TAMAI Minori 玉井望雅

… Alternative Names

玉井望雅タマイミノリ

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Researcher Number	90747453
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 特任研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 山梨大学, 大学院総合研究部, 臨床助教 2021: 山梨大学, 大学院総合研究部, 医学研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 幹細胞 / BCR-ABL1 / 急性リンパ性白血病 / 慢性骨髄性白血病 / 白血病 / BCR::ABL1 / ゲノム編集 Except Principal Investigator 白血病 / 個別化治療 / ゲノム編集 … More / 難治性 / ゲノム編集技術 / ゲノム解析 / ゲノム情報 / 薬剤感受性 / 急性リンパ性白血病 Less

難治性急性リンパ性白血病に対するプレシジョン・メディシンを目指した多分野融合研究
- Principal Investigator
  
  犬飼岳史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Yamanashi
Hematopoietic Stem Cell Diversity in the Development of Chronic Myelogenous Leukemia (CML)Principal Investigator
- Principal Investigator
  
  玉井望雅
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  University of Yamanashi

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Application of prime editing system to introduce P53 R248Q hotspot mutation in acute lymphoblastic leukemia cell line2024
- Author(s)
  Nguyen Thao、Aida Tomomi、Iijima‐Yamashita Yuka、Tamai Minori、Nagamachi Akiko、Kagami Keiko、Komatsu Chiaki、Kasai Shin、Akahane Koshi、Goi Kumiko、Inaba Toshiya、Sanada Masashi、Inukai Takeshi
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 0-0
- DOI
  10.1111/cas.16162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08395, KAKENHI-PROJECT-23K24298
[Journal Article] Generation of Philadelphia chromosome in human leukemia by DNA breaks on the BCR and ABL1 genes using CRISPR/Cas9 system.2023
- Author(s)
  Tamai M, Fujisawa S, Nguyen Thao TT, Komatsu C, Kagami K, Kamimoto K, Omachi K, Kasai S, Harama D, Watanabe A, Akahane K, Goi K, Naka K, Kaname T, Teshima T, and Inukai T
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: 30 Issue: 1 Pages: 38-50
- DOI
  10.1038/s41417-022-00522-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19353, KAKENHI-PROJECT-21K15528, KAKENHI-PROJECT-20H03517, KAKENHI-PROJECT-23K24298
[Journal Article] CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model2023
- Author(s)
  Nguyen Thao Thu Thi、Tanaka Yoichi、Sanada Masashi、Hosaka Masumi、Tamai Minori、Kagami Keiko、Komatsu Chiaki、Somazu Shinpei、Harama Daisuke、Kasai Shin、Watanabe Atsushi、Akahane Koushi、Goi Kumiko、Inukai Takeshi
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 103 Issue: 4 Pages: 199-210
- DOI
  10.1124/molpharm.122.000546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24298
[Journal Article] Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL2023
- Author(s)
  Watanabe Atsushi、Miyake Kunio、Yamada Yuriko、Sunamura Ei-Ichiro、Yotani Takuya、Kagami Keiko、Kasai Shin、Tamai Minori、Harama Daisuke、Akahane Koshi、Goi Kumiko、Sakaguchi Kimiyoshi、Goto Hiroaki、Kitahara Shinichiro、Inukai Takeshi
- Journal Title
  
  Epigenetics
  
  Volume: 18 Issue: 1 Pages: 2268814-2268814
- DOI
  10.1080/15592294.2023.2268814
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24298
[Journal Article] Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia2022
- Author(s)
  Tamai Minori、Kasai Shin、Akahane Koshi、Thu Thao Nguyen、Kagami Keiko、Komatsu Chiaki、Abe Masako、Watanabe Atsushi、Goi Kumiko、Miyake Kunio、Inaba Toshiya、Takita Junko、Goto Hiroaki、Minegishi Masayoshi、Iwamoto Shotaro、Sugita Kanji、Inukai Takeshi
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 218 Pages: 106068-106068
- DOI
  10.1016/j.jsbmb.2022.106068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21K19405, KAKENHI-PROJECT-23K24298
[Journal Article] Introduction of the T315I gatekeeper mutation of BCR/ABL1 into a Philadelphia chromosome-positive lymphoid leukemia cell line using the CRISPR/Cas9 system2022
- Author(s)
  Nguyen Thao T. T.、Tamai Minori、Harama Daisuke、Kagami Keiko、Kasai Shin、Watanabe Atsushi、Akahane Koshi、Goi Kumiko、Inukai Takeshi
- Journal Title
  
  International Journal of Hematology
  
  Volume: 116 Issue: 4 Pages: 534-543
- DOI
  10.1007/s12185-022-03369-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24298
[Presentation] BCP-ALL細胞株のinotuzumab ozogamicin感受性におけるCD22陽性率の意義2023
- Author(s)
  笠井慎, 赤羽弘資, 玉井望雅, 加賀美恵子, 小松千亜紀, 清河信敬, Nguyen TT, 後藤裕明, 峯岸正好, 稲葉俊哉, 岩本彰太郎, 合井久美子, 犬飼岳史
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24298
[Presentation] TKI-resistance in a human Ph+ leukemia model with T315I-containing compound mutations of BCR::ABL12023
- Author(s)
  Nguyen Thao TT, Tamai Minori, Harama Daisuke, Kagami Keiko, Komatsu Chiaki, Kasai Shin, Akahane Koushi, Goi Kumiko, Inukai Takeshi
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24298
[Presentation] Ph陽性ALLにおけるインテグリンα6の発現誘導を介するラミニン接着へのBCR::ABL1の関与2023
- Author(s)
  高橋和也, Nguyen TT, 玉井望雅, 原間大輔, 笠井慎, 赤羽弘資, 合井久美子, 加賀美恵子, 小松千亜紀, 犬飼岳史
- Organizer
  第65回日本小児血液がん学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24298
[Presentation] p210 and p190 BCR::ABL1 induce different gene expression profiles in the artificial Philadelphia chromosome-positive leukemias created by CRISPR/Cas9 system2022
- Author(s)
  Tamai Minori, Nguyen Thao, Komatsu Chiaki, Kagami Keiko, Kasai Shin, Harama Daisuke, Akahane Koshi, Goi Kumiko, Inukai Takeshi
- Organizer
  第64回日本小児血液がん学会
- Data Source
  KAKENHI-PROJECT-23K24298
[Presentation] Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes2022
- Author(s)
  Minori Tamai, Shinichi Fujisawa, Thao T Nguyen, Chiaki Komatsu, Keiko Kagami, Shin Kasai, Daisuke Harama, Atsushi Watanabe, Koshi Akahane, Kumiko Goi, Kazuhito Naka, Tadashi Kaname, Teshima Takanori, Takeshi Inukai
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15528
[Presentation] CRISPR/Cas9 によるゲノム編集技術を用いたフィラデルフィア染色体の生成 ~BCR::ABL1陽性白血病細胞のモデル実験系の樹立~2022
- Author(s)
  玉井望雅
- Organizer
  第5回日本遺伝子細胞治療学会若手研究会セミナー
- Data Source
  KAKENHI-PROJECT-21K15528
[Presentation] Establishment of a human acute lymphoblastic leukemia model with relapse-specific mutation of the TP53 gene using the prime editing system2022
- Author(s)
  Nguyen Thao, Tamai Minori, Inaba Toshiya, Nagamachi Akiko, Kagami Keiko, Harama Daisuke, Kasai Shin, Akahane Koshi, Goi Kumiko, Inukai Takeshi
- Organizer
  第64回日本小児血液がん学会
- Data Source
  KAKENHI-PROJECT-23K24298
[Presentation] CRISPR/Cas9を用いた人工フィラデルフィア染色体誘導系におけるp210とp190 BCR::ABL1による発現遺伝子解析2022
- Author(s)
  玉井望雅、Nguyen Thao、小松千亜紀、加賀美恵子、笠井慎、原間大輔、赤羽弘資、合井久美子、犬飼岳史
- Organizer
  第64回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15528

1. 犬飼岳史 (30293450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. 大城浩子 (50377537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 合井久美子 (70324192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. 赤羽弘資 (90377531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. 原間大輔 (10774078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 仲一仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 長町安希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 渡邊敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAMAI Minori 玉井 望雅

玉井 望雅 タマイ ミノリ

Research Projects

Research Products

Co-Researchers

難治性急性リンパ性白血病に対するプレシジョン・メディシンを目指した多分野融合研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Hematopoietic Stem Cell Diversity in the Development of Chronic Myelogenous Leukemia (CML)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Application of prime editing system to introduce P53 R248Q hotspot mutation in acute lymphoblastic leukemia cell line2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of Philadelphia chromosome in human leukemia by DNA breaks on the BCR and ABL1 genes using CRISPR/Cas9 system.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Introduction of the T315I gatekeeper mutation of BCR/ABL1 into a Philadelphia chromosome-positive lymphoid leukemia cell line using the CRISPR/Cas9 system2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] BCP-ALL細胞株のinotuzumab ozogamicin感受性におけるCD22陽性率の意義2023

Author(s)

Organizer

Data Source

[Presentation] TKI-resistance in a human Ph+ leukemia model with T315I-containing compound mutations of BCR::ABL12023

Author(s)

Organizer

Data Source

[Presentation] Ph陽性ALLにおけるインテグリンα6の発現誘導を介するラミニン接着へのBCR::ABL1の関与2023

Author(s)

Organizer

Data Source

[Presentation] p210 and p190 BCR::ABL1 induce different gene expression profiles in the artificial Philadelphia chromosome-positive leukemias created by CRISPR/Cas9 system2022

Author(s)

Organizer

Data Source

[Presentation] Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes2022

Author(s)

Organizer

Data Source

[Presentation] CRISPR/Cas9 によるゲノム編集技術を用いた フィラデルフィア 染色体の生成 ~BCR::ABL1陽性白血病細胞のモデル実験系の樹立~2022

Author(s)

Organizer

Data Source

[Presentation] Establishment of a human acute lymphoblastic leukemia model with relapse-specific mutation of the TP53 gene using the prime editing system2022

Author(s)

Organizer

Data Source

[Presentation] CRISPR/Cas9を用いた人工フィラデルフィア染色体誘導系におけるp210とp190 BCR::ABL1による発現遺伝子解析2022

Author(s)

Organizer

Data Source

TAMAI Minori 玉井望雅

玉井望雅タマイミノリ

[Presentation] CRISPR/Cas9 によるゲノム編集技術を用いたフィラデルフィア染色体の生成 ~BCR::ABL1陽性白血病細胞のモデル実験系の樹立~2022