Shiwaku Hiroki 塩飽裕紀

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Hiroki Shiwaku 塩飽裕紀

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Researcher Number	90747502
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 准教授
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 大学院医歯学総合研究科, テニュアトラック准教授 2022 – 2023: 東京医科歯科大学, 大学院医歯学総合研究科, テニュアトラック准教授 2019 – 2021: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2018: 東京医科歯科大学, 医学部附属病院, 特任助教 2016 – 2017: 東京医科歯科大学, 医学部附属病院, 医員 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science
Keywords	Principal Investigator 統合失調症 / シナプス / 精神疾患 / 自己免疫 / neurexin 1 / 自己免疫性精神病 / 自己抗体 / GABA受容体 / シナプス分子 / NRXN1 … More / NCAM1 / DNA損傷 / クロマチン / DNAダメージ / phencyclidine / NMDA受容体 / primary cilia Less

統合失調症の新規リン酸化分子の探索と病態解明Principal Investigator
- Principal Investigator
  
  塩飽裕紀
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Institute of Science Tokyo
新規自己抗体が形成する進行性・難治性精神疾患のシナプス病態の解明Principal Investigator
- Principal Investigator
  
  塩飽裕紀
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tokyo Medical and Dental University
Analysis of the Pathogenesis of Novel Autoantibodies Targeting Synaptic Molecules in Psychiatric DisordersPrincipal Investigator
- Principal Investigator
  
  Shiwaku Hiroki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tokyo Medical and Dental University
Intranuclear molecular pathology of schizophreniaPrincipal Investigator
- Principal Investigator
  
  Shiwaku Hiroki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo Medical and Dental University
Investigation of primary cilia pathology in schizophreniaPrincipal Investigator
- Principal Investigator
  
  Hiroki Shiwaku
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo Medical and Dental University

All 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Patent Other

[Journal Article] Anti-rods/rings autoantibodies in a patient with pancreatic injury2022
- Author(s)
  Katayama S, Kubota T, Takahashi H, Shiwaku H.
- Journal Title
  
  Autoimmun Rev
  
  Volume: 21(1) Issue: 1 Pages: 102922-102922
- DOI
  10.1016/j.autrev.2021.102922
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08011, KAKENHI-PROJECT-20K07821
[Journal Article] Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice2022
- Author(s)
  Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, Fujita K, Tamaki H, Takebayashi H, Terasaki O, Nagase Y, Nagase T, Kubota T, Ishikawa K, Okazawa H, Takahashi H.
- Journal Title
  
  Cell Rep Med.
  
  Volume: 3(4) Issue: 4 Pages: 100597-100597
- DOI
  10.1016/j.xcrm.2022.100597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08011, KAKENHI-PROJECT-20K07821, KAKENHI-PROJECT-22H00464
[Journal Article] Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia2022
- Author(s)
  Kubota Manabu、Takahata Keisuke、Matsuoka Kiwamu、Sano Yasunori、Yamamoto Yasuharu、Tagai Kenji、Tarumi Ryosuke、Suzuki Hisaomi、Kurose Shin、Nakajima Shinichiro、Shiwaku Hiroki、Seki Chie、Kawamura Kazunori、Zhang Ming-Rong、Takahashi Hidehiko、Takado Yuhei、Higuchi Makoto
- Journal Title
  
  Schizophrenia Bulletin
  
  Volume: ー Issue: 3 Pages: 688-696
- DOI
  10.1093/schbul/sbac181
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15757, KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-20K07935, KAKENHI-PROJECT-19K17101, KAKENHI-PROJECT-19K08011, KAKENHI-PROJECT-22K07553, KAKENHI-PROJECT-23K24263
[Journal Article] Dopamine dysfunction in depression: application of texture analysis to dopamine transporter single-photon emission computed tomography imaging2022
- Author(s)
  Tamura Takehiro、Sugihara Genichi、Okita Kyoji、Mukai Yohei、Matsuda Hiroshi、Shiwaku Hiroki、Takagi Shunsuke、Daisaki Hiromitsu、Tateishi Ukihide、Takahashi Hidehiko
- Journal Title
  
  Translational Psychiatry
  
  Volume: 12 Issue: 1 Pages: 309-309
- DOI
  10.1038/s41398-022-02080-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07668, KAKENHI-PROJECT-20K16618, KAKENHI-PROJECT-19K08011, KAKENHI-PROJECT-22K07553
[Journal Article] Factors affecting mental illness and social stress in hospital workers treating COVID-19: Paradoxical distress during pandemic era2021
- Author(s)
  Matsumoto Yukiko、Fujino Junya、et al、Jitoku Daisuke、Takagi Shunsuke、Tamura Takehiro、Maruo Takashi、Shidei Yuki、Kobayashi Nanase、Ichihashi Masanori、Noguchi Shiori、Oohashi Kanako、Takeuchi Takashi、Sugihara Genichi、Okada Takayuki、Fujiwara Takeo、Takahashi Hidehiko
- Journal Title
  
  Journal of Psychiatric Research
  
  Volume: 137 Pages: 298-302
- DOI
  10.1016/j.jpsychires.2021.03.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06572, KAKENHI-PROJECT-20J00381, KAKENHI-PROJECT-19K08011
[Journal Article] Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation2021
- Author(s)
  Jin Meihua、Shiwaku Hiroki、Tanaka Hikari、Obita Takayuki、Ohuchi Sakurako、Yoshioka Yuki、Jin Xiaocen、Kondo Kanoh、Fujita Kyota、Homma Hidenori、Nakajima Kazuyuki、Mizuguchi Mineyuki、Okazawa Hitoshi
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 6565-6565
- DOI
  10.1038/s41467-021-26851-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J13728, KAKENHI-PROJECT-19K08011, KAKENHI-PROJECT-20K06540
[Journal Article] Novel brief screening scale, Tokyo Metropolitan Distress Scale for Pandemic (TMDP), for assessing mental and social stress of medical personnel in COVID-19 pandemic2020
- Author(s)
  Shiwaku H, Doi S, Miyajima M, Matsumoto Y, Fujino J, Hirai N, Jitoku D, Takagi S, Tamura T, Maruo T, Shidei Y, Kobayashi N, Ichihashi M, Noguchi S, Oohashi K, Takeuchi T, Sugihara G, Okada T, Fujiwara T, Takahashi H.
- Journal Title
  
  Psychiatry Clin Neurosci.
  
  Volume: 75 Issue: 1 Pages: 24-25
- DOI
  10.1111/pcn.13168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08011, KAKENHI-PLANNED-16H06572
[Journal Article] Detection of autoantibodies against GABAARα1 in patients with schizophrenia.2020
- Author(s)
  Shiwaku H, Nakano Y, Kato M, Takahashi H.
- Journal Title
  
  Schizophr Res.
  
  Volume: 216 Pages: 543-546
- DOI
  10.1016/j.schres.2019.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16367, KAKENHI-PROJECT-19K08011
[Journal Article] Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression.2020
- Author(s)
  Shiwaku H, Fujita M, Takahashi H.
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 9(6) Issue: 6 Pages: 1938-1938
- DOI
  10.3390/jcm9061938
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08011
[Journal Article] Donepezil により精神病症状を伴う重症うつ病エピソードが誘発された1例2019
- Author(s)
  塩飽裕紀、田村赳紘、治徳大介、車地暁生、西川徹
- Journal Title
  
  精神科治療学
  
  Volume: 34 Pages: 231-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16367
[Journal Article] Effect of Tandospirone, a Partial Agonist of the 5-HT1A Receptor, in a Patient With Chronic Poststroke Emotional Incontinence With Anxiousness.2019
- Author(s)
  Tamura T, Shiwaku H, Jitoku D, Kurumaji A.
- Journal Title
  
  Prim Care Companion CNS Disord.
  
  Volume: 21(5) Issue: 5
- DOI
  10.4088/pcc.18l02403
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16367, KAKENHI-PROJECT-19K08011
[Journal Article] Paroxetine ameliorates whole-body allodynia.2018
- Author(s)
  Shiwaku H, Nishikawa T
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 74 Issue: 7 Pages: 979-980
- DOI
  10.1007/s00228-018-2438-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16367
[Journal Article] Unilateral atonia and asynmetric cholinergic dysfunction in the ROSS syndrome2017
- Author(s)
  Hiroki Shiwaku, Yukio Kimura, Kenji Narushima, Hiroshi Matsuda, Toru Nishikawa
- Journal Title
  
  Biological Psychiatry
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19714
[Journal Article] Phencyclidine-induced dysregulation of primary cilia in the rodent brain.2017
- Author(s)
  Shiwaku H, Umino A, Umino M, Nishikawa T.
- Journal Title
  
  Brain Research
  
  Volume: 1674 Pages: 62-69
- DOI
  10.1016/j.brainres.2017.08.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16367
[Journal Article] Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.2017
- Author(s)
  Fujita K, Mao Y, Uchida S, Chen X, Shiwaku H, Tamura T, Ito H, Watase K, Homma H, Tagawa K, Sudol M, Okazawa H.
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 1864-1864
- DOI
  10.1038/s41467-017-01790-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16367, KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-16H07001
[Journal Article] 神経変性疾患・精神疾患・神経発達障害の共通病態2016
- Author(s)
  塩飽裕紀
- Journal Title
  
  お茶の水医学雑誌
  
  Volume: 64 Pages: 121-130
- Data Source
  KAKENHI-PROJECT-15K19714
[Journal Article] 統合失調症の分子機序という視点で今後の薬物治療展開を考える2016
- Author(s)
  塩飽裕紀、西川徹
- Journal Title
  
  臨床精神薬理
  
  Volume: 19(10) Pages: 1403-1410
- NAID
  40020967040
- Data Source
  KAKENHI-PROJECT-15K19714
[Patent] 脳神経疾患の検査、治療もしくは予防のための方法2022
- Inventor(s)
  塩飽裕紀高橋英彦岡澤均
- Industrial Property Rights Holder
  塩飽裕紀高橋英彦岡澤均
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-161399
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-22K07553
[Patent] 脳神経疾患の検査、治療もしくは予防のための方法2022
- Inventor(s)
  塩飽裕紀高橋英彦岡澤均
- Industrial Property Rights Holder
  塩飽裕紀高橋英彦岡澤均
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-161399
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-19K08011
[Presentation] 統合失調症の抗NCAM1自己抗体はマウスで統合失調症関連行動とシナプス変化を誘発する2022
- Author(s)
  塩飽裕紀, 片山真吾, 髙橋英彦
- Organizer
  第44回日本生物学的精神医学会, BPCNPNPPP4学会合同年会.
- Data Source
  KAKENHI-PROJECT-19K08011
[Presentation] 統合失調症の抗NCAM1自己抗体はマウスで統合失調症関連行動とシナプス変化を誘発する2022
- Author(s)
  塩飽裕紀, 片山真吾, 髙橋英彦
- Organizer
  第44回日本生物学的精神医学会, BPCNPNPPP4学会合同年会.
- Data Source
  KAKENHI-PROJECT-22K07553
[Presentation] 統合失調症の新規自己抗体病態の発見と病態解析2021
- Author(s)
  塩飽裕紀, 片山真吾, 髙橋英彦
- Organizer
  第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08011
[Presentation] 統合失調症における抗GABAA受容体α1抗体の検出2020
- Author(s)
  塩飽裕紀, 中野悠里, 髙橋英彦
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08011
[Presentation] 統合失調症における抗GABA受容体抗体および新規シナプス抗体の解析2020
- Author(s)
  塩飽裕紀, 中野悠里, 髙橋英彦
- Organizer
  NPBPPP2020 合同年会（第42回日本生物学的精神医学会年会・第50回日本神経精神薬理学会年会・第4回日本精神薬学会総会）
- Data Source
  KAKENHI-PROJECT-19K08011
[Presentation] Effect of Tandospirone, a Partial Agonist of the 5-HT1A Receptor, in a Patient With Chronic Poststroke Emotional Incontinence With Anxiousness.2019
- Author(s)
  Hiroki Shiwaku, Yuri Nakano, Hidehiko Takahashi
- Organizer
  Australasian Neuroscience society annual scientific meeting 2019.12.04 Aderaide
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16367
[Presentation] Detection of autoantibodies against GABAARα1 in patients with schizophrenia.2019
- Author(s)
  Hiroki Shiwaku, Yuri Nakano, Hidehiko Takahashi
- Organizer
  Australasian Neuroscience society annual scientific meeting 2019.12.04 Aderaide
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08011
[Presentation] ドネペジルにより精神病症状を伴う重症うつ病エピソードが誘発された1例2018
- Author(s)
  塩飽裕紀、田村赳紘、治徳大介、車地暁生、西川徹
- Organizer
  第114回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16367
[Presentation] ROSS 症候群における片側の脱力発作と脳幹の新規アセチルコリン病態2017
- Author(s)
  塩飽裕紀、西川徹
- Organizer
  第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-17K16367
[Presentation] ROSS症候群における中枢神経系のアセチルコリン病態と精神症状2017
- Author(s)
  塩飽裕紀、西川徹
- Organizer
  第8回 CBIRシンポジウム
- Place of Presentation
  東京医科歯科大学（東京都、文京区）
- Year and Date
  2017-02-11
- Data Source
  KAKENHI-PROJECT-15K19714
[Presentation] CBIR若手シンポジウム2016
- Author(s)
  塩飽裕紀、西川徹
- Organizer
  統合失調症のprimary cilia 病態の解析
- Place of Presentation
  東京医科歯科大学(東京都文京区)
- Year and Date
  2016-02-20
- Data Source
  KAKENHI-PROJECT-15K19714
[Presentation] 統合失調症におけるGABA神経細胞に蓄積するDNAダメージ2016
- Author(s)
  塩飽裕紀、西川徹
- Organizer
  第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
- Place of Presentation
  福岡国際会議場（福岡県、福岡市）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-15K19714
[Presentation] 第37回日本生物学的精神医学会2015
- Author(s)
  塩飽裕紀、西川徹
- Organizer
  統合失調症のprimary cilia 病態の解析
- Place of Presentation
  タワーホール船堀(東京都江戸川区)
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-15K19714
[]

1. TATEISHI Ukihide

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 高橋英彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 垂水良介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shiwaku Hiroki 塩飽 裕紀

Hiroki Shiwaku 塩飽 裕紀

Research Projects

Research Products

Co-Researchers

統合失調症の新規リン酸化分子の探索と病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規自己抗体が形成する進行性・難治性精神疾患のシナプス病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the Pathogenesis of Novel Autoantibodies Targeting Synaptic Molecules in Psychiatric DisordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intranuclear molecular pathology of schizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of primary cilia pathology in schizophreniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Anti-rods/rings autoantibodies in a patient with pancreatic injury2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dopamine dysfunction in depression: application of texture analysis to dopamine transporter single-photon emission computed tomography imaging2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Factors affecting mental illness and social stress in hospital workers treating COVID-19: Paradoxical distress during pandemic era2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel brief screening scale, Tokyo Metropolitan Distress Scale for Pandemic (TMDP), for assessing mental and social stress of medical personnel in COVID-19 pandemic2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of autoantibodies against GABAARα1 in patients with schizophrenia.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression.2020

Author(s)

Journal Title

DOI

Data Source

Shiwaku Hiroki 塩飽裕紀

Hiroki Shiwaku 塩飽裕紀