell carcinogenesis by enhancing DNA damage repair through the ATM and c-FOS pathways2020
- Author(s)
  Montecillo Gulay Kevin Christian、Aoshima Keisuke、Shibata Yuki、Yasui Hironobu、Yan Qin、Kobayashi Atsushi、Kimura Takashi
- Organizer
  第6回北海道大学部局横断シンポジウム
- Data Source
  KAKENHI-PROJECT-20K15654
[Presentation] The role of lysine-specific demethylase 2B (KDM2B) in endothelial cell carcinogenesis2019
- Author(s)
  Kevin Christian Montecillo Gulay, keisuke Aoshima, Atsushi Kobayashi, Takashi Kimura
- Organizer
  7th Sapporo Summer Symposium for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022
[Presentation] Pathology of equine glanders in Mongolia2018
- Author(s)
  Erdemsurakh O, Aoshima K, Kobayashi A, Kimura T
- Organizer
  The 6th Sapporo Summer Symposium for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022
[Presentation] Analysis of the KDM2B-mediated Regulation of the Growth, Development, and Maintenance of Canine Hemangiosarcoma.2018
- Author(s)
  Gulay, K.C.M., Aoshima, K., Kobayashi, A., and Kimura, T.
- Organizer
  The 6th SaSSOH seminar for One Health. Sapporo, Japan, 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14575
[Presentation] Establishment of the in vitro model of EHV-1 latent infection2018
- Author(s)
  Minato E, Aoshima K, Kobayashi A, Kimura T
- Organizer
  The 6th Sapporo Summer Symposium for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022
[Presentation] Analysis of the KDM2B-mediated Regulation of the Growth, Development, and Maintenance of Canine Hemangiosarcoma2018
- Author(s)
  Gulay, K.C.M., Aoshima, K., Kobayashi, A., and Kimura, T.
- Organizer
  第41回日本分子生物学会，横浜
- Data Source
  KAKENHI-PROJECT-18K14575
[Presentation] Studies on the difference in the susceptibility of avian fibroblast cell and neurons to DTMUV and JEV infection2018
- Author(s)
  Kulprasertsri S, Kobayashi S, Aoshima K, Kobayashi A, Kimura T
- Organizer
  The 6th Sapporo Summer Symposium for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022
[Presentation] Analysis of the KDM2B-mediated regulation of the growth, development, and maintenance of canine hemangiosarcoma2018
- Author(s)
  Gulay KCM, Aoshima K, Kobayashi A, Kimura T
- Organizer
  The 6th Sapporo Summer Symposium for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022
[Presentation] Studies on the difference in the susceptibility of duck neurons to DTMUV and JEV infection2017
- Author(s)
  Sittinee Kulprasertsri, Shintaro Kobayashi, Keisuke Aoshima, Atsushi Kobayashi, Takashi Kimura
- Organizer
  The 5th Sapporo Summer Seminar for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022
[Presentation] Investigation of the mechanism of latent infection of equine herpesvirus-12017
- Author(s)
  Erina Minato, Keisuke Aoshima, Atsushi Kobayashi, Takashi Kimura
- Organizer
  The 5th Sapporo Summer Seminar for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022
[Presentation] Pathology of equine glanders in Mongolia2017
- Author(s)
  Ochbayar Erdemsurakh, Keisuke Aoshima, Atsushi Kobayashi, Takashi Kimura
- Organizer
  The 5th Sapporo Summer Seminar for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022

1. Kimura Takashi (90261338)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. 小林篤史

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results

Aoshima Keisuke 青島 圭佑

Research Projects

Research Products

Co-Researchers

Epigenetics for cancer metabolism regulation -elucidation of hemangiosarcoma pathogenesis and search for a novel therapeutic target -Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of control mechanisms of viral gene expression in equine herpesvirus type 1-infected neurons

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetics of Hemangiosarcoma - The Role of KDM2B and Generation of Hemangiosarcoma Mouse Model -Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unveiling the epigenetic mechanism of cellular differentiation in undifferentiated canine hemangiosarcoma cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism of equine herpesvirus-1 latency using mice expressing a viral receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Malignant oligoastrocytoma in the spinal cord of a cat2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Manipulating histone acetylation leads to antitumor effects in hemangiosarcoma cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Susceptibility of rat immortalized neuronal cell line Rn33B expressing equine major histocompatibility class 1 to equine herpesvirus‐1 infection is differentiation dependent2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel combination of prion strain co-occurrence in patients with sporadic Creutzfeldt-Jakob disease2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models2019

Aoshima Keisuke 青島圭佑